Eman045590.1
Basic Information
- Insect
- Ephialtes manifestator
- Gene Symbol
- Poxn
- Assembly
- GCA_963970395.1
- Location
- OZ019982.1:16981592-16995963[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 7.8e-14 3.9e-10 41.2 0.0 88 125 2 39 1 39 0.97 2 2 1.5 7.4e+03 -1.7 0.0 38 67 266 295 234 300 0.62
Sequence Information
- Coding Sequence
- ATGAAGCAAGAGCAACCGACGATGTTTGCTTGGGAGATAAGAGAGCAATTGGCGAGACAAGGTGCCTGCGATCCTCAGAGCTTACCGTCCGTTTCATCGGTCAATCGAATCCTGAGGGGCAACGGCTTGCATACGGATCATCCGGCAATGGAACCCGGCTCGACAACCGCCTATCAATCTCACGTTCCCACAAATTCCGAAGCGAGagAAGCTCTGATGAGGACAGACTACCAACTATTTTATCCTGGAGCTTTAGGACCCCTTCACATATCAACGGGCTCAAGTGGTTCAGGCGCACCTACGTGGAATCCAAGTGGCTTCTACTCGTCCCTCTATCAGGCGACCACCTTGCACTTGCACCATGGAATGCAGGCATTCACatcttTAGATACCGAACGTCTTTCGGAGCAACAAAACGGTCAGGCTCAGGTGGAACTAAAATCCAGCTCGAGTTCCATGGCTGGAAGTGACGATTCTCTGGACAAGAGTGACCTCGACGATAACAACGAGTCCCAAGATAATTACAAGTCCTTTCAGAGCTCACCGATTATTTTGGAACTCGGTCAAAAAATCGGCAGCGATCGAAGCGCCTTCGTCAGACACGGGACTCCAAATCCCGGTGGAAATTTTGACAATTCTCGAGGCAGTCCAACAAGCTCAACGGTTGTCGAGGATTCAACCAGTCAGAATTCTAACAGTCAAAGAAtatccgaaaattcgaacgagCGCAGCTCGATCGATTTAGCTGCGATCGAAAATCGACAGCCCCAGCCACAGAGAAAAAGAAATCCGTACTCCATAGAAGAATTGCTTAAAAAAGACGAGACTAAGGTTGTTGTTAAGAGGCCCAGACTCGTCAATACTGGAATCGTTCAACCACGTGGTATTGTTGTTGGCAAGGAATTgttataa
- Protein Sequence
- MKQEQPTMFAWEIREQLARQGACDPQSLPSVSSVNRILRGNGLHTDHPAMEPGSTTAYQSHVPTNSEAREALMRTDYQLFYPGALGPLHISTGSSGSGAPTWNPSGFYSSLYQATTLHLHHGMQAFTSLDTERLSEQQNGQAQVELKSSSSSMAGSDDSLDKSDLDDNNESQDNYKSFQSSPIILELGQKIGSDRSAFVRHGTPNPGGNFDNSRGSPTSSTVVEDSTSQNSNSQRISENSNERSSIDLAAIENRQPQPQRKRNPYSIEELLKKDETKVVVKRPRLVNTGIVQPRGIVVGKELL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00905378; iTF_00057891; iTF_00059411; iTF_01364598; iTF_00721213; iTF_00058654; iTF_00397245; iTF_00841025; iTF_00398032;
- 90% Identity
- iTF_00057891; iTF_00905378; iTF_00059411; iTF_01364598; iTF_00721213; iTF_00058654; iTF_00397245; iTF_00841025; iTF_00398032;
- 80% Identity
- -