Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.0082 50 5.2 0.0 4 20 23 39 20 44 0.86

2 4 0.0085 51 5.1 0.0 4 20 53 69 50 75 0.85

3 4 0.0076 45 5.3 0.0 4 21 145 162 142 189 0.86

4 4 0.0041 24 6.1 0.0 6 20 207 221 202 224 0.85

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.0082	50	5.2	4	20	23	39	20	44	0.86
2	4	0.0085	51	5.1	4	20	53	69	50	75	0.85
3	4	0.0076	45	5.3	4	21	145	162	142	189	0.86
4	4	0.0041	24	6.1	6	20	207	221	202	224	0.85

Coding Sequence: ATGCTGGGCTGGCAGCAGACAGTATACCTGGCCACGGAGGTGACGGCCCCGCACACGGCCACCCCGAGCTCCAGCTGCAGGCGCCCCCTGCAGCTGGGCTGGCAGCAGACAGTATACCTGGCCACGGAGGTGACGGCCCCGCACACGGCCACCCCGAGCTCCAGCTGCAGGCGCCCCCTGCAGCTGGGCTGGCAGCAGACAGTATACTCTGGCCACGGAGGTGACGGCCCCGGCACACGGCCACCCCGAGCTCCAGCTGCAGGCGCCTCCCTGCAGTTGGCCATGGCAGAGAAGCAGCACCCGGGCCTGCTGGAGGTGACGGCCCCGCACACGCCACCCTCTGAGCTCCAGCTGCAGGCCTCCTGCAGCTGGGCTGGCAGCAGACAGTATACTCTGGCCACGGAGGTGACGGCCCCGCACACGGCCACCCCGAGCTCCAGCTGCAGGCGCCCCCTGCAGCTGGGCTGGCAGCAGACAGTATGCCTGGCCACGGAGAGCGGCCCCGCACACGGCCACCCCGAGCTCCAGCTGCAGGCGCCCCCTGCAGCTGGGCTGGCAGCAAGACGGTATACCTGGCCCACGGAGGTGACGGCCCCGCACACGGCCACCCCGGAGCTCCAGCTGCAGGCGCCCCTGCAGCTGGGCTGGCAACGAACGGTATACCTGGCCACGGAGTGA
Protein Sequence: MLGWQQTVYLATEVTAPHTATPSSSCRRPLQLGWQQTVYLATEVTAPHTATPSSSCRRPLQLGWQQTVYSGHGGDGPGTRPPRAPAAGASLQLAMAEKQHPGLLEVTAPHTPPSELQLQASCSWAGSRQYTLATEVTAPHTATPSSSCRRPLQLGWQQTVCLATESGPAHGHPELQLQAPPAAGLAARRYTWPTEVTAPHTATPELQLQAPLQLGWQRTVYLATE*

Sequence clustering based on sequence similarity using MMseqs2