Basic Information

Gene Symbol
Mbd2
Assembly
GCA_000507165.2
Location
KZ497831.1:249092-270278[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.1e-26 1.8e-22 78.7 0.1 2 73 4 70 3 74 0.92
2 2 0.0014 6.3 6.5 0.1 29 73 106 158 71 161 0.80

Sequence Information

Coding Sequence
atgtcAGTTGAGAGGAAAAAGTACGATTGCACGGCGCTGCCAAAAGGGTGGCAAAGAGAAGAAGTCATTAGAAAAACAGGTCTCTCTGCTGgcaaaattgatgtgtattattataGTCCCAGTGGGAAGAAATTTCGTAGCAAACCTCAGCTAGCACGATACATTGGAGATTCACTTGACCTCGCCACATTTGATTTCCGTACAGGTCGTATTAACAACATGTTGGTGCGCAAGAACAAGAAGCAGAAGGGAGCTCAATTCGATTATACCGAGGCAACACCACTCCGCCCTGATATGGCTCCTTCCAGCAGAGGCATGCGTAATGATGCATCTTTGGTTCCTCCTATTCGCCAGACTGCATCCATCTTTAAACAACCTGTCACAGTATACAAGACACAGGAGGGCAAAGTAAAATCTGACTACAAACATGGCTCTCAAGAGAAACCAAAACAATTGTTTTGGGAGAAACGTCTGGAAGGCTTGAAAGCGTGTGATCTGGATGGAGTAGAGTTCAACTCAATGGAACTGCCTCGAGGACTGAAACCAGTGGGACCTCACGTCTCTGAAGAAACCATCTTGCAGTCTGTAGCAACAGCACTGCATGTGTCGGCACAGCCAGTCACAGGTCAGACAGGTTCACGCTCCGCTCTGGACCGCAACCCAGGAGTTTTTCTTAACCCAGAACAACCTCTTGTACAGGCTGTGGCAGTAGCGGATGAAGATATACGTCGGCAAGAAGATCGTGTGATTGCTGCAAGAAAGAAGTTAGAAGAAGCTCTTAAAGTAGAGATGGGATCATTACCGGTAGTTATAAAATCCAAATGA
Protein Sequence
MSVERKKYDCTALPKGWQREEVIRKTGLSAGKIDVYYYSPSGKKFRSKPQLARYIGDSLDLATFDFRTGRINNMLVRKNKKQKGAQFDYTEATPLRPDMAPSSRGMRNDASLVPPIRQTASIFKQPVTVYKTQEGKVKSDYKHGSQEKPKQLFWEKRLEGLKACDLDGVEFNSMELPRGLKPVGPHVSEETILQSVATALHVSAQPVTGQTGSRSALDRNPGVFLNPEQPLVQAVAVADEDIRRQEDRVIAARKKLEEALKVEMGSLPVVIKSK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01348017;
90% Identity
iTF_01348017;
80% Identity
-