Edan016430.1
Basic Information
- Insect
- Ephemera danica
- Gene Symbol
- prd
- Assembly
- GCA_000507165.2
- Location
- KZ497873.1:1340537-1347083[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 1.4e-75 2.3e-72 240.8 1.2 1 125 18 142 18 142 0.99
Sequence Information
- Coding Sequence
- ATGATGCGTCCGTGCTTCACAGGATACCCTTTCCAagGTGCGTCTGTTTCAGGCCAAGGACGCGTGAACCAACTGGGTGGCGTGTTCATCAATGGACGTCCCTTGCCCAACCACATTCGTCTCAAGATTGTGGAGATGGCTGCTGCTGGCGTGAGGCCCTGCGTCATCTCGAGACAACTTCGTGTCTCTCATGGCTGTGTTTCCAAGATCCTCAACCGCTACCAGGAGACAGGGTCGATCAGGCCTGGTGTGATTGGCGGCTCTAAACCTCGCGTGGCGACCCCAGAGGTCGAGCGTAGAGTCGAGGATTATCGGCGAGAGAACCCAGGCATCTTCAGCTGGGAGATCAGAGATCGTTTGATCAAGGATGGAATTTGCGACCGCAGCAGCGCTCCTTCAGTCAGCGCCATTTCCAGGTTGCTCCGAGGTCGAGACGGAGACGATGACAAGAAGCTCAGCGACGGTGAGTGCTGTGAGTGCCAACCCCCTCCc
- Protein Sequence
- MMRPCFTGYPFQGASVSGQGRVNQLGGVFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVERRVEDYRRENPGIFSWEIRDRLIKDGICDRSSAPSVSAISRLLRGRDGDDDKKLSDGECCECQPPP
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00005416; iTF_00090360; iTF_00849765; iTF_00242136; iTF_01444729;
- 90% Identity
- iTF_01383558;
- 80% Identity
- -