Basic Information

Gene Symbol
-
Assembly
GCA_905220475.1
Location
HG992025.1:12282016-12291323[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 4 3.7e+02 2.6 1.2 1 23 54 77 54 77 0.94
2 20 0.13 12 7.2 6.5 1 23 84 107 84 107 0.98
3 20 2.4 2.3e+02 3.3 4.5 1 23 192 214 192 214 0.97
4 20 0.0016 0.15 13.2 1.0 2 23 220 241 219 241 0.97
5 20 2.1 1.9e+02 3.5 1.5 1 23 247 269 247 270 0.94
6 20 0.76 71 4.8 3.0 2 21 506 525 505 526 0.94
7 20 2.5 2.4e+02 3.2 0.6 1 23 624 646 624 646 0.81
8 20 0.52 49 5.4 0.4 2 23 781 802 780 802 0.96
9 20 0.025 2.4 9.5 0.8 3 23 883 903 882 903 0.98
10 20 0.03 2.8 9.3 0.5 1 23 911 933 911 933 0.97
11 20 0.089 8.4 7.8 3.6 1 23 973 995 973 995 0.95
12 20 0.00023 0.022 15.9 4.0 1 23 1003 1025 1003 1025 0.99
13 20 0.3 28 6.1 0.8 1 23 1188 1210 1188 1210 0.96
14 20 0.06 5.6 8.3 0.1 1 23 1216 1238 1216 1238 0.95
15 20 0.0077 0.73 11.1 1.6 1 23 1304 1326 1304 1326 0.95
16 20 0.014 1.3 10.3 0.9 1 23 1332 1354 1332 1354 0.95
17 20 0.0064 0.61 11.4 2.6 1 23 1444 1466 1444 1466 0.97
18 20 0.00016 0.015 16.4 1.4 1 23 1472 1494 1472 1494 0.99
19 20 0.3 29 6.1 2.0 1 23 1585 1607 1585 1607 0.96
20 20 0.0058 0.55 11.5 3.5 1 23 1618 1640 1618 1640 0.98

Sequence Information

Coding Sequence
ATGCTACAGCAGATGTCCTCGTCGCTGAGCGTGCAAGTCGGCGAGGTCATAGCTAACGCGCGTCCACACGAAGGCCGCCACTGTGTGGACGTCCTCTCGGAGGCCTCTTCCGACGCGGCTGAAGATTTTGAATTGCCGCATTGCAAGATAAGAAGGAACTATAGCTGTACGAAGTGCACGTTCTATACCCAGAACCCGCGCGCTTATCTCTTGCATACGCGCGACGTTCACTTTGGAAGATTTAAGATATACGAGTGTCAACATTGTTTGTATGCCTCGAGACACCACCAGAAGCTCCTGAGACATATGAAGATGGTACATACAGGATTACCCATGCCCTCGGCTTCGGCCACCAAAAGCGATGCAGAACCTCTTGTAAAAGCAGAGATAGAACCACCACCGCAAGCCCCTGCTAGTCCGGCTGATAGCATCGAGCGGATGGAAGACTTGCTAGAAGAAATAGAAGAATGCGAAGAAATACAGATAGACGACGAGGGCGAGGATCAATCCGAACGAATGGAAGACATTGATCCTAGAACTAATTTGTCCTCAGGAACCAAAAGAAACAAATTTTTCTCTTGTGACAAATGCAACTACGTTACCCATTTAAAGGCGAGATTCACGAAGCACGTCAAGTACCACTCGATGCCGATGATCAAGTGTACAATGTGCGACTTCCGCACTCCATACAAATGGAATTTAGATCGCCACATGAAAAATCACGGTGGGACCGGAATCTTCGTTTGTTCAAAGTGCACCTTCACTGCTGACATCAAGCAGAGTCTGACCGTACATGAAATGAATCATCACACACCGCCGGTGGGGCACTCCGTCGCAAGCCGGCGGCGCAACCGGGTGGGCGCTAGTGACTTGACGGCCGCCGACCCGATGGGCGCGCTGCTCCCCAAGGAGGAGGAAGGGAGCGGCGACTCGCACTCCTCACACTCGGCTTTGGACATCATGGGGTTACAATACGCCGAAAGAGACGTAGTCAGCTGCACCAGCGATTCTAATGATGCGAGTTCGTCGCACGCTGATACAAACAGAGACGGGTCCCACGACGCGCCCGGCCAACATTCGCCTAACTCATCGACCGACGACCCAAAGTCACAAAAACAAAGCAGGAAGGCCCCCCGGCCGATACCGCAACTCATCCCACTGAACGCATCAACTCCTAATCAAAAAACATCCGGCGAACCGCCGGCAAAGAAATTCAAAGAATCCACGAGCACAGAAGTTTTCGGGAAAATCGAAAACTTACCGGAAGACATAACTTTAATTCCCGTTAACAATATTCCAGCCAAAGAAACGATAGCGCGTAAGAAAAATAATTCATTTTTCGACAAGCTGAAAGAAAGGCTTTTAACTGAAACAGGTGAAGAAGGATCGTTAAAGTGCAAAAGCTGTGGTTTCGAAAGCAAATGTCTGTCGGAACATTCCGTACATGAGAAAAATTGCACTAATCAGTCCAACCGCATTTCGATGAACACGGCGCTTCCAAGCATGGGATCCACTCGTTGCCAAAACTGTAGACATAGATGTAAATCGAGCGCAGATTTATATGTGCATTTGCAGTCTTGTAAAAGGAAAGATAATGTCGCAAATGAACCCGCCTCAGATTCTAAATATAACAATCAAGCATCGACATCGCAGCTTGAAAAAGAAGCAGAACCACATCCTATGGAAAACGTTGTTTTTGTCTGGAATAACATCAATCAAGAATCCAACAAATTCGACAGACCTTTAGACATAAACATTAACGATGATTCAACTACTGCGGACCCGAATAGACATTATGACACTGAAATAGTTGATGACAATGAGAGCATGAATTTGTCACCGAACGGTTTAACGTATGGCAAGAGCGTTTATAAATGTCCAGATTGTAAATTCTGGGCAAGCACCGCATCGAGATTTCACGTACACATCGTTGGTCACTTGAATAAAAAACCATTTGAATGTTCACTATGCAAATATAAATCAAATTGGCGGTGGGATATCACCAAACACATAAAGTTGAAATCTGCTAGAGACCCGGAACACAACGACGCTAAGGTTCTAATGACAGATGAAACCGGCAGAAGAAACTACAGCAAGTACAACAAGTTTCTTGCAGTACCGGTTCCGGTTGAAGTAAACGAGACAGAGTTTCAATACATAGATCCGAATGCAGCGGCCGATTCGTCAATGGAAGTAGATGAACCATTCGGAAATGAGTCATCCGACATTTTGCACGTATCGTATGAGATGCAACCGCTGAACCTGCAGACTCAGCCTATTGATAACTATAACATAGACAGCAGGAATCAAGATGTTAAAAAACCTAAGAAAACATTGTGGAAATGCAAAAAATGCAATTACAAAGATCCATCAAAAGAAGCATTGCTGGAGCACGTCAGACAACACTCAAAGGAAGGCGGAGCGGAAGACCTGCCTCATAGTAACAACAAGAAACTCGAGAACGCTCCCGATCCCGCAGACCTGGCATACCGCTGCGGACATTGCAACCAGCTTTCGAACTGGAAACATGTTATACAGAGACACTGCCGCTTGAAGCATGACGGCATCATCAAAGTCATCACTACAGTGAAGATTAAACCGGATCCGAGTCTTGTGCCAGGCAGTGAAGGATCATACAGCGATCTTTGTACTAAGTGTCCATATAAAGCCAATGATAAAAAGCAGCTCCAGGAACATTTGCAACAGCATCAACCGTCGCCAGATTCTATATTCAAGTGCTACTTTTGTCCTTACTTTGTTAGAGATGAACAGGATTTGATACAGCATCTTCTGTTACATGGAATAACCGACCCCGAAGATTATATTTCTAAAGCCATGGGTTGTAGGTCACCATTACCGGACCGAATTTTGACCAACGCAGAAATACCGCCCCCATCCAGTAGTGCGACAAAGCGTCACAAGTGTACTGAATGCCCTTACGAAACAAACAGCAAATCTCAATTCATGTATCACGAACAATTCCACCGGCTTCCGGCAGATACTCCATACAAATGTCCAGAATGTAATTATAGCGTTTCGAAGAGACATTTGCTTCACCAGCATCTGAGAGTACATGGAATTCATCCCTCAACCGATCGCAAGAAACATGAGTCGGAAGCAGACCTGGAAGCCAATACGCCGGATCAAAACAAACCAGACTATAAATCAGACGTTCCTGACGAAATACCATTTGTATGGGTTTCAGCGAGAAATGAATTCCACAAAATGTACAAGTGTCGCTTTTGCTCTTATGTAAACTCTCAAAAATGTAAACTACCTAACCATGAAAAAATCCATTGTCTTGAGTTTGAGAACAGCGACGTTATCATTTACAAATGTTTAGAGTGTAAATTCACCTGTGATGACCCAGAAAAAGGGGCAGAACATTCCAAAAAGCATGGCCTGTTGTACGGTCGCATCTACAGTTATGTGGAAAATGATATTCCAGACGAAGAACAAATCTCTAAATTACGTAGAGTGATTGAACAAGAAAAGGCTTTGGAAGAATCTACAAAGGAGGACGGCGCCATAGCTGATCTACTATCTGAAAGTAAAATTATGTACTATTGCCAGAAATGTCCTGCCAATTATTTCAATGAAAGTGAAATTAAAGTACATGAAAAGTTCCATGATCTTGCTTTGGAATATAAATGTGGAATCTGTAAATTCTCGGTTTCGGAAGAAAATGAGCTGACTGCTCACTCGGTTATGCATTCAGATGATTACCATATTAGAACAAACATGTATAAATTTTTACACAACTACCACTCCCTTTACAAACCACCTCGCCTGGAATGTAGCCGCGATCCGGATTCTTCGGAAATTACGTGGATAGCAATAGCAAACAAACCCATCGAACACACTGAGCCAGTACAGAAAAAAACAGAATATAAACACACACCAAAGCAATATCACTGCAAAGAATGTCCTGCCAAATTCTTCAAGAGTTCTGCACTCTCATATCACATGGGGTTACATGGCGGTGAAGGGGAACATAAATGTAAAAAATGTACATATGCTGTCAAAAATGTTGGTAATTTAGCCAAACATGAAATATTGCACGAAATTGAAAATAAACCGACCGGTTGTGATTATGACTCGGGTGAAGATTTGGATTACAAAAATATTCCACTGTCTGGTACAGATTTGTTCCAAAGAAAGACTGAAGCTCTGAAAAGGGTACTGATTGACAAAGATAAGTTAGTCAAACCAAATGATCACTTTCCGCCTGTCCTACAAGCCGATCCGCAGTTTGGGTACCTTATGCATGGTAATCCAGAATTTATCTACCCAACATACTTGAAAAATGGGCGTCAAAAGGAGAAACGGTACAAATGCCACAAGTGCCCGTCCGCTTTCGAAAAGAGAGAACAGTATAAGATCCATTTATCACTTCACGGCTCTAAACAAAGATATAAGTGCGAGCTGTGCGATTACTCTGTTAAGTATTACGCAAATTACGTTCAGCATATGAGGAAACACCAAATGAATGATGAAGCTCTAGCTGAGAGGAAGAAAGGCAGTAATGACATTGCTGAACCTGATAGTCAGGATGTAAAACTAGACGATAGCGGGGATAACATCAAATTAGCCATCAAAACGATGCCCAAAGGCGCGCCTAAGACCGATTTTCAACAATTTTCAATTAGAGACCAGCAGACTCTGAGGCTTTTGCAGCGGAGAAGATCTATGAACGCTGGTGGAAAGGACGCCTGCTCCACTGAAGCTTCGCCAGCGAAAGAACGCAAGTTACACATGTGTCTACTCTGCCCGTACACCAACCAGCGACAAGACGCTCTGAACAATCACTACAGGAGACACGATGCCGGCGATATAGTCAATATTGGAAACCATAAATGCTCCTACTGCGATTTAGTCGTCGTTCAATCACATTTTCTACGTGACCATTTGAAATCTCATTTCAGTTATCACAAAACTCTGACTCCTGAATGTTTCGTAGCTAATGAAAACGTGACTTTCACTATCAGTAAACTGGACGAAGAAAGCGAACCTCTCGATCTCAAATTGGACGTGAAAAGCAAAATTGTGTTTGATGAAGAAAGAATATTTGTAAATATTAAAACTGGCGAATTAATAGTAGAATAG
Protein Sequence
MLQQMSSSLSVQVGEVIANARPHEGRHCVDVLSEASSDAAEDFELPHCKIRRNYSCTKCTFYTQNPRAYLLHTRDVHFGRFKIYECQHCLYASRHHQKLLRHMKMVHTGLPMPSASATKSDAEPLVKAEIEPPPQAPASPADSIERMEDLLEEIEECEEIQIDDEGEDQSERMEDIDPRTNLSSGTKRNKFFSCDKCNYVTHLKARFTKHVKYHSMPMIKCTMCDFRTPYKWNLDRHMKNHGGTGIFVCSKCTFTADIKQSLTVHEMNHHTPPVGHSVASRRRNRVGASDLTAADPMGALLPKEEEGSGDSHSSHSALDIMGLQYAERDVVSCTSDSNDASSSHADTNRDGSHDAPGQHSPNSSTDDPKSQKQSRKAPRPIPQLIPLNASTPNQKTSGEPPAKKFKESTSTEVFGKIENLPEDITLIPVNNIPAKETIARKKNNSFFDKLKERLLTETGEEGSLKCKSCGFESKCLSEHSVHEKNCTNQSNRISMNTALPSMGSTRCQNCRHRCKSSADLYVHLQSCKRKDNVANEPASDSKYNNQASTSQLEKEAEPHPMENVVFVWNNINQESNKFDRPLDININDDSTTADPNRHYDTEIVDDNESMNLSPNGLTYGKSVYKCPDCKFWASTASRFHVHIVGHLNKKPFECSLCKYKSNWRWDITKHIKLKSARDPEHNDAKVLMTDETGRRNYSKYNKFLAVPVPVEVNETEFQYIDPNAAADSSMEVDEPFGNESSDILHVSYEMQPLNLQTQPIDNYNIDSRNQDVKKPKKTLWKCKKCNYKDPSKEALLEHVRQHSKEGGAEDLPHSNNKKLENAPDPADLAYRCGHCNQLSNWKHVIQRHCRLKHDGIIKVITTVKIKPDPSLVPGSEGSYSDLCTKCPYKANDKKQLQEHLQQHQPSPDSIFKCYFCPYFVRDEQDLIQHLLLHGITDPEDYISKAMGCRSPLPDRILTNAEIPPPSSSATKRHKCTECPYETNSKSQFMYHEQFHRLPADTPYKCPECNYSVSKRHLLHQHLRVHGIHPSTDRKKHESEADLEANTPDQNKPDYKSDVPDEIPFVWVSARNEFHKMYKCRFCSYVNSQKCKLPNHEKIHCLEFENSDVIIYKCLECKFTCDDPEKGAEHSKKHGLLYGRIYSYVENDIPDEEQISKLRRVIEQEKALEESTKEDGAIADLLSESKIMYYCQKCPANYFNESEIKVHEKFHDLALEYKCGICKFSVSEENELTAHSVMHSDDYHIRTNMYKFLHNYHSLYKPPRLECSRDPDSSEITWIAIANKPIEHTEPVQKKTEYKHTPKQYHCKECPAKFFKSSALSYHMGLHGGEGEHKCKKCTYAVKNVGNLAKHEILHEIENKPTGCDYDSGEDLDYKNIPLSGTDLFQRKTEALKRVLIDKDKLVKPNDHFPPVLQADPQFGYLMHGNPEFIYPTYLKNGRQKEKRYKCHKCPSAFEKREQYKIHLSLHGSKQRYKCELCDYSVKYYANYVQHMRKHQMNDEALAERKKGSNDIAEPDSQDVKLDDSGDNIKLAIKTMPKGAPKTDFQQFSIRDQQTLRLLQRRRSMNAGGKDACSTEASPAKERKLHMCLLCPYTNQRQDALNNHYRRHDAGDIVNIGNHKCSYCDLVVVQSHFLRDHLKSHFSYHKTLTPECFVANENVTFTISKLDEESEPLDLKLDVKSKIVFDEERIFVNIKTGELIVE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00927143;
90% Identity
iTF_00649631;
80% Identity
-