Basic Information

Gene Symbol
L
Assembly
GCA_905220475.1
Location
HG992024.1:9852354-9861126[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.58 54 5.2 5.8 1 23 103 125 103 125 0.97
2 16 7.7e-06 0.00073 20.6 4.1 1 23 131 153 131 153 0.99
3 16 2.4e-05 0.0023 19.0 0.1 1 23 159 181 159 181 0.98
4 16 7.4e-06 0.0007 20.6 0.0 2 23 197 219 196 219 0.96
5 16 2.5 2.4e+02 3.2 0.2 3 23 243 265 241 265 0.79
6 16 0.28 26 6.2 0.0 3 23 315 335 314 335 0.97
7 16 0.15 14 7.0 0.0 3 23 350 370 349 370 0.91
8 16 0.00076 0.072 14.3 0.3 1 23 378 401 378 401 0.94
9 16 0.03 2.8 9.3 0.1 1 23 406 429 406 429 0.92
10 16 0.042 3.9 8.8 0.5 1 23 483 507 483 508 0.93
11 16 0.00091 0.086 14.0 0.0 2 23 563 584 562 584 0.96
12 16 0.053 5 8.5 0.0 1 23 592 614 592 614 0.97
13 16 2.7 2.6e+02 3.1 0.5 2 23 622 643 621 644 0.92
14 16 0.8 75 4.8 0.3 1 23 718 740 718 740 0.94
15 16 0.0032 0.3 12.3 0.1 1 20 748 767 748 770 0.95
16 16 0.14 13 7.2 0.3 1 23 777 799 777 799 0.94

Sequence Information

Coding Sequence
ATGCAGCGTCGTGGCGGGAGCAGCACGGGGCGGCCCGCAAGGCTCCGCGTGCACCCAGGGGCCGAGCCCCCGCGGCGCTTGAGCGCGCCGAGCTTATTGAATTCTCGCACGAAGCACTACGATGACAAGAATCAATATTTTGCAAAATACACACACCCGTCCCGAAAGAGCTCGTTCATCAGCATTATCTATTTGCATTCACAGTGGGATTTTGAAAACAAATGCCGACGGCTGAGGTGGGCAGCTCACGCCGCCGCCGCAGCGGTAGTCTACCCATTGTTCGAAACGCACTCGGATCAGATGCCATTCCGCTGCGAGTTCTGCTCGCGGTTGTTCAAGCACAAACGGTCCCGGGATCGACACGTTAAACTGCACACCGGCGACCGCAAGTACCGATGCGCTCACTGCGAGTCCGCCTTCTCGAGGAGTGATCACCTGAAGATCCATATGAAGACTCATGATAACCAGAAACCGTTCCAATGTACGGTTTGCAACCGTGGATATAACACAGCCGCCGCGCTCACGTCACACATGCAGGGCCACAAACGGGAGAGGGAAGGTCGAGAGCCGGACAGAAGAAGAGCTTTACGATGTTTGAGATGTGGGGAGGCGTTTCGACGGCCTGATCTTTTACAGGCTCACATGGCAACAGCTCACGTGGTGGATGCAGCAGCATTAACTCCACCTCGGCGCGTGGCGTCGCAACCACCTCCGACCCTACTGGCCTGCATGTATTGCACTCGCGACACATTCACAAGCATGGAACAACTGCAATTACATGTACGGGCGGCTCACTCAGCCTTACTCAACGGAGAAGGTTCTCTGCCGAGCGTAGAGCAACCAGCGCCAACTGACCTCAGTCGAAGAGCATCCGACGATGTCCCAGCCAAGCGTCCGCGATCCGGAACGCCGCAGATTACGCTATCTCCTAACACGTTACTGTGTAATCAATGTGACGCTGCGTTGCCCGATTTTGAAGCCTTTCGTGCGCATTTAAAAGGACATTTGGAGGAGGGTGGAGAGTTGGCTCGCACGAGTCCGGCGCCGTGCGTGCACTGTGGAGCTACGTTTGCGGATGCAGCGGCGTCGGAACGTCACCTGACTGCACATTATCTGGCCGTATCCTGTGAATACACCTGTCATAGTTGTGCGAGAAGCTTTCCTGCACCAGATGACCTGCAAAAGCATTTGTTGGATCTTCACGCGCACCATCTTTATCGCTGCTCTTTGTGCAAGGAGATCTTCGACTCGAAAGTTGCTATCCAGGTCCATTTCGCGGTGGCACACAGCGGCGAGAGTAAAGTGTGGTTGTGCCGCGGCTGCGGGTCGAGCAGCGCCGGCACGCTGCGGTCCGAGGCGGAGGGTGCGGCGCACGTACGCGCGGCACACGGCGGCGCGCGCTGTGCGTGCGGCGCGCTTCTCGCCGGCCCGCGCCGTCCGCGAGCCTATCGCTGTCCCGTTCCCGCGTGTACGGATGCCTTTGCCGTACACTACCTGTTAGAACGGCACATGCAGATACACCACGCTCAACCACAGGTGTTAAATGGTCAGTTACCTCAACCAAAACGCGTAGAGAACAACAACGGAACAGATGCAGATGGTACCTGCTCGCCTTGCACGGAGGGTGGAGAGGGTGGTGCGGGGGGGACGGAGGAACGTCGACGGAAGAACGGCGCCGTTGCGTTACAGTGCGCCTACTGCGGCGAGCGGGCGAGGAGCCGAGCGGAGTTGGAGGCGCACACTCGGGCGCACTCTGGCGCCGCCACCGCGCGGCACAAGTGTCTCATCTGTGACGAAGTGTTGCCTTCTGCTGCTGTGCTGGCAGAACATAAGCTTACACATTGCAAGGTTGTGGCAGGCGACACATGTGCCCGATGTCGTGCTCGACTAGGCTCAGAGGAGTCGTTTCTGGCGCACATGGCGCGACACCACCCCGCGTTGCCGGCACCATGCGTAGTATGTCGCCAGACGCTCGCCTCCGAACCCGAGGCGAGGCTGCATGCGCGCTTCCACCTGCGCCCCAGCGAGGACGAGCAGAGGTGCGCGATCTGCCTCCGCGCGCTGTCGGAGAGCGAGGGCGGGTCAGGCGCGCGCGCGTGCACCGCGTGCTACGCTCGGCACGCTGCGCCGCGCGCGCCGCCGCCCGCCGACCACGACTGCCGCCTGTGTCGCCGCGCGCTCGGCTCACCTACTAGACTACAGGCGCACCTAATCGAGCACACATTCGCGGGCATCGGCGCATTCACGTGCTATCTCTGCTCAGCTGTGTTCACAAGCGCCGCCGGATTACAGCGTCACCTTCCAGAACATTCCAGCGCGCCGCGCCCTTACGACTGCGCGCGTTGCGGACTTAAATTCTTCTTCCGAGCAGAGTTAGACAACCACGCGTTTGTGCATCTAGAAGAAGCAGAGATAGCCCAGCGAGCATTCTACGAAGCTTATGCTAGAGGTGCGGCGACAGCATGGGCGGCATTGGCTCCGCCTGAGCCGAGACCACCTTCTAATACAATAAAACAAGAGCCGGAGGTAAAAGAAGAGCGGACTGACGAGTACATCGAGGTGGGATCACCTCCACCCCCTGCGCCTCCTGTTATGGAATCTCCTCCCGTGGTTAAGCAAGAGAAACCCGATGAGGATTGA
Protein Sequence
MQRRGGSSTGRPARLRVHPGAEPPRRLSAPSLLNSRTKHYDDKNQYFAKYTHPSRKSSFISIIYLHSQWDFENKCRRLRWAAHAAAAAVVYPLFETHSDQMPFRCEFCSRLFKHKRSRDRHVKLHTGDRKYRCAHCESAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQGHKREREGREPDRRRALRCLRCGEAFRRPDLLQAHMATAHVVDAAALTPPRRVASQPPPTLLACMYCTRDTFTSMEQLQLHVRAAHSALLNGEGSLPSVEQPAPTDLSRRASDDVPAKRPRSGTPQITLSPNTLLCNQCDAALPDFEAFRAHLKGHLEEGGELARTSPAPCVHCGATFADAAASERHLTAHYLAVSCEYTCHSCARSFPAPDDLQKHLLDLHAHHLYRCSLCKEIFDSKVAIQVHFAVAHSGESKVWLCRGCGSSSAGTLRSEAEGAAHVRAAHGGARCACGALLAGPRRPRAYRCPVPACTDAFAVHYLLERHMQIHHAQPQVLNGQLPQPKRVENNNGTDADGTCSPCTEGGEGGAGGTEERRRKNGAVALQCAYCGERARSRAELEAHTRAHSGAATARHKCLICDEVLPSAAVLAEHKLTHCKVVAGDTCARCRARLGSEESFLAHMARHHPALPAPCVVCRQTLASEPEARLHARFHLRPSEDEQRCAICLRALSESEGGSGARACTACYARHAAPRAPPPADHDCRLCRRALGSPTRLQAHLIEHTFAGIGAFTCYLCSAVFTSAAGLQRHLPEHSSAPRPYDCARCGLKFFFRAELDNHAFVHLEEAEIAQRAFYEAYARGAATAWAALAPPEPRPPSNTIKQEPEVKEERTDEYIEVGSPPPPAPPVMESPPVVKQEKPDED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00635642;
90% Identity
iTF_00926852;
80% Identity
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