Basic Information

Gene Symbol
KLHL10
Assembly
GCA_963580505.1
Location
OY756982.1:11384968-11394444[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.2e-25 4.4e-23 82.4 0.1 2 106 27 130 26 133 0.93

Sequence Information

Coding Sequence
ATGGAAAACGACCCGAATAACACTACGGCGGGTCGCGAGACGGGACGGTGCATGTCGGTGGCGGCGATGCAGGCGCTGCACCGGCTGCGCGAGTGCCGGCTGCTTTGCGACGCGATCGTGCGCGCAGACGACGGCGCCGCCTTCCCCGTGCACCGCGCCATCCTCTCAGCCTGTAGTCCATACTTCCTGGCATTATTTACAACAACATTGCACTCGCGAGAGCAAAGCGATGTCTTAATATCGGGAGTGCGGTCGGAAATCCTGCTGCTTCTGATAGAATACGCGTACCTTCGGCGCATCGATGTAACCGATACAAACGTGCACGAGCTGCTGATGACCGCTGACTACCTCGCATTTCTCGGCGTGTTGCAGCTCTGCTGTGATCATCTACGTATCGCATTAAACCCAAAAAACTGCCTCGGTATAATGATGTTTGCAAGGCGTGTATTTTGCTACAAGCTCGAAGCGGACGCTCGCCGATACTTGCTGCGGTATTTTGTGACGGTAGCAACTCAGAGCGATGAGTTTCTTCACTTGCCACTTGATGAGCTGAATTCTATTATTCTGGAAGACGAACTTAATGTGAAGAGTGAGGAAGCGGTCTGGGAAGCTGTGTTACGTTGGGTGAATTACGACCCTGATGCTCGCTGGCAGCACACCGTCAAACTGATGGGCAGTATTCGCCTAGGCCTGCTAGATACTCAGTTCTTCCTAGAAAACGTCAAGGATCATCCATACGTCACCGGCAATGAAGGTTCTCGTCCAATTATAATCGAAACCCTGAAGTTTCTGTACGACCTAGAAATGATTGCCCAAAGGGACGGTGAAGTGGCTACACCGGAAATCGCTAGGCCGAGAGTACCTCACGAGGTTCTATTTGCGATTGGAGGATGGAGTGGTGGTTCACCGACGGCCTTTATTGAAACCTATGACACTAGAGCTGATCGTTGGATTAAAGTAGAAGAAGTGGATCCAGCTGGACCTCGGGCGTACCATGGAACAGCTGTGCTGGGCTACTGCATCTACGTTATTGGAGGTTTTGATGGAATGGACTATTTCAACTCGTGCCGATGCTTTGACGCCGTAACTAAAACTTGGCGCGAGGTGGCGCCAATGAATGCAAGACGTTGTTATGTGTCAGTAGCTGTGCTTGTAGAGACGATATACGCCATGGGAGGATACGATGGTCACCACCGTCAGAACACGGCCGAGAGATTTAACCATCGCACTAACCAGTGGTCTCTCGTTGCTCCTATGAATGCTCAGAGATCTGATGCTAGTGCTGCTGCTCTTGATAATAAAATCTACATCACGGGCGGCTTCAACGGCCAGGAGTGCATGAATAGTGTGGAGGTTTACGACCCTGACGCGAATCAGTGGACGACTCTCGCTCCCATGCGCTCCCGCCGCTCTGGCGTCTCTTGCATCGCTTACCACAACAAGATATACGTGATAGGCGGTTTCAATGGTATCTCAAGAATGTGCAGTGGAGAAGTATACGACCCTGCCACCAACACCTGGTCTCCAGTACCTGACATGTACAACCCACGCAGTAACTTTGCTATAGAAGTCATCGACGACATGATATTCGCGATCGGAGGGTTCAACGGCGTCACCACCATCTACCATGTCGAGTGCTATGATGAGAGGACTAATGAGTGGTACGAAGCAACAGACATGAACATCTACCGGTCCGCTCTATCCGCCTGCGTCATCATGGGTTTGCCTAACGTGTATGACTACATCCACAAGCATCGGGAGCGGCTCATGGAGGAGAAGCGTCAGAAGATCCTGCTCTCGGAGACGGCGCGCCATGGCCAGCATCGAACGGCTTTACCCGACGTCCACCTGATGGAGGACAATGACGACATGTTGGAGCAGCTGGGGCTGATGGAGAACCCTGGCCTGAACAACgaggcgccgccgccgccaccgccaccgccaccGCTGCCTGTGCAGGAACCGATGGAACAGGATTAG
Protein Sequence
MENDPNNTTAGRETGRCMSVAAMQALHRLRECRLLCDAIVRADDGAAFPVHRAILSACSPYFLALFTTTLHSREQSDVLISGVRSEILLLLIEYAYLRRIDVTDTNVHELLMTADYLAFLGVLQLCCDHLRIALNPKNCLGIMMFARRVFCYKLEADARRYLLRYFVTVATQSDEFLHLPLDELNSIILEDELNVKSEEAVWEAVLRWVNYDPDARWQHTVKLMGSIRLGLLDTQFFLENVKDHPYVTGNEGSRPIIIETLKFLYDLEMIAQRDGEVATPEIARPRVPHEVLFAIGGWSGGSPTAFIETYDTRADRWIKVEEVDPAGPRAYHGTAVLGYCIYVIGGFDGMDYFNSCRCFDAVTKTWREVAPMNARRCYVSVAVLVETIYAMGGYDGHHRQNTAERFNHRTNQWSLVAPMNAQRSDASAAALDNKIYITGGFNGQECMNSVEVYDPDANQWTTLAPMRSRRSGVSCIAYHNKIYVIGGFNGISRMCSGEVYDPATNTWSPVPDMYNPRSNFAIEVIDDMIFAIGGFNGVTTIYHVECYDERTNEWYEATDMNIYRSALSACVIMGLPNVYDYIHKHRERLMEEKRQKILLSETARHGQHRTALPDVHLMEDNDDMLEQLGLMENPGLNNEAPPPPPPPPPLPVQEPMEQD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00177319;
90% Identity
iTF_00157345; iTF_00318209; iTF_00689505; iTF_00926753; iTF_00207115; iTF_00347587; iTF_00447395; iTF_01487843; iTF_00720484; iTF_01220771; iTF_00640548; iTF_00146565; iTF_00651884; iTF_01302526; iTF_00724068; iTF_01204196; iTF_01206692; iTF_00878960; iTF_01203358; iTF_01205023; iTF_01341444; iTF_00034917; iTF_00010277; iTF_00114213; iTF_00449316; iTF_00112621; iTF_01316504; iTF_00365061; iTF_00667682; iTF_00408586; iTF_00752205; iTF_00836709; iTF_00874598; iTF_00875447; iTF_00876314; iTF_00889382; iTF_01115814; iTF_01495146; iTF_01495884; iTF_01496718; iTF_01176276; iTF_01494425; iTF_01156763; iTF_00197472; iTF_00276583; iTF_00837704; iTF_01146600; iTF_00144777; iTF_00027905; iTF_00195273; iTF_01509723; iTF_00235977; iTF_00345953; iTF_01076674; iTF_00033042; iTF_00206227; iTF_00236755; iTF_01337847; iTF_00033945; iTF_00666649; iTF_01490271; iTF_00257065; iTF_01222601; iTF_00357770; iTF_01562121; iTF_00358763; iTF_00931594; iTF_00077636; iTF_01444038; iTF_00932784; iTF_00390539; iTF_00143180; iTF_00925868; iTF_00786928; iTF_00824013; iTF_00281518; iTF_00825934; iTF_00942958; iTF_00149615; iTF_00148584; iTF_00213671; iTF_01544071; iTF_00791336; iTF_00953672; iTF_00204459; iTF_00773006; iTF_01545007; iTF_01543089; iTF_01546773; iTF_01561238; iTF_00149561; iTF_00148640; iTF_00835728; iTF_01193712; iTF_00771195; iTF_00419857; iTF_00041938; iTF_00290834; iTF_00429170; iTF_00650162; iTF_00913746; iTF_01279410; iTF_01441234; iTF_00180595; iTF_00411603; iTF_00383841; iTF_00712065; iTF_00844513; iTF_01209441; iTF_01402817; iTF_01538913; iTF_00634626; iTF_01031266; iTF_01440226; iTF_00050083; iTF_00300387; iTF_00302275; iTF_00342339; iTF_00462531; iTF_00726595; iTF_00806851; iTF_01064803; iTF_01251971; iTF_01260259; iTF_00017476; iTF_00375460; iTF_00622116; iTF_00622980; iTF_00637828; iTF_01118468; iTF_00445349; iTF_00922981; iTF_01135909; iTF_01464293; iTF_00208038; iTF_00908998; iTF_00994470; iTF_01148934; iTF_01463430; iTF_00155431; iTF_00177319; iTF_00656263; iTF_00951975; iTF_01083495; iTF_01173415; iTF_00037960; iTF_00412648; iTF_00810248; iTF_00855976; iTF_00968168; iTF_01071752; iTF_01141032; iTF_01221736; iTF_01534088; iTF_00124425; iTF_00758409; iTF_00958057; iTF_01153129; iTF_01155497; iTF_01503113; iTF_00289770; iTF_00907178; iTF_01073738; iTF_01172522; iTF_00041035; iTF_00355339; iTF_00906315; iTF_01280523; iTF_01340363; iTF_01569483; iTF_00147660; iTF_00185452; iTF_00237900; iTF_00319052; iTF_00680716; iTF_00859628; iTF_01143212; iTF_01385932; iTF_00284685; iTF_00928845; iTF_01166861; iTF_01547981; iTF_00009198; iTF_00150766; iTF_00674414; iTF_00831374; iTF_01246062; iTF_00000463; iTF_00250607; iTF_00279247; iTF_00410447; iTF_00658543; iTF_01180431; iTF_00042800; iTF_00709392; iTF_00745936; iTF_01063888; iTF_01094192; iTF_01149712; iTF_00012145; iTF_00178353; iTF_00325553; iTF_00448273; iTF_00783665; iTF_01144657; iTF_01337009; iTF_01416977; iTF_00374354; iTF_00411602; iTF_01492146; iTF_01140307; iTF_01502227; iTF_00026996; iTF_00055572; iTF_00071636; iTF_00654420; iTF_00785332; iTF_01095092; iTF_01358996; iTF_01363252; iTF_01387732; iTF_00321717; iTF_00364181; iTF_00701205; iTF_00784533; iTF_00871445; iTF_00924917; iTF_01388629; iTF_01436245; iTF_00001302; iTF_00007254; iTF_01021430; iTF_01092182; iTF_00409431; iTF_00428279; iTF_01093271; iTF_01152311; iTF_00022936; iTF_00273752; iTF_00467512; iTF_01192856; iTF_00382809; iTF_01010521; iTF_01179609; iTF_01532249; iTF_01533209; iTF_00173210; iTF_00301338; iTF_00341466; iTF_01075642; iTF_01133914; iTF_01134938; iTF_01368250; iTF_00008155; iTF_00261979; iTF_00275451; iTF_00683483; iTF_00809307; iTF_00822107; iTF_00888411; iTF_01535067; iTF_00043708; iTF_00120668; iTF_00122556; iTF_00156380; iTF_00274556; iTF_00660444; iTF_00908060; iTF_01084412; iTF_01161500; iTF_01336060; iTF_01360828; iTF_01403580; iTF_00040029; iTF_00044637; iTF_00075677; iTF_00121597; iTF_00446365; iTF_00685597; iTF_00772157; iTF_01141789; iTF_01281469; iTF_01335133; iTF_00018302; iTF_00468286; iTF_00736734; iTF_00823166; iTF_01029406; iTF_01147486; iTF_01208414; iTF_01285694; iTF_00123519; iTF_00790431; iTF_01062015; iTF_01085535; iTF_00787808; iTF_01072672; iTF_01142496; iTF_01377632; iTF_01437216; iTF_00659554; iTF_01081731; iTF_00006400; iTF_00657344; iTF_00282564; iTF_00441664; iTF_01026468; iTF_01028455; iTF_00828072; iTF_01099917; iTF_00356433; iTF_01027484; iTF_01452479; iTF_01430067; iTF_00820226; iTF_00819311; iTF_00858708; iTF_01416024; iTF_01124724; iTF_01125604; iTF_00249813; iTF_00818453; iTF_00761818; iTF_00834773; iTF_01183039; iTF_01219893; iTF_01504022; iTF_01062964; iTF_00035863; iTF_00074679; iTF_00662359; iTF_00632897; iTF_00811169; iTF_01171586; iTF_00361766; iTF_00267337; iTF_00663215; iTF_01529328; iTF_00635541; iTF_01429175; iTF_01170718; iTF_00715895; iTF_01545874; iTF_01453386; iTF_01451634; iTF_01401423; iTF_00125240; iTF_00686488; iTF_00856777; iTF_00119724; iTF_00737613; iTF_00377231; iTF_00638771; iTF_01528440; iTF_00699362; iTF_00696584; iTF_00702120; iTF_00698442; iTF_00705166; iTF_00704146; iTF_00706164; iTF_00697493; iTF_00700248; iTF_00703100; iTF_00432377; iTF_01041945; iTF_01332953; iTF_00198362; iTF_00948026; iTF_01507354; iTF_00850918; iTF_00973921; iTF_00682566; iTF_01508198; iTF_01078349; iTF_01079182; iTF_01080850; iTF_01117490; iTF_01230771; iTF_00425592; iTF_01506488; iTF_00851961; iTF_01080027; iTF_00450302; iTF_00681760; iTF_00072956; iTF_00187292; iTF_00406876; iTF_00833212; iTF_01202588; iTF_00076701; iTF_00827133; iTF_00163103; iTF_00430783; iTF_00909823; iTF_01020448;
80% Identity
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