Basic Information

Gene Symbol
POL
Assembly
GCA_949752835.1
Location
OX457089.1:36814057-36833501[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 0.0087 46 4.5 0.0 6 22 15 31 11 38 0.84
2 5 1.6 8.4e+03 -2.7 0.0 36 51 89 104 89 106 0.90
3 5 0.0054 28 5.2 0.0 5 22 262 279 260 285 0.85
4 5 0.00088 4.7 7.7 0.0 2 22 404 424 403 430 0.87
5 5 0.026 1.4e+02 3.0 0.0 8 22 562 576 560 582 0.84

Sequence Information

Coding Sequence
ATGTTTCACAACgggttcaataataataataattttaattaccagcAACAACCTCCGCTACCAACTGGATGGGATCGTCAATTTCATGATATGTCGAATGTGATTGCGGAACAACAAGGGAATGAACTGCGGGAGTTGCTCGCTAGGCAACAAATCGCGCCATCAGTACCACAGCCCCGGCATCAAATTCAAACAGCTGTCCGGTATGATTTACCGTCTACGCCACTGCCGCAATCGCCAGCAACTTCCGTACCATCCACTGGATATGCACCCAGACGGGATCGAGCTGAAAGTATTAGTGAGGatgaagaaattaattatagatCGCCGAAACCAGGGAATCGTAGAAATCCGGTAGCGAATTGGAAGATCCAGTTCGATGGTTCTGGAAAGGGGCTACCGTTACCGGAATTAATTTTCAGGGTGGAAACCTTAGCTCGTGGTGACCAATATCCAGTGGAGAGTCTTGTCCTGTCCATAAACCAACTCTTAAAAGGCAGGGCATACACATGGTACTGGCAGTTCATTCGGCGGAATCCACAGACAACTTGGTCCCTACTGAAAAAGGCGATAAAGGAGGAATTCGACGAAGGTGAAGAAGATGGGGACATCAACCGATTGATGGAAGCTCGGAAGCAGAGGTCGCGCGAGAAATTTTCGGATTTTAGGTTGGACATGGAGGGTCTGCGATTGCGTCTGAGACAGGAAATTTCGGACGATGATTTTCTGAACCGTCTCTTGTACAATTTGTATCCAGGCTATGAAAAGGCACTGATTTTGGAAAACGTGcAACAACCTCCGCTACCAACTGGATGGGATCGTCAGTTTCATGATATGTCGAATGTGATTGCGGAACAACAAGGGAATGAACTGCGGGAGTTGCTCGCTAGGCAACAAATCGCGCCATCAGCACCACAGCCCCGGCATCAAATTCAAACAGCTGTCCGGTATGATTTACTCGTGCAAGGAAATCGACCAATGCGAGAATTCATCACAGACATTGAAGGTCTGATTTCACGCATGACTGAATTGGAAGTTCAGCAACAAAGCGAAACGGCAAGACCAACATTAACAGCAGCGAATAACCGAAGGGGTTTAGCTTTTCTAAAAAAAGGAGTTAACGACAGGTACAAAATTGTGTTGGACTGTAATAGATATACAGAATTTAAGGAAGCCTGTAATCATCTACTTGAATTGGATCCAGGTACCGAAAGATCCAGCGAAcAACAACCTCCGCTACCAACTGGATGGGATCGTCAGTTTCATGATATGTCGAATGTGATTGCGGAACAACAAGGGAATGAACTGCGGGAGTTGCTCGCTAGGCAACAAATCGCGCTATCAGTACCACAGCCCCGGCATCAAATTCAAACAGCTGTCCGATCCCTAGAAATAAATGAGATAGAGCAAAGTAGTGAGAATACGCATAAATTAACTCTAGATAAAAAACAAACCTCACTGGAAATAATCGAGCTCTTTACATCCTACAGTGTGGCCGGGTTAGGTAAAACTAGCCTGTTGAAGCACGAAATCGATGTAGGTGATGCTAAGCCACAAGTTGTCCGTCCGTATCCTTTGTCTGTTCCAATGCAGAAAATCTTAGATGCTGAAATTgataaaatgttgaaagaaGATATAATAGAAGAGAGCAGAAGTGGATGGGCCTCGCCCTTGCTTATAcAACAACCTCCGCTACCAACTGGATGGGATCGTCAGTTTCATGATATGTCGAATGTGATTGCGGAACAACAAGGGAATGAACTGCGGGAGTTGCTCGCTAGGCAACAAATCGCGCTATCAGTACCACAGCCCCGGCATCAAATTCAAACAGCTGTCCGATCCCTAGAAATAAATGAGATAGAGCCAAGTAGTGAGAATACGCATAAATTAACTCTAGATAAAAAACAAACCTCACTGGAAATAATCGAGCTCTTTACATCCTACAGTGTGGCCGGGTTAGGTAAAACTAGCCTGTTGAAGCACGAAATCGATGTAGGTGATGCTAAGCCACAAGTTGTCCGTCCGTATCCTTTGTCTATTCCAATGCAGAAAATCTTAGATGCTGAAATTgataaaatgttgaaagaaGATATAATAGAAGATAGCAGAAGTGGATGGGCCTCGCCCTTGCTTATAGTGAAAAAGAACGGCACAATTAGACTGTGGCTAGACGCGAGAAAATTAAATGCAGTAACCAAGAGTGACGCGTATCCACTTCCGcatagaaattcaatttttagtacAGTTAAGGATACAAAATTCATTATCAGGCTCGACCTTAAAATGGCCTTCTGGCAAGTAGAGCTCGAAGAAGTCAAGAGACAAGACCGCATTCATAGTGCCAGGTCGTGGCCTattccaatttaa
Protein Sequence
MFHNGFNNNNNFNYQQQPPLPTGWDRQFHDMSNVIAEQQGNELRELLARQQIAPSVPQPRHQIQTAVRYDLPSTPLPQSPATSVPSTGYAPRRDRAESISEDEEINYRSPKPGNRRNPVANWKIQFDGSGKGLPLPELIFRVETLARGDQYPVESLVLSINQLLKGRAYTWYWQFIRRNPQTTWSLLKKAIKEEFDEGEEDGDINRLMEARKQRSREKFSDFRLDMEGLRLRLRQEISDDDFLNRLLYNLYPGYEKALILENVQQPPLPTGWDRQFHDMSNVIAEQQGNELRELLARQQIAPSAPQPRHQIQTAVRYDLLVQGNRPMREFITDIEGLISRMTELEVQQQSETARPTLTAANNRRGLAFLKKGVNDRYKIVLDCNRYTEFKEACNHLLELDPGTERSSEQQPPLPTGWDRQFHDMSNVIAEQQGNELRELLARQQIALSVPQPRHQIQTAVRSLEINEIEQSSENTHKLTLDKKQTSLEIIELFTSYSVAGLGKTSLLKHEIDVGDAKPQVVRPYPLSVPMQKILDAEIDKMLKEDIIEESRSGWASPLLIQQPPLPTGWDRQFHDMSNVIAEQQGNELRELLARQQIALSVPQPRHQIQTAVRSLEINEIEPSSENTHKLTLDKKQTSLEIIELFTSYSVAGLGKTSLLKHEIDVGDAKPQVVRPYPLSIPMQKILDAEIDKMLKEDIIEDSRSGWASPLLIVKKNGTIRLWLDARKLNAVTKSDAYPLPHRNSIFSTVKDTKFIIRLDLKMAFWQVELEEVKRQDRIHSARSWPIPI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-