Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0015 17 6.6 0.1 22 45 114 137 111 141 0.91

2 5 0.0069 79 4.4 0.0 21 52 141 172 138 173 0.88

3 5 0.012 1.4e+02 3.6 0.1 21 48 169 196 167 200 0.85

4 5 2.4e-05 0.28 12.3 0.0 23 45 199 221 189 227 0.85

5 5 0.0078 90 4.2 0.0 19 44 222 247 221 253 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0015	17	6.6	0.1	22	45	114	137	111	141	0.91
2	5	0.0069	79	4.4	0.0	21	52	141	172	138	173	0.88
3	5	0.012	1.4e+02	3.6	0.1	21	48	169	196	167	200	0.85
4	5	2.4e-05	0.28	12.3	0.0	23	45	199	221	189	227	0.85
5	5	0.0078	90	4.2	0.0	19	44	222	247	221	253	0.89

Coding Sequence: ATGTCCGAGCAAATTATATTCGAGTATACAGAAACCGAAGAAGATGCAGATGAAGAGTATCAGTTCATGTCTTTTATGAAAGTCGCTGACAGCGCATTTATAGTAAACGGCCAGCATTTTTACAAAGCTGGAGAAGAAAATGTGTACCCAGATCCTTTATCATATCTCACTGGAAATGATTTAAAGCAGACATATGTGATTAAGACTGTACAACCACAGACCATTTTGGAAGAATGTTCAGAAAATGAAATTATTATACAAACTGCGATAAACGGTACAACTACTGAAGATATTGAGACAGATATAGAAGAAATAAGAGAAAACGTATTTATCGTAGGTGAACGACCATTCCATTGCCCTCATTGTGATAAGAAATTCTCTCAGAGAGCGAATATGCAGAAACATCTAGTAATCCATAACGAAGAACGGCCGTTTCAGTGTCTTACATGCGGACGTGGTTTTACACAGATGGCGAACCTTTCCAAGCATATGCGACTTCACACAGGCGAGAAGCCCTTTAGCTGCAAGTACTGCAACAAGTCGTTCGCCCAGCGTGCCAACATGCAGAAACATCAACATGTTCACGAAGGAATTAAACCATACACCTGCGATATATGTACAATGTCGTTTACGCAAATGAGCAATTTAAAAAAACATTTGCGACAGCACAATGACAAGCCATTCACTTGTGAAAACTGCAATAAAAAGTTCTTGCAAGAAGATAATTTATCGAAACATATGTTAAAATGTTCATGGTTTCGTGTAGAAAATGTTTTGGACCTTGGATCGGATAGCACTATACATTTTCTACATGCAGACGGAGATAGAAAGATATATTATATCTCTGAAGATAGTCCTGTTAAGATAGAAGCAGACATTATGGATGATGATCTTCAAGAACCTGAAGACGACTTTGAAGATGAGTTGGAATTAGATCAATCTAAGGAAGTATTATTGGCTAAAATTCTCTGCTAG
Protein Sequence: MSEQIIFEYTETEEDADEEYQFMSFMKVADSAFIVNGQHFYKAGEENVYPDPLSYLTGNDLKQTYVIKTVQPQTILEECSENEIIIQTAINGTTTEDIETDIEEIRENVFIVGERPFHCPHCDKKFSQRANMQKHLVIHNEERPFQCLTCGRGFTQMANLSKHMRLHTGEKPFSCKYCNKSFAQRANMQKHQHVHEGIKPYTCDICTMSFTQMSNLKKHLRQHNDKPFTCENCNKKFLQEDNLSKHMLKCSWFRVENVLDLGSDSTIHFLHADGDRKIYYISEDSPVKIEADIMDDDLQEPEDDFEDELELDQSKEVLLAKILC

Sequence clustering based on sequence similarity using MMseqs2