Esim004820.3
Basic Information
- Insect
- Elegia similella
- Gene Symbol
- FANCI
- Assembly
- GCA_947532085.1
- Location
- OX383934.1:6207096-6215301[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 6 0.098 2.9e+02 2.2 0.0 40 63 9 32 4 38 0.88 2 6 0.41 1.2e+03 0.2 0.0 39 63 46 70 37 77 0.85 3 6 0.032 95 3.8 0.0 38 64 111 137 105 172 0.91 4 6 0.028 84 3.9 0.0 38 64 177 203 163 241 0.90 5 6 0.036 1.1e+02 3.6 0.0 38 63 243 268 239 275 0.89 6 6 0.015 45 4.8 0.0 38 68 309 339 299 388 0.72
Sequence Information
- Coding Sequence
- ATGAGAATGATGCGGCGCTCAAAAACTAGAATACTTAAAGCCGCAGCATCATGCGTAGTAGCGATCCTAGAGAAGATATACGAAGCTTTCACTATAACCTCAGAAGAAAGTGAGGAAGATGAGAATGATGCGGCGCTCAAAAAAATACTTGAAGCCGCAGCATCATGCGTAGTAGCGATCCTAGAGAAGATATACGAAGCTTTAACTATAACCTCGGAAGACAGTGCAGAAGATGAGAATGATGCGGCGCTCAAAAAGTCAGTGGCCGCGCTGGGACAGTTAGCTGAAGTGTGCTTGCTCATACCTGGGCTATATTCCAGCGAGATGAACAGTGTAACTAGAATACTTAAAGCCGCAGCATCATGCGTAGTAGCGATCCTAGAGAAGATATACGAAGCTTTAACTATAACCTCGGAAGACAGTGCAGAAGATGAGAATGATGCGGCGCTCAAAAAGTCAGTGGCCGCGCTGGGACAGTTAGCTGAAGTGTGCTTGCTCATACCTGGGCTATATTCCAGCGAGATGAACAGTGTAACTAGAATACTTAAAGCCGCAGCATCATGCGTAGTAGCGATCCTAGAGAAGATATACGAAGCTTTAACTATAACCTCGGAAGACAGTGCAGAAGATGAGAATGATGCGGCGCTCAAAAAGTCAGTGGCCGCGCTGGGACAGTTAGCTGAAGTGTGCTTGCTCATACCTGGGCTATATTCCAGCGAGATGAACAGTGTAACTAGAATACTTAAAGCCGCAGCATCATGCGTAGTAGCGATCCTAGAGAAGATATACGAAGCTTTCACTATAACCTCAGAAGAAAGTGAGGAAGATGAGAATGATGCGGCGCTCAAAAAGTCAGTGGCCGCGCTGGGACAGCTAGCTGAAGTGTGCTTGCTCATACCTGGGCTATATTCCAGCGAGATGAACAGTGTAACTAGAATACTTAAAGCCGCAGCATCATGCGTAGTAGCGATCCTAGAGAAGATATACGAAGCTTTAACTATAACCTCGGAAGACAGTGCAGAAGATGAGAATGATGCGGCGCTCAAAAAGTCAGTGGCCGCGCTGGGACAGTTAGCTGAAGTGTGCTTGCTCATACCTGGGCTATATTCCAGCGAGATGAACAGTAAGATATACGAAGCTTTCACTATAACCTCAGAAGAAAGTGAGGAAGATGAGAATGATGCGGCGCTCAAAAAGTCAGTGGCCGCGCTGGGACAGCTAGCTGAAGTGTGCTTGCTCATACCTGGGTTATATTCCAGCGAGATGAACAGTGCCATAATCAAACTGGAGCAGTACATCCGGTCCAACAAACAAGACTGCCTGTCGCTGATCCCCGCATTACTAGCGGCCAGTTACCGCGAGCAGCAAGAAGCTGCTTTCTTGGATGAGCTCCTGACGAAGTTGTCAAGTAGTCTCGGCAGGATTGATGAAGAAGACACATCCGCCGGTGCCGATGAAACCACTGACTTCCCGAGCATCGACTCCAGGACGGGTCACACAGTCCTAAGCCACATCTGCTCACACTTAGCCGGTCGTATGAAATGCGTGGAGCATCTTATATTACGCGCCAAAGATTTGACGGTCGCTGCTTCATGCTCGCAGCAGAACAACCAGCAGAGAATCGATAGAGAGTTAAAAGAGCTATACAAGAGCATTATAATCCAACTATGTCAGCTCACAAGCTGGACGTCTCGCGTCTGCAAGCTCCGCTGCAGCGTTGGCAGTGGCACTGAGAAAGTTGTGGGCACTGCACTTAAACTATACACCGTGCTGGCTACACTCGCTAAGTGTATCACTGCTGAGATGGCGGTTTTAGTGAGGTTCGAACGCCTCCTAAAACTGTGCGGTAAAAAGCTATCGACCGTAACGGACAACCTCATCACCTATCTGGAAGCCTCACAACAGCAACAGACTGCAAGCAAAGTGCTCAAGGACACTAAGCTTATACCGCGGCTGGTGCTGCAGTGCGAACAGTTCAGCAAATTCGTTATACTACTGGCCAATAAGGGAAAGTTGAACTACCAGCAGTACCTGTCGCTGGGTACGGCGCGCGACTTCAGGATAAGAGCGCCCGTACTGCAGGAGGCGCTCCATGCCGCGGACCACAGGATCGAGGACACCAGCGACAACGAAGAACAAGTGGACATCAACGACGCCGAGACAGAAATTCTGGGGCGTCGCAGAAGTGTGTCCGACGCGAGCGATGATGACAGTCACACTAAGAGAAGGCGCGTGTCATGA
- Protein Sequence
- MRMMRRSKTRILKAAASCVVAILEKIYEAFTITSEESEEDENDAALKKILEAAASCVVAILEKIYEALTITSEDSAEDENDAALKKSVAALGQLAEVCLLIPGLYSSEMNSVTRILKAAASCVVAILEKIYEALTITSEDSAEDENDAALKKSVAALGQLAEVCLLIPGLYSSEMNSVTRILKAAASCVVAILEKIYEALTITSEDSAEDENDAALKKSVAALGQLAEVCLLIPGLYSSEMNSVTRILKAAASCVVAILEKIYEAFTITSEESEEDENDAALKKSVAALGQLAEVCLLIPGLYSSEMNSVTRILKAAASCVVAILEKIYEALTITSEDSAEDENDAALKKSVAALGQLAEVCLLIPGLYSSEMNSKIYEAFTITSEESEEDENDAALKKSVAALGQLAEVCLLIPGLYSSEMNSAIIKLEQYIRSNKQDCLSLIPALLAASYREQQEAAFLDELLTKLSSSLGRIDEEDTSAGADETTDFPSIDSRTGHTVLSHICSHLAGRMKCVEHLILRAKDLTVAASCSQQNNQQRIDRELKELYKSIIIQLCQLTSWTSRVCKLRCSVGSGTEKVVGTALKLYTVLATLAKCITAEMAVLVRFERLLKLCGKKLSTVTDNLITYLEASQQQQTASKVLKDTKLIPRLVLQCEQFSKFVILLANKGKLNYQQYLSLGTARDFRIRAPVLQEALHAADHRIEDTSDNEEQVDINDAETEILGRRRSVSDASDDDSHTKRRRVS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -