Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.35 7.9e+02 0.3 0.1 22 39 128 145 126 148 0.81

2 3 5.7e-10 1.3e-06 28.5 0.1 44 69 166 191 165 192 0.95

3 3 3 6.9e+03 -2.7 0.1 37 46 288 298 276 305 0.56

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.35	7.9e+02	0.3	0.1	22	39	128	145	126	148	0.81
2	3	5.7e-10	1.3e-06	28.5	0.1	44	69	166	191	165	192	0.95
3	3	3	6.9e+03	-2.7	0.1	37	46	288	298	276	305	0.56

Coding Sequence: TTTCATTTCTTTGAaagctttttttgtttgaaaactagAGACGGCTCCTCACGTCAAAATAatattcttctaccttcttggcGGACACTTGAAGTTGGTGGAGCAGTGTTTCGATTTTTAAGCTCCCAATACAATtatgtacaacgggcgaagccgtgCCGGACCGTTAGTCTAAAAGTGAATAGGACAAATATTTTTGAGGTTATGTTTACAAGATTAAGATTACCTGGATTTGGTCTGGACAGATGAGCTTTCAAAAGGTTTGGGTCGAGCAGagtcaaactctgcgaatgcatctataactttttagtggctttcgttgagtataaaaatttagttaaaaaattcattagtttagtcataaacttgaaaaaactttttgaaAACTCTACGCTGACGCATATCATTGCCATCGTTCTTGGAATCCTGTTTTGGTGAGTAATGTACTAATGAATTTGAAAGGAAATCTCTCTATCAAATAGTAGCAGTTGAAGTATTATACCATACTTGAGTAAAAGGTGGAAGAACGTTGAGCACTACTGTCCTAACTGTAGTAAATTTTTGGGCGTGTACGCTAGAAAGTCTATAATTTAGCAAATACGATATTGTAGTCATTTGAATTTCTCGAGATTATTGTATAATGTAAGGTGATAAAAAGCCAATCTGTACAACATCAATGGAGCAAGGAGCagtgaagagtaggtaggtacctaggtacttgAGAAAGCagctaaataaaacattaaaaattaattgtCAATGGGACTTTAACAAGTATGCCTTATACGTATTTGATGATTGACAGCATTGAattcgaAATGATTAATGACGATGATTATGACGAACAATGGTACCAGCTTAACTATGTCGGACCTATGTTCTTGTTATTTACCTCTGAACCATAGTCAATATTTCaacattaatgtatttttataaagtaaaacgGCGTAATGAGCCTGA
Protein Sequence: FHFFESFFCLKTRDGSSRQNNILLPSWRTLEVGGAVFRFLSSQYNYVQRAKPCRTVSLKVNRTNIFEVMFTRLRLPGFGLDR*AFKRFGSSRVKLCECIYNFLVAFVEYKNLVKKFISLVINLKKLFENSTLTHIIAIVLGILFW*VMY**I*KEISLSNSSS*SIIPYLSKRWKNVEHYCPNCSKFLGVYARKSII*QIRYCSHLNFSRLLYNVR**KANLYNINGARSSEE*VGT*VLEKAAK*NIKN*LSMGL*QVCLIRI**LTALNSK*LMTMIMTNNGTSLTMSDLCSCYLPLNHSQYFNINVFL*SKTA**A

Sequence clustering based on sequence similarity using MMseqs2