Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.033 1e+02 3.2 0.0 23 45 92 114 88 117 0.83

2 6 0.0019 5.7 7.2 0.2 18 44 115 141 111 149 0.86

3 6 0.0015 4.6 7.5 0.0 21 45 146 170 143 179 0.85

4 6 0.96 2.9e+03 -1.5 0.0 22 44 175 197 170 201 0.78

5 6 0.00034 1 9.5 0.0 21 44 202 225 194 230 0.84

6 6 0.0056 17 5.7 0.1 21 45 230 254 227 258 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.033	1e+02	3.2	0.0	23	45	92	114	88	117	0.83
2	6	0.0019	5.7	7.2	0.2	18	44	115	141	111	149	0.86
3	6	0.0015	4.6	7.5	0.0	21	45	146	170	143	179	0.85
4	6	0.96	2.9e+03	-1.5	0.0	22	44	175	197	170	201	0.78
5	6	0.00034	1	9.5	0.0	21	44	202	225	194	230	0.84
6	6	0.0056	17	5.7	0.1	21	45	230	254	227	258	0.91

Coding Sequence: ATGGCACCCGAATTACTAAATTCTAACTACAAAATGGACTCAATCTCGATAAGAGAAAAACCTGAAAAAGAAAAGCATTTGAACTCTTCAAGAAAGTCTAATTCTAACAAAAAGAACTTAAACCAAACTGGTTCAGATCATAATGTTACAACATCAACAACATATGTTATAACTACAGAGTCCGGCGAAATAGTGCATGCTTGCGAAACCTGTGGGTATACAACTACAAAGATTAGCAGTTTCAAACGTCACACAATGACACACACCGGACTGAAGCCTTACTCGTGTGATATCTGCGAATACACCACCAGCGAACAGGGGAACTTAAAAAAGCATGTGAGACGACACACAGGTGAAAAACCATACGAATGTAGTCAATGTAAATTCACTACGGCAGTTGCAGCTAACTTACGAAGGCATATGATGAATCATACTGGTGAAAAACCTTATCAATGCGATATTTGTGACTATACTACAAGCGAAACACATAAATTGAAAAGGCATCTAATGAAGCACACAGGCGATAAACCCCACAAATGCAACTTCTGTAAATTTAAAGCATCTATATCGAcccatttaaaaatacatttgagaACACACACAGGCGAAAAGCcatttaaatgtaatatatgTGATTATGCAACTATTGAGGCGCGTGGTTTAAAAAGACATATTTTGGTCCACACCGGTGAGAAGCCATATAAATGTACAATATGTGAATTTAAAGCGTCAGATCCGAGGCCGTTGAAGCGTCATATCAAAACACATACACAGGTAACACAGGTAAAGCATAAATGTGATTTTTGTGAATTTACAGCAGACATAATTAGCTTAGAAGAGCATAgaaaaacacatcaaaataataacaaaattgcAATGACAGCCAAACTTCAATAG
Protein Sequence: MAPELLNSNYKMDSISIREKPEKEKHLNSSRKSNSNKKNLNQTGSDHNVTTSTTYVITTESGEIVHACETCGYTTTKISSFKRHTMTHTGLKPYSCDICEYTTSEQGNLKKHVRRHTGEKPYECSQCKFTTAVAANLRRHMMNHTGEKPYQCDICDYTTSETHKLKRHLMKHTGDKPHKCNFCKFKASISTHLKIHLRTHTGEKPFKCNICDYATIEARGLKRHILVHTGEKPYKCTICEFKASDPRPLKRHIKTHTQVTQVKHKCDFCEFTADIISLEEHRKTHQNNNKIAMTAKLQ

Sequence clustering based on sequence similarity using MMseqs2