Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.027 82 3.5 0.0 23 45 7 29 4 33 0.82

2 7 0.0013 4 7.7 0.1 17 44 29 56 21 60 0.87

3 7 0.0012 3.7 7.8 0.0 21 45 61 85 57 94 0.85

4 7 0.79 2.4e+03 -1.2 0.0 22 44 90 112 86 116 0.79

5 7 0.00031 0.96 9.7 0.0 21 44 117 140 112 145 0.84

6 7 0.0047 14 5.9 0.1 21 45 145 169 142 173 0.91

7 7 0.0067 20 5.4 0.1 23 45 205 227 194 230 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.027	82	3.5	0.0	23	45	7	29	4	33	0.82
2	7	0.0013	4	7.7	0.1	17	44	29	56	21	60	0.87
3	7	0.0012	3.7	7.8	0.0	21	45	61	85	57	94	0.85
4	7	0.79	2.4e+03	-1.2	0.0	22	44	90	112	86	116	0.79
5	7	0.00031	0.96	9.7	0.0	21	44	117	140	112	145	0.84
6	7	0.0047	14	5.9	0.1	21	45	145	169	142	173	0.91
7	7	0.0067	20	5.4	0.1	23	45	205	227	194	230	0.87

Coding Sequence: ATGACACACACCGGACTGAAGCCTTACTCGTGTGATATCTGCGAATACACCACCAGCGAACAGGGGAACTTAAAAAAGCATGTGAGACGACACACAGGTGAAAAACCATACGAATGTAGTCAATGTAAATTCACTACGGCAGTTGCAGCTAACTTACGAAGGCATATGATGAATCATACTGGTGAAAAACCTTATCAATGCGATATTTGTGACTATACTACAAGCGAAACACATAAATTGAAAAGGCATCTAATGAAGCACACAGGCGATAAACCCCACAAATGCAACTTCTGTAATTTTAAAGCATCTATATCGAcccatttaaaaatacatttgagaACACACACAGGCGAAAAGCcatttaaatgtaatatatgTGATTATGCAACTATTGAGGCGCGTGGTTTAAAAAGACATATTTTGGTCCACACCGGTGAGAAGCCATATAAATGTACAATATGTGAATTTAAAGCGTCAGATCCGAGGCCGTTGAAGCGTCATATCAAAACACATATACAAGTAACACAGgttacttattttaaaagcaGAATATTCACATACATCACACTTTCTGTGCACCTGAAGCAGCATATGAGGACCCACACCAACGTGGCGCCCTTCCAGTGCGGGATCTGCGAGAAGAGGTTTAAGCAGAGCAGCCACCTGAACTACCACCTGAAGAACCACGACCCCAGCAACCTGTCTGCGGAGCAGCGCGCCGTGTACGAGCTGCTGGTGGGGCAGATCACGCGCGACCTGGCGGAGCCCGAGCCGCGGGACGTGGCCGAG
Protein Sequence: MTHTGLKPYSCDICEYTTSEQGNLKKHVRRHTGEKPYECSQCKFTTAVAANLRRHMMNHTGEKPYQCDICDYTTSETHKLKRHLMKHTGDKPHKCNFCNFKASISTHLKIHLRTHTGEKPFKCNICDYATIEARGLKRHILVHTGEKPYKCTICEFKASDPRPLKRHIKTHIQVTQVTYFKSRIFTYITLSVHLKQHMRTHTNVAPFQCGICEKRFKQSSHLNYHLKNHDPSNLSAEQRAVYELLVGQITRDLAEPEPRDVAE

Sequence clustering based on sequence similarity using MMseqs2