Basic Information

Gene Symbol
-
Assembly
GCA_963693475.1
Location
OY856344.1:30895820-30900419[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.019 2e+02 3.3 0.0 11 42 242 280 237 282 0.78
2 9 2.2 2.3e+04 -3.3 0.0 9 42 357 390 350 391 0.74
3 9 0.11 1.2e+03 0.8 0.1 12 41 462 494 457 508 0.79
4 9 0.019 2e+02 3.3 0.0 27 44 603 620 591 645 0.86
5 9 0.71 7.5e+03 -1.7 0.0 14 41 683 716 676 724 0.69
6 9 0.47 5e+03 -1.2 0.0 9 42 736 769 729 770 0.88
7 9 0.0025 27 6.1 0.0 21 44 823 846 814 847 0.84
8 9 1 1.1e+04 -2.3 0.0 24 44 910 930 895 934 0.69
9 9 0.014 1.5e+02 3.7 0.0 5 42 1067 1103 1058 1105 0.79

Sequence Information

Coding Sequence
ATGCGCGACGTGTCGACTTGTACTTGTAACATTGAGATGCCAGTCTGCACGTCCACGCCGAACTGCAGCCAGAGGAACCTCGTGGACTGCTGCGGGGAGGTGTCTGTGGTAATATGTGATAATGTTTGCCCACCGTCACCAATTCTGATGTCCCACAACTGCAGCGACCTGGACGAAGATATCGTCCTTCAATGCTCGAGAGGCAGCTCGCCTGCCTCAGTGCATAACGGATCCAACACGGGACGGCGTGGAGACGCGCACCTACTGAACACCACGTACGAGATCTGTGAACCTCGCGGCGACAGAACTTTCATCCACTCGTCGCCTACCCATTCCACTAAGGAAGGGTTCATGGAGAAAACTTTCGAACACAAAAACAAGAACCAAGACTTTGGCAACCCTAAGCCCTGTGGAAGTAGACATGTTGATTTCTCCAGCTCGTGTGAACTGCGCCCTCCCTGTCCGGCCGAACACCGCACTGAGCCATGTGTGAGCTGCACCAAGCCAGAGGAAGTCCTGTATTGCGCTGCCAAATCTGTTGGTTTTGTTGACATTGTGGGCAAGCTGTGCGATCTATGCAGACAAATCCTGAACCCTGCTCCGTGCCAACCCGGGTCATGCACACATGTTGACGTTTCCGACAGTCTGTGTGAACCTTGCCAGCACATCCTGAGCTCTGCCCCGTGTCCGCCCGGGGAATGTCGGTATTGTGCCGTTGCAGAACAGTTCTGTAAACATTGCAAGCATGTAACGGTAACTGCGTCATCACAGCCTGCTAAAACGATGAGTTATATTGACATAGCCGCGAAGCTTTGTGATCTGTGTCGCCGCGTGCTGGACCCGGCTCTGAGCCAGTCTGACAGAACCTGCAGACGAATTTCTGACAAACTGTGCGAGCGGTGCAGGCCTCTGCTAGCTGCTGCTCCGTGCCAGGTGGAACCTCCCTGCCGGCATTGTGACATCTCTTCCAGGCTGTGCGACTCATGCAGAAAAGTTGCCGACGCTACTCCGTGCCAGTTGAATAAACCATGCGCGTTTATCGACCTCACTGACAAGCTATGCGGTCGTTGCAAGCTAGTGGTAGACCCCATCTCGATTGAAGCCAATAGTTCGTGCAAACATTGTGACATGGCTAAGAATCTTTGTCCAGAATGCAAACGTATAGTTGATTCATCTTCGAGTCTACCTGACGAATCTTGTCGAAACCTCGTCATCGCTGACAAGTTATGTGAGCACTGTAAGGGTGTATACGACTCTGCTCCGTGCCAGCCCGTCAAATCGTGCAAAATAATTGGTGTAGCTGACAAACTGTGCATGTCGTGTAAACAAGCTATAGACCCATGCCAGTTCAATATTTGCAGGCATTGTGATATTTCTAATAAGCTGTGCAAAGAGTGTAAAATAATTGACTGTCAGACCAGCAGAACTTGTAATTATGTTGACATAGCCAGCAAATTATGTCAACACTGTAGAAGTGTTTACATGAATGCTTTATGTCTTTCCATGAAGTATTGCACGAAACATGTAAATATTCCCGACTACTCGTGTGAACATTGTAAACTAGATCCGTGCAAATCGAATAAACCCTGCAAACATTGCGATATCTCCAAAACATTATGTGAGGATTGTAGAAGTATTTTCAAGGCTGTACCGTGCGCTGATAAATCATGTGAAAATAAAAAGCTATGCgagaactgtagaaatgttAATGAATCTGCTCTGTGTACACCGCACGAGTCGTGCGTAGAACACGCTACCGTCAATAAATCGTGTGATCAGTGTATTCCAGTTGATCCATGCAAGCACTGCGACGTATCCAAGAAATTATGCAAGGAATGTAGACGTATATTTGATGCCGTACCTTGTGCTGATAAATCGTGTAAAAATGACGATATCGCCGGCAGGTTATGCGAGCATTGCAGACAGATTTACAACTCAACGCCTTGCCACTCAATAAAGTCCTGTTTGAAATGTACCAACAAATCATGTGAGGACTGCAGGCCGGAGAACCCCTGCAAACATTGTAACATATCTAAAAAATTATGCAAAGATTGCCGAAGTATTTTCGATGCCATCCCGTGTGCCGACAAATCTTgcaaaaattacgaaattgccaATAAGTTATGTGAACACTGTAGAGAGATCTATGCCTCCGCTCTGTGTCCCATGAAACATGTCAATATCGCCGAAAAGTCATGCGGACACTGCAAGTTTGTTGTGGAACGTTTTTCGTGCGCCCAAAAGAATACGTGTAAACAATATGATATGTCGAAAAACTTATGTCATGAACGTAAAAGTATTTTTGATGCCGAACCGTGTGGTGAAACATCatgtcaaaatattgctatagcCAATAAATTAAGCGATAACAGTATAAAAGCAAATCAATCCGTTCTGTGTCTACCTATAGAGACATGCATACAATACTCAGATATGGGCAATAAGTCGTGTGATCAGTGTATACAAGATAATTCATGCAAGCACTGTGACATTTCCAAGAAATTATGCAATGAATGCAGACGTATATTTGATGCCGTGCCTTGTGCGGATAAATCATGTAAAAATGATGACATACCCAGCAGGCTATGCGAGCATTGCAGGCAGATTTACAACTCTGCTCCTTGCCGGTCGATCGGTTCATGTAGTAAACATCTCGACACCCCTGGTAAGACGTGCGAACATTGCAAACATATTCCGGACCTTGCTCCTTGCAATCCTGGTAGTCTGTGCAAAAACTATGACATCACAAAAACGTTGTGCAAATATTGCAAACGTATTTTCGATGCCATAACGTGCGCTGATAAATCTTGTCAAAATACTGATAACGGAAATGAGTTATGCGAACACTGTAGAAATGCTTCTGACACCGCCCTATGTCCACCCACCACGTGCACAGAGCGACCTGATGCCTCCATGAACTCGTGTGATCAGTGTAAACCCGAGAACCCTTGTAAAAATTGCAATATGTCGAAAACATTGTGCAAAGAGTGCAATCGAATTTTCGACGCTATACCGTGCGCTGACAAATCTTGTCAAAATATTGACATCGGGAGTAAGTTATGCGGACACTGTCGAAGTATGTATGAATCCGCCCCGTGTCCGCCTGCCACGTGCACAGAGAGTGATGATGGTAGTAATAAGTCATGTGATCAGTGCAAGCCCTGTAACCTTTGCAAAAATTGTGACATCTCGAAAAAGTTATGCAAACAGTGCAAACGAATCTTTGATGCTGTACCGTGCGCTGATAAATCATGCAAAAATGCCGAAATCGCAAATAAGTTATGCGAGCCTTGCAGACAAATATACGATTCCGCTCCGTATCCAGCGGACCCATGCACGAAACACGCAGACATTACCAAGTCATGCGAACATTGTAAATATATCCTAGACCTCACTCCCTGCACTTCTGTAAACGTGTGCAAAAAGTGTGACATTACGAAGAGTTTATGTAAAGgatgcaaatatattttcaaaaggaTTCCGTGCGCTGATAGATCTTGCCGGAACCTCGATATCATGGATCGTTTGTGCGATCATTGTAGTGAATTGTTCGTCTCCGTGTCTTGTCAGGAAGAAGAAGTGTGTCAAGGGATCGACTTGACCAAAAAACCCTGTGATTTGGATCCCTCTTCCTCTATGAGATCATGTGACCCCGTCGACCAGTCATGTGTTATTGAGACTGAGTCCTGTAGACGATGCAGGCATGTGCCAGACTCGCTACTCGCCCGCCTCTTCAAGGCTTGTAAGGATGTCTACGTGCAGGTGCCAGAGAAGGGTGGAAGGTGCAAGCCTTTCGAGGAGTTGTTCTTCAACGACCGGTCTGCGGGTTCTTCCGGGGCTGATCTGTGGTTAGTGTCTTTTATTATGAAACCCATCATTTaa
Protein Sequence
MRDVSTCTCNIEMPVCTSTPNCSQRNLVDCCGEVSVVICDNVCPPSPILMSHNCSDLDEDIVLQCSRGSSPASVHNGSNTGRRGDAHLLNTTYEICEPRGDRTFIHSSPTHSTKEGFMEKTFEHKNKNQDFGNPKPCGSRHVDFSSSCELRPPCPAEHRTEPCVSCTKPEEVLYCAAKSVGFVDIVGKLCDLCRQILNPAPCQPGSCTHVDVSDSLCEPCQHILSSAPCPPGECRYCAVAEQFCKHCKHVTVTASSQPAKTMSYIDIAAKLCDLCRRVLDPALSQSDRTCRRISDKLCERCRPLLAAAPCQVEPPCRHCDISSRLCDSCRKVADATPCQLNKPCAFIDLTDKLCGRCKLVVDPISIEANSSCKHCDMAKNLCPECKRIVDSSSSLPDESCRNLVIADKLCEHCKGVYDSAPCQPVKSCKIIGVADKLCMSCKQAIDPCQFNICRHCDISNKLCKECKIIDCQTSRTCNYVDIASKLCQHCRSVYMNALCLSMKYCTKHVNIPDYSCEHCKLDPCKSNKPCKHCDISKTLCEDCRSIFKAVPCADKSCENKKLCENCRNVNESALCTPHESCVEHATVNKSCDQCIPVDPCKHCDVSKKLCKECRRIFDAVPCADKSCKNDDIAGRLCEHCRQIYNSTPCHSIKSCLKCTNKSCEDCRPENPCKHCNISKKLCKDCRSIFDAIPCADKSCKNYEIANKLCEHCREIYASALCPMKHVNIAEKSCGHCKFVVERFSCAQKNTCKQYDMSKNLCHERKSIFDAEPCGETSCQNIAIANKLSDNSIKANQSVLCLPIETCIQYSDMGNKSCDQCIQDNSCKHCDISKKLCNECRRIFDAVPCADKSCKNDDIPSRLCEHCRQIYNSAPCRSIGSCSKHLDTPGKTCEHCKHIPDLAPCNPGSLCKNYDITKTLCKYCKRIFDAITCADKSCQNTDNGNELCEHCRNASDTALCPPTTCTERPDASMNSCDQCKPENPCKNCNMSKTLCKECNRIFDAIPCADKSCQNIDIGSKLCGHCRSMYESAPCPPATCTESDDGSNKSCDQCKPCNLCKNCDISKKLCKQCKRIFDAVPCADKSCKNAEIANKLCEPCRQIYDSAPYPADPCTKHADITKSCEHCKYILDLTPCTSVNVCKKCDITKSLCKGCKYIFKRIPCADRSCRNLDIMDRLCDHCSELFVSVSCQEEEVCQGIDLTKKPCDLDPSSSMRSCDPVDQSCVIETESCRRCRHVPDSLLARLFKACKDVYVQVPEKGGRCKPFEELFFNDRSAGSSGADLWLVSFIMKPII

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-