Basic Information

Gene Symbol
PRDM9
Assembly
GCA_949318235.1
Location
OX439131.1:49005378-49022207[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.76 54 4.9 1.4 1 14 158 171 158 174 0.86
2 9 0.14 9.8 7.2 1.2 2 23 590 612 589 612 0.95
3 9 1.6e-07 1.2e-05 25.9 0.9 1 23 683 705 683 705 0.98
4 9 0.034 2.4 9.1 3.3 2 23 712 733 711 733 0.97
5 9 4e-06 0.00028 21.5 0.8 1 23 739 762 739 762 0.95
6 9 1.4e-07 9.7e-06 26.1 1.9 2 23 769 790 768 790 0.98
7 9 0.00014 0.0097 16.7 4.3 1 23 796 818 796 818 0.99
8 9 2.7e-05 0.0019 18.9 2.2 1 23 824 846 824 846 0.99
9 9 0.0043 0.31 11.9 4.2 1 23 852 874 852 875 0.96

Sequence Information

Coding Sequence
ATGTTTGCAGATCATCTTTGTCATGCTTGTGCAGAGAAGAAACAAGCCACAGCTTCTTTGCTGgaccaaaagtttgaaaaagCAGTAGATTTTCTAAATATTCAGAATGATGACAAAGATAAAGAGGTATGCAGAGACTGTGAGCAGGAACTTGATCACTGGTCCATGTTTCTACGTAGAGCAGAGAAAGCTCAAGCATTGTTCGAAGTTGCTGCTCAACGTGCTGCGTCAATCACAGAGCGCGCCTTGTGTGAGAAATTTGACATCCAAGCTTGCATAGTGAGAGTGGAGAGAGTTGTCAGTGATGTGAGTGAGCAAGAAGTTGACGTGGAGTCCAGCGACGTTGTAGAGAGCAACATTGCAAGTGTCAGTAACAGTGCAGCGTTAGAGAATATTGTTGCAAGTAACAGTGCAGAAGTTGATAATGTAAAATCTGTAGTGTCTCAGGAAAAtctaaaacttacaaaatgttACAAGTGTCATGAATGTCAGATTGACTTTAACTTTCGCTCGTTCTTCGCGATGGAGGAAAACTTTGAAGACATGGACGGCGAGATGTTGGCAGCCAAAGCAGCCACAGAGACTTCCATGTATTTCTCGCCTGAACAATGGGAGCAGTTCTCACCTATCGAACGTCAGCGGCGAGTCTCGCAATTGAGGAATCATTTTGTAATGCAGAAAATTGGCATGACAAATACTCCACCTGAGTTCGTACTTCAGTTCAGAAAACTCGAAGCAAGAAAGATAGCTGCGGAGTTGAAGAAATTAACTCGTGACCAGAATCAAGAAAGACCCATCAAGCCCCCTGTAGTCAAAGACGTAAAGATCCTCAAGAACAAGGACGGCTACTACTATGGTAAAGTACCCAGGCAAACACCAGACTGGCCTGGAGTCGACTACGTACTCAAAGAGAGAGACCCAGAACCTCAGAAGCAGAGAGGAAATGTGTTGAAGAGAAGCTACACCCCTGCACTACAGAGTGGTGGGCAGGCCTCGTGTAGTAGAGTCTTGACAGTCAAGCAGACAGACAGAAGCTACGTACAGGCCTCGAGTAGTAGGGCCTTGCCAGCCAAGCAGATGGACAAACCAGAGCAAGGGGACCAGGAAGACCAGCCTAGGTACCCCAAGAGAAACATCAAGAGGCCGTATTACAAAGAAGACCCTGTACCTGAGGAGGAAGACTTCAGCTACTGCTGTGTATGTGAAGGTTCTGTGCTGGGAGCGTGTGAAGACCACGGCAGACCTTTCAGATTGTTTAGCACTCCAGTCAAGTCATCTGTATGCAAGGACAGAGCAGCTCGCACGCTACCCAAGGGGTTACGTATTGGAAAGTCGTCAATCCCTAATGCAGGTATGGGAGTTTTTGCAGTGCTCCCCATTCCTCCACACACCATGCTGGGGCCTTACGATGGCCAGCTACTGACCAAGAGCAACAATGACGGCTACTGCTGGATGATTCGTCGAGGCAGCGCAGGCAACCTGAGTGTTGACGCCAAAGACGAGACGAGAGCCAGCTGGTTGCGCTACGTCAACTGTGCCACTCATGACTCCATGCAGAACCTGGTGCCTGTGCAAGAGAAGGGACAAATCTTCTACCTCACCAGGCAGTGGATTGCTCCAGGAGATGAACTGCTGACGTGGTATGGCAAAAGTTTCATGCTAGACCTAGGGATTGACCTGCAGGCTTACTTCGAGCCTAAGACTGATGAGGCTAAGACTGAGCGAGCCTTGTCACCTGTCATCTGGAAGAAAGTCGGCAAGGCGCTGCAGTGCGTGTGGTGCTCCATCAGTTTCTCCAGCGTCAACTTTGTCCAACGTCACGTGCACACCAAGCATGGCTCAGAACATTCTCTTCTTGTCCTGCAGCACAAAGCAACCATCGTGTTCCCTCCGTCACGAAGCAGCACGGCTATCGGCGCATGTTTTGTGCAGAATGAGGTGACGTCAAGCCTCATGATGAAGCTACAGCAACGGGCAGGGGGGGaagtgacagagagagacaaAGTGTTAGCTAGGAGAGTGAGAGATGATGGTAAAGACAGACCTTTTGTGTGCAGTATCTGTGGTAAGAAATATACTACCCAGAATAACTTGACTGCACATAAGAGAGTACATGATGAAGCTAGGGCTCTCAAGTGCAGTCATTGTCCTTATGTAACTGGACTCAAACAAAATTATGATCATCACATGATGACTCATACGGGACAAAGAGATCATGTGTGTCAAGTGTGTGACAAATCTTTCACCCAGAAAGTTAATCTAGTGACACATGTGAAGGAAGTTCATGACAAAGTGAGAGATCAGCAATGTCCTCATTGTGATAAAACTTTTGCTCAGAAGTCAAGCTTGGTCAGTCATGTCAGGACACATACAGGTGACAAACCTTATCAATGTAGTCAATGTGAATATAAGTGTGCAGTCAGTGGTCACTTAACTTCACATATGAGAACACACTCAGGTGACAAACCTTATCAATGTAGTCAATGTGAATATAAGTGTGCAGTCAGTGCTAACTTAACTTCACATATGAGAACCCACTCAGGTGAGAAGCCTTACCAGTGCACCATGTGTGACTACAAGGCTGCACACAGTAACAGTCTCAAGAGTCATGTCAACAAACATCACTGA
Protein Sequence
MFADHLCHACAEKKQATASLLDQKFEKAVDFLNIQNDDKDKEVCRDCEQELDHWSMFLRRAEKAQALFEVAAQRAASITERALCEKFDIQACIVRVERVVSDVSEQEVDVESSDVVESNIASVSNSAALENIVASNSAEVDNVKSVVSQENLKLTKCYKCHECQIDFNFRSFFAMEENFEDMDGEMLAAKAATETSMYFSPEQWEQFSPIERQRRVSQLRNHFVMQKIGMTNTPPEFVLQFRKLEARKIAAELKKLTRDQNQERPIKPPVVKDVKILKNKDGYYYGKVPRQTPDWPGVDYVLKERDPEPQKQRGNVLKRSYTPALQSGGQASCSRVLTVKQTDRSYVQASSSRALPAKQMDKPEQGDQEDQPRYPKRNIKRPYYKEDPVPEEEDFSYCCVCEGSVLGACEDHGRPFRLFSTPVKSSVCKDRAARTLPKGLRIGKSSIPNAGMGVFAVLPIPPHTMLGPYDGQLLTKSNNDGYCWMIRRGSAGNLSVDAKDETRASWLRYVNCATHDSMQNLVPVQEKGQIFYLTRQWIAPGDELLTWYGKSFMLDLGIDLQAYFEPKTDEAKTERALSPVIWKKVGKALQCVWCSISFSSVNFVQRHVHTKHGSEHSLLVLQHKATIVFPPSRSSTAIGACFVQNEVTSSLMMKLQQRAGGEVTERDKVLARRVRDDGKDRPFVCSICGKKYTTQNNLTAHKRVHDEARALKCSHCPYVTGLKQNYDHHMMTHTGQRDHVCQVCDKSFTQKVNLVTHVKEVHDKVRDQQCPHCDKTFAQKSSLVSHVRTHTGDKPYQCSQCEYKCAVSGHLTSHMRTHSGDKPYQCSQCEYKCAVSANLTSHMRTHSGEKPYQCTMCDYKAAHSNSLKSHVNKHH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00630975;
80% Identity
-