Basic Information

Gene Symbol
Mbd2
Assembly
GCA_949318235.1
Location
OX439131.1:40855654-40866931[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 7.2e-25 2.3e-21 75.5 0.1 2 73 4 70 3 74 0.92
2 2 0.00042 1.4 8.9 0.1 24 73 104 160 72 163 0.81

Sequence Information

Coding Sequence
ATGTCAGTTGAAAGGAAAAAGTACGATTGTACCGCGCTGCCCAAAGGGTGGCAAAGAGAGGAGGTCATCCGAAAAACTGGTCTATCTGCTGGAAAAGTAGATGTTTATTATTAcagCCCGAGTGGAAAGAAGTTCCGCAGCAAACCCCAGCTTGCTCGTCATATCGGAGACTCTCTGGATCTAGCCACCTTTGACTTCCGTACTGGAAGAGTCAACAACATGTTGGTTCGTAAGAACAAGAAGCAGAAAGGATCACAGTTTGATTACAGCAGCAATGAGTCTCAGAACATTAGACCAGACTGCATGCCCTCGGGTCGAGGAGTTCGAAGTGATGCTTCCTTGGTCCCTCCTATCCGACAAACTGCTTCCATCTTCAAGCAGCCAGTTACTGTGTACAAAACACAGGAGGGAAAGGTTAAGTCGGATTACAAACATGGGCCACAGGAGAAGCCAAAGCAgTTATTCTGGGAAAAACGGCTAGAAGGTTTGAAGGCATGTGATCTTGATGGGATGGAGTTTAACTCTATGGAACTACCACGAGGACTAAAACCAGTGGGACCTCATGTCACTGATGAGACCATCTTACAATCTGTTGCCACTGCTCTACATGTATCTACCCAGCCAGTTACTGGACAGACTGGTTCTCGTTCAGCTTTAGATCGCAATCCTGGGGTCTTTCTCAACCCTGAGCAGCCTCTCGTACAGGCTGTAGCTGTGGCTGATGATGACATCAGAAGACAAGAAGATCGTGTGCTGGCTGCAAGGAAGAAGCTAGAAGAGGCTCTAAAAGCTTAA
Protein Sequence
MSVERKKYDCTALPKGWQREEVIRKTGLSAGKVDVYYYSPSGKKFRSKPQLARHIGDSLDLATFDFRTGRVNNMLVRKNKKQKGSQFDYSSNESQNIRPDCMPSGRGVRSDASLVPPIRQTASIFKQPVTVYKTQEGKVKSDYKHGPQEKPKQLFWEKRLEGLKACDLDGMEFNSMELPRGLKPVGPHVTDETILQSVATALHVSTQPVTGQTGSRSALDRNPGVFLNPEQPLVQAVAVADDDIRRQEDRVLAARKKLEEALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01348017;
90% Identity
iTF_01348017;
80% Identity
-