Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2e-33 1.3e-29 103.6 2.3 202 300 1 96 1 96 0.88

2 3 0.016 1.1e+02 2.1 4.6 121 170 95 144 94 156 0.81

3 3 0.17 1.2e+03 -1.3 5.3 6 230 127 162 117 171 0.37

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2e-33	1.3e-29	103.6	2.3	202	300	1	96	1	96	0.88
2	3	0.016	1.1e+02	2.1	4.6	121	170	95	144	94	156	0.81
3	3	0.17	1.2e+03	-1.3	5.3	6	230	127	162	117	171	0.37

Coding Sequence: CGCGCGCTGGTCAGCGCCGAGAACGCGCACCTGCTGGAGAACGCCGGCGAGGGCAGCCTAGACGTGCGGCTGGCGCGCTTCGCTGCCGAGCGCTGCGACCTGCTCGACCAGATCAGCCATCTCaagctggagctggaggaggagaagaGCGCCAGGCGGCGGAAGAGCAGCAGCGCACTCAATGGACCTGATTCGGATAGTGATGCTGCCGATATTCAACGCGAGGCAAGTAAACAGTTGGCCGAGTTCAAGTTCCGCGCGCAGAAGGCCGAGCAGGACGTGGCGACGATGCAGGCGACGGTCGCGCGGCTGGAGAGCCAGGTGATTCGGTACAAATCGGCGGCGGAGATCTCCGAGAAGTCCGAGGAGGCGCTCAAGGCCGAGAAGCGCAAGCTGCAGCGAGAGGCACGGGAGGCTCAGAATAGAGCGGAGGAGTTGGAAGTGTCCAACACGCACCTCATCAAGCGCCTGGACAAGCTCAAAAACGCCAAGTCGGCGCTGCTCAAGGAGCTCTGA
Protein Sequence: RALVSAENAHLLENAGEGSLDVRLARFAAERCDLLDQISHLKLELEEEKSARRRKSSSALNGPDSDSDAADIQREASKQLAEFKFRAQKAEQDVATMQATVARLESQVIRYKSAAEISEKSEEALKAEKRKLQREAREAQNRAEELEVSNTHLIKRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2