Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 0.11 7.9e+02 -0.7 0.6 34 75 30 71 3 95 0.58

2 2 2.3e-51 1.6e-47 162.5 15.6 1 126 136 250 136 250 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	0.11	7.9e+02	-0.7	0.6	34	75	30	71	3	95	0.58
2	2	2.3e-51	1.6e-47	162.5	15.6	1	126	136	250	136	250	0.93

Coding Sequence: ATGGAACGAGAACGGGAACGGGAAGTTGCGCCGCATTCCGACGCGCTGATAAGCAGCGAGAATAATTGTGAAGAAACAGGTCACAGTCACGACgcgcaggtgcaggtgcaacaGTTACGTGTCGTTCGTGCGgatgaggacgaggacgaggatgAGGGTGAAATGGGGCAAGTGAACTCGAAGCGCGCAAGTTCGAAGAGTTCGCAGGATGCGTTGCGGCCGTTGAGGGAGAGCTTGGATGGCGGCCAACAAGACGGCGTTATTTCCAACGCTGGTGCTAGTTTGACGAAATCCGATTTGCGACCGCCGGCGCAACCACAACCGCAGGAAGCAGTTTTTGTGAATGTGCCGGATTACGGCGGCGATCGCTGCGTCGAGCAGTACtttgaaagtgaaaaagaTGATGCCGAGGCGAGactgctggcgcggcgcgcagcgcgggcgGAAGCGCGCGAGATCCGCATGCGAGACCTGGAGCGGCAGCAGCGCGAGCAGGAGGAGAACGCCGACCGGCAGTTTGATATGCTCAGCGAGCCGACGCTTCGGCGGCCGGTGGCCACCGCCGGCAGCCGCTTTCTGTCGTCCCGCCGCTCGTCTGAGGACTCGCTGGAGGACACTGGCAGCCTGCGCGATCTCCGACATGAGCTCAAGGAGGTCGAGGAGAAGTTCCGCAAGGCGATGATCGCCAATGCCCAGCTGGACAATGACAAATCAGCGCAGACTTATCAATTGGAGCTTCTCAAAGACAGGTAA
Protein Sequence: MEREREREVAPHSDALISSENNCEETGHSHDAQVQVQQLRVVRADEDEDEDEGEMGQVNSKRASSKSSQDALRPLRESLDGGQQDGVISNAGASLTKSDLRPPAQPQPQEAVFVNVPDYGGDRCVEQYFESEKDDAEARLLARRAARAEAREIRMRDLERQQREQEENADRQFDMLSEPTLRRPVATAGSRFLSSRRSSEDSLEDTGSLRDLRHELKEVEEKFRKAMIANAQLDNDKSAQTYQLELLKDR

Sequence clustering based on sequence similarity using MMseqs2