Basic Information

Gene Symbol
topi
Assembly
GCA_949715965.1
Location
OX454320.1:80042337-80045618[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.79 1.5e+02 4.4 0.6 2 21 167 185 166 186 0.91
2 11 2.1e-05 0.0041 18.8 1.9 1 23 246 268 246 268 0.96
3 11 8.6 1.7e+03 1.2 0.1 2 19 291 308 290 313 0.67
4 11 0.015 3 9.8 0.1 2 23 367 388 366 388 0.95
5 11 5.9 1.1e+03 1.7 0.0 1 20 394 413 394 415 0.89
6 11 0.09 17 7.4 1.3 2 22 435 455 434 458 0.89
7 11 7e-07 0.00014 23.5 1.9 1 23 510 532 510 532 0.95
8 11 0.001 0.2 13.5 1.3 1 23 538 563 538 563 0.96
9 11 0.34 67 5.6 1.7 1 23 569 591 569 591 0.88
10 11 4.2e-07 8e-05 24.2 0.3 3 23 599 619 597 619 0.98
11 11 0.00013 0.024 16.4 0.7 1 23 625 648 625 648 0.95

Sequence Information

Coding Sequence
ATGGAATACAATGACGAACAATATAATTCAGATATTCTGCttgtggaaaaaatattttcccaacTTAAAGAGTACAATCCAGGGAACTATAATGAAGAACTATCGAATCATACtacaaataatgaaatatcaaaGGATATTAAGTCTGAAGACAATTATCCTTCTGCATCAAGCACTGGCGTCCAAGATCAATGCGACATCTCTAACCAAAAATCTTTAGATCAATGCGAGGTTTCGAACCAAACACCTCTAGATCAATGTGGAACGTGTAACCAACAATGCTCCTCCGAAGGACCAATAGACCTAACTGGCCAGGATGCAGAGCAAATTGAAATGAACGAAATATCCAATTTGAGTCGAGAATCAAAAGATTCGGAAGTCGTAATCGACGAAAACTCCCAGCGTTATTTAGACCTGTTAATTGCTTCACTGCCTCCTGAATGCTACTCAGATCATGTAATCGTTGTGAAAAATTCTCTGAATGAAAAATGTGCCATAAAATGCACTAACTGCGAACAGATCTTCAACGAAGAGATGTTCAATGAACACATTTGCGACTACGAtgagaataagaatttcataaaaGATGAAGAGCCGCTAAAATGTTCTACAATTGAATTAGAAGAACAGCCATGTTTACGCCAATTGCAAGAAAATAACATACGAATTAGGAAGTTTCTGAAGGACGAACTTAAAATAGACATAGGAGGTCCTACCAAAAGGAATGATGGCCCTCATGCGTGTAACATGTGCGAAAGAAAATTTGTACACGCTTCTGGGCTCGCAAGGCATATGGAAAAACACGCAATGGATTTGATCCCGATCACAACCAACACTACGCAAAGTGGGAGTCAATTGAAAGTAGTGATAAAGTGCCTGATTTGTGGGAGAATTCTTTTTGGGCATGTTGAAGCCTTAGAGCACTTAAATGAAAACCACGCTCATTTGCTAATCGAGGGTGAAACTGATAGCGAAAAGGATTTTCCAAGTGAAAGAATTGACGAAGCGATTGAGTTGATTTTAAAAGAGACATACGATGACCAAGCAGACAAAACAACAAACCCATATTTAAAAGTGGTGATTTTGACCTGCACTTTGCAGTGTGAGTTTTGTGATTTGCAATTTTCAGAAGTCTCAGATCTTCTACTTCACGCTTCGTCCCATGATCCGATGCGAGGATTTGAATGCTCCTCTTGTGAGATAAATGTTTCAACAGCTAAGGAAATATTTCTCCATTGGCAAGCAGAATGCCCTTATGCCAGAGATGAATTAAGAAAGATAAACACTTTGCAAAAGTATCTTGTTTGTAACGTTTGTGAGAATAAATATACTTCACACGAACAACTATACGACCACAGATACACcgaatttcatttatttccgaGGTTAAACAGGAGTATGGGAATTATGCAAATTTGCTGTGAGTACTGTGGGAGTTTCCACGACAGTGCTAAAGCAATTATGCGACACCACGAGGAGAGACACATGAAAAGAGTAACAAAGGAGACAACTACTAAATATAGACAGTATCTTTGTGATGTTTGTGGAAAATCGTATACTCAATCAAGTCATTTGTGGCAGCATTTGCGTTTTCATAGAGgTGTTAAACCATTTGCTTGCAAAGAGCTAGGTTGCAATCGCCGATTTACAATCCGGCCGGATCTCAATGATCACATTCGAAAGTGTCACACAGGAGAACGTCCCTATCACTGCCTTGTATGCGGAAAACGTTTCCTCACAGGATCTGTTTTTTACCAACATCGATTAATTCATCGCGGTGAAAGGCGATACGGTTGTGATGAATGCGGGAAGCGTTTCTATCGCGCAGATGCTCtgaaaaatcatcaaagaaTTCATACTGGTGAAAAACCCTACGCTTGTATGTATTGTCCGAAGAGTTTCAGGCAACGTGGCGATCGAGACAAACATATTAGAGCTCGACATGCTAATTTAGATGCAAATGCAAGATCgtttaatatgaaaaataaagacaattcGCATAACAATGTAGTATTTGTTGGAAACGTTGCGTTCCCAACTAGTATGTTTAAGCCGATGATGAGAGACATTGACGAATGCCAAAATGTGTATTAA
Protein Sequence
MEYNDEQYNSDILLVEKIFSQLKEYNPGNYNEELSNHTTNNEISKDIKSEDNYPSASSTGVQDQCDISNQKSLDQCEVSNQTPLDQCGTCNQQCSSEGPIDLTGQDAEQIEMNEISNLSRESKDSEVVIDENSQRYLDLLIASLPPECYSDHVIVVKNSLNEKCAIKCTNCEQIFNEEMFNEHICDYDENKNFIKDEEPLKCSTIELEEQPCLRQLQENNIRIRKFLKDELKIDIGGPTKRNDGPHACNMCERKFVHASGLARHMEKHAMDLIPITTNTTQSGSQLKVVIKCLICGRILFGHVEALEHLNENHAHLLIEGETDSEKDFPSERIDEAIELILKETYDDQADKTTNPYLKVVILTCTLQCEFCDLQFSEVSDLLLHASSHDPMRGFECSSCEINVSTAKEIFLHWQAECPYARDELRKINTLQKYLVCNVCENKYTSHEQLYDHRYTEFHLFPRLNRSMGIMQICCEYCGSFHDSAKAIMRHHEERHMKRVTKETTTKYRQYLCDVCGKSYTQSSHLWQHLRFHRGVKPFACKELGCNRRFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHQRIHTGEKPYACMYCPKSFRQRGDRDKHIRARHANLDANARSFNMKNKDNSHNNVVFVGNVAFPTSMFKPMMRDIDECQNVY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00718060;
90% Identity
-
80% Identity
-