Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.056 1.6e+02 4.1 0.3 23 44 25 46 20 54 0.87

2 8 5.8e-06 0.017 16.9 0.3 21 48 136 163 131 167 0.86

3 8 0.013 37 6.2 0.1 21 44 164 187 160 190 0.89

4 8 0.016 47 5.8 0.0 21 46 192 217 189 223 0.85

5 8 0.33 9.6e+02 1.7 0.1 21 31 220 230 216 248 0.77

6 8 0.012 35 6.2 0.0 21 46 248 273 242 279 0.80

7 8 0.007 20 7.0 0.0 22 45 277 300 272 304 0.89

8 8 5.8e-05 0.17 13.7 0.1 22 47 305 330 301 334 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.056	1.6e+02	4.1	0.3	23	44	25	46	20	54	0.87
2	8	5.8e-06	0.017	16.9	0.3	21	48	136	163	131	167	0.86
3	8	0.013	37	6.2	0.1	21	44	164	187	160	190	0.89
4	8	0.016	47	5.8	0.0	21	46	192	217	189	223	0.85
5	8	0.33	9.6e+02	1.7	0.1	21	31	220	230	216	248	0.77
6	8	0.012	35	6.2	0.0	21	46	248	273	242	279	0.80
7	8	0.007	20	7.0	0.0	22	45	277	300	272	304	0.89
8	8	5.8e-05	0.17	13.7	0.1	22	47	305	330	301	334	0.90

Coding Sequence: ATGGCCACAGAATACGATAAGTTGCATGAACATTACGATAATAactttgaaaaatTTTTACATTCCAAGAGTAGACCATATTCGTGCAAGATCTGTGGGAAATGCTTCACACAGAAAAAGGATTGTAAAAGGCATCAAGTCATACATTCCGACGATAGACCTTTCCCCTGTAACCAGTGCGATAAAAGCTTTAAATACAATCAACAATTAAAAGTTCACAAGGTCTCTCATAAGCCCGGCAAGATTGTTGTGTGCACTGACTGTGGAAAATCGTTCGACGGGAAAAGGAAACTAAATCATCATATTAGGAGCATACATCCGGTCAAGAAAGTTTACAGGTGTAGTTATTGTGGGCGGACCTGTTATCACAAGGCCGATCTGAACGTTCATATTAGAAcgcacactggtgaaaagccaTTTACTTGTGAGATTTGTGAAGCGTCATTTTGTCAGAGGACTAATCTAAGGAGTCATATTAGaatacacaccggtgaaaagccatTTACTTGCAAAGTTTGTAAAACGTCATTTCGTCACAGATGTGGACTGAAGACTCATATTAAAACCCACACAGGTGAAAAGCCTCttacttgcgaagtttgtaagAAATCATTTTGTCGGGGTGGAGATTTGACGAGGCATATTCAAAcgcacaccggtgaaaagccttttacttgcgaagtttgtaagTTGTCGTTTTGTAGGAAAACTATATTGATGAATCATATTAGAAAACACACCGGAGAAAAGCCCTTTACCTGCGATGTGTGTAAGAAGTCATTTTGTACCCAGGATGGATTGTCAAGACATCTTAGAACACACACTGGTGACAAGCCTTAtacttgcgaagtttgtaaaatgtcattTGGCTACTCTTCAAGACTAAAAAGACATATGACTGTGCATTTGGGAGAGTGCCCTTATTCTTGCGAATTATGTTCAGCTAAATTCAAAAGTTCACAAAATTTAACACGGCATATGAAgctgcatattaaaaaaaaagtctaA
Protein Sequence: MATEYDKLHEHYDNNFEKFLHSKSRPYSCKICGKCFTQKKDCKRHQVIHSDDRPFPCNQCDKSFKYNQQLKVHKVSHKPGKIVVCTDCGKSFDGKRKLNHHIRSIHPVKKVYRCSYCGRTCYHKADLNVHIRTHTGEKPFTCEICEASFCQRTNLRSHIRIHTGEKPFTCKVCKTSFRHRCGLKTHIKTHTGEKPLTCEVCKKSFCRGGDLTRHIQTHTGEKPFTCEVCKLSFCRKTILMNHIRKHTGEKPFTCDVCKKSFCTQDGLSRHLRTHTGDKPYTCEVCKMSFGYSSRLKRHMTVHLGECPYSCELCSAKFKSSQNLTRHMKLHIKKKV

Sequence clustering based on sequence similarity using MMseqs2