Basic Information

Insect: Dryococelus australis
Gene Symbol: Pax5
Assembly: GCA_029891345.1
Location: CM057005.1:110548357-110569207[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.5e-34 3.3e-30 108.1 1.0 1 58 22 79 22 82 0.97

2 6 0.00051 11 9.5 0.9 39 59 89 108 82 111 0.71

3 6 0.009 2e+02 5.4 0.1 46 58 109 121 107 123 0.88

4 6 0.0012 26 8.3 0.1 45 58 122 135 117 137 0.81

5 6 0.0026 57 7.2 0.1 46 58 137 149 135 151 0.89

6 6 0.00041 9.1 9.8 0.7 46 67 151 172 146 188 0.71

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.5e-34	3.3e-30	108.1	1.0	1	58	22	79	22	82	0.97
2	6	0.00051	11	9.5	0.9	39	59	89	108	82	111	0.71
3	6	0.009	2e+02	5.4	0.1	46	58	109	121	107	123	0.88
4	6	0.0012	26	8.3	0.1	45	58	122	135	117	137	0.81
5	6	0.0026	57	7.2	0.1	46	58	137	149	135	151	0.89
6	6	0.00041	9.1	9.8	0.7	46	67	151	172	146	188	0.71

Sequence Information

Coding Sequence: ATGGTGACCAGAGGACGTAACCAGGGAGAGGAGGTGACACACAGGGGGCTGGCTGTGCTTGCAGGTCACGGCGGAGTGAACCAGCTGGGTGGCGTGTTCGTGAACGGGAGGCCGCTTCCCGACGTCGTGCGACAGAGGATCGTCGAGCTGGCGCACAACGGCGTGCGTCCCTGCGACATCTCCCGCCAGCTGCGCGTCTCCCACGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTTCATGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTTCATGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCTAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCCCTGCGACATCTCCCGCCAGCTGCGCGTCTCCCACGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCTAGGTACGTGTACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCTAGGTACGTGTACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTACGTGCACTCTCGAGGCTGCGTCTCCAAGATACTCTCCAGGTTCATGTACTCTCGAGGCGCGTAGAGCGTCTCTCAGGCAAACCGGGTTACACTCCTGGCGGAGTCTCCCCTGCACACGTGGGATGCCGATAACAGCTGAGTGTTTGGTGCTGGCGGACAGGACACGTGTTGATGGTGGGATAGCAGGCGGCACTCGCTCGCACCTTGATGGGGGATACAGGGGGGCGAGGCACCCACTTATCACCCCGGCCGCATCATTTGTTTCTGgtttccaccccctcccccttccactccACGGGGGTTGCCTGTTCTCTCAATCCGTCTTGTGGAGGCTCAGTTTTAAACCCACACCGACACGCCCTCCACATCGCCGCCGCCACACCCCAGGGCAACAACGGCGCATGCGCCAGGCTTCACGGGGGTCAGGGGTCGCGCCTCGACCGTCCGCCATAAGGGCGAGAATGACACGGCCCCACCACCTCTACTCGTATGGCACCCTGCTGGTGTGCACACATCTCGACTTCCTACAAGCAACTATCGGCAGACTTCTAATTTCCCTACCAAACATCATTGCAGCATCTCCTGGTCCAGCTACAGCTTGCAGTAACTCCCTCCCCGCTGGTTCTTGGTCCTTGTCGGCGAAACTTCTCTCCTATCTCAGGTCGGTGGAGGTCTCCACGTGCCTGCCGGGGTCTAAGCCCTGGCGACGCTCTCTGATACCACGCCTAGCACCGGTATTTATACTCCATAAAATCCCCACCAGCGTGCCTCGCGCGTTCGGCATGCAGGTAAataacccccccacccccaccccctcctggCCTAACTCTCTACAATCCCTCCATCTGCCCATCGCGCGGCGCGAGGAGGGAAATAAACACGAGCGCGAGCCAGCCCGGGGCGACTTTCTACTTTCACGTCTGCGCCGCCTTAACGTTCCCGCTCTCCTCAGCTACGACCGCATGCTCATTCCGCTCATTAGCACCACCCAGCACCTCTGGTCGTCAGCCGGACGGCGTCCTGGATTCGCTTCGTGTGTCCTTAGCCCCGTCGTGCGTCGCGGCCAGAGACAAAAGATTACACCCTCCCATCCCCATCCCTTCTACACGGCCCCCTACCCTCGTCGACACTTGCGCGCAGATGAAAAATCGTCGCCCGCTAATGTCCTCTTATTTGTAACTGTCTGCCCTTACATCCCCGACCTCGCATGGCCGTGCCCCTAA
Protein Sequence: MVTRGRNQGEEVTHRGLAVLAGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYVHSRGCVSKILSRFMHSRGCVSKILSRYVHSRGCVSKILSRFMHSRGCVSKILSRYVHSRGCVSKILSRYVHSRGCVSKILSRYVHSRGCVPATSPASCASPTAASPRYSPGTCTLEAASPRYSPGTCTLEAASPRYSPGTCTLEAASPRYSLGTCTLEAASPRYSPGTCTLEAASPRYSPGTCTLEAASPRYSPGTCTLEAASPRYSPGTCTLEAASPRYSLGTCTLEAASPRYSPGTCTLEAASPRYSPGSCTLEARRASLRQTGLHSWRSLPCTRGMPITAECLVLADRTRVDGGIAGGTRSHLDGGYRGARHPLITPAASFVSGFHPLPLPLHGGCLFSQSVLWRLSFKPTPTRPPHRRRHTPGQQRRMRQASRGSGVAPRPSAIRARMTRPHHLYSYGTLLVCTHLDFLQATIGRLLISLPNIIAASPGPATACSNSLPAGSWSLSAKLLSYLRSVEVSTCLPGSKPWRRSLIPRLAPVFILHKIPTSVPRAFGMQVNNPPTPTPSWPNSLQSLHLPIARREEGNKHEREPARGDFLLSRLRRLNVPALLSYDRMLIPLISTTQHLWSSAGRRPGFASCVLSPVVRRGQRQKITPSHPHPFYTAPYPRRHLRADEKSSPANVLLFVTVCPYIPDLAWPCP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -