Basic Information

Gene Symbol
Lztr1
Assembly
GCA_947523025.1
Location
OX383303.1:6714500-6742913[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 9.2e-13 3.6e-10 40.6 0.1 4 80 365 462 362 476 0.85
2 7 0.00053 0.21 12.4 0.0 54 80 481 507 468 513 0.86
3 7 0.089 34 5.3 0.0 54 80 526 553 509 561 0.75
4 7 0.023 8.9 7.2 0.0 54 80 572 599 559 613 0.85
5 7 4.4e-05 0.017 15.9 0.0 54 109 618 684 602 685 0.89
6 7 7.7e-16 3e-13 50.5 0.0 9 97 781 869 776 884 0.85
7 7 1.6 6.1e+02 1.3 0.0 77 106 883 912 872 915 0.80

Sequence Information

Coding Sequence
ATGAATCAGAACCTAGGGAAGATGATAACAGAGCAGCTCCGCAATCCAAATGAGCTGGACATCAGCCTAAGGATGGAGTTCGGACCATTTGAAACAGTACACAAGTGGAAACGCATGTCAGAGTGCTATGAGTTTGTTGGTGCCAGGAGGAGCAAACACACCGCTGTAGCGTACAAAGATGCAATTTATGTGTTTGGAGGTGACAACGGCAAGTCTATGCTAAATGATCTGATCAGATTTGACATCAGAGAGAAGTCGTGGACCAAGACTGGCTGCATGGGAGTGCCGCCCGCGCCGAGATACCATCATTCTGCTGTGGTACATCGTTCTTCAATGTTCGTGTTCGGCGGATACACAGGGGATATCCTAGCGAACTCCAACCTGACCAATAAGAACGATCTGTTTGAGTACAAGTTCTCCAGCGCGCAGTGGGTGCAGTGGAAGTTTAGTGGACAAGAGCCCGTGCCTCGATCAGCACACGGGGCCGCAGTATACGATGACAAGCTATGGATATTCGCTGGCTACGACGGCAATGCGCGACTCAATGATATGTGGACTATAAATCTGTTGGGAGGAAACCATCAATGGGAGCGCATAGAGCAGAAGGGTCAATGCCCCCCCACGTGCTGCAACTTCCCCGTGGCCGTGGCGCGAGGCAAGATGTTCGTGTTCAGCGGACAGAGCGGCGCCAAGATCACGAATGCGCTGTTCCAGTTCGATTTTGAGACACACACCTGGTCGCGCGTGTGCACGGAGCACCTGCTGCGCTCGGCGGGCGGCGCGCCGGCGCGGCGCTACGGCCACGTCATGGTGGCGCACCGCGCGCATCTCTACGTGTTCGGGGGCGCCGCCGACAACACGCTGCCCAACGACTTGCACTGCTACGATCTGGACACGCAGATATGGTCAGTAGTGCAGCCGGCCACAGACTCGCAGATCCCTTCAGGCCGGCTGTTCCACGCAGGCGCCGTGGTGGGAGACGCGCTGTACATCTTCGGAGGAACCGTCGACAATAACGTCAGGAGCGGCGAGCTGTTCCGCTTTCAGTTATCAAACTACCCTCGGTGCACTCTACACGATGACTTCGGCCGAATATTGAAGTCTCATCAGTTCTGCGACGTACAGATACTAGTGGGCCCTGAGAAGACGTCTATTTTGGCCCACCAGGCCATATTAGCCGCCAGGTCGCAGTTTTTACGAGCTAAGATCAAGGAAGCACGAGACGAACTAACAAAACGTATAACAGCCGGCGAGGAAGAAGCTTCCGAAGTATGCTCATACAAGACACCGCCACAACTGTCTGTTTTGCTACCCGAAGCCACGCCCGAGTCGTTCAACATGGTGCTCAACTACATATACACCGACAGAATAGACCCCACGGAGAAAGGTAACGTGCTCAATAGAGAATTATGCTCATACAAGACACCACTACAACTGTGCGTTTTGCTACCCGAAGCCACGCCCGAGTCGTTCAACATGGTGCTCAACTACATATACACCGACAAAATAGACCCCACGGAGAAAGGTAACGTTTTCAATAGAGAATTCTCATACAAGACACCGCTACAATTGTGCGTTTTGCTATCCGAAGCCACGCTCGAGTCGTTCAACATGGGGCTCAACTACATATACACCGATAGAATAGACCCCACGGAGAAAGGTAACGTGCTCAATAGAGAAGTATACTCATACAAGACACCACCAAAACTGTGCGTTTTGCTACCCGAAGCTACGCCCGAGTCGTTCAACATGGGGCTCAACTACATATACACCGATAGAATAGACCCCACGGAGAAAGGTAACGTGCTCAATAGAGAAGTATACTCATACAAGACACCGCCACGACTGTGCGTTTTGCTCCCCGAAGCCACGCCCGAGTCGTTCAACATGGGGCTCAACTACATATACACCGATAGAATAGACCCCACAGAGATAGACGAAGACCCCGCGTCCCCGGCCACAGTACTCCTCGTGATGGCAGTGTTACGCCTCGCGCTACGCCTGAACATCCCGCGCCTGCGCGGACTGTGCGCGCGCTTCCTGCGAGCGAACCTCTGCTACGGCAACGTGTTGCAAGCGTTGCACGCCGCGCATCACGCCAATCTGACGTGTATCAAGGAGTATTGTTTGAGATTCGTGGTGAAAGACTACAATTTCACTCCGATAGTGATGTCGAAGGAGTTCGAGGAGATGGAGCAGAGTCTGATGGTGGAAGTGATCAGGAGACGGCAGCAGCCGCCGCCCAAACAAACCAACGCGGTTGTACAACAAGAGTACGACGAGGAGATTATTGGCACGACCCTGGAGCAAGACATGTGCGTGCTCCTGGGCGGCGGCGCGGAGCTGTCGGACGTGCGCCTGCGCGTGGGCGCGGCGTCGCGCGCGGCGCACCGCTCCGTGCTGGCGGCTAGAGCGGCCTACTTCGAAGCTATGTTCCGCTCCTTCTCGCCGCTCGATAATATTGTTAATATACAAATCTGCGACACGGTGCCATCAGAGGAAGCGTTCGACTCTCTACTTCGATATATCTATTACGGCGACACCAACATGCCGACTGAAGACTCACTGTATCTGTTCCAAGCGCCGATATATTATGGTTTCACAAATAACCGCCTGCAAGTATTCTGTAAGCACAACTTGCAGAGCAACGTGTCCCCAGAGAATGTTCTCGCTATCCTGCAAGCAGCTGACCGCATGCGAGCAACCGACATCAAGGAGTATGCGCTCAAAATGATCGTGCATCACTTTGGCCTTGTCGCGAGGCAGGACGCCATCAAGAACTTGGCCCAACCACTCTTAGTTGACATCATATGGGCGCTAGCAGAGGAACCACACTTCGACTCGCCCCTCCCAGTACAGCCGAGGTCGTTGCCTTCATCATCATCAGCTGATACACTGACTGATGACCCTGAGTATTCTCGACATAGATGCGGAAAATCGTAG
Protein Sequence
MNQNLGKMITEQLRNPNELDISLRMEFGPFETVHKWKRMSECYEFVGARRSKHTAVAYKDAIYVFGGDNGKSMLNDLIRFDIREKSWTKTGCMGVPPAPRYHHSAVVHRSSMFVFGGYTGDILANSNLTNKNDLFEYKFSSAQWVQWKFSGQEPVPRSAHGAAVYDDKLWIFAGYDGNARLNDMWTINLLGGNHQWERIEQKGQCPPTCCNFPVAVARGKMFVFSGQSGAKITNALFQFDFETHTWSRVCTEHLLRSAGGAPARRYGHVMVAHRAHLYVFGGAADNTLPNDLHCYDLDTQIWSVVQPATDSQIPSGRLFHAGAVVGDALYIFGGTVDNNVRSGELFRFQLSNYPRCTLHDDFGRILKSHQFCDVQILVGPEKTSILAHQAILAARSQFLRAKIKEARDELTKRITAGEEEASEVCSYKTPPQLSVLLPEATPESFNMVLNYIYTDRIDPTEKGNVLNRELCSYKTPLQLCVLLPEATPESFNMVLNYIYTDKIDPTEKGNVFNREFSYKTPLQLCVLLSEATLESFNMGLNYIYTDRIDPTEKGNVLNREVYSYKTPPKLCVLLPEATPESFNMGLNYIYTDRIDPTEKGNVLNREVYSYKTPPRLCVLLPEATPESFNMGLNYIYTDRIDPTEIDEDPASPATVLLVMAVLRLALRLNIPRLRGLCARFLRANLCYGNVLQALHAAHHANLTCIKEYCLRFVVKDYNFTPIVMSKEFEEMEQSLMVEVIRRRQQPPPKQTNAVVQQEYDEEIIGTTLEQDMCVLLGGGAELSDVRLRVGAASRAAHRSVLAARAAYFEAMFRSFSPLDNIVNIQICDTVPSEEAFDSLLRYIYYGDTNMPTEDSLYLFQAPIYYGFTNNRLQVFCKHNLQSNVSPENVLAILQAADRMRATDIKEYALKMIVHHFGLVARQDAIKNLAQPLLVDIIWALAEEPHFDSPLPVQPRSLPSSSSADTLTDDPEYSRHRCGKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00449289;
90% Identity
-
80% Identity
-