Dvii005638.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila virilis
Gene Symbol
ABTB2
Assembly
GCA_007989325.2
Location
CM017606.2:26372132-26381149[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5.3e-21 1.2e-18 67.0 0.1 6 104 1395 1495 1392 1500 0.86
2 2 9.4 2.1e+03 -1.5 0.0 80 108 1503 1531 1488 1532 0.80

Sequence Information

Coding Sequence
ATGTACTGCACCAAAGATTGCGCCTGCCGTTTGTGCCGCGAGCTACGCGACTATAAGCTGAGCACCAAAAAGCCAGCAGTACTTCCTccgcagcaactgctgctcgCCAAGTCCAAGTCGAAGCTGGCTGGGAAGGGAACGCCTCCAAGCTCCCTGCTGGGTCGCATGCTCAATGAGAATTTCATACTGCGGCGACGCGGCATTTCGCTGAAGAACTTTCAGCCGCAATCGCTGCGCAATAGCGAAATGTGTCAGTCGCAGCCGCGCgatgtgccacgcccagcgcAGACACCATCGCCCACACCTATCGAGGAGCTGCCCGACTGGGCGGCCACACAGCACCGGCGGGCAGAGGATCGTGATGGGAATGGAAATCTGGGTGATCGCGAGGTTAAACCAAATCACAAAGTGGTCATCTATTTTGGTGACTCCATGAATCGAGctcagcagccgccgcagcagcagcagcagcatccaccCGCAGCATTGGTTTCGAAACTGCCCGCAGATGCAGCCAATCTCCACTcacagctgctgcaggagATGTCCCACAAACTGCAGTCCAATGACAAAGTCAGGCCAGAGACGGAGCCGAGAATAGCGTTAGAGGCGGTGGAGGAGTTGGAACTGCCGCAgtcggcggcggtggtggcggcggaggcggaggcggaggcAAACGTTGATGATGAACTGCCGCCCTACATTGAGAGCGTGCAGAATGGCGTAATTAATATCAAAATTGAAGGCAATTACCGGCGCGCCAGTGCGCTGGTGGAAACGGTGGCAAAGCCAACTTTGGCCGTTGTTGGCCAAATGAAATCCGATGCTGCCAACAGCGAACTAACTGCAGCTGATCATGAtaatgatgacgacgacgacgacgacgatgatgatgatgacagcGTCTCTGGCCCTGGCCACGATGCGGAGACCGCGAGTCAGTCAGATTCATGCGATTGGAGCTACGTTCAGGAGTGGCGACGCGCTGCGAGACGACCCACGGGAAACTTGCCGCCAAACTTTGGACAGCAGGCGCCCGCACAGGTAACTGGATTGCCGCCAGTGCCGGTGCCGTTGCAGACGCAGCTGCAGACACAGCAACAGGCGCAACCAGCCCTTGCAGCACATAGTACACCACAAGTGGGAGCCGGCGGTGGTGGGCATGCGGTGGCTATGGCTACGCCAGCACCACGCGTCTTCAAGGAGCTGGCGCAGCAGCCGAACAAGGCGCCTGTGAGCGTTAATAAGATAACAGCGAATGCGCTGCCAGTGGTAACCAGCCCCTTGcccctgcagcagcagcagcagctgacgtCGCCCATCTCCAAGGCGGCAATGCCGCAGCGGGCGGTGGCCGGACCCGCTAGGCTGACGGTGCAAAGTACGCCAGTAAAGTCTCAGCCACCGCAGCTGAGTGGCAGCCTGCAAAGCTCTCCCAGTCGGCCCACACTGGGCATACCGACATccacgacgacgacgcagGCGACGCGAACGCATCAGCACGAACAGTTTCGGGCGCTGCAGCGGGTGCAGGAGTGCCACAGTTCCTCGGATGAGAATCGCAGCTCGGGCCATGCTAGCATGTCGGATACGGGCGGGCACAGTTCCTCGCCTGCGGGCGGCATGACTTTGGGACCGCTGCCCGAGGATCGGCTGGCCGCCGGTGTTACCAATCGGAGCACACGCTCGAGACGCCATCGTGGTATATTACCAGCTGGCAAGGCACCCTGGAGCGGCAGCGGCCTAGAGGACATAAAGCTGGCCATACAGCAGCTGACTATGCGCTCCCAGACTAGCAGCAGCACCTACAGCAGCCTGAGCGCCGGCTCGGAGAGCTCAGAGCCGGCCAGGCGACTGGGACGCTATTCATCGCTGGAGACGGTGATCACCAGCACCAGCGCGGATGAGTTTGTGTGGGTGGATTCGCACAATCGGCTCGTGGAGCTGCAGCATCCACCGTGGAGCCAACAGTGCATTATGCGTGTGCTGCGGAATGGACGCTGCAAGCAGCAGGCGGAGCATGTGTCTGTCGAGGTCATATCCCGGCTAGGTTATCTGCTGCAGCGTGCTCTGGTGCGCATCGCACGGGAGATACAACGTTTCTCGGCTGGGTTGGGTTTGTGCTCCAAGCAGGAGGTGACCGGCGCTTTCAAGGTGGTACTTTGCTCCACACTTGCCGACTCCTGCACGAAGGCGTGCCTGCGTGCAGCAGCCATGTTCGCAGTGCCCGGCGAGAGCGCCCTCAAGCAAAGCAAGTCCTCACGCGCTGGTCTACAGCTGTCGGTGGGCAGCTTCTTCAGATGGATGACTGATGCTCGGCTGGGCAAGTTCATACACGAGTATGCTGCCGTTTACCTGTGCGCTGGCATTGAGAATCTGCTCGAGGAGATTATGTTGCAGTGTGGCGGCGGTGCCGGTGGCACCACAGCCCAGGCTCTAGATCAGAACATTGCCAGTTCAGGCGATTTCTGGGGTTTGTTGCAGCCGTTTGCACATTTGAATGCCGGACGCATTGCCTCCGGCGCTTTGGCCATGCCACGCTGGGCAAGCGCCTTTTCGCTGGCCACCTGTGTGGGCAGCATACGCGAGCTGAAGGAGAAGGCGCTGCGCACACAGCAGGAGTTCCAGCATGCGACCGCCCTCTCCAATGCGGCGCTAAGTGCATTGTTCTATTTTATGCGCTGCTCCCAGCTGGAGCACACAGAACTGGCTGCCCAGAGCTCAACGGCCGGCCAGGCACCACCTAATAGTGGCACCCAAAACGTTCAGGAGCTGTGCTATGAACGCGCCTACGTGGTGCTACCACCGCTGGCCGAATGGCTGCGAGTGGCATCGGCGCACGCTGAGCATCGCAATGGCTTAATGATTGACAAGGATGATATTTTACAGGCTGCGCGTTTATTGCTGCCCGGCGTGGATTGTCCCATACGTCCTGTGGCCCATGATGAGGAGCTGCCCACAAAGAAGACGCACtttagcagcggcagcagccaggGTGGCAGCGCCACGGGCACTGGCAGCTCCAGCTCTAGTTCCCCGGCCGTGAGCAGTATTGGCGAGGACACCTCAGAACTGGGCAGGCGTGCTACCATTGGTGTCGCCTTCAAGTTGTTGCTGACGGGTCGCGCCGAGCTTCTAGCCCAAGccgcgcagctgctgccgcccaCCACACGCTATGATACACAAAATAGCGCCGGGTTAACAGCTCTGATGATTGCCAGCATACGGAATGATGAGGTCGCCTTGCATGCCCTGCTCGATGCCGGCTGTGATCCGAATGTGGAGGTGCCGGCGGCAGGAAGCACTGGCTATCCGGCCATACAACCGGACACACAACACTGGACGGCACTCAGTTTTGCCGCCAGCCGTGCTAACTATGTGGCGCTGCGCATTCTGTTGGAACGCGGCGGCAAGGTGGAGGGCGGTGCTCGCAGCAGCGAGGAGAAGTGCACATTGACGCCGCTGCAACTGGCCGCGGGCACAGGCAATCTGGAGATGGTGGCACTTCTACTGGCGCATGGCGCCAATGCGTTCCTGTCCACACAGCAGAAGGATACACTGTGCTTTGCGGGTGCCGCGCAGAAGGGTTGCTTCTGTGCCATCTCCGTGGCGGCAGCGCATGGGCATCGCTCGTGCTTGCGCAAGCTGCTTACGCATCCGCTGTCGCCGGGCACGCGGGATGTGCTCTCGCTGGAGGAGATGCTTGCCGAGGGCGATGTGGTGGGTGTGCGCGGCTCTGGCGCCGCCGCGGCCACAGTCGCTGGAGAGGACCTGTTGCCGCTTCTGAACAAGACGCAGATCAAGCGACTCCAGGAGGCCATGTACCACAGCGCAGAGAACAATCACTTGGACATAACCATAGAGTTACGCAAGCTGGGCGTGCCCTGGACCTTGCACTGCTGGATGCATGCGCTGTCGGCGGCTCACGAGTTGCGACTGGACGCGGTCATTGATCAGCTGCTGCAGGACTTTCTGCAGGTTTGCCCCGATGATTATAGCGCCCAGTTTGTTAGTGAGTGCCTGCCCCTGCTTTTCAACATCTTTCGCAATAAGAACGAGGGCACCACACTGCTCCTGGCGGACATATTCGCCACATGCTTTGGCTGGGAGGCACTGCATCCACTGAAAGAGCAGCCGCCACTGCAGCCAGTCCAGGGCACACGCATAGATCCAAAGTTTGTCAACAATCCAGAACTAAGCGATGTCACCTTTCGCGTCGAGGGTAAAATATTCTATGGCCACAAAATAGTGCTGGTCACGGCCTCGCCACGTTTTCAGAGCATGCTCAGTGCCAAGCTAAGCGATGCCACCAGCACGCCCACTGTCCAGATCAACGATATACGCTATCACATCTTCCAGCTGGTCATGCAGTTTCTATATAGCGGCGGCTGCAGTGCTCTGGATGTATCCCATGGCGACGTGCTCGAACTGATGGCTGCCGCCAGCTTCTTTCAGCTGGAGGCGCTGCTGCGCTACACAGAGGCGCGCTGCTCCGAGATGGTTGATGTGGACAATGTGGTCGCcatgtatatacatgctaAGGTTTACAATGCCAATAATCTCTTGGAGTATTGCCAGTGCTTTCTGCTACAGAATATGGTCGCGCTGCTGACCTACGATGATTCAGTGAAGCGTCTGCTGTTTGCCAAGAAGATACCAAATCATGATGTCCTGGCCGGCCTGCTCCAGACGCTGCAGCAGCGACTCAAGAGCCGCAAGCCGAATGCTGGTGGATTGGTCAACGTCTATCGCTCTCCGCCGGTTACGCCTGTCAAGAAGTAG
Protein Sequence
MYCTKDCACRLCRELRDYKLSTKKPAVLPPQQLLLAKSKSKLAGKGTPPSSLLGRMLNENFILRRRGISLKNFQPQSLRNSEMCQSQPRDVPRPAQTPSPTPIEELPDWAATQHRRAEDRDGNGNLGDREVKPNHKVVIYFGDSMNRAQQPPQQQQQHPPAALVSKLPADAANLHSQLLQEMSHKLQSNDKVRPETEPRIALEAVEELELPQSAAVVAAEAEAEANVDDELPPYIESVQNGVINIKIEGNYRRASALVETVAKPTLAVVGQMKSDAANSELTAADHDNDDDDDDDDDDDDSVSGPGHDAETASQSDSCDWSYVQEWRRAARRPTGNLPPNFGQQAPAQVTGLPPVPVPLQTQLQTQQQAQPALAAHSTPQVGAGGGGHAVAMATPAPRVFKELAQQPNKAPVSVNKITANALPVVTSPLPLQQQQQLTSPISKAAMPQRAVAGPARLTVQSTPVKSQPPQLSGSLQSSPSRPTLGIPTSTTTTQATRTHQHEQFRALQRVQECHSSSDENRSSGHASMSDTGGHSSSPAGGMTLGPLPEDRLAAGVTNRSTRSRRHRGILPAGKAPWSGSGLEDIKLAIQQLTMRSQTSSSTYSSLSAGSESSEPARRLGRYSSLETVITSTSADEFVWVDSHNRLVELQHPPWSQQCIMRVLRNGRCKQQAEHVSVEVISRLGYLLQRALVRIAREIQRFSAGLGLCSKQEVTGAFKVVLCSTLADSCTKACLRAAAMFAVPGESALKQSKSSRAGLQLSVGSFFRWMTDARLGKFIHEYAAVYLCAGIENLLEEIMLQCGGGAGGTTAQALDQNIASSGDFWGLLQPFAHLNAGRIASGALAMPRWASAFSLATCVGSIRELKEKALRTQQEFQHATALSNAALSALFYFMRCSQLEHTELAAQSSTAGQAPPNSGTQNVQELCYERAYVVLPPLAEWLRVASAHAEHRNGLMIDKDDILQAARLLLPGVDCPIRPVAHDEELPTKKTHFSSGSSQGGSATGTGSSSSSSPAVSSIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVPAAGSTGYPAIQPDTQHWTALSFAASRANYVALRILLERGGKVEGGARSSEEKCTLTPLQLAAGTGNLEMVALLLAHGANAFLSTQQKDTLCFAGAAQKGCFCAISVAAAHGHRSCLRKLLTHPLSPGTRDVLSLEEMLAEGDVVGVRGSGAAAATVAGEDLLPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWMHALSAAHELRLDAVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFRNKNEGTTLLLADIFATCFGWEALHPLKEQPPLQPVQGTRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSAKLSDATSTPTVQINDIRYHIFQLVMQFLYSGGCSALDVSHGDVLELMAAASFFQLEALLRYTEARCSEMVDVDNVVAMYIHAKVYNANNLLEYCQCFLLQNMVALLTYDDSVKRLLFAKKIPNHDVLAGLLQTLQQRLKSRKPNAGGLVNVYRSPPVTPVKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00563271; iTF_00563272; iTF_00475315; iTF_00551682; iTF_00473162; iTF_00584514; iTF_00562563; iTF_01356227; iTF_00559588; iTF_00589637; iTF_00599685; iTF_00493749; iTF_00585311; iTF_00522311; iTF_00550983; iTF_00506216; iTF_00587496; iTF_00573417; iTF_00532475; iTF_00531051; iTF_00595341; iTF_00554478; iTF_00564750; iTF_00616292; iTF_00598254; iTF_00561130; iTF_00541851; iTF_00567631; iTF_00495957; iTF_00547449; iTF_01324238; iTF_01322024; iTF_00549647; iTF_00520016; iTF_00586064; iTF_00476722; iTF_00540466; iTF_00569074; iTF_01320564; iTF_01326516; iTF_01325763; iTF_01322749; iTF_00526677; iTF_00534677; iTF_00479574; iTF_00513559; iTF_00577154; iTF_00497509; iTF_00498247; iTF_00518537; iTF_00553130; iTF_00525261; iTF_00482351; iTF_00557296; iTF_00583057; iTF_00619958; iTF_00566905; iTF_00570489; iTF_00496730; iTF_00597500; iTF_00548927; iTF_00485952; iTF_00598977; iTF_00500418; iTF_00535427; iTF_00543846; iTF_00558823; iTF_00560393; iTF_00607179; iTF_00501901; iTF_00574162; iTF_00528157; iTF_00511384; iTF_00495225; iTF_00610009; iTF_00593216; iTF_00576442; iTF_00552412; iTF_00499678; iTF_00521502; iTF_00596031; iTF_00498976; iTF_00509912; iTF_00601912; iTF_00572697; iTF_01556219; iTF_00806081; iTF_00610754; iTF_00802947; iTF_00583782; iTF_00805287; iTF_00803698; iTF_00537608; iTF_00510644; iTF_00575688; iTF_00528905; iTF_00509194; iTF_00516363; iTF_00582347; iTF_01321291; iTF_00544593; iTF_00512819; iTF_00538324; iTF_00520726; iTF_00470967; iTF_00478823; iTF_00508439; iTF_01327992; iTF_00519258; iTF_00506971; iTF_01325019; iTF_01323485; iTF_00608542; iTF_01570334; iTF_00545343; iTF_00558015; iTF_01327264; iTF_00568349; iTF_00586774; iTF_01549661; iTF_00490878; iTF_00502622; iTF_00901599; iTF_00546752;
90% Identity
iTF_00582347;
80% Identity
-