Dval011840.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila vallismaia
Gene Symbol
gsb-n
Assembly
GCA_035047325.1
Location
JAWNPU010000066.1:22274761-22286189[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.7e-72 1.2e-68 229.0 0.6 1 125 20 141 20 141 0.99

Sequence Information

Coding Sequence
ATGGATATGTCCAGCGCCAATTCATTGAGACCGCTCTTTGCGGGCTACCCCTTTCAAGGACAAGGCCGCGTCAACCAGCTCGGAGGCGTTTTCATCAACGGTCGTCCGCTCCCCAATCACATTCGCCTTAAGATCGTGGAAATGGCGGCCAGTGGAGTGCGGCCCTGCGTGATTTCCCGTCAGCTGCGCGTCTCCCATGGTTGTGTCTCGAAGATCCTCAACCGGTACCAGGAAACGGGATCCATCCGGCCGGGGGTCATTGGTGGGTCGAAGCCTAAGGTCACCTCCCCTGAGATTGAGACCCGGATCGATGAACTGCGCAAGGAAAACCCCGGAATTTTTAGTTGGGAGATACGCGAGAAGCTGATCAAGGAAGGCTTTGCGGATCCACCCTCAACCTCGTCCATCAGCCGGCTGTTGCGGGGAAACGATCGGAGCAGCGAAGACGGGCGGAAGGACTACACCATACATGGAATACTTGGAGGACGCGACTCGGACATCAGCGACACTGAGTCGGAGCCTGGGATTCCCCTCAAGCGCAAGCAGCGCCGCTCTCGCACCACATTTACCGCCGAGCAATTGGAGGCCTTGGAGCGGGCATTTGCCAGGACACAGTATCCGGATGTGTACACTCGGGAGGAGCTTGCACAGACCACGGGCTTGACCGAGGCACGTATCCAGGTGTGGTTCTCCAACCGAAGGGCTCGTCTTCGAAAGCACTCCGGCGGCTCCAGCTCGGGACTTTCACCAATGAACAGCGGCAGCTCGGGTGTGGGCGTCGGAGTGGGCGTGGGGCCTAGTGGGGCAACTGCTCCGCTTGGCTTTGGTCCCCTAGGAGTGGGGTCCATGGCGGGCTACAGTCCGGCGGCAGGTACCACCGCCAACGGAGCGGCAATGAACGAGGGCGGTGTTCACCACACCGCCCATGCCCCGAGCTCGCACCACAGCGCAGCGGCAGCCGCGGCGGTGGCGCACCACCACACGCAGATGGGTGGCTACGATTTGGTACAGAGTGCGGCACAGCACGGATTCCCCGGAAGCTTTGCCCAGCCCGGCCACTTTGGCAGCCAGAACTACTACCATCAAGACTACTCCAAGCTGAGCATCGACGACTTCTCCAAATTGACTGCTGACAGCGTCTCGAAGATCTCGCCCTCGCTACACCTGAGCGACAACTACTCCAAGCTGGAGTCGCCCTCGAACTGGTCCCAGGCTGCCTACCACCTCAACCAGTCGGCGGTGGCGGCAGCCAACTACAATGCCCACGTGGCTCAGCACCAGCTGAACGACTACGCCGCTGCGGCGGTCCACGGGAatgcggcggcggcggcggcctACAACCACCCCTTGCCGGCCCAGGGTCAGGCCAAGTACTGGTCGTGA
Protein Sequence
MDMSSANSLRPLFAGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEIETRIDELRKENPGIFSWEIREKLIKEGFADPPSTSSISRLLRGNDRSSEDGRKDYTIHGILGGRDSDISDTESEPGIPLKRKQRRSRTTFTAEQLEALERAFARTQYPDVYTREELAQTTGLTEARIQVWFSNRRARLRKHSGGSSSGLSPMNSGSSGVGVGVGVGPSGATAPLGFGPLGVGSMAGYSPAAGTTANGAAMNEGGVHHTAHAPSSHHSAAAAAAVAHHHTQMGGYDLVQSAAQHGFPGSFAQPGHFGSQNYYHQDYSKLSIDDFSKLTADSVSKISPSLHLSDNYSKLESPSNWSQAAYHLNQSAVAAANYNAHVAQHQLNDYAAAAVHGNAAAAAAYNHPLPAQGQAKYWS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00901334;
90% Identity
iTF_00545803; iTF_00545912; iTF_00614744; iTF_00475777; iTF_00477285; iTF_00475880; iTF_00481384; iTF_00481489; iTF_00550097; iTF_00550200; iTF_00477179; iTF_00483522; iTF_00590917; iTF_00500875; iTF_00577614; iTF_00555794; iTF_00483635; iTF_00590806; iTF_00555678; iTF_00500991; iTF_00577727; iTF_00619010; iTF_00592337; iTF_00539606; iTF_00592248; iTF_00619097; iTF_00539515; iTF_00915171; iTF_00918029; iTF_00915279; iTF_00917907; iTF_00574756; iTF_00574659; iTF_00914341; iTF_00916071; iTF_00918891; iTF_00917036; iTF_00914449; iTF_00916178; iTF_00918996; iTF_00917151; iTF_00487943; iTF_00566026; iTF_00487838; iTF_00565918; iTF_00602439; iTF_00602531; iTF_00529417; iTF_00529513; iTF_00511953; iTF_00511860; iTF_00494331; iTF_00494238; iTF_00487242; iTF_00487201; iTF_00505258; iTF_00505348; iTF_00565229; iTF_00565321; iTF_00507470; iTF_00507560; iTF_00600910; iTF_00601001; iTF_00503215; iTF_00503116; iTF_00618211; iTF_00618344; iTF_00523641; iTF_00523547; iTF_00612020; iTF_00611914; iTF_00486421; iTF_00486513; iTF_00579925; iTF_00579820; iTF_00517654; iTF_00603201; iTF_00473635; iTF_00480805; iTF_00484293; iTF_00484389; iTF_00471558; iTF_00563752; iTF_00563848; iTF_00471467; iTF_00474449; iTF_00480725; iTF_00611221; iTF_00603289; iTF_00474362; iTF_00473725; iTF_00517565; iTF_00611296; iTF_00503831; iTF_00503937; iTF_00515543; iTF_00515444; iTF_00538903; iTF_00538796; iTF_00612759; iTF_00612656; iTF_00514744; iTF_00514834; iTF_00554936; iTF_00555029; iTF_00604696; iTF_00604789; iTF_00609018; iTF_00477857; iTF_00606145; iTF_00617474; iTF_00569539; iTF_00482820; iTF_00524260; iTF_00569636; iTF_00525829; iTF_00590086; iTF_00590184; iTF_00524362; iTF_00527146; iTF_00480011; iTF_00606252; iTF_00477965; iTF_00482925; iTF_00593678; iTF_00480111; iTF_00531601; iTF_00492178; iTF_00617588; iTF_00527253; iTF_00593783; iTF_00531517; iTF_00609117; iTF_00525726; iTF_00492064; iTF_00536712; iTF_00581480; iTF_00536618; iTF_00581386; iTF_00578384; iTF_00605520; iTF_00605426; iTF_00578484; iTF_00484970; iTF_00613453; iTF_00485082; iTF_00613343; iTF_00594495; iTF_00594384; iTF_00504541; iTF_00504634; iTF_00603933; iTF_00604036; iTF_00543070; iTF_00542986; iTF_00591646; iTF_00591559; iTF_00489216; iTF_00489321;
80% Identity
iTF_00614744;