Basic Information

Gene Symbol
RREB1
Assembly
GCA_014170255.2
Location
CM024333.1:23306326-23313984[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.03 2.3 8.8 0.8 1 21 258 278 258 280 0.93
2 12 0.00028 0.022 15.2 0.2 1 23 290 312 290 312 0.98
3 12 6.9e-05 0.0053 17.1 7.3 1 23 318 340 318 340 0.98
4 12 1.8 1.4e+02 3.2 3.7 2 19 543 560 543 562 0.97
5 12 0.0075 0.58 10.7 0.1 1 23 699 721 699 721 0.97
6 12 1e-05 0.00081 19.7 0.7 1 23 731 753 731 753 0.99
7 12 0.00071 0.054 13.9 2.0 1 23 759 782 759 782 0.97
8 12 0.0025 0.19 12.2 2.0 1 23 1051 1074 1051 1074 0.95
9 12 7.3e-05 0.0056 17.0 0.3 2 23 1446 1467 1445 1467 0.97
10 12 0.12 9.5 6.9 6.3 1 23 1473 1496 1473 1496 0.97
11 12 0.0072 0.55 10.8 0.5 3 23 1701 1721 1699 1721 0.96
12 12 0.0012 0.091 13.2 4.8 1 23 1727 1749 1727 1749 0.99

Sequence Information

Coding Sequence
ATGCTCGCGACACAGCAACAACAACAGCAGCAGCAGCAGCACGGCAGCGGCAGCAACAACGCAGCCGCCGCCACCCACACCAACACAGACCTGGTGGAGATGGAGCGGAAGCGGAGAGAGTCCACCACGTCCGAGTCCTCTCTCGAGCATCTCGACCTCGGCCGAACGCCAANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGCCAGGATCCGCTCAGCGACGAGGACGAGGACGAGGAGGAGGCAGCGGCACGGCCCCTCAATCGCCACAAGCAGCGACGTGGCGCCGCCGCCGCCACTCAGGGATCCTCCTCTGCCTCCGCCTCCATTGTGGTGGACTACTCCGCCGGCGACGCCAGCTCGCTGCGCAAGAAGTTCCGTCTCAACCGCTCGGCGGCCAGTCTCTCGGAGTCGGGATTCGTGGACGCCAGCAGCACCGCCCACAGCGGCTATCTGGGCAACAACAGCAGCAGCGCCAGCGCCAGCACCAGCCTGGCCGTGCCTCCTGCCTCCTCCACATCCGCATCCGCCGGCGGAGCAGCTGCCTCCAGCAGCAGCACCAGCTCGAGCAGCAACAGCAGCAACTCCGGCGGCTCCTCGCCGCAGGGCCTGTGCCTCTCCAGCGGCGAGTCGGGCATCGGGGCGGGCGACGAGCACATGAAGTACCTCTGCCCCATCTGCGAGGTGGTCTCCGCCACCCCGCACGAGTTCACCAATCACATCCGATGCCACAACTATGCCAACGGCGACACCGAGAACTTCACCTGCCGCATCTGCTCCAAGGTGCTTTCCTCGGCCTCATCCCTGGACAGGCACGTGCTGGTGCACACGGGCGAGCGGCCGTTCAACTGCCGCTACTGCCACCTGACCTTCACCACCAACGGCAACATGCACCGCCACATGCGCACCCACAAGCAGCACCAGACGGCGCAGTCCCACTCCCAGACCCACTCCCAGTCCCAGACCCAGGCCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGCTGGAGGAGCTGGAGCTGGAGGACAACAAGCAGCAGCTGCGTGGCCTCAAGACGACCATCAACAACAACGTGATCGAGGCGGAGGAGGACGAGGAGGAGGCCGACGATGCCGACGACGTGGCCATGCTTACTAGTACACCCGATGTGGCCACTCTCCTAGCCGGAGCCAGTGCTTCTGGAGCAGCCTCCCGTTCGCCCTCGCCTTCACCACCAGGTTCCCCCTCCGGGCTGCTCCTGAGCTGTCCCGCCTGCGGAGCCTCCGACTTCGAGACCCTGCCCGCGCTGTGCGCCCACCTGGACGCCCGGCACTCGGACATTCCGGCCAAGTGCCGCGACTGCGAGGTGATCTTCGCCAGCCACCGCCAGCTGCAGGCCCACTGCTGTCGCGGAGTAGTGAATCTGCCGCCCATGCTGGGCTCCAGCAGCTCGCCCCTGCACGCAGCCGACGAGGATGCCGAGGACGAGGAGGAGCAGCAGGATGACGAGGAAATGGAGCAGAAGCGCGATGACTTCTTCCACAAGCTGTATCTGAAGGGAACCGCTGTGGCAAGCGGCGTCTCCCATCCTCCCTCCCCCATCAAGCACGAACCGGCGGACAGCAAGGACCTGGCCGACATCCAGAGCATCCTGAACATGACCAGCTCCAGCTGCACCAGCAGCTTCCTGCGCAACTTCGAGCAGTCGGTGAACACGCCCAGCTCCAGCCAGTACAGCCTGGACGGGCGCGACCAGGAGGAGGAGGCCCAGGACGCCTTCACCTCCGAGTTCCGGCGCATGAAGCTGCGCGGCGAGTTCCCCTGCAAGCTCTGCTCGGCGGTCTTTCCCAATCTGCGGGCTCTCAAAGGCCACAATCGGGTTCACCTAGGAGCCGTGGGTCCTGCGGGACCCTTCCGCTGCAACATGTGTCCCTACGCCGTCTGCGACAAGGCGGCTTTGGTAAGGCACATGCGGACCCACAACGGCGACCGGCCCTACGAGTGCGCCGTCTGCAACTACGCCTTCACCACGAAGGCCAACTGCGAGCGGCACCTGAGGAACCGCCATGGCAAGACCAGCCGCGAGGAGGTCAAGCGGGCCATTGTCTACCATCCGGCGGAGGACGCGGGCTGCGAGGACAGCAAGTCGCGGCTGGGCGAGGATCTGGCGGATCTCAGCTTCCGCTCCATTAGTCCCACGCCCCCGCCGCCGCCCATGTCCACTGAGAGTGGCAGCAGCAGCTCCTCCCAGCTGAAGCACATGCTCATGGGCGAGCACCAGCATTCCCTTCATCCAGTGGTTCCTGCCCAGCCGCCGCTCAAGATCCAGGTCAAGAGCCTGGACCAGCTGGTGGACAAGAAGCCAGCTCCTCAGCCAGTCTCGGAGAAGAACTCCTCCTCCTCCGCCTTGGACTTTAGCATGGATGTGCTGGATCTCAGCAAGAAGCCAACGGAGCCTACACCTAGCACCCAGCCTGCTCCCCCAGCTGCACCTGTACCTCCTCCCGCTGCCGACCTGGCCGCCGCCTTGGAGCAGCAGCAGCTGCTCCTGGCCCAGCAGCAGCTCTTCGGCGGCGTGGGCGGCGATGCTGCCTCCCAGTACATGCAGCAGCTGTTCCGCAGCCTAGTGTTCCAGTCCCAGACCCCGGGCTTCTCCTTCTTCCCCTTCATGGCGCCCCCGCCGCCGCAGCAGCAGCAGCAGGCGGTCAATCCCGACAAGCAGCCGCCTCTGGTGAGTCCCCCCTCGAGGATGAACCCCCTGCCGGTGGGTGTGGGTGTTCCTGTGCCCCCCGGCGGCCCCGTCAAGATGGTCATCAAGAATGGCGTCCTCATGCCCAAGCAGAAGCAGCGTCGCTACCGCACCGAGCGGCCCTTCGCCTGCGAGCACTGCTCCGCGCGGTTCACCCTGCGCTCCAACATGGAGCGGCATGTGAAGCAGCAGCATCCGCAGTTCTATGCCCAGCGCCAGAGGAGCGGCCACCATGTGATGCGGGGCAGGGGCGCCTCCAATGCGGCCGCAGCTGCTGCCGCCGCCGCCGCTGCAGCGACTGCCATGGGTCCTGGCGGAGGCTCCTCCCATCACCATGCTCACTCGCACAGTCACGGACATGGACATGGTCATGGACACGCTCCCATCTCGGAGCAGGTCAAGTACGCCATTCTGGCGCAGCAGCTGAAGGCGCACAAGAACACCGATCTCCTGCAGCAGGCCTTGGCCCATGGCTCCAGCAGCGTGGCGGGGAATCCCCTCCTGCATTTCGGCTACCCTTTGGGACCGGCTCCTGGCGCTCCTCTGAGTGTGAGTGGCCAGGGAAACGGAGCCACGCCCATGGCCATCGACGATGATGAGCCCAAGCTGGTGATCGACGAGGATGAGAACGAGCACGAGGTGGAGCCCGAGGATGTGGATGACTACGAGGACGAGGAGGATGAGGAGGAGGACGAGCCCGAGGATGAGCCAGAGGTGATCCTAGACGAGCCCCAAGTGGTGGTTGTGGAGAAGGAGGAGCCCCTGGAGGAAGCGGAGGAGAACGACCTCGAGGAGCTGCCCAAGCCCCTGGAGCAGCTCAGGGCCAGTCCCAGCCACAACGAGGCGGCCCAGAAGATGGCCGAGACCATCCTGGAGCAGGCCATCAAGGCGGGCAAGCCTTCGCCATCCTCCGTCCAGGAGGAGCATCCCCCTCCAGCGGCCACCCCGCCCTCGGCCATGCAGGAGCCCAGCAGCAATCCGAGCAGCCTGAAGACCATGATCGCCCAGGCCGAGTCCGTGGGCAAGTCCCTCAAGGAGGTGGCCAGTTCCCCCTTTAAAGACGAGTCCCAGGACCTGGTGCCGGTGGCCAAGCTGGTGGACAACGCCACCAGCCAGAACATGAGCTTCAACAGCTACTTCCGGCCCAGCGACGTGGCCAACCACATGGAGCAGAGCGACGAGGAGGGCCTGGTGGCCTCCGGCAGTGCCAGCGAGAGCAACAACAGCGGCACCGAGGACGTGACCAGCTCCAGCTCCGGCAGCGAGCCCAAGAAGAAGTCCGCCTACAGCCTGGCTCCGAATCGGGTGTCCTGCCCCTACTGCCAGCGCATGTTCCCCTGGAGCAGCTCCCTGCGCCGCCACATCCTCACCCACACCGGCCAGAAGCCCTTCAAGTGCTCCCACTGTCCTCTTCTCTTCACCACCAAGAGCAACTGCGACCGCCATCTGCTGCGCAAGCACGGCAACGTCGAGTCCGCCATGTCCGTCTACGTGCCCACCGAGGATGTCAGCGAGCCCATCCCCGTGCCCAAGTCCGTGGAGGAGATCGAGCTGGAGGAGCAGCGTCGCCGCCAGGAGGCTGAGCGGGAGAGGGAGCGGGAACTCGAGAGGGAGCGAGAGCTGGAGCGGGAGAGGGAGCTTGAAAGGGAGCGAGAGCTGGAGAAGGAGAAGGAGCGCGAGCGCCAGCAGCTCATCCACAAGCTGGCCGCCCAGATGAGCGCCGCTGCCGCTGCAGCAGCCGCCCAGGTCGCTGTCTCCGCTGCCTCCTGTGCCGGTTCGCCAGGGAATGGCTCCTCCTCCATCGGAGGTGATCCCTCGGCCGGCGGCGATCTGCCCTACAAGTGCCACCTGTGCGAGGGCTCCTTCGCCGAGCGTCTGCAGTGCCTGGAGCACATCAAGCAGACCCATGCCCACGAGTTCGCCCTGCTGCTGGCCAAGGGAGCCATCGAGAACGAGTCCCTGGACGCCTCGAATCCCCAGCAACAGCAGCTGCAGCACCACCACTCGGATGACGAGGCCACCAATGGCCTGGGACGCGGCAAGTATCCGGACTACAGCAACCGCAAGGTGATCTGCGCCTTCTGCGTGCGCCGCTTCTGGTCCACCGAGGACCTGCGCCGCCACATGCGCACCCACTCCGGCGAGCGGCCCTTCCAGTGCGACATCTGCCTGCGCAAGTTCACTTTGAAGCACAGCATGCTCCGGCACATGAAGAAGCACAGCGGCCGAGCCCACAACGGGGACACGCCCGGCTCCGACTGCTCCGACGACGAGCAGGCCATGAGCAGTCCCCCAGGCACCCCGGCGCCCTCGCCCATGCCCACGCTGCCCGCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGCTGGGCCTGAAGCTGCCCAAGCTGCACGAGCTGCTGGACAAGGCCAACGAGTGGCGGGCCAGCCGGCTGGGCGAGCACAAGGAGAACCTGGGCGAGGCCACGCCCTCGGGAGCAGCGGCCGCGGGCTCGGATCTGATAGGCAACCTCCTGGGGATCAGCGACCAGGGCATACTCAATAAGCTGCTGTCCTCGGCGGACGAGGCGGCCAAGCTCCTGGGCGTGGACAACAAGTGA
Protein Sequence
MLATQQQQQQQQQHGSGSNNAAAATHTNTDLVEMERKRRESTTSESSLEHLDLGRTPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGQDPLSDEDEDEEEAAARPLNRHKQRRGAAAATQGSSSASASIVVDYSAGDASSLRKKFRLNRSAASLSESGFVDASSTAHSGYLGNNSSSASASTSLAVPPASSTSASAGGAAASSSSTSSSSNSSNSGGSSPQGLCLSSGESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQTAQSHSQTHSQSQTQAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLEELELEDNKQQLRGLKTTINNNVIEAEEDEEEADDADDVAMLTSTPDVATLLAGASASGAASRSPSPSPPGSPSGLLLSCPACGASDFETLPALCAHLDARHSDIPAKCRDCEVIFASHRQLQAHCCRGVVNLPPMLGSSSSPLHAADEDAEDEEEQQDDEEMEQKRDDFFHKLYLKGTAVASGVSHPPSPIKHEPADSKDLADIQSILNMTSSSCTSSFLRNFEQSVNTPSSSQYSLDGRDQEEEAQDAFTSEFRRMKLRGEFPCKLCSAVFPNLRALKGHNRVHLGAVGPAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSREEVKRAIVYHPAEDAGCEDSKSRLGEDLADLSFRSISPTPPPPPMSTESGSSSSSQLKHMLMGEHQHSLHPVVPAQPPLKIQVKSLDQLVDKKPAPQPVSEKNSSSSALDFSMDVLDLSKKPTEPTPSTQPAPPAAPVPPPAADLAAALEQQQLLLAQQQLFGGVGGDAASQYMQQLFRSLVFQSQTPGFSFFPFMAPPPPQQQQQAVNPDKQPPLVSPPSRMNPLPVGVGVPVPPGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRGASNAAAAAAAAAAAATAMGPGGGSSHHHAHSHSHGHGHGHGHAPISEQVKYAILAQQLKAHKNTDLLQQALAHGSSSVAGNPLLHFGYPLGPAPGAPLSVSGQGNGATPMAIDDDEPKLVIDEDENEHEVEPEDVDDYEDEEDEEEDEPEDEPEVILDEPQVVVVEKEEPLEEAEENDLEELPKPLEQLRASPSHNEAAQKMAETILEQAIKAGKPSPSSVQEEHPPPAATPPSAMQEPSSNPSSLKTMIAQAESVGKSLKEVASSPFKDESQDLVPVAKLVDNATSQNMSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSGSEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQEAERERERELERERELERERELERERELEKEKERERQQLIHKLAAQMSAAAAAAAAQVAVSAASCAGSPGNGSSSIGGDPSAGGDLPYKCHLCEGSFAERLQCLEHIKQTHAHEFALLLAKGAIENESLDASNPQQQQLQHHHSDDEATNGLGRGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRHMKKHSGRAHNGDTPGSDCSDDEQAMSSPPGTPAPSPMPTLPAXXXXXXXXXXXXXXXXXXXXXXXXXLGLKLPKLHELLDKANEWRASRLGEHKENLGEATPSGAAAAGSDLIGNLLGISDQGILNKLLSSADEAAKLLGVDNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00491706;
90% Identity
-
80% Identity
-