Basic Information

Gene Symbol
su(Hw)
Assembly
GCA_035043275.1
Location
JAWNNC010000509.1:6620551-6625185[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.001 0.072 13.7 1.6 1 20 269 288 269 290 0.94
2 12 3.1e-06 0.00021 21.7 0.4 3 23 341 362 339 362 0.93
3 12 0.019 1.3 9.8 0.0 1 23 368 390 368 390 0.97
4 12 8.3e-07 5.8e-05 23.4 2.5 1 21 397 417 397 418 0.95
5 12 3.6e-06 0.00025 21.4 0.6 2 23 430 451 429 451 0.96
6 12 0.00012 0.0081 16.7 5.3 1 23 462 484 462 484 0.99
7 12 9e-05 0.0063 17.1 0.9 1 23 490 512 490 512 0.97
8 12 2e-05 0.0014 19.1 0.7 1 23 518 540 518 540 0.99
9 12 1.6e-06 0.00012 22.5 3.0 1 23 546 568 546 568 0.98
10 12 4.4e-05 0.0031 18.0 1.2 1 23 572 594 572 594 0.97
11 12 8.2e-05 0.0057 17.2 0.1 1 20 602 621 602 626 0.93
12 12 3.1e-05 0.0022 18.5 0.4 3 23 646 667 644 667 0.96

Sequence Information

Coding Sequence
ATGTCACTAACAATGCTGTCGATGACAAGATTAGCTTCTGATTGGCTGTGCACGAATCCAGTGAATAGTCAGACGCTAACGCCATTGTATACGTGCCTGCGATCGCGCTGTGAACTATCACTTCCAATGAGCGCGAGAAAGGACGCCTCCGAGGCGAACTCCCTCAGCTCCAGCAGCGATGTCGGCGGCGGCAACGTGGTCAAAATCTTGGACGTTGAGAAAATATCATCAGCCAAGGATAAACGTCCTGGCACCCGCATGAAACTGCTCAACGATGTGACAGCGAGTAAAGCAAAAATATCTGCACGCGTCAAGCAAGAGAAACGCACCAGCATCAAAATACTCAACAACGATGATTCAGCAAAGAGTCCCAAAGGCAGCAGCGATAAGCGCTCCAGTGGCAAAACAGCGACTGCAACACCTGTCGTCAAGATCTTAAATGAGAAACGCATTGCGCCGGCCTCGACGCCCGTGGAGACGGCCAAAATTAAGACATCGCCcggcaaaaagaagaaaatggatCACTATGTCCTGCAGGCCATCAAGAATGAGAACAGCAAATTGGACAATACGACGGCCAGCAGCGTGGAGATCGAGGATGATGAAGATACCATTGATTTTATACTCGCCGATGAAGATGTCGAGTTGGGTGCCGCCAAGGAGAAATACGAAGAGTTCATTGTCACCGGTGTGGAGGaagacgacgatgatgatgatgatgatgaggatgagggCACCGCTGAGGGCACTGGTGCAACGAATCGCAATGCCGGCAATGACAGTGAACTCAAGGAGATTATGGAGCATGTGTGCGGCAAGTGCTACAAGACATTTCGGCGCGTCAAGAGCCTGATGAAGCACTTAGAATTCTGCCGCTATGACAGTGGGTATCATCTGCGCAAAGCTGACATGCTCGACAATCTGGAGAAGATCGAAAAGGATGCGGTGGTCATGGAGAAGAAGGAcatctgcttctgctgcagcGAGAGTTACGACACCTTCCACCTGGGCCACATCAATTGCCCCGATTGCCCCAAGTCATTTAAGACACAGACCAGCTACGAGCGTCACATCTTCATCACTCATTCCGAGTGCAATGATTATCCCTGCTCCATATGCAATGCGAAATTACGCAGCGCCGCCTTACTCGAACTgcacgagcagcagcatcaattgCGTGGCAAGCCCTTCGCCTGCAAGATCTGTGGCAAGGACTTTACGCGCTCCTACCACTTGAAGCGCCACCAGAAGTATTCGTCGTGCTCGGCCAACGAGAATGATACCATGAGCTGTAAGGTTTGCGATCGCGTCTTTTATCGTCTCGACAATCTGCGCGCCCATCTCAAACAGCACCTGGGTACCCAGGTGGTCAAGAAGCCGGAGTACATGTGTCATGTGTGCAAGAATTGCTTCTACAGTCTGTCGACGCTCAAcatacacatacgcacCCACACTGGAGAGAAGCCCTTCGATTGCGATCTTTGCGACAAGAAGTTTTCCGCCTTGGTGGCGCTTAAGAAGCATCGACGCTATCACACCGGCGAGAAACCCTACACCTGTTCAGTGTGCAGTCAATCTTTTGCCGTCAAGGAGGTGCTCAATCGCCACATGAAACGGCACACGGGCGAGCGTCCACACAAGTGCAATGAGTGCGGCAAGAGCTTCATTCAGGCCACACAGCTCCGCACGCATTCCAAGACGCATCTGCGTCCCTTCCCCTGCTCCAAGTGCACCGAAAAGTTTAAGACAGAGAAACAACTTGAGCGTCACGTTAAGGCGCATTCGCGGCAGAAGCGTCGCTCCTTTCCCTGCTCGAAATGCCCCCGAAGTTTCCGCACTAGCGCGCTGCTGCAGGAGCATGTTGATGCTGGCGATCACTCACCTGATAAGCAGGTGAGGGCTAAGCGCTCGGCCAAGACGATTGAGCGCACCGATTGCGCCATCTGCGACAAGAACTTCGACAGCACCGATACGCTGAGGAATCACATTCGCCGCGTGCACGAGTGCGATCCGGATGACATTTTTGGCACGGAGCCACCGCCAGCAAAGCGACGGGCTAAGAAGACCGTCCAAGTTGTGGCACCGATAGAGGGgatcgacgacgacgaagacgcGGAGGAAGATGAAGGGGAAGATGTGCCGGCTGCCAACACTTCGGCGGGCTCGCTCATCTCCAGCCAAACGGATGGCAATGGGGTTGTGGTGCGCGAGTTTCTGGTGGATGAGGGCGACGGCAGCGCTCAGACAATTGTCCTCGAAAATGAGGTGTACACCATATTGCCCTTGGAGGGTGCCGGTGCTACCGAAGCGACGTCAGCGGAGGGCGACGTTAAGGCCGAATCCAAGGAGAAGCAGAAACAGGCTGTGTCGCCAGTGGTCAAGAAGGAGCAACGGAAATCGTTGGCGGCCAGTTTGGCCGCTGCCATAGCGGATAATCAGGATGAGCCGCTGAGCGAAGATGATTTCAGTGGCGAGGTGCTCACCGAAGACGATATAAAGCTCAAGGAGAACATAGCCAAGCTAATTGATATGCTCGTCGATCCGCAGACACTCAAGAAATACGGCTGGCCAAACAGCAGCGAGGAGTCGGTGCTCTGCAAGGTCATCGAGAACTGTGGCCACGATCTGGACAAAGGCGGCGAGAACTATGCCGAATTGGATTATGGCAGTCGCATGCGTGAATATTGCAAGCTCCTCTTCACGGTGGTCATACACAATGACTCGATAAAATCGTTGCTCAACAATTTTCCCATCGACGATGTCATTGAGTATGTGCTGGGCGATGAGGATCAGGATCTGGAGCAGGACCCGGACATGGAAAAGGACAAGGAGAAGGGCAAAGACATGGAGACTGAGCAATCAGACACGGACACTAGGCAGGATGCCATTGAAACCGATGCCTAA
Protein Sequence
MSLTMLSMTRLASDWLCTNPVNSQTLTPLYTCLRSRCELSLPMSARKDASEANSLSSSSDVGGGNVVKILDVEKISSAKDKRPGTRMKLLNDVTASKAKISARVKQEKRTSIKILNNDDSAKSPKGSSDKRSSGKTATATPVVKILNEKRIAPASTPVETAKIKTSPGKKKKMDHYVLQAIKNENSKLDNTTASSVEIEDDEDTIDFILADEDVELGAAKEKYEEFIVTGVEEDDDDDDDDEDEGTAEGTGATNRNAGNDSELKEIMEHVCGKCYKTFRRVKSLMKHLEFCRYDSGYHLRKADMLDNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSECNDYPCSICNAKLRSAALLELHEQQHQLRGKPFACKICGKDFTRSYHLKRHQKYSSCSANENDTMSCKVCDRVFYRLDNLRAHLKQHLGTQVVKKPEYMCHVCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYTCSVCSQSFAVKEVLNRHMKRHTGERPHKCNECGKSFIQATQLRTHSKTHLRPFPCSKCTEKFKTEKQLERHVKAHSRQKRRSFPCSKCPRSFRTSALLQEHVDAGDHSPDKQVRAKRSAKTIERTDCAICDKNFDSTDTLRNHIRRVHECDPDDIFGTEPPPAKRRAKKTVQVVAPIEGIDDDEDAEEDEGEDVPAANTSAGSLISSQTDGNGVVVREFLVDEGDGSAQTIVLENEVYTILPLEGAGATEATSAEGDVKAESKEKQKQAVSPVVKKEQRKSLAASLAAAIADNQDEPLSEDDFSGEVLTEDDIKLKENIAKLIDMLVDPQTLKKYGWPNSSEESVLCKVIENCGHDLDKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDLEQDPDMEKDKEKGKDMETEQSDTDTRQDAIETDA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01325058;
90% Identity
iTF_00511421;
80% Identity
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