Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.6e-16 2e-13 50.5 0.1 33 83 15 62 13 67 0.89

2 2 9.1 1.2e+04 -3.2 0.2 82 82 101 101 79 118 0.52

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.6e-16	2e-13	50.5	0.1	33	83	15	62	13	67	0.89
2	2	9.1	1.2e+04	-3.2	0.2	82	82	101	101	79	118	0.52

Coding Sequence: atgaagctcTCGCCGGAGAGCGAGGTGAGGCGAGGTGAGGCGAGCGATCGCTTTCCCTACTACAAATCGAACGACGACCGCTGGAAGAACTCGGTGCGACACAATCTGTCCATTAATCCGCATTTCCGCAAGGGCGTGAAGGCGCCCCAAGGTGCCGGCCACCTGTGGGCCATCTCCAGCGGCGACTCGGCGGAGAATGTGCTGGCCTGGGAGCATAAGAAGCAGCGCCTGGATTTGTTCTTTAAAATGGAGTCCATCAATCGGGAGCGCatccagcagcaccagcagcagctccagcagcaacatcagcagcatcagcagcagcaacagcagcagcagcagcagcacaactGTCActcgccgcagcagcagcagcatcagacacagcagcagcagcagccgcatccAACGCAGACCAGCAGTTGTCTGTACGATgaggcggcggtggccgccGCCACGCTCACCCAAGAGATGCTGCAGCAGACGCCCGGGGGCGGCAGTGAGGCctcccagcaccagcaccatgCCCATGGCCATCACAGCCATCACCAGCAGAGGCTGTTGCCGTTCAACGATCTGCTGAGCGACGACGAGCTGCGAAAGACGGCGGGCCAGATCCTGAATGGAATCCACCGCGAGGTGGAGGTGCAGTCGGTCAACTCCATCATCAGCACCTACCACGATGTGCTGCTGGATAATGAAGACTATCTCAATCCCATACACAAGGACGTCGTGGTCACGGAAAGCGGCCTGCGCCAGCAGCATGGCCACCTGGGCAGCAGTCTGGGCAACGGCAGCCACATGGGCGGCAGCTCGCAGTACTACATCACCGAGATCGATCCCATGGAGCTGGGCATCCAGATGTCGCACCAGGTGGAGCCCTCCGAAGAGGAGGTGCTCTTCAGCGACGAGTTCAACCTGAACTACTTTGGCTACAATCCCGGCAGCGACATTGTCGCCTGA
Protein Sequence: MKLSPESEVRRGEASDRFPYYKSNDDRWKNSVRHNLSINPHFRKGVKAPQGAGHLWAISSGDSAENVLAWEHKKQRLDLFFKMESINRERIQQHQQQLQQQHQQHQQQQQQQQQQHNCHSPQQQQHQTQQQQQPHPTQTSSCLYDEAAVAAATLTQEMLQQTPGGGSEASQHQHHAHGHHSHHQQRLLPFNDLLSDDELRKTAGQILNGIHREVEVQSVNSIISTYHDVLLDNEDYLNPIHKDVVVTESGLRQQHGHLGSSLGNGSHMGGSSQYYITEIDPMELGIQMSHQVEPSEEEVLFSDEFNLNYFGYNPGSDIVA

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00479991; iTF_00491331; iTF_00581349; iTF_00536583; iTF_00489195; iTF_00571723; iTF_00482801; iTF_00477836; iTF_00525708; iTF_00484955; iTF_00545787; iTF_00614727;
90% Identity: iTF_00479991; iTF_00571723; iTF_00482801;
80% Identity: -