Dsuz004283.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila suzukii
Gene Symbol
ey
Assembly
GCA_013340165.1
Location
CM023447.1:1522920-1551558[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.4e-72 2.3e-69 230.9 0.9 2 125 98 221 97 221 0.99
2 2 3.1 4.9e+03 -2.8 0.0 56 80 365 390 364 395 0.79

Sequence Information

Coding Sequence
ATGTTTACTCTGCAACCAACTCCAACGGCTATAGGCACCGTAGTTCCTCCCTGGTCAGCGGGTACATTGATAGAGCGTCTTCCGACCTTGGAGGACATGGCTCACAAGGACAATGTGATTGCAATGAGAAATTTACCCTGTTTGGGTCCCGCTGGTGGAAGCGGACTAGGCGGTATTGCTGGAAAGCCTTCCCCTACAATGGAAGGTGTGGAAGCCAGCACAGCGTCACAGCCCCATTCGACATCGTCCTACTTCGCAACAACTTACTACCATTTAACTGATGATGAATGTCACAGTGGAGTAAATCAGTTGGGTGGAGTTTTCGTTGGCGGAAGACCTTTGCCAGACTCAACACGACAGAAAATTGTCGAACTGGCCCACTCTGGAGCAAGGCCATGTGATATTTCTCGGATTCTTCAAGTTTCCAATGGATGTGTGAGCAAAATTCTCGGAAGGTACTATGAAACAGGCAGTATAAGACCACGGGCTATCGGTGGTTCCAAGCCACGAGTGGCCACCGCTGAAGTTGTTAGCAAAATATCACAGTATAAGCGCGAGTGCCCGAGTATATTTGCTTGGGAAATTCGGGATAGATTGCTTCAGGAGAACGTTTGTACCAACGATAATATTCCAAGCGTGTCCTCAATAAACCGTGTGTTGAGGAACCTGGCGGCCCAGAAGGAACAACAAAGCTCGGGAACTAGTAGCTCTGGTACCGGCCCCGGTAACTCGAGCAGCGCAAAAGTGGCCGCCAACAGCAGTGGAAACATCAGCAACGGCTCGAACGGGACGCGAACCACACTGACCTCCTCCGCCGATCTCATGCAGACGGCCACGCCGTTGAACTCATCGGAAAGCGGCGGCGCGAGCAATTCCGGCGAGGGGAGCGAGCAGGAGTCGATTTATGAGAAGCTGCGGCTCCTGAACACACAGCACGCGGCCGGATCGGGATCGGGGTCGCTGGACCCGGCCATAGCTGTCCCGTTAGTGGGTCAAGCGCCGAGCCACTTTGGACCCCATTCCAGCCACCCCCTCAACCAGCTGGTGCACGGTAACCAGCAGgttctgcagcagcagcagagctGGCCGCCCCGCCACTACTCCTCCGGATCCTGGTACCCCTCCTCCCTAAGTGGCAGTGAACTTCCCATCTCATCGGCTCCCAACGTCGCGCCGATGACGGCGTACGCGTCGGGTCCTCCGCTGGCTCAGCCTCTGAGTCCGTCGAACGACATCGCAGGTCTGGGGAGTTCCGGTCACCTGAGAAATTGCCCCGTGATCACGGAGGACATTCATCTAAAAAAGGAACTCGATGGTCATCAGTCCGATGAAACAGGCTCCGGTGAGGGTGAAAACTCCAATGGTGGCGCTTCAAATTTAGGAAACAATGAGGATGATCAAGCACGGCTAATACTTAAAAGAAAGTTGCAACGTAATCGAACATCTTTTACAAATGACCAGATAGACAGTCTAGAAAAAGaGTTTGAACGAACACACTACCCAGATGTTTTTGCGCGAGAACGATTGGCTGGAAAGATTGGTTTGCCGGAGGCCAGGATTCAGGTTTGGTTCTCGAACCGCCGAGCAAAATGGCGTCGAGAGGAAAAACTCCGAAACCAGAGAAGAACACCAAATTCCACAGGAGCTAGTGGAACCTCTTCCTCGACATCAGCAACTGCCTCCTTAACAGATAGCCCCAACAGCCTAAGTGCTTGTTCGTCTTTGCTGTCCGGATCAGCTGCGGGTCCTTCAGTTAATACCATTAATGGTTTATCCTCGCCAAATACATTGTCCACCGTTGCCAGTGCCCCAGCGGTTGGTGCTGGCATTGAGGGTACCGGCAGCCCAACACCGACCCTGCATATTCGATCCGGCTGCCCCTCTGACATAGCCGCTGGACGTCACAGTGAAGACTGTAGAAGAGCTTGTTCTCCGGGCGGGATTGGGATTGGCGGCCAACAAAGTAGCCATCATCACCAGAGCAATGGTCACACCCATGCCCATGCACATGCGCTTGTTCCTGCTATTTCGCCTCGACTCAATTTTAACAGTGGCGGCTTTGGAGCGATGTATTCAAACATGCATCACACGGCCTTATCTATGAGCGATACTTAtggaACGGTAACACCAATATCGAGCTTCAACCACGTCGGATCGTTGGCCCCACCATCTCCAATATCGCAACAGGGCGACCTTACGCCCCCATCTTTGTATCCGTGCCACATGAGTCTACGACCACCGCCAATCGCACCGCCACACCACCACATAGTGGCGGGTGACGTGGGCAGCCCTGCGGGAGGTATAGGCAATGCCCAGTCGGGAAATCTGGGAGCAAACTGCGGTGGATCGGGATACGAAGTTCTGTCCGCCTACGCTTTGCCCCCTCCCCCGTTACCATCGAGCAGTGCACCTGCATCAAGCTTCTCAACATCATCCAGTACTAGCGCTAATGTGACCTCCCATCACAACATGCCACAAGAACCATGCCCCTCACCATGCAATTCAAACTCAAACCACCTGGGAGTTGGACACAGCTCTGTATTCGCGACCGACCCGATTTCGCCGGCCGTATCTTCATATGCACACATGAGCTACAACTACGCTTCGGCTGCCAACAACGTGACATCCTCCTCTTCCGGCGGAGCCTCAGCGCACGTTGCTCCAGGAAAGCAACAGTTCTTCGCCTCATGCTTCTATTCACCTTGGGTATAA
Protein Sequence
MFTLQPTPTAIGTVVPPWSAGTLIERLPTLEDMAHKDNVIAMRNLPCLGPAGGSGLGGIAGKPSPTMEGVEASTASQPHSTSSYFATTYYHLTDDECHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSSGTSSSGTGPGNSSSAKVAANSSGNISNGSNGTRTTLTSSADLMQTATPLNSSESGGASNSGEGSEQESIYEKLRLLNTQHAAGSGSGSLDPAIAVPLVGQAPSHFGPHSSHPLNQLVHGNQQVLQQQQSWPPRHYSSGSWYPSSLSGSELPISSAPNVAPMTAYASGPPLAQPLSPSNDIAGLGSSGHLRNCPVITEDIHLKKELDGHQSDETGSGEGENSNGGASNLGNNEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASGTSSSTSATASLTDSPNSLSACSSLLSGSAAGPSVNTINGLSSPNTLSTVASAPAVGAGIEGTGSPTPTLHIRSGCPSDIAAGRHSEDCRRACSPGGIGIGGQQSSHHHQSNGHTHAHAHALVPAISPRLNFNSGGFGAMYSNMHHTALSMSDTYGTVTPISSFNHVGSLAPPSPISQQGDLTPPSLYPCHMSLRPPPIAPPHHHIVAGDVGSPAGGIGNAQSGNLGANCGGSGYEVLSAYALPPPPLPSSSAPASSFSTSSSTSANVTSHHNMPQEPCPSPCNSNSNHLGVGHSSVFATDPISPAVSSYAHMSYNYASAANNVTSSSSGGASAHVAPGKQQFFASCFYSPWV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00605519;
90% Identity
iTF_00578371;
80% Identity
iTF_00604680;