Dsub000977.3


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila subsilvestris
Gene Symbol
hang
Assembly
GCA_035043285.1
Location
JAWNNB010000133.1:6646123-6660814[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.37 27 5.6 1.0 3 23 587 608 586 608 0.93
2 18 0.24 17 6.2 2.7 3 22 716 735 714 735 0.89
3 18 0.00081 0.058 14.0 3.3 1 22 835 856 835 858 0.90
4 18 0.093 6.7 7.5 0.1 2 21 870 889 869 890 0.93
5 18 0.00093 0.067 13.8 0.2 2 23 1033 1055 1032 1055 0.95
6 18 0.0027 0.19 12.3 0.1 1 23 1063 1086 1063 1086 0.96
7 18 0.00035 0.025 15.1 0.2 2 23 1172 1193 1171 1193 0.97
8 18 0.00039 0.028 15.0 2.9 2 23 1294 1316 1293 1316 0.97
9 18 0.03 2.2 9.0 0.2 2 23 1325 1347 1324 1347 0.95
10 18 0.0027 0.19 12.3 0.2 1 23 1360 1383 1360 1383 0.97
11 18 0.00017 0.012 16.1 1.1 1 23 1465 1487 1465 1487 0.99
12 18 0.0026 0.19 12.4 0.9 1 23 1495 1518 1495 1518 0.96
13 18 1.9 1.4e+02 3.4 0.4 2 19 1526 1543 1525 1544 0.92
14 18 4.3e-05 0.0031 18.0 1.4 3 23 1637 1657 1636 1657 0.98
15 18 0.00093 0.067 13.8 0.2 1 23 1692 1714 1692 1714 0.97
16 18 8.3e-05 0.006 17.1 0.6 2 23 1811 1833 1810 1833 0.93
17 18 0.006 0.43 11.2 0.5 3 23 1889 1909 1889 1909 0.98
18 18 0.00014 0.0098 16.4 2.1 1 23 2237 2259 2237 2259 0.98

Sequence Information

Coding Sequence
ATGTGCGACACGGCGGCAACAACAGCTACTACAACtttggtggcagtggcagcaccagcagcgtcGTCGGTGTCTGGCACTGGAacgagccagagccagagccagggaaCGGCCGCGGCATTGGCTACAGCAacgacgacagcagcaggagccacaCCGCCAGCTACAACCACAGCGAAACccgagcaacagcagcgggcGCGACAAAATTGCTGCCGCCTCTGCATTGCCCCGGCCACGGAATGCATTTCGATCATCAATAGCTATGCGGCCGACAAGGAGCCGCTCTCTACAAAAATCCACAACTGTGTGAACATCAAGATAACACCACAAGATCGGCTATCACTGCAGATCTGTCACGCCTGCATCAGCTACTTAAACTCGTGGCAGAGCTTTAAGAATCGCTCGGTTAGCGCACAGAACAAACAGCGCCAGTGGCTGGAGGCCAACAAGAGCAAGCTACTTAGCTATTTGGATTTGAACAGTGCCGAGAATGGAGGAggtcatcagcagcagcagcatcaccaacagaaccagaaccagtcacagtcacagcagcagcagcagcatcattcGGAGAATGAAATTGATTTGGAGAAGCCATCGGCCGCCCAAATATTGGACGGCATACCCTCGCTGAAGAAACGCAAATCCCTAACAGTCTATGTGAGTCCTaaaccgcaacaacaacagctgcagcaacagcagcagcagtcgcagcaacCGGCCAGAttgacggcgacggcgacagcAACATCGTCACAGCAGCAAACCCTGCAGACCCTTCTATTGCAGGTGCCAACGATAACGgtcagctcctcctccacaaCACCAGCATCTGGTGgtggatcagcagcagcagcagcagcagcatcagtatctcagcagcagcagcgccagcatcATTATCGTAAatatcagcagcatcagcaacagcagcagcagcagcagcggggtaAACAGAtgatgcagcaacagcagcagcaacaacatcatcaacagctgcaacatcatcagcaaaagcagcagcagaagagacGACAGCGACAGGCGCCGCGACGTCCTGCTCCTCAATCTTCTGGTCTGCCTGGGCAGCGAAAATTTAAGCCAAAAGTTTATTTACCCTTGGATATAGCAGTGCCACCATTGCCGCCTCTACCAGCATCAGCTACtacgctgctgctccaccagcaccaggaccATTGGCAGTGCCAATTCcggctcccgctgctgctaACCATCCGGTTCTTCATGCTGCTGAAATACTGCCAACGGCTGCCACTGTGGTGGGGGAATCTGCCGTTGTCGCTGCCACTTGATTTCAGCCAATGTAGCAGCAAGATCGGCATCGGCCTCGGCCTCTTACCGTCCACATCCACATACAGCCATAGCAGCACCATAGCACACGCCTCCGCTGCGGcggcatctgcatctgccacCGGCATCTcgtccgtctccgtctccatgCAACATGCGACAGCACCGCTGCTAATGCCGCCACTGCCCGCAATTCCCATCAAGGATGAGCCCATTGACACAGATGATGACTATCAAATGAAATCGTTGGACGAATCCGACGACATGGTCGATCCCACAATGTTCTTAGAACGCTCCGAGCACGAGGGCGATGTACCACTGATGACCTCCGACTATGATTATACGGCGCAGCATGGTGTGAATGCAGAGACAGCGGCCGCGTCGCTGCCGCCTAATGCCGTGGCTAATGTGGCCGCCGCCGGAGACTCAAAGGTGGCCAGCTGCCGTGCATGCAGTCTCCAGTTTTCGACACGTGCCAATGCCCGACGCCATGAGCGAAATTTGCACCCAAATCTATTCCAATTGTCGACAGACTCGCCCAACAATACGCCCATCACAAAGCCCACACCGGCACTGGCGGCCGCATTGGAGATACAGCGTGCCGCTGCAGAGGCGGCCACCGAGGAGGCCAGCAAAGCTGCCGGCGCTGCCGGGGGTAATATATCGACCCAAAAGTATCGTCAGGTGGTGATGAATGCCTTCATCAAGTGCGAGGGTGGGGGCTTCAACTATGACAGTCCGGAGCAATATCAGCCGCTGCTCACCCGCGACAAGGTGGAGTTTATCGAGCAGAATTATGAATTCCTGGAGCAGTACCAGACGATGACATGCCGCTGCTGCGACAAATACTTTAGTACGTACAAGAACTTTATGGCCCATGTGCGCAAAAAGTATCCGCTTTTGCCGCGCAATCTCTGCTTCAACTGCCTCAAGATGAACGAATCGAAGGCGCTGTTCATTTCACATCTCAAGAAGCGCAACTGCATCAATCTGTATCGTGTGCTGAACGCCCTGCGCGGCAAGCAGCCTAACTTTCATCCCACATCATCGGACATTGGATCGTTTGGTGGCGAGACGACGACCCAAACCAGTCCCACTATCgttgtgccgctgctgctggataaCAGCTCGAGCGGCGAACGGCCAGAGAAGCTGCGCGCCAAGGAGCTGCTGGTGAATAAGCTTTACGAGTGCAAACTCTGTCCAAAGGGCTTCCGCACCAAGCACGAGTTTCGCACCCATGTGTACGACAAGCATGCGGATGTGCAGCGCAAGGACAACAATTCGATTCAGTGCAGCTTCTGTGGCTTGGACTTTGCCGATCCCGTGGACAGGCGACGCCACTACAACAATATGGACTGCATTGTCCGGCTACGCTGCATGACGTGCGATGCCAAGGTGGAGACGCATCAGCGTTTCCTCGATCATGTCTATCAGGATCATTTGGGAGGTATAAGCAGCGATAATGCCTCCAGTGTGAGTGGaatgggcggcggcggcggtggaggtgGCGGTGGTAGGAGCAGCAGTATTGAGAACTCACCTGGCAAGCGGAGTTTACTGGGTGCCCTTGGTATTGGAGTTAGCTCTCCCGCCGATGAGTCACGCAGCGgcagtgcagcagcggcagcagcacccaaTCAAACCTCAACGCCAAAGCCAACATCGGGAGGAGtcggtggtggtgttggtggggCGGCGGCGTGCACAACACCTGGCTCCCTAAATCGTGACGCTGGTGGTGCCCCAAAATCACAGTATTTCTCACGAATGCCACAGGTATGCCCCATCTGTGGCCAACAgtacaacaactacaacaacgtGCTGCGACACATGGAATCGAAGCATCCCAACAAACTGCCCGAGACATACAAATGTGTGCGTTGCGGCCTGGGCTATCCAAGAATCTCGTATCTACGGGAGCACATGATCAACGTGCATGGCGTGGACAAGAATCGTCATTCCGGTGGCTTTGAGTACATTGTGAATGCGGATGCCGTGAAGCTGGCCGATGGCAGTACACCGAATGTGTCCACGGGTCGTTACGACTATGTGATGAAGGATCTGATGTCAATAACAAATGGTGGGACACTCGAtgatgacgaggaggagaccgGCAGCATGGCCAAGAAGATACGCCTGGACgatagcagcaacaacagcagtctGGTGGGTGGAGTGGCCAGCCAGCAAAAGGAGTGCCCCATCTGCAATGCACTGTTCAGCAACAATATTGGCCTGTCCAATCACATGCGCTCACATTACACGGCCTCGAACTCCGTGAATGCCGCTCTGGTGGCGGCCAATCGCATGACACCCAAATCGCTGACCATAACCGCCACACCAGCCACAgagacggtgacatcatcggcAGCCTCAATGGATGtggaagatgatgatgagggcATGCTAGCGCTCGAAACAGGAAAGCTGATGGCCAGCGTCAGGGGCTCtacctctggcgttgctgtgcCCCCTGCCATGGTGAATCAGACGCCCCAGGAGCAGGCCGTATTTCGTCGTAGCCTTGATCAGGCGGCGGATCGTCGCTTTCGCCGGATGCGCTGCCGTATCTGTCAGCGGCGTTTTAGCTCAAAGAAATCATACCGCTATCACATGCTCACCGACCATCAGGTGCAGAATGTGCAGTTCATCAAATGCAAGCTGTGCAATGCAGAGTTTGCCTACGAGAAGGGTCTGAAGGTGCATCTGTTCAAGGTGCACGGACGTGCGATCAAGGATGAGATGATTGTGAAGCAGTTTGAGTGCGATGTCTGTTCGATTGTCTACAGctcggagctggagctgaagcagcaCAAGAGGAGTGTCCATAAACTAACATCTGTGTCGGTGTCTGCATCCGCCTCGGCATCAGCGtcggcctctgcctctgcatcCACATCCTCGAAAATCAATGATGATGACCTTATGATGATGGAGGAGATTGGTGGCAACAGAAGCcgccatcatcagcagcaccaccaccacagcaaGTCTTCTGGCGACTTGGCCGATCAGGCCatcatttccgctgtggctgccacagccactgccacaacgACGCCGCTGTACTGGTACCAATGCAAATACTGTCCCTCCAActttaacacaaacaaaaagctgGCCATCCACATCAACTCGCACGATGAGTTCGACTCGAATGATTATTCGTGCAAGGACTGCGGCAATGTTTATAGCGGCCGCAAGAGTCTATGGGTTCATCGCTACAAAAAGCATCCGCAGGTGCCCGACCCAATCGAGTGCATGCTGTGCCGCAAGGTGTTCTTTGACCATCAGATGCTGGACAATCATACGCCAACCTGCAACCGCAAACCGATTACCGCCACGGGTGCGCATCAACAAGAGCTGCTGACGCAGACAAATTCATCGCAGGGTCGGGCCGTATTCAGGCACAAGACTggagacgatgatgatgaggaagacgtgcagcagcaccaccgtcaccagcagcagcagcagcagcgtaacCATCAGGAGGATGCTGGtgatggaggagcagcagcaacaacaacgacagcagcagccacatcgaGTGGCAGTACCAAAAAGTTGCGCATACCGGAGGTGGCCTGTACAATTTGTGGTGCCCGTTTCACCGATCAGGAGCACTTTAGCAAGCACATACAGAAGCATGAACAGGATCTATATGTGGATAATCCGTTGGCGGCGATGTTCGATGATGGGCCAGCGGATGCGGCCCAATTTAAGGTGGAGGGCCAGAACGAGAATGGGGAATATGCGTGCGATATGTGTACAAAGACATTCCCCCAAGTGATTGCACTCAAAGTGCATCGCAAGTGGCATTTCAGAGGTGATAGCAAGCAGAACCACATCGACAGCGAAACGACgaacatcatcaacaacaacaacaacaattcgGTGAACAACTCCACATCGATGCTACGGGAGCTGCATGCAGTGGGTCTGACGCccaaccaacaacagcaacaacagcagcagcagcagcagagccaacaACAGAACTCCACGTCCACGccgaacagcaacagcaacaacaacaacagcaggagcaacaacaacagcatcagcagcagcagcaggagcaaatCAATGAAACGTAAACGTGAATTGAAATGCGAATACTGCCCATCGACCTTCATCAGTAACAACAACCTGCGACGACACATGTATGAGCTGCATAAGCATGAAGTGAGTAGCCTGCCAGCACCGCCAGTGATTGTGGTGGATGAGCCACTGAGCTGTCGACGTTGTGGCAATGTGAAATTCGAGACAAAAGAACTATGGATCGAACACAAGCTGGCCGATGCGAAGGTGGTGCGACCGTTTTGTCCCTTCCAATGGGGCTGTGATATGTGTGGCGAGTACTTGTCGCGCAAGGAGAAGCTCATGAATCACATCAATAATCATTTGAAGGAGGATGTCATTGTACCAGTGACCACACAAGCGGCCATCGACAGAGAACGTGCATCGACATTAGCATCCGAGGCAACAACATCCAAAGCAAAATCAGCATCATCCGCATTGGTTGAGCCACCCAGCGCCGCAGCGTTGCAAAAGAAAACGGAAGAGAATGGTGGACTTGATGCAGCGGaggcgacagcagcagaggcggCGAAGCCAGAGGAAGAAGATAGTGAAATGGAGGACAGCTCAGACGCTGATGAAGAAAGCTCTGGCACAGGGgatgaggacgacgacgaggacgacgacgatgatgaggatgaggaagATGAGCTACAGGATGAGGACGATGATGAAGATGAGGGCGAAGATGAGGAGGGAGTGCCCCCAACAACACCTGCCACACAATTGTTGCAACTCAAACAGCCAGAACACAAGGCcaataatattgaaaatgaTGATGATCTCGTCGAGGAAGTGAACAGCTCAGATGATGAGGAGCCAGACGATGGAGGCGAAGTCGGCAGCGAAAGCGACGGCGAAACCCAaagcgatgatgatgacgacgatgacgatgaagacgaggacgatgacgaggagggggaaggggaggaagaagaggcagaggcagaggcacagggTTCGTCACAGCCCCTGATGAATGGCAAGTCAAAAAAGCATCATACCACGCCCCAACAGCAACGGGATGATGAGATATTGCCCAGCtccgacgacgacaacgaagaggatggggaggaggaggatggcaATGCAGATGGCCAGCCACTGGCCATTGAAGACATTATTGAAGAAGAATTTGATGAAGACGATGATGTGGAGGAGGTGTATGATGAGCAGAATGTCGATGGGGGGGCCACATCGTCGGCCTCTTCATCAGAGAGCGAATCAACATCGACGACCACATCCAATTCGCATTCAACTGGTGAGCGGCGTAAGAAGGCTGGCGATCAGTCGTCAAATCCCAGCTTTACCTGTGATCTATGTCAACTTTGTTTCGATTCCCAGGAGCTTCTCCAGTCTCACATCAAAAGCCATTTTCTCAATGGTCCAAAAATCTCTGCCTCACAAGCAACAAgcaatgcaacagcaacagcaacggtaGCGGTAGCGGTAACGACGACGAgcacggcaacggcaacggcgacggcgacgactGTCCCCAGCAGCTGTAACAACAATGCCTCGACCAAATCCTCGAAGCTCtctccagcaacagcagcggcagcggcagcagtcaacaaaaacaacaaccggCAAAGAAGTGCCGCCACAGAAATGGGGGCCagcggtagcagcagcagaagcagcagcaacagcaacagcaattgA
Protein Sequence
MCDTAATTATTTLVAVAAPAASSVSGTGTSQSQSQGTAAALATATTTAAGATPPATTTAKPEQQQRARQNCCRLCIAPATECISIINSYAADKEPLSTKIHNCVNIKITPQDRLSLQICHACISYLNSWQSFKNRSVSAQNKQRQWLEANKSKLLSYLDLNSAENGGGHQQQQHHQQNQNQSQSQQQQQHHSENEIDLEKPSAAQILDGIPSLKKRKSLTVYVSPKPQQQQLQQQQQQSQQPARLTATATATSSQQQTLQTLLLQVPTITVSSSSTTPASGGGSAAAAAAASVSQQQQRQHHYRKYQQHQQQQQQQQRGKQMMQQQQQQQHHQQLQHHQQKQQQKRRQRQAPRRPAPQSSGLPGQRKFKPKVYLPLDIAVPPLPPLPASATTLLLHQHQDHWQCQFRLPLLLTIRFFMLLKYCQRLPLWWGNLPLSLPLDFSQCSSKIGIGLGLLPSTSTYSHSSTIAHASAAAASASATGISSVSVSMQHATAPLLMPPLPAIPIKDEPIDTDDDYQMKSLDESDDMVDPTMFLERSEHEGDVPLMTSDYDYTAQHGVNAETAAASLPPNAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPNNTPITKPTPALAAALEIQRAAAEAATEEASKAAGAAGGNISTQKYRQVVMNAFIKCEGGGFNYDSPEQYQPLLTRDKVEFIEQNYEFLEQYQTMTCRCCDKYFSTYKNFMAHVRKKYPLLPRNLCFNCLKMNESKALFISHLKKRNCINLYRVLNALRGKQPNFHPTSSDIGSFGGETTTQTSPTIVVPLLLDNSSSGERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKVETHQRFLDHVYQDHLGGISSDNASSVSGMGGGGGGGGGGRSSSIENSPGKRSLLGALGIGVSSPADESRSGSAAAAAAPNQTSTPKPTSGGVGGGVGGAAACTTPGSLNRDAGGAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVSTGRYDYVMKDLMSITNGGTLDDDEEETGSMAKKIRLDDSSNNSSLVGGVASQQKECPICNALFSNNIGLSNHMRSHYTASNSVNAALVAANRMTPKSLTITATPATETVTSSAASMDVEDDDEGMLALETGKLMASVRGSTSGVAVPPAMVNQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGRAIKDEMIVKQFECDVCSIVYSSELELKQHKRSVHKLTSVSVSASASASASASASASTSSKINDDDLMMMEEIGGNRSRHHQQHHHHSKSSGDLADQAIISAVAATATATTTPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPDPIECMLCRKVFFDHQMLDNHTPTCNRKPITATGAHQQELLTQTNSSQGRAVFRHKTGDDDDEEDVQQHHRHQQQQQQRNHQEDAGDGGAAATTTTAAATSSGSTKKLRIPEVACTICGARFTDQEHFSKHIQKHEQDLYVDNPLAAMFDDGPADAAQFKVEGQNENGEYACDMCTKTFPQVIALKVHRKWHFRGDSKQNHIDSETTNIINNNNNNSVNNSTSMLRELHAVGLTPNQQQQQQQQQQQSQQQNSTSTPNSNSNNNNSRSNNNSISSSSRSKSMKRKRELKCEYCPSTFISNNNLRRHMYELHKHEVSSLPAPPVIVVDEPLSCRRCGNVKFETKELWIEHKLADAKVVRPFCPFQWGCDMCGEYLSRKEKLMNHINNHLKEDVIVPVTTQAAIDRERASTLASEATTSKAKSASSALVEPPSAAALQKKTEENGGLDAAEATAAEAAKPEEEDSEMEDSSDADEESSGTGDEDDDEDDDDDEDEEDELQDEDDDEDEGEDEEGVPPTTPATQLLQLKQPEHKANNIENDDDLVEEVNSSDDEEPDDGGEVGSESDGETQSDDDDDDDDEDEDDDEEGEGEEEEAEAEAQGSSQPLMNGKSKKHHTTPQQQRDDEILPSSDDDNEEDGEEEDGNADGQPLAIEDIIEEEFDEDDDVEEVYDEQNVDGGATSSASSSESESTSTTTSNSHSTGERRKKAGDQSSNPSFTCDLCQLCFDSQELLQSHIKSHFLNGPKISASQATSNATATATVAVAVTTTSTATATATATTVPSSCNNNASTKSSKLSPATAAAAAAVNKNNNRQRSAATEMGASGSSSRSSSNSNSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00536223;
90% Identity
-
80% Identity
-