Basic Information

Gene Symbol
RREB1
Assembly
GCA_014743375.2
Location
NC:23056116-23066578[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.034 2 8.8 0.8 1 21 240 260 240 262 0.93
2 12 0.00032 0.018 15.2 0.2 1 23 272 294 272 294 0.98
3 12 7.7e-05 0.0044 17.1 7.3 1 23 300 322 300 322 0.98
4 12 2 1.1e+02 3.2 3.7 2 19 544 561 544 563 0.97
5 12 0.0084 0.48 10.7 0.1 1 23 701 723 701 723 0.97
6 12 1.2e-05 0.00067 19.7 0.7 1 23 733 755 733 755 0.99
7 12 0.00079 0.045 13.9 2.0 1 23 761 784 761 784 0.97
8 12 0.0028 0.16 12.2 2.0 1 23 1061 1084 1061 1084 0.95
9 12 8.2e-05 0.0047 17.0 0.3 2 23 1450 1471 1449 1471 0.97
10 12 0.14 7.9 6.9 6.3 1 23 1477 1500 1477 1500 0.97
11 12 0.008 0.46 10.8 0.5 3 23 1708 1728 1706 1728 0.96
12 12 0.0013 0.076 13.2 4.8 1 23 1734 1756 1734 1756 0.99

Sequence Information

Coding Sequence
ATGCTCGCCgcacagcaacagcagcagcagcagcacaacAGCACAGGTGAGGCGGAAATGGAGCGCCAGCGACGGGACTCCACCACCTCGGAATCCTCCCTGGAGCACCTGGACTTGGGTCGCACGCCCAAGAAGCTGGCCGGAAATGGTGGCTCCGCGCAGACCACATCCACGCCCCACGAACTCACGACTGTCACATCGCGCAAGCGCAAACTTCGCCAACTGCAACAGCAGATGAATCATCTCCATCAGCAGGAGGTGTTGAgcgacgaggacgaggaggaggaggatgagcacgaggatGGGGAGCACCCGGCCACGGCAGCCCGGAATCTAGGGCGGCACAAGCAACGGCGCAGCACCCAGGCCTCCATTGTGGTGGACTACAGCAGTGGCGATGCCAGCTCCCTGCGCAAAAAGTTCCGGCTCAATCGCTCGACGGCCAGTCTCTCGGAATCGGGATTCGTGGATGCCAGCAGCACGGTCCACAGTGGCTATCTGGGCAATAGCAGTGGCAGTGCCACCAAtaccacaaccaccaccaccagcggTGGTGCAGTGGCTCCAGCCTCGGTGGCCGGTGGTGGAGTGGCCGGAGCAACTgcctccagcagcagcagtagcagcagcagcggcggaTCCGGCGGCTCCTCGCCCCAAGGCCCCAGCCTCTCCAGCGGCGAGTCGGGCATCGGAGCCGGGGACGAGCACATGAAGTACCTGTGCCCCATCTGCGAGGTGGTCTCGGCCACGCCGCACGAGTTCACCAACCACATCCGGTGCCACAACTACGCCAACGGCGACACGGAGAACTTCACCTGCCGCATTTGCTCCAAGGTGCTATCCTCGGCCTCATCCCTGGACAGACACGTGCTGGTTCACACGGGCGAGCGGCCCTTCAACTGCCGCTACTGCCACCTGACCTTCACCACCAACGGCAACATGCACCGCCACATGCGCACCCACAAGCAGCACCAAGTTgcgcagtcgcagtcgcaacagcagcagtcgcagcagcaacagtcgcagcagcagcagcagcagcagcaacaccagcgacgacagcagcaacaccagccggcgcagcagcagcagcagaatcCCGCCCAGCAACTGGTGGCCACCGCCTTGTCCGCTGGACGTGCCGAGAGCTACGAGAGCGATGCCAGCTGCTCCACAGATGTGTCCAGTGGTCATAGTCACTCGcacagccgcagcagcagctccctcaacaacaacaacaactcgCACAAGGCTAACAACAACCTGAGGGAACTGGATGTGGATCAGGCGGAGGATCAGGATCAGTTGGAGGGCAAGCAGCGCCGCCTGAAGACgaccatcaacaacaacaacatcataGACAGTGGCCACCAGGAGGAGATCgaggaggatgaggaggaGGCCGATGATGCGGATGTGGCCATGCTGACCAGCACGCCCGATGTGGCCACCCTTCTGGCCGGAGCCAGTGCCTCCGGAGCGGCCTCGCGCTCACCGTCGCCCTCCCCCTCGCCATCCGCCTCGCCGTCGCTGCTCCTGAGCTGTCCCGCCTGCGGAGCCTCCGACTTCGAGACCCTGCCCGCCCTGTGTGCCCACCTGGATGCGAGGCACTCGGACATACCGGCCAAGTGTCGCGATTGCGAGGTGATCTTCGCCAGCCATCGCCAGCTGCAGGCCCACTGCTGTCGGGGATCCACGGGACTGCCGCCGCTCCTCGGAGCCAGCAGTTCACCCTTGCACCAGGAGGAGGATCAGGAGaacgaggaggatgaggagCTGGAGCGGAAGATGGGTGTGCCCAGCCAGAGCGAGGACTTTTTCCACCAGCTGTATCTGAAGCAGAAGACAGCCGGAGCTGGTGGTGCCATCTCCCATCCCCCGTCGCCCATTAAACACGAGCCGGCGGACAGCAAGGATCTGGCGGATATACAAAGCATCCTGAACATGACCAGCTCTAGTTCCAGTTTTCTGCGCAACTTCGAGCAGTCGGTGAACACGCCCAGCTCCAGTCAGTACAGTTTGGATGGCAGGGATCAGGAGGAGGAGGCCCAGGATGCCTTCACTTCGGAGTTCCGGCGGATGAAGTTGCGCGGTGAGTTCCCCTGCAAGCTCTGCAGCGCCGTCTTTCCCAATCTGCGCGCCCTCAAGGGTCACAACCGGGTGCATCTGGGTGCAGTGGGCCCAGCCGGACCCTTCCGCTGCAACATGTGTCCCTATGCCGTCTGCGACAAGGCCGCCCTGGTGCGCCACATGCGCACCCACAACGGCGATCGTCCCTACGAATGCGCCGTCTGCAACTATGCCTTCACCACCAAGGCCAACTGCGAGCGCCACCTGAGGAACCGGCACGGCAAGACCAGTCGGGACGAGGTGAAGCGGGCCATTGTCTACCATCCGGCGGAGGATGCCGGCTGCGAGGACAGCAAGTCCCGCCTGGGCGAGGATCTGGCCGATCTCAGTTTCCGTTCCATCAGTCCCacgccaccgccgccgcctgTTATCATCAGTGGCGAGAGCAGCAGTTCCCAGCTGAAGCACATGCTCCTGGGCGAGAGTCATCTGGCACCGGTGGTCCAACCGCCGCTCAAGATCCAGGTGAAGAGTCTCGACCAGCTGGTGGACAAGAAGCCAGCCAAGCCAGCTGCCCCGGctccacagcagcagcagcagcagctccagGAGAAGATCGGAGCTGCCCTGGACTTTAGCATGGATGTGTTGGATCTCAGCAAGAAGCCAACTGGTGGAGCAGCAGCCCTCACACCCTCGGTCACACCCACTCCGCCCACGCCGGCACCTGGAGTTGTGGCACCGGGAGTGGGAGCCCCTGCCGACCTGGCCGCCGCCctggagcagcagcaactgctcCTTGCGCAGCAGCAGCTCTTCGGCGCTGGCGGAGATGCCGCCTCCCAGTACATGCAGCAGCTGTTCCGCATGTTCCAGTTCCAGTCCCAGACGCCTGGATTCCCCTTCTTTCCCTTCATGGCACCACCACCGCCGCAGGCCAATCCAGAGAAGCCACCGCTGGTGAGTCCACCCAATCGCATGAATCCCCTGCCCGTGGGTGTGGGCGTGGGCGTTCCAGTGCCACCTGGTGGCCCCGTCAAGATGGTCATCAAGAATGGCGTCCTGATGCCCAAGCAGAAGCAGCGTCGCTATCGCACCGAGCGTCCCTTTGCCTGCGAGCACTGCTCGGCGAGATTCACCCTGCGCTCGAACATGGAGCGCCATGTGAAGCAACAGCATCCGCAGTTCTATGCCCAGCGCCAGAGGAGCGGTCACCATGTGATGAGGGGCAGGGGAGCCTCCAGTGCCGCAgccgctgctgccgccgccgccgccgctgcagCTGCCATGGGTCCAGGATCTGCCTCCTCCGTCGGCAGCAATCACCATCATGGCCATGGCCATGGCTCCCACGGACATGCCCCCATCTCGGAGCAGGTCAAGTACGCCATTCTCGCCCAGCAACTGAAGGCCCACAAGAACACCGATCTGCTGCAGCAGGCCTTGGCCCACGGTTCCAGCAGTGTGGCCGGCAATCCCCTCCTGCACTTCGGCTACCCACTGGCCACGCCCAGTCCCCTGCACAATGGCTCCGGCCAGGGCAATGGCCAGGCCATCACCATGGACGACGATGAGCCCAAGCTGATCATCGATGAGGATGACAACGAGCATGATGAGGTGGAACCGGAGGAGGTGGATGACTTCGAGGAGGATGAGGACGATGAGGAGATGGATGAGCCGGAGGAGGAGCCCGAGCTGATCCCGGATGAGCAGCCagccgaggaggaggaggaggaggagcaagAGGAGCCGGAGCTGCCCAAGCCGCTGGAGCAGCTGTCCCTGGTGGCGCCCACCAATGAGGCGGCCCAGAAGATGGCCGAGACCATCCTGGAGCAGGCCATCAAGGCGGGCAAGCCAACCAGTCCGCCGCCCCAGGAGAATGCCCTGCCAGTTGACCCCAAAGTGGTGACCACCATGCAGGAACCAGCCGCCACCAGCAATCCCAGCAGCCTGAAGACCATGATTGCCCAGGCCGAATCCGTGGGCAAGTCCCTGAAAGAGGTGGCCAGTTCGCCGTTCAAGGACGAGTCGCAGGATCTGGTGCCGGTGGCCAAGTTGGTGGACAATGCCACCAGCCAGAACATGAGCTTCAACAGCTATTTCCGGCCCAGCGATGTGGCCAATCACATGGAGCAGAGCGACGAGGAGGGCCTGGTGGCCTCCGGCAGTGCCAGCGAGAGCAACAACAGCGGCACCGAGGATGTGACCAGCAGCAGCTCCGGCAGCGAGCCCAAGAAGAAGTCCGCCTACAGCTTGGCGCCCAATCGCGTCTCCTGCCCCTACTGCCAGCGGATGTTCCCGTGGAGCAGCTCGCTGCGCAGGCACATCCTCACCCACACCGGCCAGAAGCCCTTCAAGTGCTCCCACTGCCCCCTGTTGTTCACCACCAAGAGCAACTGCGACCGCCATCTGCTGCGCAAGCACGGCAACGTGGAGTCGGCCATGTCGGTGTATGTGCCCACCGAGGATGTGAGCGAGCCGATCCCGGTGCCCAAGTCCGTGGAGGAGATCGAGCTGGAGGAGCAGCGCCGGCGGCAGGAGGCGGAGCGCGAGAAGGAGCGTGAGCTGAAGCGGGAGCGGGAGTTGGAGCGTGAGCGCGAGCTGGAGCGGGAGAAGGAGCGGGAGCAGGAGAAGGAACGGGAGCGCCAACAGCTCATCCAAAAGCTGGCTGCCCAAATGAATGCCGCTGCCAatgccgctgccgccgccgccgctgcagCAGCTGCATCTTCGGTGGGCAATGGCAATGGTGGAGCACCGAATGGCCCACTGGGAGATGGCCTCGCTGGCGGAGATCTGCCCTACAAGTGCCACCTGTGCGAGGGCTCCTTTGGCGAGCGTCTGCAGTGCCTGGAGCATATCAAGCAGGCCCATGCCCATGAGTTTGCCCTGCTGCTGGCCAAGGGTGCCATCGAGAATGAGTCCCTGGAGGGGCCCAATCCCCACCAGCAGATGTCCCAGCAGTCGGCCGTGCATTCGGACGATGAGGCCGCCAATGGCGGGGGTCGTGGCAAGTATCCGGACTACAGCAACCGCAAGGTGATCTGTGCCTTCTGCGTGCGCCGCTTCTGGTCCACCGAGGATCTGCGTCGCCACATGCGCACCCATTCGGGCGAGAGGCCCTTCCAGTGCGACATCTGCCTGAGGAAGTTCACCCTGAAGCACAGCATGCTGCGGCACATGAAGAAACACAGTGGTCGGGCCCACAATGGGGACACACCGGGTTCCGATTGCTCCGATGATGAGCAGGTGGCCAGTCCGCCCAGCACACCGGCTCCGCTGCCCCTGCCTCTGCCCAATCCCGGCCAGCCCACCagcgccaacaacaacaacagctgccacaacaacaacaacaacaacaacaactttgGTAGCTCCAAGCTGGGCCTGAAGCTGCCCAAGCTGCACGAGCTGCTGGACAAGGCGAGCGAGTGGCGGGCCAGTCGGCTGGGCGAGCACAAGGAGAACATGGGCGAGGCCACGCCCTCGGCGGCAGCCGTCGCCGGATCGGATCTGATTGGCAACCTGCTGGGGATCAGCGACCAGGGCATCCTCAACAAGCTGCTCTCCTCCGCCGACGAGGCGGCCAAGCTCCTGGGCGTGGACAACAAGTAA
Protein Sequence
MLAAQQQQQQQHNSTGEAEMERQRRDSTTSESSLEHLDLGRTPKKLAGNGGSAQTTSTPHELTTVTSRKRKLRQLQQQMNHLHQQEVLSDEDEEEEDEHEDGEHPATAARNLGRHKQRRSTQASIVVDYSSGDASSLRKKFRLNRSTASLSESGFVDASSTVHSGYLGNSSGSATNTTTTTTSGGAVAPASVAGGGVAGATASSSSSSSSSGGSGGSSPQGPSLSSGESGIGAGDEHMKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCRYCHLTFTTNGNMHRHMRTHKQHQVAQSQSQQQQSQQQQSQQQQQQQQHQRRQQQHQPAQQQQQNPAQQLVATALSAGRAESYESDASCSTDVSSGHSHSHSRSSSSLNNNNNSHKANNNLRELDVDQAEDQDQLEGKQRRLKTTINNNNIIDSGHQEEIEEDEEEADDADVAMLTSTPDVATLLAGASASGAASRSPSPSPSPSASPSLLLSCPACGASDFETLPALCAHLDARHSDIPAKCRDCEVIFASHRQLQAHCCRGSTGLPPLLGASSSPLHQEEDQENEEDEELERKMGVPSQSEDFFHQLYLKQKTAGAGGAISHPPSPIKHEPADSKDLADIQSILNMTSSSSSFLRNFEQSVNTPSSSQYSLDGRDQEEEAQDAFTSEFRRMKLRGEFPCKLCSAVFPNLRALKGHNRVHLGAVGPAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHGKTSRDEVKRAIVYHPAEDAGCEDSKSRLGEDLADLSFRSISPTPPPPPVIISGESSSSQLKHMLLGESHLAPVVQPPLKIQVKSLDQLVDKKPAKPAAPAPQQQQQQLQEKIGAALDFSMDVLDLSKKPTGGAAALTPSVTPTPPTPAPGVVAPGVGAPADLAAALEQQQLLLAQQQLFGAGGDAASQYMQQLFRMFQFQSQTPGFPFFPFMAPPPPQANPEKPPLVSPPNRMNPLPVGVGVGVPVPPGGPVKMVIKNGVLMPKQKQRRYRTERPFACEHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHVMRGRGASSAAAAAAAAAAAAAAMGPGSASSVGSNHHHGHGHGSHGHAPISEQVKYAILAQQLKAHKNTDLLQQALAHGSSSVAGNPLLHFGYPLATPSPLHNGSGQGNGQAITMDDDEPKLIIDEDDNEHDEVEPEEVDDFEEDEDDEEMDEPEEEPELIPDEQPAEEEEEEEQEEPELPKPLEQLSLVAPTNEAAQKMAETILEQAIKAGKPTSPPPQENALPVDPKVVTTMQEPAATSNPSSLKTMIAQAESVGKSLKEVASSPFKDESQDLVPVAKLVDNATSQNMSFNSYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDVTSSSSGSEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAMSVYVPTEDVSEPIPVPKSVEEIELEEQRRRQEAEREKERELKRERELERERELEREKEREQEKERERQQLIQKLAAQMNAAANAAAAAAAAAAASSVGNGNGGAPNGPLGDGLAGGDLPYKCHLCEGSFGERLQCLEHIKQAHAHEFALLLAKGAIENESLEGPNPHQQMSQQSAVHSDDEAANGGGRGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRHMKKHSGRAHNGDTPGSDCSDDEQVASPPSTPAPLPLPLPNPGQPTSANNNNSCHNNNNNNNNFGSSKLGLKLPKLHELLDKASEWRASRLGEHKENMGEATPSAAAVAGSDLIGNLLGISDQGILNKLLSSADEAAKLLGVDNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00605068;
90% Identity
-
80% Identity
-