Dsup005768.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila subpulchrella
Gene Symbol
gsb
Assembly
GCA_014743375.2
Location
NC:21858888-21861356[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.5e-71 8.1e-68 225.8 1.3 1 125 19 143 19 143 0.99

Sequence Information

Coding Sequence
ATGGCTGTTTCGGCTCTCAACATGACACCCTACTTTGCTGGATATCCCTTCCAAGGACAAGGTCGCGTCAACCAACTTGGCGGCGTCTTCATCAACGGGCGTCCGTTGCCCAACCACATCCGTCGGCAAATCGTGGAGATGGCGGCCGCTGGGGTCCGTCCCTGCGTCATCTCGCGCCAGCTGCGCGTCTCTCACGGCTGCGTCTCGAAGATTCTGAACCGCTTCCAGGAGACAGGCTCCATCCGCCCGGGAGTGATCGGCGGCAGCAAGCCCCGAGTGGCCACGCCCGACATTGAGTCCAGGATCGAGGAACTGAAGCAGTCACAGCCCGGCATCTTCAGCTGGGAAATCCGCGCCAAACTGATTGAGGCCGGAGTCTGTGACAAGCAGAGTGCCCCGTCGGTGAGCTCTATTTCACGCCTTCTGCGTGGATCCTCCGGATCGGGAACCTCCCACAGCATCGATGGCATCCTCGGCGGAGGAGCTGGCTCAGCAGGAAGCGAGGATGAGAGCGAGGACGACGCTGAGCCCAGTGTGCAGCTGAAGAGGAAGCAGAGGCGCTCCCGCACCACCTTCTCCAACGACCAGATCGACGCCCTCGAGCGCATCTTTGCCCGTACTCAGTATCCCGACGTCTACACCCGCGAGGAGCTGGCCCAGAGCACCGGACTGACCGAGGCCCGCGTCCAAGTCTGGTTCTCCAACCGCCGTGCACGTCTACGCAAGCAGCTGAACACCCAGCAGGTGCCCAGTTTCGCCCCCACTGCCGCTTCCTACGGCGCCACTGCCACCGCCAGCTCCGCCCCTGCTCCCAACATGGGCATGAGTCTGTACGGTTCCCAGACCTGGCCGACATCGGGAGCTACCTATGAGAATCACGCCGGCTACGGTGGCTCGGTGGCGTCCATGTCCCCGGCCAGCAGTACCTCTGGTAGCAGCTCCGCCGCCCACAGTCCCGTGCAGACACAAGCCCAGCAGCCCGCAGCCGGAAACGAGTTCATAAACTCCGCCTACGGCGTGGGATCGACCAGTGCTGCCTACCCATCCACTGGAACAGCTGCCTACTCCATGCCCCCGACTGCTGCCACATCTGCGGAGCATCTCCGATCCCAGTTTGCATCCGCCGCTGCCTCCGGCTCTCACCACCCCTCCTCCTGGGACAGCTACAACTTCGCTGGATCCTTCTTCCCACCCACTGCTGCCGCAGGCAACCACATTGGCGGCTACCATCATCAGGTCGACCAGAAGAGCTCAATGATGACCAGTGCTCCCGCCTATCCCTACTTCGGTTTCTAA
Protein Sequence
MAVSALNMTPYFAGYPFQGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRPGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQSAPSVSSISRLLRGSSGSGTSHSIDGILGGGAGSAGSEDESEDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFAPTAASYGATATASSAPAPNMGMSLYGSQTWPTSGATYENHAGYGGSVASMSPASSTSGSSSAAHSPVQTQAQQPAAGNEFINSAYGVGSTSAAYPSTGTAAYSMPPTAATSAEHLRSQFASAAASGSHHPSSWDSYNFAGSFFPPTAAAGNHIGGYHHQVDQKSSMMTSAPAYPYFGF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00486409; iTF_00529514; iTF_00486514; iTF_00602423; iTF_00529404; iTF_00477858; iTF_00477964; iTF_00541019; iTF_00540926; iTF_00569541; iTF_00569635; iTF_00561702; iTF_00617481; iTF_00593683; iTF_00617587; iTF_00593782; iTF_00561595; iTF_00613350; iTF_00613452; iTF_00484977; iTF_00485081; iTF_00489320; iTF_00489223; iTF_00490024; iTF_00489924; iTF_00524361; iTF_00524264; iTF_00565322; iTF_00565217; iTF_00481389; iTF_00477185; iTF_00487842; iTF_00565922; iTF_00475780; iTF_00477286; iTF_00487944; iTF_00475881; iTF_00566027; iTF_00538799; iTF_00579824; iTF_00481490; iTF_00550098; iTF_00579926; iTF_00538904; iTF_00550201; iTF_00503938; iTF_00614854; iTF_00545809; iTF_00545913; iTF_00503835; iTF_00614747; iTF_00615510; iTF_00487245; iTF_00487139; iTF_00514727; iTF_00474344; iTF_00563849; iTF_00601002; iTF_00474450; iTF_00514835; iTF_00563734; iTF_00600893; iTF_00492177; iTF_00492068; iTF_00605521; iTF_00605410; iTF_00511954; iTF_00511845; iTF_00535989; iTF_00535888; iTF_00580545; iTF_00574757; iTF_00480806; iTF_00484390; iTF_00471559; iTF_00480715; iTF_00517552; iTF_00603184; iTF_00473618; iTF_00580658; iTF_00471446; iTF_00517655; iTF_00574647; iTF_00484281; iTF_00603290; iTF_00473726; iTF_00612758; iTF_00612657; iTF_00571735; iTF_00571844; iTF_00527256; iTF_00527152; iTF_00533048; iTF_00532949; iTF_00581371; iTF_00581481; iTF_00578369; iTF_00604677; iTF_00587974; iTF_00536714; iTF_00515435; iTF_00548012; iTF_00494222; iTF_00578485; iTF_00588085; iTF_00604790; iTF_00515544; iTF_00536602; iTF_00494332; iTF_00547900; iTF_00505244; iTF_00505349; iTF_00594493; iTF_00594392; iTF_00491358; iTF_00491457; iTF_00507454; iTF_00507561; iTF_00609022; iTF_00609116; iTF_00543071; iTF_00543014; iTF_00504523; iTF_00592231; iTF_00539498; iTF_00596493; iTF_00618993; iTF_00592338; iTF_00596594; iTF_00591539; iTF_00539607; iTF_00619098; iTF_00504635; iTF_00607741; iTF_00591647; iTF_00607647;
90% Identity
iTF_00504523;
80% Identity
iTF_00602423;