Basic Information

Insect: Drosophila suboccidentalis
Gene Symbol: ftz-f1
Assembly: GCA_037043435.1
Location: JBAMBK010001933.1:51938-57955[-]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.9e-14 3.1e-10 40.3 0.3 7 79 1 72 1 106 0.74

2 3 4e-28 4.2e-24 86.0 3.4 156 260 195 295 166 305 0.82

3 3 1.8e-37 1.9e-33 116.7 0.1 299 408 306 415 301 417 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.9e-14	3.1e-10	40.3	0.3	7	79	1	72	1	106	0.74
2	3	4e-28	4.2e-24	86.0	3.4	156	260	195	295	166	305	0.82
3	3	1.8e-37	1.9e-33	116.7	0.1	299	408	306	415	301	417	0.98

Sequence Information

Coding Sequence: ATGCGTGGCGGACGGAACAAGTTTGGGCCGATGTACAAAAGGGATCGGGCGCGAAAGCTGCAGGTGATGCGTCAACGGCAATTGGCGCTTCAGGCGCTGCGCAGCTCCATGGGAACGGACATAAAGCCGACGCCGCTGTCGCCGGGCTATCAGCAAGCATATCcaaatatgaatattaagcaagaaatacaaatacctCAGGTATCCTCACTCACACAGTCGCCGGATTCATCGCCTAgtcccattgccattgccttgGGGCAGGTGAATGCGAGCGGGGGCGGTGTGATAGCCACGCCCATGAATGCCGGCAATGTGAGTggcggcaatggcaacggcagctCCTCATTGGgcggtggcaacaacaacagcaacaacaacaacaccaccaacaacaacagtggaggtggcAACAACGCTGGcggtggcaacagcaacagcaacaacaacaacaatgccgaTGGCCTGCAACGCAACGGAAACGgcggcaatggcaacagcaacagcagctgccacgAAACCGGAACTGGATCTCTGCAGAACACGGCCGAATCGAAATTGTGCTTCGATTCTGGCACACATCCATCGAGCACAGCCGATGCGCTCATCGAGCCACTGAGggtatcgcCAATGATACGTGAATTTGTGCAATCGATCGATGATCGGGAATGGCAGACACAGCTTTTCGCGCTGCTGCAGAAGCAGACGTACAATCAGGTTGAAGTGGATCTCTTTGAGTTATTGTGCAAAGTGCTCGATCAGAATTTGTTCTCGCAAGTCGATTGGGCAAGAAACACCGTCTTCTTTAAGGATTTGAAGGTGGACGATCAGATGAAGCTGCTGCAGCATTCGTGGTCCGACATGCTTGTGCTTGATCATCTGCATCATCGCGCATACATAATGTTGGGCGATTACTTCAATGAATTGCAGAATAAACTGCAGGATCTAAAGTTCGATATGGGCGATTATGTGTGCATGAAATTCCTAATACTGTTAAATCCAGATGTGCGCGGCATTGTCAACAAGAAGACCGTCTTGGAGGGGCACGAGCGGGTGCAGGCAGCGCTGCTCGATTACACGCTCACGTGTTATCCCTCAGTCAATGACAAATTCAGGAGGCTATTAAACATACTACCGGAAATCCACGCCATGGCCGCACGCGGCGAGGAGCATCTTTATTCGAAGCACTGTGCGGGCAGTGCGCCAACGCAGACGCTGCTCATGGAGATGTTGCATGCCAAGCGGAAGGTGtaa
Protein Sequence: MRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSMGTDIKPTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASGGGVIATPMNAGNVSGGNGNGSSSLGGGNNNSNNNNTTNNNSGGGNNAGGGNSNSNNNNNADGLQRNGNGGNGNSNSSCHETGTGSLQNTAESKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELLCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRAYIMLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPDVRGIVNKKTVLEGHERVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00832222;
90% Identity: iTF_00601856;
80% Identity: iTF_00601856;