Dsub017735.1
Basic Information
- Insect
- Drosophila suboccidentalis
- Gene Symbol
- foxo
- Assembly
- GCA_037043435.1
- Location
- JBAMBK010002589.1:397435-397944[-]
Transcription Factor Domain
- TF Family
- Fork_head
- Domain
- Fork_head domain
- PFAM
- PF00250
- TF Group
- Helix-turn-helix
- Description
- The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 7.2e-15 5.9e-12 45.8 0.0 4 51 96 147 93 148 0.91
Sequence Information
- Coding Sequence
- ATGGACGACTTTGCACAAGACTGGCCCAATCTGCCCAGATCAGACAATGGACTACAAATGGATCAACTGGTGGGTGAACTTCATGCAGATATCGGCTTTGAGCCACAACAACGCGCCCGCTCAAACACTTGGCCATGTCCGCGTCCCGAGAACTTTGTGGAGCCCAACGATGAACTGGATAGCACAAAGGCCAGCAATCAACAGTTGGCAGCTGGTGATTCACAGCAGGCCATACAGAATGCCAATGCGGCCAAAAAGAACTCATCCCGTCGCAATGCATGGGGAAATCTATCCTATGCCGATCTCATAACGCACGCCATCGGTTCCGCCACCGACAAGAGATTGACTCTGAGTCAAATCTACGAGTGGATGGTTCAAAATGTGCCATACTTTAAGGATAAAGGCGATTCGAATAGCAGTGCCGGCTGGAAGGTGAGTGTTCAATGA
- Protein Sequence
- MDDFAQDWPNLPRSDNGLQMDQLVGELHADIGFEPQQRARSNTWPCPRPENFVEPNDELDSTKASNQQLAAGDSQQAIQNANAAKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKVSVQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00510354; iTF_00528615; iTF_00610465; iTF_00593669; iTF_00578345; iTF_00537324; iTF_01355948; iTF_00569517; iTF_00338959; iTF_00511823; iTF_00359283; iTF_00587955; iTF_00506676; iTF_00585780; iTF_00556375; iTF_00550747; iTF_00532925; iTF_00831967; iTF_00335685; iTF_00335684; iTF_00335686; iTF_00251161; iTF_00567353; iTF_00541590; iTF_00577597; iTF_00919678; iTF_00521983; iTF_00570214; iTF_00557031; iTF_00516809; iTF_00542256; iTF_00527860; iTF_00496409; iTF_00584999;
- 90% Identity
- iTF_00528615;
- 80% Identity
- iTF_00584999;