Basic Information

Insect: Drosophila subobscura
Gene Symbol: KLHL4
Assembly: GCA_008121235.1
Location: NC:17749853-17754948[+]

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.8e-28 7.2e-26 90.1 0.0 6 109 179 282 174 283 0.93

2 2 0.94 1.8e+02 1.9 0.1 80 104 297 321 291 324 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.8e-28	7.2e-26	90.1	0.0	6	109	179	282	174	283	0.93
2	2	0.94	1.8e+02	1.9	0.1	80	104	297	321	291	324	0.86

Sequence Information

Coding Sequence: ATGggtgagggagagagcggcagcagcacaaacacagGCAAATTGAAACAAGAGTTCTTTgttgcaacggcaacggcaacggcgacggcAGCAACGCAAACGCAACGCTACGCGACGCAAATTATAGTTGGAGCAACAAGCCGATCGACCACGCTccataacaacaacaagcgacGCGACAGTAGGTTCAAGACAGAGCTCCAATGCAGACgttccgcagcagcagcaacggaaacggtaactgcaactgcaactgcatttgaCGCAGGGGAGAATCTGTGGAACATAGtcgaaggaaaggaaaaccaaattCAAGCATCCAGCATCATGTCAGCAGCTAATCAAAAGGAGAGTCCCAGCCGGGATTCCACTGCCTCCACATCGGGACACATATCCATGCTGGCCGACAGCACACTGGAGTCCCTCTCCCGGGACTACAGCCTGGGCAGCCTGAACTCCGCCGGCAGCCAGGACGAGTTCTTCCGTTGCCGGGATCATGCCGACAACATCCTTAAGCGGATGCAGCTGTACGTggacagccagcagctgtgCGATGTCACCCTAATCGCTGGGATCGATGGGAAGCGAGTGCCCGCCCATCGCCTGGTGCTATCAGCTTCCAGTGCCTACTTCTCGGCAATGTTCACGGGCTCACTGCGCGAGaccaaggagcaggaggtgaCGCTCGGCGAGGTGCCAGGGGACGCACTGAATCTGCTGGTTCAATACTGCTACACGGGCTTCATCGAGCTGCGCGAGGACACCGTGGAGACACTGCTGGCGAcggcctgcctgctgcagctcacATCGGTGGTCACTGCTTGCTGCAACTTCCTCGCGAGGCAGCTGCACCCCTCCAACTGTCTGGGATTCGCTTTCTTCGCCGAGCAGCAGAGCTGCACGACATTGCTGCGATTGGCCCAGTCCTACACGTGCCAGTACTTCATGCAGGTGTGCCAGAACCAGGAGTTCTTCCAACTGAACGCCGACCAGCTGGGCAAGCTGCTGTGCAGCGATGATCTCAATGTGCCCTCCGAACAGGACGTCTTTCACAGCCTCATGTCATGGGTGCGGCACGACTCCCCCAACCGGGAGCAGCACATTCCCGAGCTGCTGGCCCTCGTCCggttgccgctgctccagccGGCCTTCATCATGGACCACGTGGAGAACGTTTGCAATGCCAACGAGTGCCAGCAGCTGGTCATGGAAGCCTTCAAGTGGCACCTAATGCCCGAGCGTCGTTCCCGCATCGCCACCGAGCGCACTACACCCAGAAAGTCAACCGTTGGCCGACTCCTAGCTGTCGGCGGCATGGATGCCCACAAGGGAGCGATCAGCATCGAAAGCTACTGCCCCCGCCTGGACAAGTGGACTCCGTTTAAGCACATGACTGGACGTCGCCTACAGTTCGGGGCCGCTGTCATGGAAGACAAACTGATCTTGGTGGGCGGACGTGATGGCCTGAAGACCCTCAACACTGTGGAGAGCCTCGACCTGAACACAATGTCCTGGGTCCCGTTGAATCCCAtggccacgccacgccacggtctgggtgtggctgtgctcGAGGGTCCGCTCTATGCTGTCGGCGGGCATGATGGCTGGAGCTACCTAAACACAGTTGAGCGGTGGGATCCCATAGCTCGTACCTGGAGCTATGTCTCGCCCATGTCCTCAATGCGTTCCACTGCAGGCGTGGCGGTGCTGAGTGGCCGCCTTTATGCGGTGGGCGGACGTGATGGTTCCGTCTGCCATCGCTCCATCGAATGCTACGATCCGCACACGAACAAATGGAGCCTGCTGGCGCCCATGAATCGTCGTCGCGGTGGTGTGGGCGTGACGGTGGCAAACGGTTTCCTTTATGCATTGGGTGGGCACGATTGCCCCGCCAGCAACCCCATGGTCTGTCGCACTGAAACTGTGGAACGCTATGATCCAGCAACCGATACATGGACACTGATTTGCTCACTGGCCTTGGGAAGAGATGCAATTGGTTGTGCCCTGCTTGGTGATCGACTGATTGTCGTTGGCGGCTACGATGGCAATCATGCGCTGAAGAGCGTTGAGGAATACGATCCAGTTCGCAACGGTTGGAACGAGCTGACCCCCATGGCATTTGCCCGGGCCGGTGCCTGCGTCGTGGCCATACCCAATGTCATACCGCCGGCGGCACAGCAGCCGCCCCCCAGTGCTACAaaaaagaagaagtggAAGCCAGTGAGATTGGATCCAATCTGCTATAGGCGTCCTAGATCCGTCGAGTTTGTCGACTACTATAATATGTAA
Protein Sequence: MGEGESGSSTNTGKLKQEFFVATATATATAATQTQRYATQIIVGATSRSTTLHNNNKRRDSRFKTELQCRRSAAAATETVTATATAFDAGENLWNIVEGKENQIQASSIMSAANQKESPSRDSTASTSGHISMLADSTLESLSRDYSLGSLNSAGSQDEFFRCRDHADNILKRMQLYVDSQQLCDVTLIAGIDGKRVPAHRLVLSASSAYFSAMFTGSLRETKEQEVTLGEVPGDALNLLVQYCYTGFIELREDTVETLLATACLLQLTSVVTACCNFLARQLHPSNCLGFAFFAEQQSCTTLLRLAQSYTCQYFMQVCQNQEFFQLNADQLGKLLCSDDLNVPSEQDVFHSLMSWVRHDSPNREQHIPELLALVRLPLLQPAFIMDHVENVCNANECQQLVMEAFKWHLMPERRSRIATERTTPRKSTVGRLLAVGGMDAHKGAISIESYCPRLDKWTPFKHMTGRRLQFGAAVMEDKLILVGGRDGLKTLNTVESLDLNTMSWVPLNPMATPRHGLGVAVLEGPLYAVGGHDGWSYLNTVERWDPIARTWSYVSPMSSMRSTAGVAVLSGRLYAVGGRDGSVCHRSIECYDPHTNKWSLLAPMNRRRGGVGVTVANGFLYALGGHDCPASNPMVCRTETVERYDPATDTWTLICSLALGRDAIGCALLGDRLIVVGGYDGNHALKSVEEYDPVRNGWNELTPMAFARAGACVVAIPNVIPPAAQQPPPSATKKKKWKPVRLDPICYRRPRSVEFVDYYNM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00495201; iTF_00495937; iTF_00577857; iTF_00609985; iTF_00476002; iTF_00507682; iTF_00528130; iTF_00566882; iTF_00591042; iTF_01557634; iTF_00480931; iTF_00490851; iTF_00509891; iTF_00521475; iTF_00529635; iTF_00532451; iTF_00571971; iTF_00572675; iTF_01548931; iTF_00505476; iTF_00530340; iTF_00597476; iTF_00613572; iTF_00339237; iTF_00489445; iTF_00576421; iTF_00596005; iTF_00517062; iTF_00552390; iTF_00577126; iTF_01570310; iTF_00535399; iTF_00590311; iTF_00600391; iTF_01556199; iTF_01559111; iTF_00478088; iTF_00490152; iTF_00502600; iTF_00514248; iTF_00547432; iTF_00568328; iTF_00901576; iTF_01322728; iTF_00541833; iTF_00545321; iTF_01323465; iTF_01556905; iTF_00558794; iTF_00574890; iTF_00580810; iTF_00593194; iTF_00338443; iTF_00471691; iTF_00474571; iTF_00481611; iTF_00486635; iTF_00487371; iTF_00497483; iTF_00518507; iTF_00546731; iTF_00565451; iTF_00581611; iTF_00602667; iTF_00917291; iTF_00485932; iTF_00498956; iTF_00500396; iTF_00506188; iTF_00536844; iTF_00548140; iTF_00559564; iTF_00561836; iTF_00604172; iTF_01549644; iTF_00551661; iTF_00592461; iTF_00607853; iTF_00616269; iTF_01550349; iTF_00512078; iTF_00536110; iTF_00533167; iTF_00563247; iTF_00605647; iTF_01325743; iTF_01552527; iTF_00498224; iTF_00527376; iTF_00539728; iTF_00550320; iTF_00563984; iTF_00599664; iTF_00802928; iTF_00805264; iTF_00514961; iTF_00522257; iTF_00543825; iTF_00550961; iTF_00580049; iTF_00616977; iTF_00480242; iTF_00492306; iTF_00555922; iTF_00560370; iTF_00566162; iTF_00619218; iTF_00919890; iTF_00542515; iTF_00593907; iTF_01321267; iTF_00517780; iTF_00531732; iTF_00573396; iTF_00588916; iTF_00612148; iTF_01322004; iTF_00473141; iTF_00516341; iTF_00546037; iTF_00553109; iTF_00615637; iTF_00618485; iTF_00832245; iTF_00918229; iTF_00587478; iTF_00591766; iTF_00596726; iTF_00612886; iTF_00804470; iTF_00918230; iTF_00501879; iTF_00508407; iTF_00525207; iTF_00548887; iTF_00604919; iTF_01324215; iTF_00482328; iTF_00483768; iTF_00519992; iTF_00549624; iTF_00554456; iTF_00564728; iTF_00578616; iTF_00582328; iTF_00609240; iTF_00914584; iTF_00337625; iTF_00504761; iTF_00525945; iTF_00555161; iTF_00561113; iTF_00916313; iTF_01559833; iTF_00335994; iTF_00475290; iTF_00523770; iTF_00598234; iTF_00806042; iTF_00890202; iTF_01554778; iTF_00336827; iTF_00488091; iTF_00494459; iTF_00539035; iTF_00541147; iTF_00567611; iTF_00574139; iTF_00583035; iTF_00588219; iTF_00617723; iTF_00476700; iTF_00477404; iTF_00540444; iTF_00544572; iTF_00557276; iTF_00569756; iTF_00803676; iTF_01319836; iTF_01551804; iTF_00484509; iTF_00594621; iTF_00619933; iTF_00504062; iTF_00512798; iTF_00526654; iTF_00479551; iTF_00501119; iTF_00513535; iTF_00538303; iTF_00915423; iTF_01320543; iTF_00488736; iTF_00491584; iTF_00493728; iTF_00496704; iTF_00534656; iTF_00571232; iTF_00586752; iTF_00611424; iTF_00614976; iTF_00919136; iTF_01320544; iTF_01551072; iTF_01044802; iTF_00473863; iTF_00624842; iTF_00351937; iTF_00894049; iTF_00974822; iTF_01212071; iTF_00665769; iTF_00426474; iTF_00694763; iTF_00427437; iTF_00693933; iTF_00664180; iTF_01396628; iTF_00664951; iTF_00984343; iTF_00188249; iTF_00389722; iTF_00976602; iTF_01555498; iTF_01558369; iTF_01364017; iTF_00531029; iTF_01432150; iTF_01431026; iTF_01554038; iTF_00891961; iTF_01195355; iTF_00251425; iTF_00062026; iTF_00891051; iTF_00061212; iTF_01356221; iTF_01196064; iTF_01542303; iTF_01223521; iTF_01395911; iTF_00240846; iTF_01541526;
90% Identity: iTF_00495201; iTF_00495937; iTF_00577857; iTF_00609985; iTF_01327969; iTF_00507682; iTF_00528130; iTF_00566882; iTF_00591042; iTF_01557634; iTF_00480931; iTF_00490851; iTF_00493027; iTF_00511363; iTF_00521475; iTF_00529635; iTF_00571971; iTF_00505476; iTF_00530340; iTF_00597476; iTF_00613572; iTF_00489445; iTF_00576421; iTF_00596005; iTF_00517062; iTF_00552390; iTF_00577126; iTF_00535399; iTF_00600391; iTF_00478088; iTF_00490152; iTF_00514248; iTF_00547432; iTF_01322728; iTF_00541833; iTF_01323465; iTF_00558794; iTF_00574890; iTF_00580810; iTF_00593194; iTF_00471691; iTF_00474571; iTF_00481611; iTF_00486635; iTF_00487371; iTF_00497483; iTF_00518507; iTF_00565451; iTF_00581611; iTF_00602667; iTF_00917291; iTF_01327243; iTF_00485932; iTF_00498956; iTF_00500396; iTF_00506188; iTF_00536844; iTF_00548140; iTF_00561836; iTF_00604172; iTF_00592461; iTF_00607853; iTF_00512078; iTF_00536110; iTF_00533167; iTF_00563247; iTF_00605647; iTF_01325743; iTF_00498224; iTF_00527376; iTF_00539728; iTF_00550320; iTF_00563984; iTF_00802928; iTF_00514961; iTF_00522257; iTF_00543825; iTF_00550961; iTF_00580049; iTF_00616977; iTF_00480242; iTF_00492306; iTF_00555922; iTF_00560370; iTF_00566162; iTF_00619218; iTF_00542515; iTF_00593907; iTF_01321267; iTF_00517780; iTF_00531732; iTF_00588916; iTF_00612148; iTF_01322004; iTF_00546037; iTF_00615637; iTF_00618485; iTF_00918229; iTF_00591766; iTF_00596726; iTF_00612886; iTF_00804470; iTF_00918230; iTF_00501879; iTF_00508407; iTF_00525207; iTF_00548887; iTF_00604919; iTF_01324215; iTF_00482328; iTF_00483768; iTF_00564728; iTF_00578616; iTF_00609240; iTF_00914584; iTF_00504761; iTF_00525945; iTF_00555161; iTF_00561113; iTF_00916313; iTF_01326489; iTF_00475290; iTF_00523770; iTF_00598234; iTF_00488091; iTF_00494459; iTF_00539035; iTF_00541147; iTF_00567611; iTF_00574139; iTF_00583035; iTF_00588219; iTF_00617723; iTF_00477404; iTF_00557276; iTF_00569756; iTF_00484509; iTF_00619933; iTF_00504062; iTF_00512798; iTF_00526654; iTF_00501119; iTF_00513535; iTF_00538303; iTF_01320543; iTF_00488736; iTF_00491584; iTF_00496704; iTF_00571232; iTF_00611424; iTF_00614976; iTF_00919136; iTF_01320544; iTF_00572675; iTF_00509891; iTF_00532451; iTF_00502600; iTF_00568328; iTF_00545321; iTF_00546731; iTF_00559564; iTF_00551661; iTF_00599664; iTF_00573396; iTF_00473141; iTF_00516341; iTF_00519992; iTF_00549624; iTF_00554456; iTF_00582328; iTF_00476700; iTF_00540444; iTF_00544572; iTF_00479551; iTF_00493728; iTF_00586752; iTF_00473863; iTF_01556199; iTF_01570310; iTF_00806042; iTF_01549644; iTF_00805264; iTF_00803676; iTF_00553109; iTF_00616269; iTF_00601880; iTF_00533882; iTF_00585279; iTF_01554778; iTF_01559111; iTF_00915423; iTF_00919890; iTF_00531029; iTF_00534656;
80% Identity: -