Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.2e-40 1.1e-37 128.0 0.0 1 88 89 181 89 181 0.96

2 2 2.1 2e+03 -1.0 0.1 52 68 193 209 191 223 0.76

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.2e-40	1.1e-37	128.0	0.0	1	88	89	181	89	181	0.96
2	2	2.1	2e+03	-1.0	0.1	52	68	193	209	191	223	0.76

Coding Sequence: ATGCTGCCTACCTCATGTTATACAACTCCATCAGCTCTACAGGATAATGAGCAGCTGGTCAACTCTTTGCTGGCCTGTCCAGAGTATTTGCGCGTCGGTCATCCCTTGGCTGCGGCAAATGCCGTCGGAGCTGTCAATATGGATGGATTGCCATGCAACAATTTCCCATCTGCCTTCTATTACAATAATATGGATAGTTTTCTGGCATTACACAATAATATTTGGACTTTACCCATCTCCTTTCTGCACAACAATCATCGACCAGAGAAACCGCCCTTCTCCTATATAGCCCTGATCGCCATGGCCATAAGCAGTGCACCCAATCAGCGATTGACACTGAGTGGCATTTACAAATTCATAATGGATAAATTTCCGTATTATCGTGAGAATAAACAAGGCTGGCAAAACTCCATAAGGCATAATCTTTCGCTGAATGATTGCTTTGTGAAGGTGCCACGGGATAAGAACACCATTGAGGACAACGACAGCGCTGGAAAGGGCAGTTACTGGATGCTGGATGCCTCCGCCACGGATATGTTCGAGCAGGGAAACTATCGAAGGCGACGCACCAGACGAAGGCACTGTTCGTCCAGCAACAGTCGCTTCGAGCGTGAGTCGGGCAAGGATTCCAATGCTAGCAACGATGGCAGCAATGGAGAGTTTCGTTCCTCGAGCGATGCCATGGCCGACTTTGACCTGTTCTGCAGCGATGGTAGTGGTAATTCTGCTGCATTGCGTCCCAACTACTCGGATCGAATTACAGAGCTGCATCGTCAGTATCTCTCTGTATCCTTCGGTTTCAACAGCCTCTTCAATAACGAACCGGCGGGCAGAAGTTTAAAGGACAACTCAGCAGCCGACAGCCCATGCTCGAACAGAACTGCAGAGCAGAGCACAGCGGATAGCGCCTTGCGTGAAGATCTACATTCCCCAAGCGCCTTTACTCCAACGCCGGCTGGACGAGAGGCGACCTTAAACGTTGAGGCATTTAAAGGACTACAACAGCTGCTGGACACGACGAACAGATCAAAGACGAACACGCTCTTTACAATTGAAAACATTATTGGCAAGCCATag
Protein Sequence: MLPTSCYTTPSALQDNEQLVNSLLACPEYLRVGHPLAAANAVGAVNMDGLPCNNFPSAFYYNNMDSFLALHNNIWTLPISFLHNNHRPEKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKVPRDKNTIEDNDSAGKGSYWMLDASATDMFEQGNYRRRRTRRRHCSSSNSRFERESGKDSNASNDGSNGEFRSSSDAMADFDLFCSDGSGNSAALRPNYSDRITELHRQYLSVSFGFNSLFNNEPAGRSLKDNSAADSPCSNRTAEQSTADSALREDLHSPSAFTPTPAGREATLNVEAFKGLQQLLDTTNRSKTNTLFTIENIIGKP

Sequence clustering based on sequence similarity using MMseqs2