Dspr011206.1
Basic Information
- Insect
- Drosophila sproati
- Gene Symbol
- MBD2
- Assembly
- GCA_018904355.1
- Location
- JAEIFY010000003.1:320358-322187[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.5e-17 1.1e-13 50.4 0.2 1 76 9 103 9 104 0.93
Sequence Information
- Coding Sequence
- ATGCAAATGAATCCGAGTATTACAATCGAGAGAAAACGCGTTGATTGCAACGCATTACCCAAAGGCTGGCAGCGTGAGGAAGTACACAGAAAATCGAGCTGCAATTCGGGCGTTGATGTTTTCTACTACAGCCGCGCTCTGCGCACAGATGTCTCACTGGTGCCGCCCATACGACAGACAGCCTCCATCTTCAAGCAGCCGGTGACTGTGGTGCGCAATCACGAGCCCAGCAAGGTGAAGCACGATGCCAAGCACGGTGGCCAGGAGAAGCCCAAGCAGCTGTTCTGGGAGAAGCGATTGGAGCGCTTGCGTGCCTGTCATGACAATGGCGAGGAACTTGACGAGATATCACTGCCAAAGACCATACGCACCGTCGGTCCCAATGTCAACGAACAGACGGTTCTACAATCTGTGGCCACGGCCCTCCATATGCTCAATGCCGGTGTGCATGGCCAGAGTTCAACAAAGGCTGAACTCACAAAGAATGCGATGGCATTTATGAATCCCGAACAGCCGCTGATGCATGCTGTTATCATCTCAGAGGACGACATACGCAAGCAGGAGGATCGCGTGGGCGTGGCACGCCGAAAACTACAGGATGCGCTCAAGACATGA
- Protein Sequence
- MQMNPSITIERKRVDCNALPKGWQREEVHRKSSCNSGVDVFYYSRALRTDVSLVPPIRQTASIFKQPVTVVRNHEPSKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDEISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00475210;
- 90% Identity
- iTF_00475210; iTF_00584417; iTF_00534572; iTF_00616896;
- 80% Identity
- -