Basic Information

Insect: Drosophila simulans
Gene Symbol: -
Assembly: GCA_016746395.1
Location: NC:20814294-20851534[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.034 2.1 8.6 2.3 1 23 1404 1426 1404 1427 0.95

2 8 0.0045 0.28 11.4 0.1 1 23 1432 1455 1432 1455 0.98

3 8 0.03 1.8 8.8 5.4 1 23 1738 1761 1738 1761 0.94

4 8 0.00047 0.029 14.5 2.1 1 23 1769 1791 1769 1791 0.98

5 8 4.9e-05 0.003 17.6 0.2 1 23 1798 1821 1798 1821 0.97

6 8 1.8e-05 0.0011 18.9 1.4 1 23 1827 1849 1827 1849 0.97

7 8 3e-06 0.00018 21.4 2.1 1 23 1854 1876 1854 1876 0.99

8 8 0.00027 0.016 15.2 3.9 1 23 1881 1903 1881 1903 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.034	2.1	8.6	2.3	1	23	1404	1426	1404	1427	0.95
2	8	0.0045	0.28	11.4	0.1	1	23	1432	1455	1432	1455	0.98
3	8	0.03	1.8	8.8	5.4	1	23	1738	1761	1738	1761	0.94
4	8	0.00047	0.029	14.5	2.1	1	23	1769	1791	1769	1791	0.98
5	8	4.9e-05	0.003	17.6	0.2	1	23	1798	1821	1798	1821	0.97
6	8	1.8e-05	0.0011	18.9	1.4	1	23	1827	1849	1827	1849	0.97
7	8	3e-06	0.00018	21.4	2.1	1	23	1854	1876	1854	1876	0.99
8	8	0.00027	0.016	15.2	3.9	1	23	1881	1903	1881	1903	0.99

Sequence Information

Coding Sequence: ATGAGTGCCAACCGAAGAAGACGCAGTGCATCAGCTGCGAGTGCAATTGCAGCAgaaagagcaacaacagcagcagcagcagcagaagcgatATCAACTGCACCCTCCAAAGAGCAACTTTCTCCAGCGATTGCTGGTGGCAGTGCTTCAGCTGATGAGGATTTACTGGAAATGCCTCGCATTTGCCGATGCTGTTGCAAACGGGATTTGAAATTACTCGGCTTATTCGAGGCCAGCCAACCAACACTGGCCAACACAACAGTGGCATCAGCATCAGTGGCATCGAACAAATCATCGGGAACATTAGCAAAAACATGTGCGACAGAAGCAGAAACCGAAACTCCACAGACATTGTCCGCAAATCCAGTAAATCCCGGGACTAAAGCTACATCATCTCCATCAGAAGCAGCTACAACGTTGTCCGCATCCACACACCCCGCGTCCGCCTCCTTCtcatccacctcctcctcgtccacatccacgtcTCCCATGAGGCGTCGCACCACTAACACCACCGCTCCATCCGCTCCGCCCGCTCCACGTGGTCGTAGCAGCGATAATGCCGTCGACTACACCCTCAGCGGGGCCCACAGCAGCATGGACATTGTCCTCGAGGAGATGACCATTTGGATGCTCAATATAAATCGCGACGATGGACTGCCGCAAGAAATCTGCCGGCAGTGCATGGCCCAGTTTTTGATGGTGGCCAAGTTCCGGCGGAAATGTGTACGGATGCAGCAGCGCCTGCAGGACTTTGCCCAGGAGATATCCGACCGCCAGACGGCCAGACAAGCGAAGCGTCAGCAAAAAGTCCAAAAGAAGACACACGATAGCTGGCTGCAGTTGGAGCCAACCAGCcacgaggagcagcagcccaTACGTAAGCGCCGCATGGTATCCGAATCGGACGGAGAttcgacagcagcagcagcagcagcaacagcaacaactccAGCCAAACAGGTGCGAACGGAGTTCGAGAGTTTGCCACCGCCCAAACCAAGTCCTCAGCAGCACCGAGTGCGCAAGTATCGAACCCTCTCCATTGGCTGTGAAATGGAGCGTCCCGCCGCGTCCATCAATGCCAGCAGCATGCCCTGGAAGACGAAGGCTGCCCGCAAACAACTTTCGGAGAGTCGGGCGTCCAGTTGCTCGACGGCGGTCATGTCGCCCAATCGCCAacgcagcagcaccagcagcagtgaACACATGAGCGACTTGTCCGTCGGTCCATGCTGTGGCTTCGAAAGCGACAGCAGTCCGTCCTCCACCTCCAACTCGGCGCGGAGATCGGTGATACTCGTTAAGCAGCAGTCGCCGGAGAAGACATCGCCCATGTATGATTTAATGCCGCGCAGGGGACGGCGGCCCAGGAAAGCGCCGATATACATGCCGGCCAAAAGACAGAGGCGATCGCTGGTTAGGAAGGAGCCGCTGAACCGAAAGGCGGCCGCGCAGCCAGTCAACGAAGAGAACAAAAAGTCTGATCAAAAGGATATATATCCGAAGGAACCAAGGATGGAAGGCCTTGCACCGTCCTGTGATGAGGCCATCGACAGCACTTCCGATGCGCCAAAGGAAGTAGCCTCTAATGTGGTCCAAAATAAGTGCGATGAAAtcagtttaaataatttgatgttgtgtaaaatgcaaaaggaCATCACATCAAATGGTTTGATAGACAGTCGCGACCAGTTagccatggaaatggagcCGGCTAACGAAATGATAGCGTCCAATGGTGTAGTGAAGGAACTACCCCAAGCTGAAATGCACGTCCTCAACGCCCAAAATTATGAGGAAACATCATCCGAAAAGCAAACATTAGAAGCCACCAGCGTTATAAAAGAATCGATTCAATCAGAACCAACTGCTGTTAGAACGGAAATCGAGTCAATTGGGAATGACATCAGGGCTGGTTCTGATCTAGTGCAGTCCGAGGAACTGACCTCATCCACAGAAACCAGCGAGTCGCAAAGGAAAGCTGTTGAGCAGTTGAAAACTATGGGACAGCAGGAATCTTGTGCGTTACTACAAACCATGAAGGATGAGGCATCTGTCCAGCAAACGGAAACTGCGGACGAATCAGACTCTGCTGACCAGAGGGAGATCATAGTGAGCATACCGCTGGAGGTTCTGGATGAGAATCTGCAGCGTCGCCTTTGCGTGGATCCGGAGACTGAGGCGGCCAATCGCCAGTCCGCTGATCCCAAGGAGTTCCCCCTGCGCCCCGATGACGTgaacaacaacgaaaacgaTGAAAATTTTTGCCAGAGTGCTACAGCAGATAGCTTCAATTCTGCTGTGGCACTCCGAACCAATAAAATTGAAGCAACACCGCCTGGGGGAACGGAATCAGATGACACGGACACGGAAGAGGTGCCGATAGTGCGATCTGGGCCAACGCCCATGGACTTCATGGCCGAGTTCGCCAAGCACTGTGCGAACGGAATTGAACAGCTCAAGGTCACTACACCGGCGCCATCACCGACTCCCTCGGATTTGGTGCCCCTCAACGATCTGGAGGCCAAGCAGAAGCTGGAGGTAGAGATGAACGACGTGGAGACCACACTCAATGGCATCCTCAATGAGATGCAGGACCAGCACATGTACACACCAAACTGTGCCCACATTGATGAGTTCCTCACTCCAGCCGATTATGCCACACTGACTGAGCAGGAGTCGCCCGTTTCGTCGCCACCAAATCCTTTCGAGCAGAGTTCTGTTGCCGAACCGAAGGACGAGAAGCCCAATGCCACTGAGGATCCCTTTGATAATAGCAACTTTACCAATGAACTGATTGGTTTCCAAAACGATATTCCCTGCTTCGAGAACATTGAGACACCGGAGCAGGGACAAAACTTGCATTTAGAACTGACCCAGTTCCTAAGGGATCTGCAGCCGGCACAATCCGATCCGCCGGCAGAGGAGCAGGTGGAAAAAGTCGAAATGCAGACACAGCCAAACACCGTCCAAATGGATGACCAATCAAACCTACCATTGCAAGCTGATACACAGCCTCAAAATGAGTCCGCAAATCATTCACCATTTGAATCTCCCATATCATCACCTCAAGTTCAGTCTCAGATCGAAATACAAATGGAACCTCAAATCGAGACTCAGATGCAACCTCAAATTGAGACTCAAATGCAACACGATGTGCTAAGCGTGCAATCTCCACAAAACCATCAGCCTCAAGTACAATCTCATGACCAATCTCAGATGCAACACCAAATCCCACCGCAAATTGAGCCTCAAATTCAAGTCCAAAACCAGGAGCAACATACTTTACAGCTCGTGCCGCAAGCACAGCAACAAGTGGTTCCACAAGTACAACTGCAGTCCCAGTTGGTGCCTCATGTCCAGTCGCAGGGCACGACGACGACAGTCACCTACGAGCAGATTTACCAGCAGCACATTGTCCAGCAGACGGTGCAGCAATCCTCCAACAAGATGCAGGTCATCTCGTTGCCCTCGGCTGGCACGGAAACAACACGACAGTGGCAGacgcagcagtcgcagcaacagcagcaagtcCAGTGGTCATCGGTGGGCGGACTTGAGGCCATCAAGAGTGCACCCGTCGAGAGTGTTGCACCCACGACCACAACGTACTACATCAGTGCGAGCGATCTTTATCCGCAGCAGACTGAAACATACACGATGCTTCAACCAGCATCCAATGAAAGCTACGTGATCGAGCAGGTGAatcaccaacagcaacatcgcCAGCAACAGATTCAGATgtcgcaacagcaacagcaacagcaacgccagcatcagcaacagcaagcgCAGCAggcgcaacagcaacagcagccgatTATGATACTGATccagcagccggagcagccAGTGGCCTCGGCCAGCAATCCGCAACAGGCACCGCTGCACATCTATAATGCTGCCACCAGCAACGATGTCCGTCAAATGCAGCACACGCAACGCCAACAGATACGGCAGCAGTATCACCACCAGCAGTATCAGCGGCTGCAACAGCCGCAACAAACTCGCGTCGTACAAAGCCATCCAGTATTGGGAATGCCGGGAGCCACTTCCATATCAACGAAAGTGACCCCCATTCCCGTCACAGCGGCCAGGGGTCGGGCGCTCACGCTGAAGTGCCGCTTCTGCCATAACGGGCCGCGATTCTCCAGCAGCCTGGAGTACAGCCGGCATATCATAGATCTGCATCCGGCGGTGGCGCCCTTCAATTGTCCGCACTGTCCGCAGGCCTTTGCCGGCAGAACGAAGCGATCGCAGCACATCCTCAGCCACCATGTGGTGCAGCAGTACCAGTGCGGTCAGTGCTCACAGGTGTTTCCCGCCCAGAAGGCACTGGACGTTCACATCCAGCGCATTCACATGACCCTGAAAACGGATCCATCGGGCACTGTGAAGGTGGAGGACGTTCAGCTGCAGATCACCAGCGAACGCAGGCCACGGGGTAGGCCGTATAAGCCAAGGCTACAGCTTCAACAGCATCAACTGCAGCCGCAGCAGAAGttgcaagtgcagcagcagcagcagcaaaaggcaCTTCAGCAACTACCCCAAGCAcaacaccaccaacagcaacagcaacagcaacctcAACTGCAACAAGAAGTGCTACAGCAGGTGCAGCAACTGCAAGTGCAACCGCAACAACAAGTGccgcagcaacaccagcaacagcagcaacatgtgtTGCAAGTGCAGCAACCACAGCAACAACCGTTAATGCAGCCACAGTCGCCGCATCCATCAACAGTGGAAATGCAAGCAAGCCCAACAACGCCACGAAAGATTCTTTGCTGTCCCGATTGCGAAGACTGCACTTCCGGTCACAGCCATGCCAACGAACAGTTCGAGGAGCTGCAGACACTGCAGCCTCCGCCAACGGTGTTGACTCCGCCATCGACCATAGTCTCGGTACCATCGCCACAGCCCATGGTGTACTCGCAGCACATAACAATGCCGTCGCCGGAACAATCCGAGCCAGATTCCACGACCACGTTGCGACAGTATCGCAAGCGAGGCGTGATCGTTGGGCCACAGGGTCCGCTGCATTTGGCCACACCGGTGGCCTCGCCATCGCCCTCGTCGTCACCCTCCTCATCGACGGTGGATCACATACCGCCGGCATCTCCGGCTCCGCCCGCATCACCAGCTCCGCCTCCGTCGCCCGCCGTCGCGTCCACGGTGCAGGTGAGCGAGCTGCGGACGAGCCACCATTGTCTGTACTGCGAGGAGCGATTCACCAACGAAATTTCCCTGAAGAAGCACCATCAGTTGGCGCACGGAGCGCTGACAACAATGCCATTTGTGTGCACAATCTGCAAGCGAGGGTATCGCATGCGTACGGCGCTGCATCGGCACATGGAGTCGCACGATGTGGAGGGACGGCCGTACGAGTGCAACATTTGTCGCGTCCGGTTCCCGCGACCATCGCAACTGACGCTGCACAAGATCACGGTGCACCTGCTCTCCAAGCCGCACACCTGCGACGAGTGTGGCAAACAGTTTGGCACGGAGAGCGCCCTCAAGACGCACATTAAGTTCCACGGAGAGCTCGGTTACCAGTGCGACGGGTGCGATCGGAGGTTCGAGTATCTGAAAGAATTGCGCAAACATCGACGCACCCACAGCGAGATGttttacaaatgcaaattctgTCCAAGCTCCTTTATGCGTTTCACGAATTTTCGGGCTCACATGAAAACCCATTTGCCGCTGGGCGTATTCCGCAACGAGGATGCCGCATCGAAGTCacccagcaacaacaatagccaCGCCAGCAGTGACAAGCTGGAGAAtccagccacgcccatcgAGGAGACACCTTTGACGCCGATGAGCAGCGGCGGACACGTGTACCACAGCCCAGATGAATACCCCAATTCGGTGGAGAGCTGTGCTGGCAACAGCGTGGCTCTGGAATCCTATGCCACAACGCCATAA
Protein Sequence: MSANRRRRSASAASAIAAERATTAAAAAEAISTAPSKEQLSPAIAGGSASADEDLLEMPRICRCCCKRDLKLLGLFEASQPTLANTTVASASVASNKSSGTLAKTCATEAETETPQTLSANPVNPGTKATSSPSEAATTLSASTHPASASFSSTSSSSTSTSPMRRRTTNTTAPSAPPAPRGRSSDNAVDYTLSGAHSSMDIVLEEMTIWMLNINRDDGLPQEICRQCMAQFLMVAKFRRKCVRMQQRLQDFAQEISDRQTARQAKRQQKVQKKTHDSWLQLEPTSHEEQQPIRKRRMVSESDGDSTAAAAAATATTPAKQVRTEFESLPPPKPSPQQHRVRKYRTLSIGCEMERPAASINASSMPWKTKAARKQLSESRASSCSTAVMSPNRQRSSTSSSEHMSDLSVGPCCGFESDSSPSSTSNSARRSVILVKQQSPEKTSPMYDLMPRRGRRPRKAPIYMPAKRQRRSLVRKEPLNRKAAAQPVNEENKKSDQKDIYPKEPRMEGLAPSCDEAIDSTSDAPKEVASNVVQNKCDEISLNNLMLCKMQKDITSNGLIDSRDQLAMEMEPANEMIASNGVVKELPQAEMHVLNAQNYEETSSEKQTLEATSVIKESIQSEPTAVRTEIESIGNDIRAGSDLVQSEELTSSTETSESQRKAVEQLKTMGQQESCALLQTMKDEASVQQTETADESDSADQREIIVSIPLEVLDENLQRRLCVDPETEAANRQSADPKEFPLRPDDVNNNENDENFCQSATADSFNSAVALRTNKIEATPPGGTESDDTDTEEVPIVRSGPTPMDFMAEFAKHCANGIEQLKVTTPAPSPTPSDLVPLNDLEAKQKLEVEMNDVETTLNGILNEMQDQHMYTPNCAHIDEFLTPADYATLTEQESPVSSPPNPFEQSSVAEPKDEKPNATEDPFDNSNFTNELIGFQNDIPCFENIETPEQGQNLHLELTQFLRDLQPAQSDPPAEEQVEKVEMQTQPNTVQMDDQSNLPLQADTQPQNESANHSPFESPISSPQVQSQIEIQMEPQIETQMQPQIETQMQHDVLSVQSPQNHQPQVQSHDQSQMQHQIPPQIEPQIQVQNQEQHTLQLVPQAQQQVVPQVQLQSQLVPHVQSQGTTTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGTETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESVAPTTTTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHRQQQIQMSQQQQQQQRQHQQQQAQQAQQQQQPIMILIQQPEQPVASASNPQQAPLHIYNAATSNDVRQMQHTQRQQIRQQYHHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRALTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPQAFAGRTKRSQHILSHHVVQQYQCGQCSQVFPAQKALDVHIQRIHMTLKTDPSGTVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQVQQQQQQKALQQLPQAQHHQQQQQQQPQLQQEVLQQVQQLQVQPQQQVPQQHQQQQQHVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEELQTLQPPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPAPPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPFVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFHGELGYQCDGCDRRFEYLKELRKHRRTHSEMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSPSNNNSHASSDKLENPATPIEETPLTPMSSGGHVYHSPDEYPNSVESCAGNSVALESYATTP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00504951;
90% Identity: iTF_00592641; iTF_00539909;
80% Identity: -