Basic Information

Insect: Drosophila simulans
Gene Symbol: -
Assembly: GCA_016746395.1
Location: NC:7492279-7496100[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 18 0.24 15 5.9 4.3 2 23 332 354 331 354 0.95

2 18 0.17 11 6.4 0.1 1 23 361 386 361 386 0.91

3 18 0.038 2.3 8.5 2.1 2 23 397 418 397 418 0.93

4 18 0.022 1.4 9.2 0.1 3 23 459 480 458 480 0.95

5 18 0.0012 0.072 13.2 0.6 3 23 488 508 486 508 0.95

6 18 0.061 3.7 7.8 0.2 1 23 516 539 516 539 0.96

7 18 0.00047 0.029 14.5 0.3 2 23 544 565 543 565 0.97

8 18 0.077 4.8 7.5 0.1 1 21 573 593 573 594 0.93

9 18 0.02 1.2 9.4 1.5 1 22 613 634 613 637 0.90

10 18 0.12 7.1 6.9 1.6 3 21 644 662 642 663 0.90

11 18 0.004 0.24 11.6 0.9 1 23 682 707 682 707 0.96

12 18 0.14 8.5 6.7 1.3 2 23 725 747 724 747 0.94

13 18 0.0071 0.44 10.8 1.2 2 23 753 775 752 775 0.93

14 18 0.0088 0.54 10.5 0.1 2 23 779 801 778 801 0.95

15 18 3.5e-05 0.0021 18.0 2.2 1 23 807 829 807 829 0.98

16 18 0.0076 0.47 10.7 0.9 1 23 833 856 833 856 0.93

17 18 4.8e-06 0.0003 20.7 1.1 1 23 862 885 862 885 0.97

18 18 1.3e-05 0.00082 19.3 0.2 1 23 889 917 889 917 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	18	0.24	15	5.9	4.3	2	23	332	354	331	354	0.95
2	18	0.17	11	6.4	0.1	1	23	361	386	361	386	0.91
3	18	0.038	2.3	8.5	2.1	2	23	397	418	397	418	0.93
4	18	0.022	1.4	9.2	0.1	3	23	459	480	458	480	0.95
5	18	0.0012	0.072	13.2	0.6	3	23	488	508	486	508	0.95
6	18	0.061	3.7	7.8	0.2	1	23	516	539	516	539	0.96
7	18	0.00047	0.029	14.5	0.3	2	23	544	565	543	565	0.97
8	18	0.077	4.8	7.5	0.1	1	21	573	593	573	594	0.93
9	18	0.02	1.2	9.4	1.5	1	22	613	634	613	637	0.90
10	18	0.12	7.1	6.9	1.6	3	21	644	662	642	663	0.90
11	18	0.004	0.24	11.6	0.9	1	23	682	707	682	707	0.96
12	18	0.14	8.5	6.7	1.3	2	23	725	747	724	747	0.94
13	18	0.0071	0.44	10.8	1.2	2	23	753	775	752	775	0.93
14	18	0.0088	0.54	10.5	0.1	2	23	779	801	778	801	0.95
15	18	3.5e-05	0.0021	18.0	2.2	1	23	807	829	807	829	0.98
16	18	0.0076	0.47	10.7	0.9	1	23	833	856	833	856	0.93
17	18	4.8e-06	0.0003	20.7	1.1	1	23	862	885	862	885	0.97
18	18	1.3e-05	0.00082	19.3	0.2	1	23	889	917	889	917	0.89

Sequence Information

Coding Sequence: ATGTCGGAAAACGCGAAAAACAATAGCTGCCTGCATTGCAGCGTATTCAGTACGAAATACCAGTACCAGGAGATCTTCGATGAGTTCGGAATCGAACTGGGACTGCAGTCCCTGCTGTCCAGGCACTATCAGCTCGAAGTGTCGCCCGATCCGCGGAAGCAGCAGCTCCTGTGCGAAGTGTGTGTCACCAATCTCATCCGCCTCTTTGACATCGATGAACTGGAAAGAGAACGGGAAGCTGCAAAGGCTGTGGCCCAGGACAAAGATCTCAAGGCAGAGGAGGACCCCATTGTGATTACCGAGGTCCAGCCAACTCCACCAGCTGCGAAACCAGCCCAGAAAACAGTGCCTTCAAGGCCCCTGACTAAGGTTCTGCGACCAGTGCCCATTATTCCCACCCGGGAACCGAGTGCCCGGATAAGGAATAAAGCGGCTGCTGCTTCCCATGTAACGCCTGATACGTCTAGATCTCCTGAGCCACCACAGACACCTTCCCCAGAAGATGCTGTTTCCAAAAGTGATGCAAAACTGGTTTCTAAAGTCGCAGATCAGGAGCAGTTCAGTGTCcttatacaaaatattctgGACGAAGAAGAAGCTATTGTTGAGGATGAAACCGCAGTCAAAGAGGAGTCCAGTGAAGCTGTCCAGGTCACAGAGGAAACAGAAACCCCTGCCCAAATAGTCATCCTAAACAGAGAGGTTGTGACAGAAACCAATCTGGATGAGAATGTTTACATATACGAGCATGAGGATGTTATGGATCCAAATTTGGACAATGTTAAGGTCAAACCCATAAGATGTTCGTCTAGATTGGTAGCTCAAGCTGAGGAAAGTCAAAGCGATGATGACATCGACGAGGGAGAGACTAGCAATATTGTTCCGTTTAACTTTGTGGACATCAAAGAAAAGGATGAAGTTGATAATATTCCGGAGTACTTGGCTACCGTGGTGAAGACGAGCTTTGAAAAGCTGACATTTCAGTGGTGCACTGTGTGCAAGCATTGCTCCCTGAAGTGTCCCACATTCGAGAGCCTTTTTAGTCACTTGTCAAAGGTACACAAAAGCCGCAGAGATGTCTACCAGTGTCCCATCGAAGGATGCAACAAGGAGTTGAAAGGACGCAAATTCCTAGCCATGCATCTTGTTTTGTTGCACGCGCCAGTGGCTGAAATTCCGATCTACGGCAGCTGTCCGGAATGTAAATTGACTTTCTCCAACATTTTGCAGTACAACAAGCATTCTTGCGCTCatgtaataaaaaagaagCGAGGTTTTCGCTCATTTTGTGAAATGTGTTCGCTGGAGTTTCCTTCCTGGAAGCGATTTAATTTCCACAGCCAGTTTCACTTAGAAAAGCACAGACCAAGAGCTTGCTTCGTCTGTGACTATGCCACCACGAACATAGATGAACTTTTCcagcatttaaattattctcATGAGCCAGTGGGCACCTTATTCTGCGACCTTTGCGACCGCACTTTCCGGGACCCCTCAGTTTTTATGGAGCACAATAAGTCGCATGCCAATGTTAGCAGCACGACCTACTCTTGCAGCGAATGTATGGCCAACTTTGAGTCGCGGGGCCGGCTAAATGGACACATGAGAGCCATGCACGGCAGTGTAATAAGCTGTGAACTCTGTTCCCGGGAATTCGCCACCGAAGCTACTTACAATATTCACATGAAGAAGCATCTGATCATCGAAAAAGATGTGCACGTGTGCAGCAAATGTGGTCTTTTAAGTGATAACCGCGAAACCCTCCAAGCTCATGTAAATTCCGTGAAGACAGCCTGTTTTGGCTCGAAGGTAGACGTGGAACTCCTACGGGATGCTTATGTGTGCGAGTACTGCTCCTCGTACTTCAAGGAAAAGGACTGTCTTCAAGCCCATCGCGATTCCGGGGTACATAAGGATGGAGTGTTTTTGTGTCAGCCCTGCGGCAAAGAATTCCCACATATGAAACTTTATCGCCATCACCTGCGCAACTATCAACAACTTCGATCGGACTCAACACATCGCAGGCTAGAAATATGTGTTTACTACATGTGCGACCAGGAGAACTGCACAGAGTCTTACGTGAACTGGAACTCCTTGTACACACACAAGCGGCGCACACACGAAACCTCGACCAAGCAGGCGGAGAAGGGTTCAAAGTCTGCCCAGGAATGGGTTTGCCAGTTTTGCTTAAAGGAATGCCGCTCAAAGATGTCCTTGTCTGTTCATGTAGCAAGGAGTCATAACAATGacAACGTCACTTGTCCGTTATGCAATTCTTCGTACAAAAGCCATGATGCTCTGGCCAAGCACCATGCCTATTGGCATGAACCAATAGAGTGTCCTGAGTGCTTTAAAATAGTCAAAAACCGACGGAATTATGACACTCATGTCAATGTGGTGCATTCGAATAAGAAGCGATATTCCTGCAGTGTCTGCCAGAAGGGCTTTTATCACAAGAGTGAAATGGAGGCTCATCAAAAGCTTCATGGGCAGTCTTACAGCTGCGAACAGTGCAGCTTCACCACCAGGAACAAAAAGTCCCTTTCTGTTCATGTTCTTGGTCAACACTACAAGCGATTCGCGTTCGAGTGCAACGTGTGTAAAAAGAGGTTTGGGCGCAGTCAAGGATTGAAGACGCACATGCAGCGAGCCCATGGGGATAAATACACGTGCCGCGACTACTTCGACGGCGGCTGTGGACGGACCTTTGTAAACAGTTCCCAGTTGAATGTGCATGTCCGAAAGGTTCACGATGGCATCATTTTGCTCCAGGATGATGTGGTTGAGGAGGACGAATACATCACCGATGATCCGCCATCCACATCTAAAAAGCGCCGTCTGAATGAAAATATTGAGTTTATAGAGGAAGCAGATGGGGATGACATAGTGATGGAAGATGATGACGAGGAGGCGGACGAATTTATAGACGAGATACCAGATCAGGACACACAGAATTAA
Protein Sequence: MSENAKNNSCLHCSVFSTKYQYQEIFDEFGIELGLQSLLSRHYQLEVSPDPRKQQLLCEVCVTNLIRLFDIDELEREREAAKAVAQDKDLKAEEDPIVITEVQPTPPAAKPAQKTVPSRPLTKVLRPVPIIPTREPSARIRNKAAAASHVTPDTSRSPEPPQTPSPEDAVSKSDAKLVSKVADQEQFSVLIQNILDEEEAIVEDETAVKEESSEAVQVTEETETPAQIVILNREVVTETNLDENVYIYEHEDVMDPNLDNVKVKPIRCSSRLVAQAEESQSDDDIDEGETSNIVPFNFVDIKEKDEVDNIPEYLATVVKTSFEKLTFQWCTVCKHCSLKCPTFESLFSHLSKVHKSRRDVYQCPIEGCNKELKGRKFLAMHLVLLHAPVAEIPIYGSCPECKLTFSNILQYNKHSCAHVIKKKRGFRSFCEMCSLEFPSWKRFNFHSQFHLEKHRPRACFVCDYATTNIDELFQHLNYSHEPVGTLFCDLCDRTFRDPSVFMEHNKSHANVSSTTYSCSECMANFESRGRLNGHMRAMHGSVISCELCSREFATEATYNIHMKKHLIIEKDVHVCSKCGLLSDNRETLQAHVNSVKTACFGSKVDVELLRDAYVCEYCSSYFKEKDCLQAHRDSGVHKDGVFLCQPCGKEFPHMKLYRHHLRNYQQLRSDSTHRRLEICVYYMCDQENCTESYVNWNSLYTHKRRTHETSTKQAEKGSKSAQEWVCQFCLKECRSKMSLSVHVARSHNNDNVTCPLCNSSYKSHDALAKHHAYWHEPIECPECFKIVKNRRNYDTHVNVVHSNKKRYSCSVCQKGFYHKSEMEAHQKLHGQSYSCEQCSFTTRNKKSLSVHVLGQHYKRFAFECNVCKKRFGRSQGLKTHMQRAHGDKYTCRDYFDGGCGRTFVNSSQLNVHVRKVHDGIILLQDDVVEEDEYITDDPPSTSKKRRLNENIEFIEEADGDDIVMEDDDEEADEFIDEIPDQDTQN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00591851;
90% Identity: iTF_00539813;
80% Identity: -