Dsim007661.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila simulans
Gene Symbol
su(Hw)
Assembly
GCA_016746395.1
Location
NC:11907304-11915930[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00076 0.046 13.8 1.9 1 20 220 239 220 241 0.94
2 12 2.4e-06 0.00015 21.7 0.4 3 23 292 313 290 313 0.93
3 12 0.081 5 7.4 0.0 1 23 319 341 319 341 0.94
4 12 4.6e-07 2.9e-05 23.9 2.4 1 21 348 368 348 369 0.95
5 12 5.2e-06 0.00032 20.6 1.0 2 23 381 402 380 402 0.96
6 12 0.00024 0.015 15.4 6.3 1 23 413 435 413 435 0.99
7 12 6.9e-05 0.0042 17.1 0.9 1 23 441 463 441 463 0.97
8 12 1.6e-05 0.00098 19.1 0.4 1 23 469 491 469 491 0.98
9 12 1.3e-06 8.3e-05 22.5 2.5 1 23 497 519 497 519 0.98
10 12 1.8e-06 0.00011 22.1 0.9 1 23 523 545 523 545 0.98
11 12 0.00011 0.0068 16.4 0.3 1 21 553 573 553 577 0.92
12 12 1.1e-06 7e-05 22.7 0.4 3 23 598 619 596 619 0.97

Sequence Information

Coding Sequence
ATGAGTGCCTCCAAGGAGGGCAAGGAAAAGAAGGGCAAGCTGCTGGGTGTGGAGAACATTTCGCCGCCTAAGGATAAGCGTCCCGCCACCAGGATGAAGCTCTTGAATGACGTAGGAGCTGGTGAGGATTCGGAGGCAAGCACTACTACTACCACATCAAGAACTCCCTCCAACAAGCAGGAGAAGCGTGGCAGTGTCGCTGGATCGCGCATCAAAATACTCAATGAAGAAATTCTGGGCACTCCGAAAACTGAGAAACGAGGAGCCACCAAGAGCACAGCTCCGGCTGCCTCCACTGTAAAGATACTGAATGAGAAAAAGACACCCAGTGCTACCGTGACAGCCGTGGAAACTGCCAAGATCAAGGCGTCTCccagtaaaaaaaagaaaatggagCACTATGTACTTCAGGCTGTGAAATCAGAAAATACCAAGGCGGACACCACGGTTACCGTGGTCACCGAAGAAGACGACACCATTGATTTTATTCTAGCAGATGATGAGGAAGTAGTTCCGGGCAGAATAGAAAGCAACAACGGCCAGGAGATCGTTGTCAccgaggacgacgaggatcTAGGTGAGGATGGGGATGAGGACGGTGAAGACTCCTCAGGCAAGGGCAACTCTGGCCAGACAAAGATCAAGGAGATCGTGGAGCATGTGTGTGGCAAGTGCTACAAAACCTTCCGTCGCGTTCAGAGTCTGAAAAAGCATCTGGAGTTCTGTCGCTATGACAGCGGGTATCATTTGCGCAAAGCCGACATGCTTAAGAACCTAGAGAAGATCGAGAAGGACGCCGTAGTGATGGAGAAGAAGGACATCTGCTTCTGTTGCAGCGAAAGTTACGACACCTTCCATcTGGGTCACATTAACTGTCCCGATTGCCCCAAGTCGTTTAAGACACAGACCAGTTACGAACGCCACATCTTCATCACCCACTCCGAGTTCAGCGATTTTCCTTGCTCCATTTGCAACGCCAATTTGCGCAGCGAGGCCTTGTTGACGCTCCACGAGGAACAGCACAAGTCACGTGGCAAGCCGTATGCATGCAAGATCTGCGGCAAGGACTTCACCCGCTCGTATCACTTGAAGCGCCACCAGAAGTACTCATCGTGCTCATCGAACGAGACCGATACCATGAGCTGCAAGGTGTGCGATCGCGTCTTCTATCGCCTGGACAACCTGCGATCGCATTTGAAGCAGCATTTGGGCACACAGGTGGTTAAAAAGCCGGAGTACATGTGCCACACGTGCAAGAATTGTTTCTACAGCCTGTCCACGCTCAACATCCACATACGCACTCATACGGGTGAGAAACCATTTGACTGCGATCTGTGCGACAAGAAGTTCTCTGCATTGGTGGCTCTTAAAAAGCATCGACGCTATCACACTGGCGAGAAACCGTACAGTTGCACTGTGTGCAACCAAGCATTTGCCGTGAAGGAAGTGCTGAATCGACACATGAAACGGCACACTGGAGAGCGCCCGCACAAGTGTGATGAATGTGGCAAGAGTTTTATCCAGGCCACCCAGCTGCGCACCCATTCCAAAACCCACATTCGCCCCTTTCCCTGCGAGCAATGCGacgaaaaattcaaaacagAGAAACAACTTGAGCGCCATGTGAAGACTCATTCTCGCACTAAGCGACCCGTCTTCTCCTGCGCCGAGTGCAAGCGTAATTTCCGCACTCCAGCCTTGCTCAAGGAGCACATGGACGAGGGAAAACACAGCCCGAAACAACAGCGGGCATCAATGCGCTCGTCCGTCAAAATTATGGAACGCACGGATTGCGCCATTTGCGATAAGAACTTTGACAGCAGCGATACCCTGCGACGGCACATACGCACCGTCCACGAATGCGATCCGGATGACATTTTTGGCGTTGAGCCGCATACAAAGCGTGCAAAGAAGGACATCGAATCGGAGGAGGTTGTACCAGTGGCGTTAAACACATCGGCGGGCTCGTTAATTTCCAGCCAAACGGACGGCAATGGCGTTGTGGTGCGTGAATTCCTGGTGGACGAAGGCGATGGCGCGGCCCAGACGATTACCCTAGAAAACGAAACATACACAATTCTGCCCCTGGACGGGGCCATTGAGGGAGAGCAGCTAACGGATGAGGCTGCTGTTAAGCCGGAGGCGAAGAAGGAGGAGGCGCAGGTCTCCCCGGTGGTCAAGAAGGAGCAGCGTAAATCCCTGGCCGCCAGTCTGGCCGCTGCCATTGCCGATAACCTGGAAGAATCGTGTAGCGAGGATGACTTCAGTGGCGAAATTCTAACTGAGGAGGACATAAAGCTCAAAGAGAATGTGGGTAAACTTATTGACATGCTAGTGGACCCACCGATCCTAAAGAAATACGGCTGGCCCAATGCGCCCGAGGAGACGGTGCTCTGCAAAGTGATCGAGAACTGTGGCTACGACCTGACCATAGGTGGCGAAAACTACTCCGAGCTTGACTACGGTAGCCGCATGCGAGAGTACTGCAAACTGCTCTTTACCGTGGTCATTCACAACGATTCCATCAAGTCGCTGCTCAATAATTTCCCCATCGACGATGTGATCGAGTATGTACTGGGAGATGAGGATCAGGACGAAGGTGGATTGGGCAAAGACAATGAAGACAATGAGTCACATTCAGATGATGAAGAATCGGTGTCGGTCACAGgcgaaactaaaaaaaatgatatCAAAGAGAAACCGGAAAAGAAGGAAGTTTCGGCCAAATCTGAAAAGAAGGAGATCATGGGGAAAGCTGTGGATAAGGATAACTCAGAGGAGAAACTCcgagaaaataagaaaaaaccaGTAGTCGAAAAAGAGAAAGCTTGA
Protein Sequence
MSASKEGKEKKGKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVETAKIKASPSKKKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIESNNGQEIVVTEDDEDLGEDGDEDGEDSSGKGNSGQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLTLHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRASMRSSVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHTKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDEAAVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGYDLTIGGENYSELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLGKDNEDNESHSDDEESVSVTGETKKNDIKEKPEKKEVSAKSEKKEIMGKAVDKDNSEEKLRENKKKPVVEKEKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00486704;
90% Identity
iTF_00619277;
80% Identity
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