Dsia005539.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila siamana
Gene Symbol
Klhl10
Assembly
GCA_035047445.1
Location
JAWNPP010000016.1:11776402-11779171[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.6e-26 8.4e-24 83.7 0.0 1 108 69 179 69 181 0.92

Sequence Information

Coding Sequence
ATGAATCGGCAACAAAACGGAAATCATTTGCATGGCATGAACGAGGGTCAATTGGAGCTGGCGCCAATGGATTTGTTGGACGCGGACTTGGATGGCAGTTATCAGGCTGATGAATTGGAGAATAACATAAACAGCATTAATCCCGCCCAGAAGCCGTCCGCCAAATCGCTATCCCCCATTGTCAGTGATCACGCCCTCAATGTGCTGAACGAGCTACGGGAGGCGAATCTACTGTGCGATGCGCAGATCTCGGTCGGGGAGCAGTCCTTCAATGTGCACCGTGCCATCATGTGTTCCTGCAGCTCATATTTTCGCGCACAGTTTACGGGGTTCAACAACCGGGCGGGAGCGGGCAGCGATGAGAGTCGGATAGTGCATATACCGGGCATCAGTGCGTCCATCATGAACTCAGTCATTCAGTATGCTTACCTGCGCAAGACCAACATCAGCGACGACAATGTGCACGAGCTGCTCATCTGTGCGGATTACGTGGGAATGGTGGGATTGGTCAAGCAATGCAAGGACTACCTCAGTCGCACTCTCAGCCCGGAGAACTGTGTCAGCATCATGGGCTTTGCGCGCTTTCGCTTTCTCGAGGACCTGTATCTGAAGGCACGCAATTATACGCTGAGATACTTCACGGATGTGGCCGCCCGCAATACGGACATACTGGACCTGAACGTGAAGGACTTTTACAGCATCATCAGCGATGATGAGCTGAACACACGCGAGGAGGATTATGTGTGGAAGTTGTGCGTCAAATGGATTGACCGAGACCCAGAGAATCGCAAACAGTATGTGGCGCATCTGATGACGGGCGTGCGCCTTGGTCTGATGACCCCCAAGTGCTTCATGGAGGAGGTCAAGGAGCATCCCTATGTCATTCAATGCGAGGCAGCCAAACCCCTGATAGTCGACACCTTTAAATTCATGTACGACCTGGACTTTCTCAACCCGCAAGCCGAAGAGCTCACCACACCGCCGCTGGCGATGCCGCGGCTGCCGCATGAGGTCATCTTCGCCATTGGCGGCTGGAGTGGTGGCACCTCCAAGGGCTGCATCGAGACCTACGACACGCGTGCCGATCGCTGGGTGAACATCAACGCCGAGGATCCAGCGGGGCCGCGTGCCTATCACGGCACCGCCGTCCTGGGCTTCAAGATCTTCTCGATTGGGGGCTACGACGGCGTCGAATACTTCAACACCTGTCGCGTCTTCGACGCGGTGAAGAAGCGCTGGAACGAGATCGCACCCATGCACTGTCGCCGCTGCTATGTCAGCGTCGCGGAGCTGAACGGCATGATCTACGCAATCGGCGGCTACGACGGCCACAATCGCCTCAACACCGTTGAGCGCTACAATCCGAAGACAAACCAATGGTCCATCATTCCGCCCATGAACATGCAGCGCTCGGATGCCAGCGCCTGCACGCTCCACGGTCGCATCTATGCGACGGGGGGTTTCAACGGGCAGGAGTGCTTGGACAGCGCCGAGTTCTACGATCCGCTGACGAACGTGTGGACGCGCATACCGAACATGAACCATCGCCGCTCCGGGGTCAGTTGTGTGGCCTTCAGGGATCAGCTGTATGTGATTGGGGGCTTCAACGGCACCTCGCGCCTGTCGACGGGCGAACGCTTTGATCCGGAGACGCAATCGTGGCACTTCATACGCCAGATGAACCATTCGCGCAGCAACTTCGGGCTCGAGATCATCGACGACATGATCTTCGCCATCGGCGGCTTCAACGGCGTCTCCACCATCTCGCACACCGAGTGCTACGTGGCCGAAACGGACGAATGGATGGAGGCCACAGACATGAACATTGTGCGCTCCGCCCTGTCGGCGAACAACGTGGCCGGGCTGCCCAACAAGCGCGACTACATCCACAAGGAGCGGGACCGTCTGATGGAGGAGCGGCGACAGCGGCTGATGGCCACGGCCATGGCACGCGAGGATGTGGGCAGCGCGAACCGATCGCACTCGCTGATCGCcgatcacaacaacaacaacaacgacaccgCCCTGGACGATGACCTGATGGATGGCGAGGAGAGTCCCAACGAGGAGGACGGCGACGTGGATGGCGAGGagctgcagctacagcagcaggtGGCAGCCTTACCACTGCCACTGCCTCTGCCACATCCGCATCCGCTACCACTGGCAGCACCAggcgcagccgcagccgcagcggcagccatGCCCTCTGCTGCAatcgcagccgctgccgcagccgccgcagcagcagcggcagctgttgaTGCCtcctcagcagcagctgccgccgccatgCCAGCCGTCCACATCAATCGCCAACTGGAGGATCGTGGtcccgacaacaacaacaataacaacaacaaccaaaacaaccaaaacaaccCGAACAACAACCGGCGCTTTCGGGTGCAGCTGCGTAATCAGCGCTATGGTTCGCATCATGAAATCCGTCGTCGCTCCTAG
Protein Sequence
MNRQQNGNHLHGMNEGQLELAPMDLLDADLDGSYQADELENNINSINPAQKPSAKSLSPIVSDHALNVLNELREANLLCDAQISVGEQSFNVHRAIMCSCSSYFRAQFTGFNNRAGAGSDESRIVHIPGISASIMNSVIQYAYLRKTNISDDNVHELLICADYVGMVGLVKQCKDYLSRTLSPENCVSIMGFARFRFLEDLYLKARNYTLRYFTDVAARNTDILDLNVKDFYSIISDDELNTREEDYVWKLCVKWIDRDPENRKQYVAHLMTGVRLGLMTPKCFMEEVKEHPYVIQCEAAKPLIVDTFKFMYDLDFLNPQAEELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVNINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKRWNEIAPMHCRRCYVSVAELNGMIYAIGGYDGHNRLNTVERYNPKTNQWSIIPPMNMQRSDASACTLHGRIYATGGFNGQECLDSAEFYDPLTNVWTRIPNMNHRRSGVSCVAFRDQLYVIGGFNGTSRLSTGERFDPETQSWHFIRQMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVRSALSANNVAGLPNKRDYIHKERDRLMEERRQRLMATAMAREDVGSANRSHSLIADHNNNNNDTALDDDLMDGEESPNEEDGDVDGEELQLQQQVAALPLPLPLPHPHPLPLAAPGAAAAAAAAMPSAAIAAAAAAAAAAAAAVDASSAAAAAAMPAVHINRQLEDRGPDNNNNNNNNQNNQNNPNNNRRFRVQLRNQRYGSHHEIRRRS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01553313; iTF_01555489; iTF_00598242; iTF_01551810; iTF_00553123; iTF_00569059; iTF_00501892; iTF_00567620; iTF_00564741; iTF_01553317; iTF_01551078; iTF_01548936; iTF_01557640; iTF_00470953; iTF_01558377; iTF_00495946; iTF_01325005; iTF_01559118; iTF_00519247; iTF_00541841; iTF_01556913; iTF_00598962; iTF_01550355; iTF_01356212; iTF_01552533; iTF_00562550; iTF_00589624; iTF_00616984; iTF_00550969; iTF_00616281; iTF_00588923; iTF_01321276; iTF_01322012; iTF_01554044; iTF_00832254; iTF_00522303; iTF_00832255; iTF_01554783; iTF_01559839; iTF_00561120; iTF_00520001; iTF_00475298; iTF_00476706; iTF_00523042; iTF_00512805; iTF_00526661; iTF_00534661; iTF_00544581; iTF_00510630; iTF_00586759; iTF_00530345; iTF_00509898; iTF_00532458; iTF_00572684; iTF_00568333; iTF_00502606; iTF_00490865; iTF_00506961; iTF_00546737; iTF_00545331; iTF_00559571; iTF_00506198; iTF_00563254; iTF_00573403; iTF_00516348; iTF_00531036; iTF_00537597; iTF_00575677; iTF_00528894; iTF_00582336; iTF_00586050; iTF_00538307; iTF_00806053; iTF_00493735; iTF_00520712; iTF_00601896; iTF_00540450; iTF_00479557; iTF_00551667; iTF_00473147; iTF_00554460; iTF_00549631; iTF_00493035; iTF_01570318; iTF_00547440; iTF_00585296; iTF_00533897; iTF_01556208; iTF_00610738; iTF_01549650; iTF_00599672; iTF_00583769; iTF_00608527; iTF_00558000; iTF_00478810; iTF_00614268; iTF_00472437; iTF_00509181; iTF_00508415; iTF_00802943; iTF_00805280; iTF_00803691;
90% Identity
iTF_00579363; iTF_00520712; iTF_00472437; iTF_00562550; iTF_00589624; iTF_00614268; iTF_00509181;
80% Identity
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