Dsia003033.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila siamana
Gene Symbol
MBD-R2
Assembly
GCA_035047445.1
Location
JAWNPP010000004.1:24129706-24133541[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 9.5e-23 1.7e-19 69.0 0.1 4 76 436 506 433 507 0.93
2 2 2.6 4.6e+03 -2.9 0.0 42 63 763 784 762 786 0.80

Sequence Information

Coding Sequence
ATGGGGCGACGGTGCTGCGTTGCAGACTGCCCATCGACATCGCGGCTATTGGAACACCATGGCGTCACCTACCATTCTTTTCCCATGGACGCTGTCATACGCGACATTTGGATAAAGAACTCGCGTATTAGCCGTGACCGACAGATTACGAAGAGTGTGCTGGTGTGCTCGCGCCATTTTCGTCGCCTCGACTTTAACACCATACGCAATGGCAAGTACTTGCTGAAGCCTCGGGTTTTTCCCACAGTCTTTCCGTGGGGCAAAATGGAACCTGCTGAAATTGAGGCCGATCATCGTGCTCTTCAGCAAGCATCAGTTGAAGGCGCTGGAACTAGCGGCTCGGCTAAAAACTCCACCAGCGAGGAAGTTATCAAGGCAACCGTTGATCAGATTGTGTCCCAAATCATGGaggagacagcaacaacggatTCGGtaacaaaatctaaaacaGAAGACACAGATTCGGTTAAGGAAACAGCTGAAAGCGAAGCAGCAAAGACGTCAACTGAAACTGCAGGCAATGATTCCTTACCTGAGGCTGTCCAAACTGCAGCGGATGCCGCAGATGAACTGCGTGCCACAGCCAATAGCTCGGCGTCTCCAGTCTCGACTTCGCCACCCAAATACAGATCGCCCACCAATCTGACCATTGGGGCACGTCTGGAGGCATTGAGCGTGGACAACGCCTGGCTGCCAGCACGTATTGTTGAGGTCAATCAAGCTGACCAGACGTTGCTCATACGCTTCGAGCGGAACACTAAGCTGAAGACAACACCCTCGACTACGGGCGGTTATCAGGAGTGGATTGGCTTCAAATCGGAGCGTTTGCGGCAGCGCGTCAGCTCGCGAGTGCTGCCCGTTTTCGAGTTGGAGGAGAAATGCATGGCACGCTGGTCGGGACCACGTAAATTTCCGGGTACCATCAAGAAACTGTTGGGCAACGACACCTATGAGGTGCTCTTTGACGATGGCTACACCAAGAACGTGCGTGCCCTGCACATGGTCAAGTTGCCACGCCAACTCTTGCCCACAAGCGACGCTGCAACTGATGGGCCTGGCACAAGTTCACAGGCAACTGGTACAGGAGTTAAACGTCCAAGTACTGGAgtcacaagcaacaacaagaagagcaaaACGACACCACAACGTAAGGATTGGCCACTGCTGGATATGTCTAATTTGGACTTGGTTGCTTTGGGACTGCCAGACATTCCACACGATGGCGAATGGACTTGCCATTGGGTGAACGATCAACCCATTGGCACTGAGGGCTTTTTGATTGTGGGCGAGCATCAGAAGCCCACGGTTATTGTGCACGACTGGCGGCTACCACCTGGATGGATCAAGCACATGTATCAACGCTCCAATGTGCTCGGCAAATGGGATGTTATACTGGTGTCTCCCAGCGGCAAACGGTTTCGATCCAAGTCGGATCTCAAGACGTTTCTTGAGTCACAAGGCCTGGTCTATAATCCAGATATCTACGATTTTAGCATCCATCGTCGTCGTGCCAAGGATATAAATGCATATGTGTACACACATGACTACAGTCCACAGCAACCGGTGAAACCCAAGCCACAGGATGTGTCGCTCGACAGTACAGCAACGTCGCAGGATCTGAACAGTAGCAAGCTATCGATTGCCACGCCCGCATCCACACCAATTTCAGCGGTCGCTTCACGTCGCGGAGCCGATGACAGCCAATACATGGAAACACCAGTGGCATCTTTGGTGCCACCCGCTGAATTGATGTCGCCCTCGCTACAAACTAAAAGCTCGGAAGTTGGATCGCCGGCTGATACTGCTGAAATCAGTACGGGTTTGGGCTTAGATGCGCAGGGCGCTTTGCAGCTCGAAGATGGTTATGCTTTCATTGGCGGTCTGAAAGTCCAGATAACGGACAACTTGTTCGTGTGTCCACGTGAGGGATGCGGGAAAACCTATCGCAAGGAAGACTTTCTACAAATACACATTCGACATTACCACAAGGAGTTTGCTCAGCATGTCAGTCACTGTCCGAAGATGCAGGAGCTGGCTGTCAAGCGCACACATCCCTCTTCAATAGAGCAGGGCGATCAGACGCCGAAGAACCAAATACCAAATCAACAATTCTTTGCCAAGCTGCATCAGCAGGACTTGCAGCATTCCCGTGGCGTTAAGCGACACCCGGCGGGAACGGATTCGTCGCCAACGGCTGTGGAAGCATCGCCCATTGTTTCGCCTACCAAACCGTTGGCATCACCCAAGGTCGAATCGCCAATCACTTTAAAAGTTACTCCACCCCAAACCGTTTCTGGGGTTCCAGAAGTGAAGCAAATAATTTTCGCAACACCCAACGAAACTCCAGCTACAGTTCCAGTTGAACCCACTAAAGTTAGTCCAGCTGAGGGCACTCCGTTACCACCCAGTCGATCCTCGAAACGAACAAGGCCTTCATCTAGCAGGCGGCAGTCTGGCTCACGTAAAAGCAGCCGACAGCGTACTCAGCGTCGCCCTGCTAACATATCAACTATCAAAAGTCCTGTGGCAAGTAAATTGCCTTCGACAGGTCTCGAAAGCGAGGATTCTCGTCCACTGATTAACACACCAGTGCCAGAGGCTCGCAATGAAGCCAAAAAGCGACGTGTAGCTGCCACGCCAGTTGGTTCGCCAGCTATCCTTGATGCTGCCTCAACGCCGCCGCATGATCAGGTGGACATAAATGCTGCACtggcaccaccaccaccgccacccaATCAGACGCCTCAGTACATCAAAGAAAATGGGGAACTGATTCGCATTGTGCGAATGCGACAGGAAGAGAtcattaattgcatttgcgaaTACGGTGAAGAGGATGGTTTGATGATACAGTGCGAGCTTTGTCTGTGCTGGCAACACGGCGCCTGTAACGGCATAGTTAAGGAGTCGGACGTGCCGGAGAAGTACGTCTGCTATATTTGCCGCAATCCACAGCGTGTGCGGGATTCAATGCGCTTTAAGCACGATCAGGACTGGCTTTTTGAGGGAAAACTACCTGTGGCTGGTTATCACACGCCGAATCCGCAGGCTTCTAAAAAATGCGAGCTGTTGAAACGTTCACACACACTGACCGGGAATCTATTAGATGCAAAGCGTTCCATGCACTCGTTGCAAGTCAAGATTAATATTGCGCGCAATCGTTGTCATCCCAAGCTGTACTTATGGGCCAAAAAATGGGATGAAGATCAGTCGGACAATTCAGCCACGCCAGTTAAGCGTCCAAAGACCGAACCATCGGATTGGCCGCCAGCGCCGCAACCTGAAGCAGCTATCGATCCTGAAGAATGTCAATACCGTCTGATAGAGCACGTCAGGGTTCAACAATCGCTGTTGTTGAATAGATTGAATGACATCGAAGCGGAAATGGATGAGCTGGAAAAAGAAGATAATCTAAACGATTATAAGGATGCAAGTATGTCCGCAACCAAGGATGCCCTAGCCACGTTCATTAAGGAATTGGAGACATTAAAACGGCTTGCAAAACTCAACAAGGTGGTCAACATGAAAAACGCACAGAAGGAACAAGAAACAGCGTCAGAAAATCCCCAACTGTGA
Protein Sequence
MGRRCCVADCPSTSRLLEHHGVTYHSFPMDAVIRDIWIKNSRISRDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMEPAEIEADHRALQQASVEGAGTSGSAKNSTSEEVIKATVDQIVSQIMEETATTDSVTKSKTEDTDSVKETAESEAAKTSTETAGNDSLPEAVQTAADAADELRATANSSASPVSTSPPKYRSPTNLTIGARLEALSVDNAWLPARIVEVNQADQTLLIRFERNTKLKTTPSTTGGYQEWIGFKSERLRQRVSSRVLPVFELEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYTKNVRALHMVKLPRQLLPTSDAATDGPGTSSQATGTGVKRPSTGVTSNNKKSKTTPQRKDWPLLDMSNLDLVALGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVHDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKTFLESQGLVYNPDIYDFSIHRRRAKDINAYVYTHDYSPQQPVKPKPQDVSLDSTATSQDLNSSKLSIATPASTPISAVASRRGADDSQYMETPVASLVPPAELMSPSLQTKSSEVGSPADTAEISTGLGLDAQGALQLEDGYAFIGGLKVQITDNLFVCPREGCGKTYRKEDFLQIHIRHYHKEFAQHVSHCPKMQELAVKRTHPSSIEQGDQTPKNQIPNQQFFAKLHQQDLQHSRGVKRHPAGTDSSPTAVEASPIVSPTKPLASPKVESPITLKVTPPQTVSGVPEVKQIIFATPNETPATVPVEPTKVSPAEGTPLPPSRSSKRTRPSSSRRQSGSRKSSRQRTQRRPANISTIKSPVASKLPSTGLESEDSRPLINTPVPEARNEAKKRRVAATPVGSPAILDAASTPPHDQVDINAALAPPPPPPNQTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPEKYVCYICRNPQRVRDSMRFKHDQDWLFEGKLPVAGYHTPNPQASKKCELLKRSHTLTGNLLDAKRSMHSLQVKINIARNRCHPKLYLWAKKWDEDQSDNSATPVKRPKTEPSDWPPAPQPEAAIDPEECQYRLIEHVRVQQSLLLNRLNDIEAEMDELEKEDNLNDYKDASMSATKDALATFIKELETLKRLAKLNKVVNMKNAQKEQETASENPQL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00553762;
90% Identity
iTF_00595280;
80% Identity
iTF_00595280;