Basic Information

Gene Symbol
L
Assembly
GCA_018903575.1
Location
JAEIGH010000050.1:86183-105956[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 1e-05 0.0012 19.8 2.9 1 23 263 285 263 285 0.98
2 16 0.36 40 5.5 6.2 1 23 291 313 291 313 0.97
3 16 1.7e-07 1.9e-05 25.4 3.2 1 23 319 341 319 341 0.99
4 16 1.3e-05 0.0014 19.5 0.4 1 23 347 369 347 369 0.99
5 16 0.012 1.3 10.1 0.2 2 23 448 472 447 472 0.92
6 16 0.0028 0.31 12.1 0.4 2 23 496 518 495 518 0.96
7 16 0.028 3.1 9.0 0.7 1 23 591 613 591 613 0.97
8 16 0.044 5 8.3 0.1 2 23 621 642 620 642 0.91
9 16 4.4e-05 0.005 17.8 0.1 1 23 650 673 650 673 0.93
10 16 0.0026 0.29 12.2 1.1 1 23 782 805 782 805 0.97
11 16 0.005 0.57 11.3 1.2 2 23 965 987 964 987 0.96
12 16 0.12 13 7.0 0.1 1 23 993 1015 993 1015 0.92
13 16 2.4 2.7e+02 2.9 1.7 2 23 1023 1044 1022 1044 0.95
14 16 0.75 84 4.5 0.5 2 23 1156 1177 1156 1177 0.94
15 16 0.0064 0.72 11.0 0.0 1 23 1187 1210 1187 1210 0.96
16 16 0.00023 0.026 15.5 1.2 1 23 1217 1239 1217 1239 0.97

Sequence Information

Coding Sequence
ATGAGGCTAGCAAAAGATGGTAGTGAAAAACGAAGAGCCATAAAATTAGCTACGGTCGATGACGATGATGATGATGCGGATGATGCGGATGATTCGGATGATGATGAATGCATTCCCAACACCCCTATAAAAACGCAAAAAGAGCCCCAAAAATTTGCAAAACTCAAAGCAACAATTCGACGAAAGCCAATTTCCGTCATACCAACGACCTCTTATTTGTCATATTTTGCAGCTGGAATTGAGCCAGGATATGGCATGGGCGAGGACCTGGTAGATGATCAGGATGATGACTTTTTGCTTAATCTCAGCGACAACGATGAAGAAGATGAACTACAAAGTCTTGACAGCTTTTACTCAGATATGTACAGCACTCACACCTCATCGAGCTACTCGCCCAGTATATCGGATGGAACCCTGACTCCCAATTCTCATCATCATTTGCCAGCATCGGTGCCAAGTGGCTTGCAAGAGGATCACCAAAACGATGTCAAGGCGCATGGCGAAGGAAAGGATCTACAGCAGCATCCGCCGAGCTTTAAGCCAAAGCGTCCCTCCCATTTCCATCATCACCATCATCATCATTATCATCATCAGCAGGCTTTGAAAATTGCCAACAAGTTACGCAAAATCAATAAGGAGAGTAACAAAATGGGTTCTGGCACGGGTACTGGCACGGCCACTGGTGCGGAAGACGGAGAAACTGGCACTGGAGCTGCCTCCGCTGATGTTACCACAAAGTTTGATAAGTTGACAGGCGAGGGCATTAAGAACCGAGGCGACGGTTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGACTCGGTTACTTGAAACATCACGTGCAGAGCCATGCCGAACATCTGCCCTTCAAGTGCGAATACTGTGCCAAGTTGTTCAAGCATAAGCGCTCCCGAGATCGTCACAAGAAACTTCATACGAATGAGCGAAACTACAAGTGTCCGCATTGTGAGGCGGCATTTTCGAGAAGTGATCATTTGAAAATCCATATGAAAACACATGACATACAGAAGCCGTTTCAGTGCAGCATGTGCAATCGTGGCTATAACACGGCGGCAGCTTTAACGTCCCACATGCAGAAACACAAGAAGAATGCCGCCATTTTGGCTGCTGGCGGTAATCCCAATGCTCTCAACTATAGTCCAAGATCGACAGGTTCCGCGTCGGTGTCATCGAGTAACAGCAGCCTGCACAAGCGTCGTTATGCCCTTGCGTTGGCCAATAATGACAGCAGTAGTCGAAGTCGTAGTCCAAGTCGTTTGGATTTTCCGAAACGTTCCAGGATCAATACAAATCACTCAACACCCACTCCAATGCTGAGGTGCAGCTATTGTCCCAAGGCTACGGAGTTCAGTAGTCTGGATCAATTGAACACGCATATACAGAATATTCATGAACAGCAGCACCAGAATCAGGAACATCAACCGCAACAACAGCAAACGGAAACCGAGTCCTTTGAATTGAACTGTGAGTACTGCACCATGAAGTTTGGTAGCATTGCGGGACTTTTTCAGCACATGCGATCCACGCATTTGGATCGCCTTAGTTCGCCACCTTCGACAATCGCCAGCTACTATGAGCACTTTAATCGTATGGAAGCCCCAAAGCAAATCAAACAGGACCTGTCTAGTCCGCAGAGGAAAACAGAAGAACCAGAGGAGCTTCCTACAGACTTAAGTAGCAACAAGAGGCAGATTGAGGAACCGACACCAAACCCATCCTCAGGACCTGTTCCAGCTCCGGGAGTCTTCTTCTGTAATCAGTGTAATGCCGGCCTCCCAGACTTTGAGAGTTTTCGCAATCATCTGAAGACCCACATAGCCGAAGGCATGCAATTGATTTGCCCTCATTGTGGCCTTACTTTACCCGAGCAGCAGGAATATGAACGTCATGTGGTAGCCCATTTCTTGATCACCAATTCGGAATTCAATTGCAGTAGCTGCGGCAAGAGTTTCGCCAAAGCTGAAGATCTCCAGCAACACTTGCTGGCGGAACACGTCGTTACCATTATGAAGTGCGCCCTGTGTTCGGAACTGTGTGACAATCGCATGGCCATGCAGTTGCATTTAGCCTGCACCCATAGTCAGGAAACCAAGCTTCTACGTTGCAGTGCATGCATGGAGCTATTCCGGTCCGATGCAGAGTTCCACGTGCATGTGAAGACACGTCATCAACTGGCCCTAGGCAATCAGAGTGGTGGAGGTGTAGGATCAGTGTCCAGCGGACTGAGTGCAGCCAATGCTTTGCAGTGCATGTTTTGTCGTGCAGTTTGCTCTTCGGAGCTGGAAATGCACTTCCATTTGGCCGCACACGCAAGACAATTTCGTTGTCCATCCTGTCCGGAAACGTTTCACGTGGAGTTCTTGCTTGACAGGCATATGCAGAGTCAACATGGTGGGGTAAAGGACACTAAGGAGCAGACGTCTCCCAATATGGGTAGTCTGTATGTTAATGCTTTGCTGCCTCCACTGGCTGCAGCCGCTGCTGCAGCAGCTGTAACCAACAACAACAGCAGCATCATTGACTACAATGTCGCATTCAAATTTAAAGGTCTGTTTGGCGGAGGAGGTCCTCCGGCGGCTGCAGCCAAGTTCTACAGTCCTTTGCAAGTGGATACAAAAGCCCCTCAGCCCTCACCACATCCGGCCTTGATGTATGGCCTAAGTCAGAGGTATCTCATGGAAATGTATAAGGCCAAGTCCATTTCACCGGCTCCACCACCGACTGCAGAGCCACCTCCAGGATCTACAGCAGCCCAACCACCAGCTACCTTTAGTTGCGGCATGTGCGAGCGTCAGGATCTACGAAGCGAGGCAGAGCTCCATTCGCATCGCAAGTTGGCCCACAATCTAAAGACCGGTGTCAGTCTACGATGTGCATATTGTGCTGGCAACTTCAAGTCCAGGGCCGAGCTGGAGCAGCACATGAAGAGCTGTCATAACTCGACAGGCAAACACAAATGCCTAATTTGCGATGAAATCTTTCCATCGCCCGCCATCCTGGCCGAGCATAAGTTGCAGCACTCTAAGGTAGGACAGTCGGGGAAATGCTCCCACTGTTCCCATCAATTGGAGGATGTGGCTGCCTTCCGCAACCATCTCAGTGAACACGGCAGTGATGGTAGTTTGCCCTTGGCCTGCATTTGCTGCCGTCAGACACTGCACTCTGAGTTCGAACTGTGTTTGCATGCCAAGTTCCATACAAAGTCATCGGTGGGCACTTCAAGGGGCAGTCTGCAGGAGCCAGTGTGTGCCTTGTGTCTGGAGCCACTTCCAGCTGTCGGCCCCACAATTGACGGACCCACCCCTGCCAAACTATGTGAGAAGTGTTTGCGAAAACACAATTTGAACGGCAAGAGAAACAAACTAGCCGAGTCCCCTTCCATCAATGTTGCGTCTGCCACAGCAGCCGTTGCTCCTAGCCACCCACCATTCCTGGAAAATCGCTGTAATCTATGCAAAATGATTCTACCCCATGCCCAAAAGCTTCAAGAGCATCTGGTTGAACACACTTTCGCTGGAACCGAACAGCGCGGCTTCAACTGCTACATCTGTTCAGCCGTCTTCACTGCCCCCGCTGGCCTACTTAACCACATGTCGGTGGAGCATGGCGCCCACTCGCGACCCTACGATTGCAATTTGTGTCCAGAGAAGTTTTACTTTCGAGCTGAGCTCGAGCACCACCAGCGCGGACATGAACTGCGACCACCGCCAGCCACGCGCCCTTCCTTAACTAAACAGGAGCCGCACTGTACCCCAATTAGTCCGACTCTTAGTCCCACAACTGTTAAACAAGAGATCTATGAATCAGAAACTCAGGCCTCTCTCGGCCAAGACGTTGATGACAATGGCGAAGAGGGGTCGGCGAATGCTGCCCAGGAGGAGGAAGAGTACATTGAAGTGGAACAAATGCCTCACGAAACACGATCGGAAGATATAATGGAACGGTCTAGCAACAGCTCTTAG
Protein Sequence
MRLAKDGSEKRRAIKLATVDDDDDDADDADDSDDDECIPNTPIKTQKEPQKFAKLKATIRRKPISVIPTTSYLSYFAAGIEPGYGMGEDLVDDQDDDFLLNLSDNDEEDELQSLDSFYSDMYSTHTSSSYSPSISDGTLTPNSHHHLPASVPSGLQEDHQNDVKAHGEGKDLQQHPPSFKPKRPSHFHHHHHHHYHHQQALKIANKLRKINKESNKMGSGTGTGTATGAEDGETGTGAASADVTTKFDKLTGEGIKNRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASVSSSNSSLHKRRYALALANNDSSSRSRSPSRLDFPKRSRINTNHSTPTPMLRCSYCPKATEFSSLDQLNTHIQNIHEQQHQNQEHQPQQQQTETESFELNCEYCTMKFGSIAGLFQHMRSTHLDRLSSPPSTIASYYEHFNRMEAPKQIKQDLSSPQRKTEEPEELPTDLSSNKRQIEEPTPNPSSGPVPAPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLTLPEQQEYERHVVAHFLITNSEFNCSSCGKSFAKAEDLQQHLLAEHVVTIMKCALCSELCDNRMAMQLHLACTHSQETKLLRCSACMELFRSDAEFHVHVKTRHQLALGNQSGGGVGSVSSGLSAANALQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDTKEQTSPNMGSLYVNALLPPLAAAAAAAAVTNNNSSIIDYNVAFKFKGLFGGGGPPAAAAKFYSPLQVDTKAPQPSPHPALMYGLSQRYLMEMYKAKSISPAPPPTAEPPPGSTAAQPPATFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCSHCSHQLEDVAAFRNHLSEHGSDGSLPLACICCRQTLHSEFELCLHAKFHTKSSVGTSRGSLQEPVCALCLEPLPAVGPTIDGPTPAKLCEKCLRKHNLNGKRNKLAESPSINVASATAAVAPSHPPFLENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPAGLLNHMSVEHGAHSRPYDCNLCPEKFYFRAELEHHQRGHELRPPPATRPSLTKQEPHCTPISPTLSPTTVKQEIYESETQASLGQDVDDNGEEGSANAAQEEEEYIEVEQMPHETRSEDIMERSSNSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00618656;
80% Identity
-