Dema020950.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila emarginata
Gene Symbol
L
Assembly
GCA_037075365.1
Location
JBAMCD010000324.1:5703213-5709745[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 1.1e-05 0.00094 19.9 2.9 1 23 179 201 179 201 0.98
2 16 0.37 33 5.6 6.2 1 23 207 229 207 229 0.97
3 16 1.8e-07 1.6e-05 25.5 3.2 1 23 235 257 235 257 0.99
4 16 1.3e-05 0.0012 19.6 0.4 1 23 263 285 263 285 0.99
5 16 0.019 1.7 9.7 0.3 2 23 364 388 363 388 0.91
6 16 0.0029 0.25 12.2 0.4 2 23 416 438 415 438 0.96
7 16 0.029 2.5 9.1 0.7 1 23 511 533 511 533 0.97
8 16 0.046 4.1 8.4 0.1 2 23 541 562 540 562 0.91
9 16 3e-05 0.0027 18.5 0.3 1 23 570 593 570 593 0.93
10 16 0.0027 0.24 12.3 1.1 1 23 702 725 702 725 0.97
11 16 0.0053 0.46 11.4 1.2 2 23 885 907 884 907 0.96
12 16 0.12 11 7.1 0.1 1 23 913 935 913 935 0.92
13 16 2.5 2.2e+02 3.0 1.7 2 23 943 964 942 964 0.95
14 16 0.78 69 4.6 0.5 2 23 1076 1097 1076 1097 0.94
15 16 0.0067 0.58 11.1 0.0 1 23 1107 1130 1107 1130 0.96
16 16 0.00024 0.021 15.6 1.2 1 23 1137 1159 1137 1159 0.97

Sequence Information

Coding Sequence
ATGATggctttaaaaatgttatatcgTGGTCCCAGTTCTCGATTGgagaatttaattgaaaaaattcaaGCCACCAAGGAGATAACAAATAACGATATGTACAGCACTCACACTTCATCGAGTTACTCGCCCAGTATTTCGGATGGAACCCTGACACCCAATTCCCATCATCAGTTGCCTGTGTCGGTTCCAAGTGCTTTGCAGGAGGATCACCAAAACGAAGTCAAGGCACATGGAGAAGGAAAGGATCCACTACAGCATCCGCAGAGCTTTAAGCCGAAGCGTCCCTCCCatttccatcatcatcatcatcaccattaCCATCATCAGCAGGCTCTGAAAATTGCCAACAAGTTACGCAAAATCAATAAAGAGAGTAACAAAATGGGTTCTGGCACGGTGACGGGCACTGGGACTGGCAGTGTCACTGGTGCGGAAGATGGAGGAACTGGCATCGGAGCTGCCTCCGCTGATGTTACCACAAAGTTTGATAAGTTGACAGGCGAGGGCATTAAGAGCCGAGGCGACGGTTCCTATCAGTGTCAGTTCTGTGATAAATCATTTCCGCGACTCGGTTACTTGAAACATCACGTGCAGAGCCATGCCGAACATCTGCCATTCAAGTGCGAATACTGTGCCAAGCTGTTCAAACATAAGCGTTCCAGAGATCGTCACAAGAAACTTCATACTAATGAGCGAAACTACAAGTGTCCGCATTGTGAGGCGGCATTTTCAAGAAGcgATCATTTGAAGATTCATATGAAAACGCATGACATTCAGAAGCCATTCCAGTGCAGCATGTGCAATCGTGGTTACAATACGGCGGCGGCTTTGACATCACACATGCAGAAGCACAAAAAGAACGCCGCCATTTTGGCTGCTGGTGGCAATCCCAATGCCCTCAACTATAGTCCGAGATCGACAGGTTCCGCTTCGGTGTCATCGAGTAACAGCAGCCTGCACAAGCGTCGTTATGCCTTAGCGTTGGCCAATAATGATAGCAGTAGTCGAAGCCGTAGTCCAAGTCGTTTGGAATATCCGAAACGTTCCAGAATCAACACAAATCACTCAACGCCTACTCCAATGCTAAGGTGCAGCTATTGTCCCAAAGTGACAGAGTTTAGTAGTCTGGATCAATTGAACACACATTTACAGAATATCCATGAACACCAGCagccgcaacagcaacaggagcatcaaaaacaagaacaacaccTGCAAAAGGAGGCCGAGTCATTTGAATTGAACTGTGAGTACTGCACCATGAAATTTGGTAGCATTGCGGGACTATTCCAGCACATGCGATCCACGCATTTGGATCGACTTAGTTCTCCACCATCGACAATCGCTAGCTACTATGAGCACTTTAACCGTCTGGAAGGCCCAAAGCAAATCAAACAGGACCTATCTAGTCCACAGCGGAAAGCAGAAGAGCCAGAGGAGCTACCCACAGATTTAAGTAGCAACAAGAGACAGATTGAGGAACACACTTCAACTCCATCCTCCGGAGCTGTTCCAGCTCCTGGAGTCTTCTTTTGCAATCAATGTAATGCTGGCCTACCGGACTTCGAGAGCTTTCGCAATCATCTGAAGACCCACATAGCCGAAGGCATGCAATTGATTTGCCCCCATTGTGGCCTCACTTTACCCGAACAGCAGGAGTATGAGCGCCATGTAGTAGCCCATTTCTTGATCACCAACTCGGAATTCAATTGCAGTAGCTGCGGAAAGAGTTTCGCCAAATCTGAAGATCTGCAGCAACATTTGCTGGCGGAGCACGTCGTAACCATTATGAAGTGCGCCCTGTGTTCGGAGCTGTGCGACAATCGCATGGCCATGCAATTACATTTAGCCTGTAGCCATAACCAAGAAACCAAGCTTCTGCGATGCAGTGCATGCATGGAGCTCTTCCGCTCCGATGCAGAGTTCCATGTTCATGTAAAGACACGTCATCAACTGGCCCTAGGCCATCAGACTGGTGGAGGTGTAGGATCGGTGTCTAGCGGACTGAGTCCAGCCAATGCTCTGCAGTGTATGTTTTGTCGAGCAGTTTGCTCTTCCGAACTGGAAATGCATTTCCACTTGGCCGCTCACGCACGACAATTTCGCTGTCCATCCTGTCCGGAGACGTTCCATGTGGAGTTCTTACTTGATCGGCATATGCAGAGTCAACATGGTGGCGTTAAGGACACCAAAGAACAGACTTCCCCCAATATGAGTAGTTTGTATGTAAATGCCTTGCTGCCTCCTCTAGCGGCAGCCGCTGCCGCAGCAGCTGTAActaacaacaatagcagcatCATTGACTACAATGTGGCATTCAAATTCAAAGGTCTATTTGGTGGAGGAGGTCCTCCAGCAGCGGCAGCCAAATTCTACAGTCCGTTACAAGTCGATACGAAAGCTCAACAGGCTTCGCCACATCCGGCTTTAATGTATGGCTTAAGTCAGAGGTATCTCATGGAAATGTATAAGGCCAAGTCAATTTCACCGGCTCCGCCACCAACCACAGAGCTACCTCCAGGATCCGCCTCAGCCCAAACACCAACTACCTTCAGTTGTGGCATGTGCGAACGTCAGGATCTTCGCAGCGAGGCAGAACTGCATTCCCATCGCAAGTTAGCCCACAATCTTAAGACCGGTGTCAGTCTGCGATGTGCATATTGTGCTGGCAATTTCAAGTCCAGGGCCGAGCTGGAACAGCACATGAAGAGTTGCCACAACTCAACGGGCAAACACAAATGCCTAATTTGTGATGAAATTTTTCCGTCGCCCGCTATTCTGGCTGAGCATAAGTTGCAACACTCTAAGGTAGGACAATCGGGCAAATGTTCCCACTGTTCCCATCAACTGGAGGATGTGGCTGCCTTCCGCAATCATCTCAGTGAACACGGTAGTGATGGTAGTTTGCCACTGGCCTGCATTTGCTGCCGTCAGACATTGCACTCTGAATTCGAACTGTGTTTGCATGCCAAATTTCATACAAAATCATCGGTGGGCAATTCTAGGGGCAGCCTGCTGGAGCCAGTGTGTGCTTTGTGTCTGGAGCCGCTTCCGGCCGTTGGACCCACAATTGACGGACCCACTCCTGCCAAACTCTGTGAGAAGTGTTTGCGCAAGCACAATTTGAATGGCAAGAGAAACAAGCTAGCAGAGTCCCCTTCCGTCAATGTTGCGTCTGGCACTGCAACTGTTGCTCCCAGCCACCAACCCTTCCTGGAAAATCGCTGTAATCTATGCAAAATGATTTTACCCCATGCCCAAAAGTTGCAAGAGCATCTGGTTGAACACACTTTTGCTGGAACCGAACAGCGCGGCTTCAACTGCTATATCTGTTCAGCCGTCTTCACTGCCCCCGCCGGCCTTCTTAATCACATGTCGGTCGAGCATGGCGCTCACTCGCGACCCTACGATTGCAATTTGTGTCCAGAGAAGTTCTATTTTCGAGCTGAGCTCGAGCACCATCAGCGCGGACATGAATTGGGACCACCGCCAGCGACACGCCCTTCTTTCACTAAACAGGAGCCGCACTGCACCCCAATTAGTCCGACTCTTAGTCCCACAATAGTTAAACAAGAGATTTATGAATCAGAAACTCAGGCCTCACTTGGCCCAGATGACAATGGTGACGAAGGGTCGACAAATGCCGCCCAGGAGGAGGAAGAGTATATTGAAGTGGAACAAATCCCTCACGAAACGCGATCGGAAGCGTTAATGGAACGGTCTAGCAACAGCTCTTAA
Protein Sequence
MMALKMLYRGPSSRLENLIEKIQATKEITNNDMYSTHTSSSYSPSISDGTLTPNSHHQLPVSVPSALQEDHQNEVKAHGEGKDPLQHPQSFKPKRPSHFHHHHHHHYHHQQALKIANKLRKINKESNKMGSGTVTGTGTGSVTGAEDGGTGIGAASADVTTKFDKLTGEGIKSRGDGSYQCQFCDKSFPRLGYLKHHVQSHAEHLPFKCEYCAKLFKHKRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASVSSSNSSLHKRRYALALANNDSSSRSRSPSRLEYPKRSRINTNHSTPTPMLRCSYCPKVTEFSSLDQLNTHLQNIHEHQQPQQQQEHQKQEQHLQKEAESFELNCEYCTMKFGSIAGLFQHMRSTHLDRLSSPPSTIASYYEHFNRLEGPKQIKQDLSSPQRKAEEPEELPTDLSSNKRQIEEHTSTPSSGAVPAPGVFFCNQCNAGLPDFESFRNHLKTHIAEGMQLICPHCGLTLPEQQEYERHVVAHFLITNSEFNCSSCGKSFAKSEDLQQHLLAEHVVTIMKCALCSELCDNRMAMQLHLACSHNQETKLLRCSACMELFRSDAEFHVHVKTRHQLALGHQTGGGVGSVSSGLSPANALQCMFCRAVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHGGVKDTKEQTSPNMSSLYVNALLPPLAAAAAAAAVTNNNSSIIDYNVAFKFKGLFGGGGPPAAAAKFYSPLQVDTKAQQASPHPALMYGLSQRYLMEMYKAKSISPAPPPTTELPPGSASAQTPTTFSCGMCERQDLRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKSCHNSTGKHKCLICDEIFPSPAILAEHKLQHSKVGQSGKCSHCSHQLEDVAAFRNHLSEHGSDGSLPLACICCRQTLHSEFELCLHAKFHTKSSVGNSRGSLLEPVCALCLEPLPAVGPTIDGPTPAKLCEKCLRKHNLNGKRNKLAESPSVNVASGTATVAPSHQPFLENRCNLCKMILPHAQKLQEHLVEHTFAGTEQRGFNCYICSAVFTAPAGLLNHMSVEHGAHSRPYDCNLCPEKFYFRAELEHHQRGHELGPPPATRPSFTKQEPHCTPISPTLSPTIVKQEIYESETQASLGPDDNGDEGSTNAAQEEEEYIEVEQIPHETRSEALMERSSNSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00618656;
90% Identity
iTF_00591187;
80% Identity
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