Basic Information

Insect: Drosophila saltans
Gene Symbol: -
Assembly: GCA_018903575.1
Location: JAEIGH010000004.1:6777468-6782147[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.2e-15 2.3e-11 43.7 0.0 7 73 451 512 445 515 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.2e-15	2.3e-11	43.7	0.0	7	73	451	512	445	515	0.91

Sequence Information

Coding Sequence: ATGAGCTCTGCTGATGATGATATTCCTGGTACGTCATCGTCCGCAATCGATGACAAGAAGCACAAACGGTCCAAGTCTCGCTATAGTAAATCTTCACCACGCAGCGTAACAAGCAAAGAATCCAAGTATACATTATTATCTTCCTCACCGGATAGACCAAACAATGTTTTCCCTCGTCGCAGTCCGGCCACTTTACGAGATCGTGTTCTTCTGGCCAATGCCAATGCTGTGGAACGCATACGCAAACCTAAGAAAAAAAAGACAAAAAAATCGAGGGAACGTCGTCATTCAAAGGATGCAGTTTTAATTGGTTGGTCAGGAAGTTTTCCAAATCTTTCCTCAACACAAAGCATTGATTCGGAATCTGAGCGGCAGTCGTCACCTGGCGATCTTCGGGCAATTGGTGCTAGTGGCCTAGGAATTTTTCCACCAGAACGGGAAGAGGAACAATCAACAGGGCAACAGCAGGAGCAGCAACAGGATTCTTTGTCTGTTTCCCCAACGGTTTCTGAACCGAACTTAAAGGAAACTACAACAATATTAACAACAACCACAACGATAACAAAACCAGAACAAGAAGAAAAAATAGAAGAAGAAAGTTCAACTATAACCGCCACAACAAAAACAGCAGCAACAACAATCACAACAACGGCAACATCAACTCTCAGTCCATGTGCAGAAGTAGAGACGTGTGAAACTGATTTATACACAGACGACCAAACAGATCTAATCAATCAGGAACAACAACAACAACAAGTACAAATCCAAAAGGAACCCAATATTGCAATTCCTGGAGTGGAGGAGGAACAACAGATGGAAAAATTGGAAGTGGAAACCGATAATGTAGTTGTTAGCCTCACGCGGAAACGTAGTGCTTCTAGTGAAAAGACCCAGCAGTTGCAAGAAGAAGCTGCAAATGAAGATCCACAGGATGTGCCCGCACAAGCTAAACGTCCGAAAATGTCACCACGGCTATCGGTACGTCAAAGTGGACGTTCGAAGTCATCGAATATCGTTATAAGTCATGGAGAGGATGTGGATAGGTCTCAAAAGCTGATTGTTAAACGATCCCGAAGTGAGGGCAATGTAGCTCTAATGGATATGGAGAATTTGCTTAAACCACAACCGCAGGAAAAAGAGGAAGAACAACAGCCAGATCAGATGAAAGATATAAAAATTGAATCGAAAAAGAATGATTCTAATAACCATGATAAACTCGACGTGGCTAAGCCAGTAGCAGAGGAACAAGATGAGGAAGAGGAATCCACAATCATTAAAAAATCAGAACGAGTAGCTGCTTATCAGTCACGGCGCCCACCAACGCCTAAAATAAAACCAACTGATGAGTTCTATCGTTTGCCTTTTGCCCATGGCTGGAAACGAGAATTGGTTTTGCCTAGCACCGACACCCATCGACGTTCTGGCGATGTCTTTTTCATATCGCCCGAGGGACGTAAACTACGCTCACGCGAGGACATTATACCCCATCTCAAGGATAATCTCACCATCGATCATTTCTGTTTTCAACGGGTATCGCAAGAGGTGGGCCCAGAGTTTGAATTAGTGCGTCGTGCCGTGCCAGTTAACTCAAGGGGTCAGCCCAGCTTCTTTTCCTCCACACCTGCAGTGTCCGGTAAGCGGGTGCCGAAGCCAAAGGTTCCAAAGGGTGCCAGTCCACCGCCCGAAGGTTGGACCTCCACAATGGCAGTTAAGGGCAATGCCAGAGCAATGGCTTCAAGCAATGGGGCAAATAATGTTGCTCATAGTCATGGAGCTGGTGGAAACAATTCCCGCAAGCGTGGTTCACAATCCTCGACAAAGCAAATGGCAGCGAAGCAGCAGCCATCACCACCATCAAAGCCACCTGATCAGAGTCAAGATTCATCTCTCGACAATGATGCCGATAATGAGGCAGATGCGGAGGATGATGACAATGGCAGTGGGGCCAGTCTGGCCGAGATGAGCGAACAAATGGAGCAACCTGGTCAATTGCCGCCCGCTCAATTGCTTAGCGATAATCTTGCCTTAAGCCCAACAACTCCACGGTGGCAGGAGATTGTGGTCATTGGAGGTCGCAAAGCCATTGCCATTTTGGATAATCCGCCTCGCATTCCAACACGTCGGTGTCCTCCAGTAGTATCCCAAGCGGTAATTGATGATTGGAATAGTAAATATGAGAGACTATATAACAAGCGAATAGCTGGACCGAAAAAACTGAACCAAAACCCCATAATGGAGAGCCTGGGCAATATGCACAATGGATGTCAAGTCCTTATGGCCATCATGAAGACCATGACCTTGAAGGAGCGCGCCAATATGGCGCATGTGTGCAAATGTTGGGCCATGGTGAGTCGGGATAGAAGCGTTTGGCGTTCGGTTACACTGAGAGATACCTACATAAGTAATTGGATAATATGCCAGCGAGAGCTGTCTCGGCATCGTACTCGGGAACTAGATATGATGGGCATGATTTGGGCCAAGGCTGAGCTGCGTTTAACCGGCGACTTGCGTCTACTTAAATCGCTGCGAGTCCTGCGTACAGATCACACAGAAGCTGACTTTTTGCATCTCGTGTTTAAGCATTTGCCGCAACTCCTTGAACTCCGCTCTATTTGCACAAGTAACATCCTCAATCTGATGCACCTAGATAATATGCAAGGGTTAAGAGTATTGCGTCTGCATATGACCGATCCCAAAGCCAAAATCAATTCATTGGCCACACTGGCCAATTTGACCCAGTTGACGGAATTGTGTGTGCGTGGGGCAACCAATTTGGGCAAGATGGAGATACGTCAGCTTAAGGCATTAACTCGCCTGGAGACTTTGGTACTGGGCTCTTGTCTGGATGTAGATCGTGTGCAGTTGGGTCAGGAGGTTTTGCCAGCTTTGAAGAATCTTAGACACTTTCGGCTGGAGAATGAACATAAGATTATGGCTGTCTTTCCCATTCATGACATTATGCAGGGGCTAGCTGTTGCTGGCCAAGTCAAACGATTGGAATTGGTTAATGTGGATGTAGATGAGGACTTTGGCCAGTTATTGTCCAAATGTAAAAATGTGGAGGAACTCCTATTGATGCCCAAATGCATGCACAACACGGCCAATATGACTAATGCCGTGATGCAGGCGGTCAGTGATAATGCGGAACAATTAAAGGTCTTGCGTATGGGCCTTGTGGCACAGCTTCTGAGTGCCACAAACAATCTGTGCAAGGGCAAGGATAAGGATGTGGTACCAGTGCGACGACCAGTTCCGGGCATACCAGCCAACGATCATCTTAATTATTGCTCCGAGGATTGCTATGAAACTGATCATGGTCAGTGTGTAGCATATTTACCCATGGAGCGATTGGAATCCATCTTGCACCACATGATGCCCCAAGCTTGGCTAACCGTTGCCAAAATAGCCATGCGTGACACCACAAAGCTACAGTTCTTGCGACGCCCAGATGCCGGCAAACAGGGTCAGAGTCATGTGTTAAACCCAAAACCGACAGCTTCTTAA
Protein Sequence: MSSADDDIPGTSSSAIDDKKHKRSKSRYSKSSPRSVTSKESKYTLLSSSPDRPNNVFPRRSPATLRDRVLLANANAVERIRKPKKKKTKKSRERRHSKDAVLIGWSGSFPNLSSTQSIDSESERQSSPGDLRAIGASGLGIFPPEREEEQSTGQQQEQQQDSLSVSPTVSEPNLKETTTILTTTTTITKPEQEEKIEEESSTITATTKTAATTITTTATSTLSPCAEVETCETDLYTDDQTDLINQEQQQQQVQIQKEPNIAIPGVEEEQQMEKLEVETDNVVVSLTRKRSASSEKTQQLQEEAANEDPQDVPAQAKRPKMSPRLSVRQSGRSKSSNIVISHGEDVDRSQKLIVKRSRSEGNVALMDMENLLKPQPQEKEEEQQPDQMKDIKIESKKNDSNNHDKLDVAKPVAEEQDEEEESTIIKKSERVAAYQSRRPPTPKIKPTDEFYRLPFAHGWKRELVLPSTDTHRRSGDVFFISPEGRKLRSREDIIPHLKDNLTIDHFCFQRVSQEVGPEFELVRRAVPVNSRGQPSFFSSTPAVSGKRVPKPKVPKGASPPPEGWTSTMAVKGNARAMASSNGANNVAHSHGAGGNNSRKRGSQSSTKQMAAKQQPSPPSKPPDQSQDSSLDNDADNEADAEDDDNGSGASLAEMSEQMEQPGQLPPAQLLSDNLALSPTTPRWQEIVVIGGRKAIAILDNPPRIPTRRCPPVVSQAVIDDWNSKYERLYNKRIAGPKKLNQNPIMESLGNMHNGCQVLMAIMKTMTLKERANMAHVCKCWAMVSRDRSVWRSVTLRDTYISNWIICQRELSRHRTRELDMMGMIWAKAELRLTGDLRLLKSLRVLRTDHTEADFLHLVFKHLPQLLELRSICTSNILNLMHLDNMQGLRVLRLHMTDPKAKINSLATLANLTQLTELCVRGATNLGKMEIRQLKALTRLETLVLGSCLDVDRVQLGQEVLPALKNLRHFRLENEHKIMAVFPIHDIMQGLAVAGQVKRLELVNVDVDEDFGQLLSKCKNVEELLLMPKCMHNTANMTNAVMQAVSDNAEQLKVLRMGLVAQLLSATNNLCKGKDKDVVPVRRPVPGIPANDHLNYCSEDCYETDHGQCVAYLPMERLESILHHMMPQAWLTVAKIAMRDTTKLQFLRRPDAGKQGQSHVLNPKPTAS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00483686;
90% Identity: iTF_00577777;
80% Identity: -