Druf006769.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila rufa
Gene Symbol
topi
Assembly
GCA_018153105.1
Location
JAECXS010000001.1:9391772-9394616[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.95 60 4.2 1.3 2 20 148 165 147 167 0.90
2 10 1.2e-05 0.00079 19.5 1.3 2 23 256 277 256 277 0.97
3 10 0.17 11 6.5 0.0 2 23 303 324 302 324 0.79
4 10 0.0092 0.59 10.5 0.1 2 23 397 418 396 418 0.96
5 10 0.0039 0.25 11.7 0.3 1 20 465 484 465 489 0.92
6 10 5.1e-07 3.3e-05 23.9 1.9 1 23 547 569 547 569 0.95
7 10 0.00021 0.013 15.7 1.0 1 23 575 600 575 600 0.97
8 10 0.62 40 4.7 1.8 1 23 606 628 606 628 0.88
9 10 3.8e-08 2.4e-06 27.4 0.4 1 23 634 656 634 656 0.99
10 10 0.0014 0.087 13.1 2.5 1 23 662 685 662 685 0.96

Sequence Information

Coding Sequence
ATGGATCCCGGAGATTTGTTGAACATCCAGACGGGTGGTGAGCAGCAGGCGGGGGAATATACCCTGGCCGAGATCGAGGTCGATATGGAGTCGCAGCTGACTCCCAGTGACCTGGAGCCCGGTGCCAAGGTGCTGCTATCCATCGAGGGCGATGGGGACGGAGAGCGCATTATGAGCCACGAAGAGCTGTCAAAGTGGTTTGTGGTGGAGCCCTCAAGCCCCGCACCAATGTCCACAGACGTGGTGGTGCAGCGCACCTTGGAAGATCCTGCTCTCAAGCAGATCCTCCTGGAGACAGATGGCAAGCCGGACTTTGATCCTAAGGCGGAGCAGATGAAGATTCGCAGCTTTCTGGCAGGCGTCACCAACAGCAAGATGACCACGGAGCAGTCGGTGTTTCAAGGATATCGCCCCAACACTACAGGCTTTAGCAGCAAGCTCAAGTGCTCCGAATGCCATGGTACTTTTGATGCCGCCTCGTTCCAGAGTCACGCCTGCAGCGGCAAGGTCGAACGGAAGCCGAAACCGAAGCCTAAGCCCGTCGCCGACTCTCTAGTTGAGAAGCAGATAGAGAAGCCACCGGCAGTGGCCACTGCAGAACCCGTGCCACCCGCTTCGCCCGCTCCGCCCAACAAGCCGAACAGCTTGCGAGTGATCCAGGAGAACCAGATCCGCCTGCGTCGATACATGAACGATGAGCTCAAGTACGACGTAACCACCGGCATGGATGGCACGCGCGGCCGTAAGTCGAGCAAGGGGCCCAACGAGTGCACCCAGTGTGACCGCAAGTTCGTTCACGCCTCCGGGCTGGTGCGCCACATGGAGAAGCACGCCCTGGACCTGATACCCTCGCAGGCTAACCCACAACCGGCCTCACCTCTGGCCGCTGGGCTCATGGTCGTAGTGAAGTGCAGCGTGTGTGGCCGCATCTTTTACGATCCGCTGGTGGCATTGGAGCATGGCCGCGTTCACTTCCTCGAGGAGGACCAGCAGCAGCAGCAGCCGAGCAAAGCTCCAGTTGCTGATAAGGCGGAGACCAAGATCGGCATCGATGAGGACTTCGCAACGTTTATGCTGGAGGGCGGGGTGCAGCTGAGAGAAGCTTGCGTGGCGACTGGAAGGTTAGAGCTCAATGGGTGCCGCCTGGAAGATGATTTGTTCTCCAGCTTTATCCTGGGCAGCGTCCTCCAGTGCGAGTTCTGCGAATATCTGTTCTCGGATATCTCGGACCTGCTCGCCCATTCGGCCACGCACTTGGCGAAGCGGCGCTTCGAGTGCACCGCCTGCGACATTACAATGAGCACGGCCAAAGAGGCCAGGCTGCATTTCGAGACGGACTGCGTCTTTGCGCGCGAGTCGATGAAGTCGCAGAGCGTCTCGGTCAGCCGCTACTTCGCGTGCAACGTGTGCGAGCTGAAGTTTGCCAACTCGGAGCTGCTGCAGGAGCATCGCTACGCCTACAATCACTACTTCCCGCGGCTCAGCGGGAAAGGTTCGCGCCTGCTGCTGCCCTGCGAGTTCTGCGATGTGTTGTTCGACTCTGCCCGCGAGGTCCAGCCGCACAACGAGGAGAAGCATCTGAGCAAGAAGAAGCGGGAGAAGGAGACGCGCAGCGCGGCCAGTGGTCGCCAGCGCCAGTATCTGTGCGACATCTGCGGCAAGTCTTACACCCAGTCGAGCCACCTGTGGCAGCACCTGCGCTTCCACCAGGGTGTAAAGCCGTTCGTCTGCCCGGAGGAGAAGTGTGACCGCAAGTTCACCATCCGCCCAGATCTCAACGACCACATTCGCAAGTGCCACACGGGCGAGCGGCCGTTCCACTGTCTGGTGTGCGGCAAGCGCTTCCTCACCGGCTCCGTCTTCTACCAGCACCGCCTCATTCATCGCGGCGAGCGACGCTACGAGTGCGAGGAGTGCGGCAAGCGCTTCTATCGCGCCGATGCTCTTAAGAACCACCAGCGTATCCACACCGGCGAGAAGCCCTTCAGCTGCCTCTTCTGCACCAAAACCTTCCGTCAGCGCGGGGATCGCGACAAGCACATGCGGGCCCGTCACTCCCACCTCGATGCCAACTCGCGCCTCATGATGCAGATGCAGAAGTTCCAGCTGGAGTCGGCCGCTGCCGCCAAGGCGAAGGGCACGAAACCCTCGTCTGGGGCGGTGGTGGCTGCCAATAGCAGTCCTCCCCAGGAGGTGGCTTCAGAGCCCGAAGAGGCGGGGGCACAAGACGAGGAGCTGCCGTATCCCATTAAGACTGAACAGGATGAGGACATGCAGTACGTGGCAATAAACGAACTGACGCCCAACTATTTCGTGGAGTACATGCGGTCTGAGCCTGCGGAGGAGGGCGACATCACCATGGAGGGGGAAGGCTTTACTATGGAAGGGGAGGGCTGCTGCCTAGAAGAGGGGGGCTGTACCATGGAGGAGGAGGAGCAGCAGATAATTCTGTACGAGACACAGCCAGGACGGGATATGATGAACTTGGACGAGGAACCAGGACAGGATCTAATCACTTTCAACTATCAGGAGTCGGATCAGCACCCCACTCAGAATGAGGGATACGTTTCAATGGTGCAGGGCGGGGGCGAAAATGCCAAGGTTGTGGTTATGCAGAACAACCCAACTCAGCCGATGTTTTCCAATTCCTACATGTAA
Protein Sequence
MDPGDLLNIQTGGEQQAGEYTLAEIEVDMESQLTPSDLEPGAKVLLSIEGDGDGERIMSHEELSKWFVVEPSSPAPMSTDVVVQRTLEDPALKQILLETDGKPDFDPKAEQMKIRSFLAGVTNSKMTTEQSVFQGYRPNTTGFSSKLKCSECHGTFDAASFQSHACSGKVERKPKPKPKPVADSLVEKQIEKPPAVATAEPVPPASPAPPNKPNSLRVIQENQIRLRRYMNDELKYDVTTGMDGTRGRKSSKGPNECTQCDRKFVHASGLVRHMEKHALDLIPSQANPQPASPLAAGLMVVVKCSVCGRIFYDPLVALEHGRVHFLEEDQQQQQPSKAPVADKAETKIGIDEDFATFMLEGGVQLREACVATGRLELNGCRLEDDLFSSFILGSVLQCEFCEYLFSDISDLLAHSATHLAKRRFECTACDITMSTAKEARLHFETDCVFARESMKSQSVSVSRYFACNVCELKFANSELLQEHRYAYNHYFPRLSGKGSRLLLPCEFCDVLFDSAREVQPHNEEKHLSKKKREKETRSAASGRQRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCPEEKCDRKFTIRPDLNDHIRKCHTGERPFHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFSCLFCTKTFRQRGDRDKHMRARHSHLDANSRLMMQMQKFQLESAAAAKAKGTKPSSGAVVAANSSPPQEVASEPEEAGAQDEELPYPIKTEQDEDMQYVAINELTPNYFVEYMRSEPAEEGDITMEGEGFTMEGEGCCLEEGGCTMEEEEQQIILYETQPGRDMMNLDEEPGQDLITFNYQESDQHPTQNEGYVSMVQGGGENAKVVVMQNNPTQPMFSNSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00572079;
90% Identity
iTF_00531832;
80% Identity
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