Druf009143.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila rufa
Gene Symbol
su(Hw)
Assembly
GCA_018153105.1
Location
JAECXS010000001.1:30715719-30718959[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00065 0.042 14.1 1.9 1 20 225 244 225 246 0.94
2 12 2.6e-06 0.00016 21.7 0.4 3 23 297 318 295 318 0.93
3 12 0.07 4.5 7.7 0.1 1 23 324 346 324 346 0.94
4 12 5e-07 3.2e-05 23.9 2.4 1 21 353 373 353 374 0.95
5 12 5.7e-06 0.00036 20.6 1.0 2 23 386 407 385 407 0.96
6 12 0.00026 0.017 15.4 6.3 1 23 418 440 418 440 0.99
7 12 0.00026 0.017 15.4 0.8 1 23 446 468 446 468 0.97
8 12 1.7e-05 0.0011 19.1 0.4 1 23 474 496 474 496 0.98
9 12 1.4e-06 8.9e-05 22.5 2.5 1 23 502 524 502 524 0.98
10 12 7.6e-05 0.0048 17.1 0.9 3 23 530 550 528 550 0.97
11 12 6e-05 0.0038 17.4 0.4 1 22 558 579 558 582 0.91
12 12 7.1e-06 0.00045 20.3 1.5 3 23 603 624 601 624 0.97

Sequence Information

Coding Sequence
ATGAGCGCCGCCAAGGAGGGCAAGGACAAGAAGGGCGGCGTCAAGATTCTGGGCGTGGAGAACGTCTCGCCGCCGAAGGACACGTCGCGCCCCGCCACGCGCATGAAGCTGCTGAACGAGGCCGCAGCAGCGGGAGCCACTGCGTCGCCGTCTGTTTCCCCCACCAAGACGGAGAAGCGCAACAGCGGCGGGGGATCCCGCATCAAAATACTCAATGACGAGGCCCTGGGCCTGCCAAAGACCGAGAAGCGAGGCTCCTTATCCAAGACCAGTCCGCGCAACAACACCACCACCACCTCCACCTCCGTGAAGATCCTCAATGTAAAGCGCCCTGCCACCGCCACCGCCGTGACGCCCCTGGAGACCAAGGTCCGAGCCTCGCCGGGCAAGAAGCAGAAGATGGATCACTATGTGCTCCAAGCGGTCAAGTTGGAGAACAGCAAGCAGCAAGCGGTCACCACGGCGCACCGCGCGGCGACGTCGGAGCACGATGAGACCGAGACTATTGCCTTTATACTGGCCGAAGACGACGAGGTGGTGCCGGGAACGTTGGAACGGACGAATGGCCAGGAAATCGTCGTCACCGAAGGCGACGAGGATGAGGAGGACGACGACGGCGTCGAGGCGGACAAGAGCGAGGGCGGCAAGGGCGGGATCAAGGAGATTGTGGAGCATGTGTGCGGCAAGTGCTACAAGACGTTCCGGCGCATCAAGAGCCTGACGAAGCACTTGGAGTTCTGTCGCTACGACAGCGGCTACCATCTGCGCAAGGCGGACATGCTCAAGAACCTGGAGAAGATCGAGAAGGATGCGGTGGTGATGGAGAAGAAGGATATCTGTTTCTGCTGCAGCGAAAGCTACGACACCTTCCATTTGGGCCACATCAACTGTCCCGACTGCCCCAAGTCGTTCAAGACGCAGACCAGCTACGAGCGCCACATCTTCATCACGCACTCGGAGTTCTGTGACTTTCCCTGCTCCATCTGCAATGCCAATCTGCGCAGCGAGGCGTTGCTGAAGCTGCACGAGGAGCAGCACAAGTCGCGGGGCAAGCCGTATGCCTGCAAGATCTGCGGCAAGGACTTTACGCGCTCTTACCATTTGAAGCGCCATCAGAAGTACTCGGCGTGCTCGGCCAATGAGACCGATACCATGAGCTGCAAGGTCTGCGACCGTGTCTTTTATCGCTTGGACAACCTGCGCTCGCACCTGAAGCAGCACCTGGGCACGCAGGTGATGAAGAAGCCCGAGTACATGTGTCACACTTGCAAGAACTGCTTCTACAGCTTGTCCACGCTCAACATTCACATACGCACGCACACGGGCGAGAAGCCCTTCGATTGCGATCTCTGCGAGAAGAAGTTCTCCGCCTTGGTGGCCCTCAAGAAGCATCGTCGCTATCACACGGGCGAGAAGCCCTACAGCTGCACTGTGTGCAACCAAGCCTTTGCCGTCAAGGAGGTGCTCAATCGGCACATGAAGCGGCACACGGGCGAGCGGCCGCACAAGTGCGAGGAGTGTGGCAAGAGCTTCATCCAGGCCACGCAGCTGCGCACCCATTCCAAGACCCACGTGCGGCCCTTTGGCTGTGATCAGTGCGAGGAGAAGTTCAAAACGCAGAAGCAACTCGAGCGCCATGTCAAGGAGCACTCTTCCCAGAAGCGTCCCGTCTTCTCCTGCACCGAATGCAAGCGCAACTTCCGCAGCACAGCCCAGCTCAAGGAACACATGGATGTCGGCGTACACACACCCAAGCCCACGCGCGCCGTCAAGCGCTCGCCCACCAAGGTTATGGAGCGCACGGATTGCGCCATTTGTGACAAGAACTTCGACAGCTGCGACACTCTCCGCCGCCACATCCGCACCGTGCACGAATGCGATCCGGATGACATCTTTGGCGTGGATCCTCAAACTGCGAAGCGTGGCAAGAGGGCCAAGCTGGCAACAGCGGAGCTGCAGGAGCAGGAGCCGGAGCCGGAGGAGATTGTACCAGTGGCGCTGAACACTTCAGCGGGATCACTGATCTCCAGCCAAACGGATGGCAACGGCGTGGTGGTGCGTGAGTATCTGGTGGACGAGACCGATGACACTGCGGCCCAGACCATTACGCTGGAGAACGAGACGTACACGATTCTCCCGCTGGACATTGAGGGCGAGCAGCTGGCGGATGAGACGGCGGCGGTGGGAGTCAAGCCCGAGGGCAAAAAGGAGGAAGGCGTGAAGGTCTCGCCGGTGGTCAAGAAGGAGAAGCGCAAATCGTTGGCCGCCAGCCTGGCGGCTGCCATTGCTGATAATCTGGAGGAGGAGCCGTCGAGCGAGGACGATGCCAGCGGCGGCGAAGTCCTGACCGAGGAGGACCTCAAGCTCAAGGAGAACATTGGCAAGCTGATCGACATGCTGGTGGATCCGCCCATCCTAAAGAAATATGGCTGGCCCAACGCCCCCGAGGAGACGGTGCTCTGCAAGGTGATCGAGAACTGCGGCTACGACCTGGTTAAGGGTGGCGAGAACTACGCGGAGTTGGACTATGGCAGCCGGATGCGCGAGTACTGCAAGCTGCTCTTCACCGTCGTCATACACAACGACTCCATCAAGTCGCTGCTGAACAACTTTCCCATCGACGACGTCATCGAGTACGTGCTGGGCGATGAGGATCAGGAGGATGGCGGCGGGCTGGGATGCAAGGGCAAGGACGCCGACGAAGAAGAGCCGGAAGAGGGGGAAAGCAGTCCAGCGAAGAAAGCCGAGAAAGCAGAGACAATCACAGGCGATCCGGAGTCTGAGGAGGAAACGGTCGGTAAGGAAAAGGACACAGCTGAAATCGAAGGAAAGAAGGCTCCTGTTTAG
Protein Sequence
MSAAKEGKDKKGGVKILGVENVSPPKDTSRPATRMKLLNEAAAAGATASPSVSPTKTEKRNSGGGSRIKILNDEALGLPKTEKRGSLSKTSPRNNTTTTSTSVKILNVKRPATATAVTPLETKVRASPGKKQKMDHYVLQAVKLENSKQQAVTTAHRAATSEHDETETIAFILAEDDEVVPGTLERTNGQEIVVTEGDEDEEDDDGVEADKSEGGKGGIKEIVEHVCGKCYKTFRRIKSLTKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFCDFPCSICNANLRSEALLKLHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSACSANETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVMKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCEKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCEECGKSFIQATQLRTHSKTHVRPFGCDQCEEKFKTQKQLERHVKEHSSQKRPVFSCTECKRNFRSTAQLKEHMDVGVHTPKPTRAVKRSPTKVMERTDCAICDKNFDSCDTLRRHIRTVHECDPDDIFGVDPQTAKRGKRAKLATAELQEQEPEPEEIVPVALNTSAGSLISSQTDGNGVVVREYLVDETDDTAAQTITLENETYTILPLDIEGEQLADETAAVGVKPEGKKEEGVKVSPVVKKEKRKSLAASLAAAIADNLEEEPSSEDDASGGEVLTEEDLKLKENIGKLIDMLVDPPILKKYGWPNAPEETVLCKVIENCGYDLVKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQEDGGGLGCKGKDADEEEPEEGESSPAKKAEKAETITGDPESEEETVGKEKDTAEIEGKKAPV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00612944;
90% Identity
iTF_00483105;
80% Identity
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