Drub010947.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila rubida
Gene Symbol
gprs
Assembly
GCA_035046165.1
Location
JAWNOF010000022.1:9184293-9190909[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-07 3.4e-05 23.8 0.0 9 45 38 75 31 94 0.81
2 2 5.4e-10 1.2e-07 31.7 0.0 48 106 127 184 114 187 0.89

Sequence Information

Coding Sequence
ATGCCCGAGGCATTGATACTACCCGGCATGGCTGACGCAGAGCCGGACCTATCCACGTTCGAGAATAAAACTGGACTCGCCGAGGACATGAAGTTCCTGGCGTCCATGCCCGAGCTATGTGACGTTACCTTCCTCGTCGGCGACACCCGCGAGCCAGTCTGTGCCGTCaagGCTGTGCTTGCGTCGCGTTCCCGCGTCTTTGCCAAAATGCTCTACGCTGCCCCGTCGCCGCAGCGGAAGCGGGAGACCACCACCAAGGAGAACAAGCTGCGGCTCTTCCTCAAACGCTCCTCGGAGCCCCTGCTGAATCTACAGAATGCGGCACAACAGAGAACCGGTTTCACCCAACAATTAGCTCCGATACCCGAGCCCTCGGGTCAGCAGCACCAAACGCTGATCATCGAGGAGTTCGAGCCGGATGTCTTCCGCCAGCTCATTGAGTACATCCACACGGGCTGTGTGACCTTGCAACCTCGCACTCTCTTAGGGGTGATGAATGCTGCCGATTACTACGGCCTGGAGGAGCTGCGACGTGCCTGCGCCGGCTTCGTGCAGTGCTGCATCAATGTGGACactgtgtgtgctctgctggCCTCCGCGGAGCGCTACATTCAGTACAAGTGCACGAAGACCCTGGTGCAGAAGGTGCTCGAATTCGTGGACGAGCACGGCAACGAGGTGCTCAATCTGGGCAGCTtcacgctgctgccgcagcatGTGGTGCGTCTGATACTGGCCCGGGAGGAGCTGCGCGCCGACGAGTTCACCAAGTTTCAGGCGGCGCTGATGTGGAGTAAGAAGTACTACGACAACAATCCAAACATTGACATCAAGGAGATACTGGGCACGTTCCTGGAGTATATACAGTTCCACAAGATACCGGCGAATGTGCTGATGCGAGAGATACATCCGCTGAATCTGGTGCCGTATGCAATCATCATGAATGCGCTGGCCTACCAGGCAGACCCAGAAAGCATCGACCCCGGAAAGCTGTCTCCCAACTCTAGCCGACAGCACCGCcatcgccaccaccaccagtcCCTGCCCAAGATACGCAAGGCCAAGTCGCAGTCCTTCCGCACGCGTCGCAGTCCCTCCGAGCGACGCAGTCCCAACGCGCCCGCGCTCACCCTCAACACGAACGCCGCCAACGGCGAGAAAAAGCGCAGTCCCCTCACGCCCAAGAGTCCCGTGCTGCCGGCCCCCGAGTCCAAGAGTCCTGGCAGCAGCTCCCAGAAGACGCCCACATCGCTGTCGCGCCAGGGCACGCTGCGCGCCTCCAGCCGTCGCAAGAACAGCGGTCAGCTGACCATATCGCTGAGCGCGCAGAACCAAGGTCGCCGCAGTCCGGTCGGCCTCAACGATCGCAGTCCGCAGGGCAGACGCAGTCCGCTCTTCCCCAGCAGCGGCCTCAGATCGCCCAACGATCAGCCCAGCCCGACGGCCAGAAGTCCCACAGGCGACTCACAGCGACGGAGTCCGACTTTCAGCATTCAGCTGCACACTCAGGAGCGACGCTCGCCGCTGGGCTCAGTGGCGCCGTCGGACTTCAGCTGCCAGGCAGGCGCGTCGGGCACCCGACGCAGTCCGACGTCGACGGTGCACGTGCAGGACATGGCCACGGAGCCCGAGGAGGCTGGATTCGTTGGCCTCAAGCGCCCGTCGATCAATCTCTTCACGCCCATCTATTTCGCCAGCGAGAAGCGCAGTCCCATGGGCCCCATACCTCCCATAACGGTCTCCAATCCTGCCGAGACGTACAAGAGCGCCGAGCGGGAACGCGAGGCGGCCGAGGCAGCGGCTCGTGAGCGCGAGCGGGAGGCTGCCCAAGCACAGCCGCCGCCAGAGAAGAAGAGCGTGATGCGCGAGATTTTGGCGTTCGTGCGCAAGCCCTCCAAGCACATATCCACGCGCACCAATCGCTTCGCGAATGCATTTACACGCGCTGAGTCTGGTTCGTCCAGCGGCCCGCTGATACGCCAGAGCACGTTCTCCGCCAGTCCGGCGGCCTCGTCGACGGCCGCCAAGAGTGCTGTGCAGAAGCAGATGTCTGAGGTGGGCTTCGAGCCGAAGATGTCGCTGAAGTTCGCCCACTACACCAAGATGTCGCTCAAGCTGCGGCGCTCGGCGCGgcgcgaggaggaggagaagcaacaacaacagcagcagcagcagcaaagggCATCCGCAGTCAACTCGGCGGCTGGCTcgaagcgagcgagcgcggACTCGAATGCAGGCACACAGGATCAGGTAGGTGGATGCGCCGGAGCCGAGGAGGAGCTGCCATTCGAGCTGGCGAATGTGCACTTTGAGAAGGTAGGTGAGTCCTATATCAAGCATGAGCGACTCCGCGAATTGGTCGAGCcagagccggagccggaggcAACCACAGTGGACACACCGGCCGACAACGAGCCCGAGTCAGCGGACGCGGCCATGGCCCAGTTCGTCGAGGAGGTCACCAACTCCCTGAAAGTGGTGGCGCTTAACGGGGAGGCGGGAGGTGTGCCAGTGGTGCACCACTTCACACGCCGCTCGGAGAGCCGCGAGCCGATTGAGCCGCGCATCAGCGAGGAGCGCGAATCGGATTCGAACGATCTGATCATACCCGAAGAGCTGCGCGCGGAGCTCGTAGAGATTTTGAAGGCCTATGCACCAGAGCCAGTTTATGTTAATCTGCAGGCGTTGCGGCGCGAAACGGAcgaggcggaggcggtggcaCGCGCCGTTGcggaagcagctgctgccgttgccgctgccgcggctgccacagctgcagccacagccacagcgacaacCGCAGCGAGTGCAGTGCTACCGCCGCTGCCGGAGAAGCTACCGCTGCAGTGTCCTACTATTGAGTTTGAGCCGCCGTCGCGTCGCTCGTCCTTCGACCCGCCGCGCTCACCGTTCCTGGAGCAGCTGCGCAGTCCGGGCgtcgacaccgacaccgaccTGATCAACCTCCAGCGCCTGGACTCGGGCGGCGACAGCTTCGAGATGGTCGACGGCGACCGCAAGTCGAGTCGCGCCGAGTCCAGCTTCGACTGCCCCTACTCGTCGCGCGACACCAGCTTCGATGTGTCGATCTCGCGCTACCAGTCCACCAGCTACGAGGATCAGACCTCCAGCTTTGAGATCGTCGACACGGACGATCGGCGGCGTCACATCGATCTGCGCAAGAGCTCCATCGAACTGGTCGATGCGGAGACCTTCCAGCGTTCCGGCTCCTCCTGTGGCCGCAAGTCGTCGCTCGAGACGCACTTCGACTACACGCCTTCGGAGACGAGCGGCGTGACACCCGCTCGCTCCCCCAACTTCCCCATGACCAAGAAGCAGAAGGCCGAACACTTCCGCCAGCTGCACATCTCGCCCTTCAGTGCCTTTTCGCGGGCACGCAGCCCGCTCTCCCAGCAGACCTCCTCGAACTACAGCTCGCGCGACAGCTACGACTCCAGCTCGTCGTATCCGCACGGCCACGAGCCGCAGCGCAGTCCGTACGCTGATCCCAGCAAGAAGCACTTCCCGCTCACCATCAAGCAGCGCGAGGAGGAGGTCAAGACGTTTCTCTGCACCGACCTGCGCTGCGCCTCGATCTTCGAGCCACGGCCCAGCTCGGTGCTCACCCAGCAGCTATCCACGGGCTCGATGTCGACGCCCTCGGCATCTGGTTACAGTGCACCCCGTGTGCCCGGCTGCGCGGtcagtgctgctgttgccatgcCCAGCGGCAGTGGCGTGGGCGGCGCGGGCGGCATGGGAGTTGGCATCACCATCGGTGCTGGGCTCGCGCATGCGAATGCATCGCTCGGCTCCTGCGGCTTctccagcggcagcgagtTCGAGCCGCCATCACCGAGGCGTGCTGCCAGCGCCTCGCCCAAGCACACCTTCACGTTCCGCATCGTGATGAAGAAGGTGGATAGCTCACCGGAAGCCCTCTGCCCCGAACGACATCGCTCGCGCATTATCGATCGCTATCGGCGTCGCGACAGCCGACGCAAGCGCATCCACGATGCGGGCAAGAGCTTCTAG
Protein Sequence
MPEALILPGMADAEPDLSTFENKTGLAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSPQRKRETTTKENKLRLFLKRSSEPLLNLQNAAQQRTGFTQQLAPIPEPSGQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQCCINVDTVCALLASAERYIQYKCTKTLVQKVLEFVDEHGNEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAALMWSKKYYDNNPNIDIKEILGTFLEYIQFHKIPANVLMREIHPLNLVPYAIIMNALAYQADPESIDPGKLSPNSSRQHRHRHHHQSLPKIRKAKSQSFRTRRSPSERRSPNAPALTLNTNAANGEKKRSPLTPKSPVLPAPESKSPGSSSQKTPTSLSRQGTLRASSRRKNSGQLTISLSAQNQGRRSPVGLNDRSPQGRRSPLFPSSGLRSPNDQPSPTARSPTGDSQRRSPTFSIQLHTQERRSPLGSVAPSDFSCQAGASGTRRSPTSTVHVQDMATEPEEAGFVGLKRPSINLFTPIYFASEKRSPMGPIPPITVSNPAETYKSAEREREAAEAAAREREREAAQAQPPPEKKSVMREILAFVRKPSKHISTRTNRFANAFTRAESGSSSGPLIRQSTFSASPAASSTAAKSAVQKQMSEVGFEPKMSLKFAHYTKMSLKLRRSARREEEEKQQQQQQQQQRASAVNSAAGSKRASADSNAGTQDQVGGCAGAEEELPFELANVHFEKVGESYIKHERLRELVEPEPEPEATTVDTPADNEPESADAAMAQFVEEVTNSLKVVALNGEAGGVPVVHHFTRRSESREPIEPRISEERESDSNDLIIPEELRAELVEILKAYAPEPVYVNLQALRRETDEAEAVARAVAEAAAAVAAAAAATAAATATATTAASAVLPPLPEKLPLQCPTIEFEPPSRRSSFDPPRSPFLEQLRSPGVDTDTDLINLQRLDSGGDSFEMVDGDRKSSRAESSFDCPYSSRDTSFDVSISRYQSTSYEDQTSSFEIVDTDDRRRHIDLRKSSIELVDAETFQRSGSSCGRKSSLETHFDYTPSETSGVTPARSPNFPMTKKQKAEHFRQLHISPFSAFSRARSPLSQQTSSNYSSRDSYDSSSSYPHGHEPQRSPYADPSKKHFPLTIKQREEEVKTFLCTDLRCASIFEPRPSSVLTQQLSTGSMSTPSASGYSAPRVPGCAVSAAVAMPSGSGVGGAGGMGVGITIGAGLAHANASLGSCGFSSGSEFEPPSPRRAASASPKHTFTFRIVMKKVDSSPEALCPERHRSRIIDRYRRRDSRRKRIHDAGKSF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00536161; iTF_00577889; iTF_00591073; iTF_00483799; iTF_00501153; iTF_00600420; iTF_00555949; iTF_00480962; iTF_00490882; iTF_01325026; iTF_01327271; iTF_01549666; iTF_01557666; iTF_01570338; iTF_00806070; iTF_00471747; iTF_00552419; iTF_00904835; iTF_00528164; iTF_01556932; iTF_00506981; iTF_00590341; iTF_00531761; iTF_00485251; iTF_00524515; iTF_00478118; iTF_00572008; iTF_00483083; iTF_00525966; iTF_00480272; iTF_00612915; iTF_00609268; iTF_00541175; iTF_00594648; iTF_00613593; iTF_00491612; iTF_00606430; iTF_00901605; iTF_01322757; iTF_01550373; iTF_00485959; iTF_00598978; iTF_00499685; iTF_00596037; iTF_00577159; iTF_00514280; iTF_00616297; iTF_00517099; iTF_00518542; iTF_00542542; iTF_00501907; iTF_00564757; iTF_00557302; iTF_00498263; iTF_00583063; iTF_00513564; iTF_00570495; iTF_00610759; iTF_00565480; iTF_00486665; iTF_00559593; iTF_00516367; iTF_00592489; iTF_00539757; iTF_00596754; iTF_01356233; iTF_00562570; iTF_00917322; iTF_00472459; iTF_00556618; iTF_00553809; iTF_00517835; iTF_00548171; iTF_00617004; iTF_00802956; iTF_01559148; iTF_01554805; iTF_00602701; iTF_00805293; iTF_00537614; iTF_00519265; iTF_00510648; iTF_00579385; iTF_00492335; iTF_00561862; iTF_00489477; iTF_00490181; iTF_00533199; iTF_00593939; iTF_00617756; iTF_00575695; iTF_01319151; iTF_00338512; iTF_00336071; iTF_00336072; iTF_00336885; iTF_00337687; iTF_00339287; iTF_00582352; iTF_00584521; iTF_00583792; iTF_00608549; iTF_00558023; iTF_01554064; iTF_01552552; iTF_01551829; iTF_01548956; iTF_00591793; iTF_00595345; iTF_01559857; iTF_01555507; iTF_00523058; iTF_00587506; iTF_00605682; iTF_00614290; iTF_01321298; iTF_00525267; iTF_00548933; iTF_00522317; iTF_00527411; iTF_00567635; iTF_00541860; iTF_00478830; iTF_00561137; iTF_00598258; iTF_00588953; iTF_00495962; iTF_00470974; iTF_00547455; iTF_00832275; iTF_00553140; iTF_00504789; iTF_00507710; iTF_00555189; iTF_00571268; iTF_00604201; iTF_00503372; iTF_00618517; iTF_00612182; iTF_00523799; iTF_00569077; iTF_00914613; iTF_01324245; iTF_01322033; iTF_01326522; iTF_00482358; iTF_00495233; iTF_00610017; iTF_00496738; iTF_00521509; iTF_00597507; iTF_00593222; iTF_00497516; iTF_00566914; iTF_00558831; iTF_00560401; iTF_00574167; iTF_00619968; iTF_00804503; iTF_00494488; iTF_00538328; iTF_00588248; iTF_00512108; iTF_00529664; iTF_01551096; iTF_00569785; iTF_00604953; iTF_00803705; iTF_00528913; iTF_01319865; iTF_01553337; iTF_01320571; iTF_00508444; iTF_00520732; iTF_00573422; iTF_00509201; iTF_00544596; iTF_00545347; iTF_00586068; iTF_00534682; iTF_00511389; iTF_00498983; iTF_00500423; iTF_00535432; iTF_00543852; iTF_00530365; iTF_00533917; iTF_00585318; iTF_00572701; iTF_00502626; iTF_00568355; iTF_00551686; iTF_00599692; iTF_00473166; iTF_00549651; iTF_00554483; iTF_00520021; iTF_00540469; iTF_00512825; iTF_00479579; iTF_00493755; iTF_00586779; iTF_00611453; iTF_00918269; iTF_00919918; iTF_00916347; iTF_00915455; iTF_01558397; iTF_00488766; iTF_00564030; iTF_00576446; iTF_01556222; iTF_00601919; iTF_00919167; iTF_01327999; iTF_01323496; iTF_01325771; iTF_00493056; iTF_00532480; iTF_00546756; iTF_00506218; iTF_00563276; iTF_00550989; iTF_00531056; iTF_00475318; iTF_00476729; iTF_00509916; iTF_00526681;
90% Identity
iTF_00901605;
80% Identity
-