Drub012601.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila rubida
Gene Symbol
Klhl26
Assembly
GCA_035046165.1
Location
JAWNOF010000023.1:14039077-14041791[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 9.9e-31 2.2e-28 98.4 0.5 1 109 58 165 58 166 0.97
2 2 5.5 1.2e+03 -0.6 0.0 57 77 208 228 193 259 0.62

Sequence Information

Coding Sequence
ATGTCCGCGACCAcggttgccgccgctgccggcgtcgctgcagcaacaccaacaagctcagcagcagccgccgccgcagcagcagcagcagcgacaacaacagcagcagcagcagctgcatcaacagcaacagcaacagctgtggGAGGCGAGAAGAACCTTCTGCTCGGCCTCAACAAGCTGCGCTCGCAGGGCAAGCTGACAGACGTCACGCTCGTCGTGGAGGATCACCGCTTCAAGgcgcaTCGCGTTGTGCTGGCGGCCAGCAGCGACTACTTCTGCGCCATGTTCGCCGACTGTGCCATGATCGAGTCGCGCAAGGAGGAGATCACCTTGTACGGCGTCACGGCACGCGCCATGGGCCGCATCATACTGTACATCTACACATCGCTGCTCGACCTCAACGTGGACAACGTGGAGGAGACGCTGGCCGCGGCCACGCACGTCCAGGTGAAGGAGGTCATCGAGCGCTGCACCGTCTTCCTCGAGCAGAAGATCAGCATGGACAACTGCCTGGCCATCGCCAGCATGGCCGAGATCTATGGCCAGCTAGCGCTGGCGGAGCGCGCCTATCGCTACATCTGTGCCCACTTCAAGGAGTTCGCGGCCAGTGGCGACTTCAAGGACGTCAAGATGGAGCAGCTGCACTTCATACTCTCCAGCAACTATCCGATTGACGTCAGCGAAGTTGAGCTGCTCAATCTGCTCTGCAGCTACGGCcacgaacagcagctggaggagagCGCGCTGCACGAACTCTTGCGCCTCATCCAGTGGCAGCACATTGGCTACGACGAGCTGAAGGCGCTGCGGCATCGCATCGACTACGCCCTGGTCGGCGAGTACCTTTCCAAGTTGCGCGAGAGTCACGGCAGCCAGGAGTCGCATGCCGATGCCGGCTTCGAGCCGGAAGCGGAGCTGGGAGCGGGGCCGGGGCCGGAGCAGGGGCCGACGAACATGCGCGGCATGGAGCTGAGCCTGCTCAAGATCGGCGGCTTCGAGTGGAAGGGTCTGACCAATGAGATTATGTGCTTCTCGCCAACCAAAATGAAGTGGTATGAGTTGACTTCCATACCGCACATCGATCAATGCAACTTCGGCACTGCCGTGCTCAACAACGAGCTGTTCATCGTGGGCGGCGCGTACGATGTCTGTCTGAAGGAGTACATTCATCCGTTCGGCTTCCGCTACTGCCCGCTGCGCGACTCCTGGGTGAGCATCGCGCCCATTCAGCTGGACCGCTGCCGCTTCTCGCTGAACGCGGTGGGCAAGCAGCATCTGTATGCCGTCGGCGGCATCGTGGAGCACGACGACAACTCGGAGGAGGCGCTGCGTCGCATGTCGAACGTCGAGCGCTACGACATCGTGAGCAACACGTGGACGTATATGCCCAGTCTTCAAGAGAATCGCAGCCAGCACGCGGGCGTTGTGGTCGGCGACAAGCTCTACATATCCGGCGGCATCCACTTGGCGAACATACTGTCGAGCATGTGGTGCTTTGATACGAAGAGCGAGCGCTGGCTGGAGCTGGCGCCGATGCCGACGCCGTGCTGTGACCACGTCCTGGTGGCCATCGACAATCGCATCTATGCCTGCGGCGGCTGGCACGAGACGCTGCGGGAGTCGCGTGTGCTCGTCGAGCACATCTATGTGTACGACATCAAGACGAATGCGTGGAGCGTCGAGACGAAGATACCGGCCCCGAAATTCTACTCGGGCGTCACCTCGATGCGGCGCACCATCTTCTTTGTGGGCGGCCTCGACTCGACGGAGTCGATCGATCGCGCCAGCTCCGAGACGATGGCCTACGACCTGGACACGGGCGACTGGTGGCATCGCAAGGACTCCTGGGACACGCCCAACGACGTCTGGGAGTCCACGTGCGCCGCCATCTACGTGCCCAGCTTCGACGCCTAA
Protein Sequence
MSATTVAAAAGVAAATPTSSAAAAAAAAAAATTTAAAAAASTATATAVGGEKNLLLGLNKLRSQGKLTDVTLVVEDHRFKAHRVVLAASSDYFCAMFADCAMIESRKEEITLYGVTARAMGRIILYIYTSLLDLNVDNVEETLAAATHVQVKEVIERCTVFLEQKISMDNCLAIASMAEIYGQLALAERAYRYICAHFKEFAASGDFKDVKMEQLHFILSSNYPIDVSEVELLNLLCSYGHEQQLEESALHELLRLIQWQHIGYDELKALRHRIDYALVGEYLSKLRESHGSQESHADAGFEPEAELGAGPGPEQGPTNMRGMELSLLKIGGFEWKGLTNEIMCFSPTKMKWYELTSIPHIDQCNFGTAVLNNELFIVGGAYDVCLKEYIHPFGFRYCPLRDSWVSIAPIQLDRCRFSLNAVGKQHLYAVGGIVEHDDNSEEALRRMSNVERYDIVSNTWTYMPSLQENRSQHAGVVVGDKLYISGGIHLANILSSMWCFDTKSERWLELAPMPTPCCDHVLVAIDNRIYACGGWHETLRESRVLVEHIYVYDIKTNAWSVETKIPAPKFYSGVTSMRRTIFFVGGLDSTESIDRASSETMAYDLDTGDWWHRKDSWDTPNDVWESTCAAIYVPSFDA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00497473; iTF_00593185; iTF_00576418; iTF_00517060; iTF_00598948; iTF_00607141; iTF_00499654; iTF_00514246; iTF_00482311; iTF_00522247; iTF_00577130; iTF_00596010; iTF_00485931; iTF_00616267; iTF_00558765; iTF_00518511; iTF_00525199; iTF_00560367; iTF_00542512; iTF_00609968; iTF_00501873; iTF_00521457; iTF_00553105; iTF_00564722; iTF_00496691; iTF_00548883; iTF_00597459; iTF_00574132; iTF_00583033; iTF_00495194; iTF_00557274; iTF_00528124; iTF_00566877; iTF_00513534; iTF_00545313; iTF_00519986; iTF_00544563; iTF_00502592; iTF_00570497; iTF_00493026; iTF_00506947; iTF_00519235; iTF_00535395; iTF_00535394; iTF_00552387; iTF_00535396; iTF_00535397; iTF_00498952; iTF_00500392; iTF_00543822; iTF_00511356; iTF_00610723; iTF_00541829; iTF_00546725; iTF_01322725; iTF_00547429; iTF_00559557; iTF_00619941; iTF_01327237; iTF_01556197; iTF_01553301; iTF_01570309; iTF_00506182; iTF_00531019; iTF_00563243; iTF_00616971; iTF_00550958; iTF_00475285; iTF_00526648; iTF_00534650; iTF_00490847; iTF_01323462; iTF_01549640; iTF_01554793; iTF_01559127; iTF_00583754; iTF_00557988; iTF_00608516; iTF_00562540; iTF_00556589; iTF_00472426; iTF_00575661; iTF_01324205; iTF_01325741; iTF_00537582; iTF_00802926; iTF_01356205; iTF_00478799; iTF_00569047; iTF_00470943; iTF_00528879; iTF_00523026; iTF_00587473; iTF_01322001; iTF_00509170; iTF_00520705; iTF_00579346; iTF_00614258; iTF_00832242; iTF_01326482; iTF_00549619; iTF_00551656; iTF_00473133; iTF_00554452; iTF_00540439; iTF_00479547; iTF_00598227; iTF_00588910; iTF_00806067; iTF_00595316; iTF_00601876; iTF_01554036; iTF_01552524; iTF_00561109; iTF_00508406; iTF_00476695; iTF_00493719; iTF_00599657; iTF_00586039; iTF_00512792; iTF_00533880; iTF_00582329; iTF_00585273; iTF_00901573; iTF_00803673; iTF_00805262; iTF_01324985; iTF_00510618; iTF_01327962; iTF_01321259; iTF_00495931; iTF_00532443; iTF_00509884; iTF_01320540; iTF_00538301; iTF_00572669; iTF_01548925; iTF_01556899; iTF_01558373; iTF_01550344; iTF_01559831; iTF_01551800; iTF_01555480; iTF_01551066; iTF_01557628; iTF_00530334;
90% Identity
iTF_00583754; iTF_00556589; iTF_00472426; iTF_00537582; iTF_00587473; iTF_00509170; iTF_00520705; iTF_00595316; iTF_00562540; iTF_00608516; iTF_00557988; iTF_00614258; iTF_00510618;
80% Identity
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