Basic Information

Insect: Drosophila rubida
Gene Symbol: MBD-R2
Assembly: GCA_035046165.1
Location: JAWNOF010000012.1:14718440-14722299[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.9e-23 7.4e-20 70.1 0.1 3 76 444 515 442 516 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.9e-23	7.4e-20	70.1	0.1	3	76	444	515	442	516	0.93

Sequence Information

Coding Sequence: ATGGGACGGCGCTGCTGCGTTCAAGACTGTCCATCGACATCGCGGCTATTGGAGCACCATGGCGTCACTTACCATTCATTTCCCATGGACGCTGTCATACGCGCCATTTGGATAAAAAATTCGCGCATTAGCCTTGATAGACAGATTACGAAGAGTGTACTCGTATGTTCGCGGCATTTTCGTCGCCTCGACTTCAACACCATACGCAATGGAAAATACTTGCTTAAGCCTCGGGTTTTTCCAACTGTTTTCCCGTGGGGCAAGATGGAACCTGCTGAAATTGAGGCCGATCACCGTGCTCTGCAACAAGCTTCAGTTGACGGCGCTGGAACTAGCGGCTCGGCTAACAACTCTACTAGCGAGGAAGTCATCAAGGCAACCGTTGATCAGATTGTTTCTCAAATTCTAGAGGAGACGGCAGAGCGCAAAGCATCAGAAACTACCACAACAGATGTGACAACCAAATCTAAAACAACAGAAGATACAGAATCGGTTAAGGAAGCACCTGAAAGTGAAGCTGCAAAGACTCCAGCTGAATCTGCAAGCAATGATGGTATACCTGAGGATGTCCAGACTCAAGCGGATGCCGCAGATGAACTGCGTGCCACGGCCAATAGCTCCGCATCGCCAGTTTCGACTTCGCCACCTAAATACAGATCGCCTACCAATCTGACCATTGGCGCACGTCTCGAGGCGTTGAGCGTAGACAACGCCTGGCTACCGGCGCGAATTGTTGAGGTTAACCAGGCCGATCAGACGCTGCTCATACGCTTCGAGCGCAACAGCAAGCTGAAGACAACTCCGTCGACTACGGGCGGTTACCAGGAGTGGATCGGCTTCAAATCGGAGCGTTTGCGGCAACGCATCAGCTCGCGAGTGCTGCCCGTTTTTGAGCTTGAGGAGAAATGCATGGCACGTTGGTCAGGACCTCGCAAATTTCCGGGTACCATCAAGAAACTGCTGGGTAATGACACCTATGAGGTGCTCTTCGACGACGGCTACACCAAGAATGTGCGAGCCTTGCATATGGTCAAGTTGCCACGCCAACTCTTGCCCACAAGCGACTCTGCAGGAAGTGATGGAACAGGCACCAGTTCGGCAGCTGGTAGTGGACTTAAACGTCCAAGCACTGGagccacaagcagcaacaagaaaagtaaaataacACCACAACGCAAGGATTGGCCACTGCTGGATATGTCGAATTTAGACTTGGTTGCTTTGGGTCTGCCGGACATTCCACACGATGGCGAATGGACTTGCCATTGGGTCAACGATCAACCCATTGGCACTGAGGGCTTTTTGATTGTGGGCGAGCATCAGAAGCCCACGGTGATTGTGCAGGACTGGCGACTGCCACCTGGCTGGATCAAGCACATGTATCAACGCTCCAATGTGCTCGGCAAATGGGATGTTATACTGGTGTCCCCCAGCGGCAAACGTTTTCGTTCCAAGTCGGATCTTAAGACATTTTTAGAATCACAAGGCCTGGTCTACAATCCAGACATATACGATTTTAGCATCCATCGTCGGCGTGCCAAGGATATAAATGCATATGTGTACACCCATGACTACAGTCCACAGCAGCCAGTAAAGCCCAAGCCGCAGGATGTGTCCCTCGACAGCACAGCAACGTCACAGGACATGAACAGTAGCAAGCTGTcaactgccacgcccacttccACACCTATTTCTACGGTGGCTGCACGTCGCGGAGCAGCTGATGACAGCCAATACATGGAGACGCCAGTGGCTTCTTTGGTGCCACCCGCTGAATTGATGTCGCCATCGCTGCAAACTAAAAGCGCTGAAGTTGTTGGTTCGCCAACTGATACTGCTGAAACTACCACAGGATTGGGCTTGGATGCTCAGGGCGCTGTGCAACTCGAAGATGGTTATGCTTTCATTGGTGGCCTCAAAGTCCAGATAACAGAtaacttgtttgtttgcccacgTGAGGGTTGCGGTAAAACATACCGCAAGGAAGACTTTCTACAGATACACATTCGACATTATCACAAGGAGTTTGCTCAGCATGTCAGTCATTGCCCCAAAATGCAGGAACTGGCTGTCAAGCGTACACATCCCTCTTCGATAGAGCAGGGCGATCAGACCCCCAAGAACCAAATACCAAATCAACAATTCTTCGCCAAGCTGCACCAACAAGATTTACAGCATTCTCGTGGCGCTAAGCGACAACCGGCGGGCACGGATTCATCGCCAACGGCTCCGGAAGCATCACCAATAGTGTCGCCTACTAAGCCGTTGTCCTCACCCAAGGTAGAGACACCAATAACTTCGAAAGTGCCTCCCCCCCAAATTCTTACTGGCGTCCCAGAAGTGAAGCAAATGATTTTGCCACCACCCGAACCTCCAGCAGCTGTTCAAGTTGAACCCACTAAAGTTAGCCCAGCTGATGCCACGCCGTTGGCACCTAATCGATCCTCGAAACGTACTAGGCCTTCATCTAGCAGACGGCAGTCAGGCTCACGTAAAAGCAGCCGACAACGCACTCAGCGTCGCCCCGCTAATGTTTCAACTAACAAAAGTCCTGTGGCAAGTAAATTGCCGTTGGCAGGTGTCGAAAACGAGGATTCTCGACCATTGATTAATACACCAGTGCCAGAGGCTCGCAATGAAGCCAAAAAGCGACGTATAGCTGCCACGCCAGTTGGCTCGCCGGCTATACTTGATGCTGCCTCAACGCCTCCGCATGATCAGGTAGACATAAACGCTGCACTGGctccaccgccaccgccgcctaATCAGACGCCTCAATACATCAAGGAGAACGGGGAACTGATTCGCATTGTGCGCATGCGGCAGGAAGAGatcattaattgcatttgcgagTATGGTGAAGAGGATGGTTTGATGATACAGTGCGAGCTCTGCCTGTGCTGGCAACACGGCGCCTGTAATGGCATAGTCAAGGAGTCGGACGTGCCGGAGAAGTACGTCTGCTATATTTGCCGCAATCCACAGCGTGTACGGGATTCGATGCGCTTTAAGCATGATCAGGATTGGCTTTTCGAGGGCAAACTACCTGTGGCTGGATATCACACGCCTAATCCTCAGGCTTCCAAAAAATGCGAGCTGTTGAagcgctcacacacactgacCGGCAATCTGTTAGACGCAAAGCGTTCCATGCACTCGTTGCAGGTCAAGATTAATATTGCTCGCAATCGCTGTCATCCCAAGCTTTACTTATGGGCAAAGAAATGGGATGAGGATATGACGGAGAACTCGGCTACGCCAGTTAAGCGTCCAAAGACCGAACCATCGGAATGGCCACCAGCGCCGCAACCTGAGGCAGCTATCGATCCTGAAGAATGTCAATACCGTCTGATAGAGCATGTTAAAATTCAGCAATCACTGTTGCTGAATAGACTGAATGACATCGAAGGTGAAATGGATGAACTGGAGAAGGAAGATAATCTAAACGATTATAAGGATGCAAGTATGTCCTCAACCAAAGATGCCCTAGCCACGTTTATCAAAGAGTTGGAGACATTGAAACGCCTTGCAAAACTTAACAAAGTGGTCAACATGAAAAACGCACAGAAGGAacaagaaacagcaacagaaaatcCCCAACTGTAA
Protein Sequence: MGRRCCVQDCPSTSRLLEHHGVTYHSFPMDAVIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMEPAEIEADHRALQQASVDGAGTSGSANNSTSEEVIKATVDQIVSQILEETAERKASETTTTDVTTKSKTTEDTESVKEAPESEAAKTPAESASNDGIPEDVQTQADAADELRATANSSASPVSTSPPKYRSPTNLTIGARLEALSVDNAWLPARIVEVNQADQTLLIRFERNSKLKTTPSTTGGYQEWIGFKSERLRQRISSRVLPVFELEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYTKNVRALHMVKLPRQLLPTSDSAGSDGTGTSSAAGSGLKRPSTGATSSNKKSKITPQRKDWPLLDMSNLDLVALGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKTFLESQGLVYNPDIYDFSIHRRRAKDINAYVYTHDYSPQQPVKPKPQDVSLDSTATSQDMNSSKLSTATPTSTPISTVAARRGAADDSQYMETPVASLVPPAELMSPSLQTKSAEVVGSPTDTAETTTGLGLDAQGAVQLEDGYAFIGGLKVQITDNLFVCPREGCGKTYRKEDFLQIHIRHYHKEFAQHVSHCPKMQELAVKRTHPSSIEQGDQTPKNQIPNQQFFAKLHQQDLQHSRGAKRQPAGTDSSPTAPEASPIVSPTKPLSSPKVETPITSKVPPPQILTGVPEVKQMILPPPEPPAAVQVEPTKVSPADATPLAPNRSSKRTRPSSSRRQSGSRKSSRQRTQRRPANVSTNKSPVASKLPLAGVENEDSRPLINTPVPEARNEAKKRRIAATPVGSPAILDAASTPPHDQVDINAALAPPPPPPNQTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPEKYVCYICRNPQRVRDSMRFKHDQDWLFEGKLPVAGYHTPNPQASKKCELLKRSHTLTGNLLDAKRSMHSLQVKINIARNRCHPKLYLWAKKWDEDMTENSATPVKRPKTEPSEWPPAPQPEAAIDPEECQYRLIEHVKIQQSLLLNRLNDIEGEMDELEKEDNLNDYKDASMSSTKDALATFIKELETLKRLAKLNKVVNMKNAQKEQETATENPQL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00553762;
90% Identity: iTF_00595280;
80% Identity: iTF_00589579;