Basic Information

Gene Symbol
KEAP1_1
Assembly
GCA_018150835.1
Location
JAECWQ010000100.1:1177629-1181939[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.2e-32 5.6e-30 103.7 0.1 4 109 51 154 48 155 0.96

Sequence Information

Coding Sequence
ATGAACGAACACTCTGACAGTTGTTCCCTCTCAACCTCGTGCGGGCGCTTTGACGCTGCGCTTTCCATAGATGAGCACGATGCTACCGATGACGACATGACTTTTTGCATGTCAAATTACGCGAAGGAAGCACTTAAAATGATGTTTATGATGCGCTCTCATGGTATGCTTACGGACGTTGTTCTTGAGGTAAAGAAGGAACTATTTCCCGCTCACAAGGTAGTCTTATCAGCAGCATCGCCTTACTTTAAGGCTATGTTTACTGGTGGCTTAAAGGAGTCGGAGATGTCGCGTGTGCAACTTCAGGGGGTGTGCCCCACGGCAATGGCCCGAATCCTATACTTTATGTACACTGGACAGATTCGTGTAACAGAGGTAACTGTGTGTCAGCTTTTGCCTGCGGCGACAATGTTCCAAGTGCAAAATGTTATTGATGCGTGCTGTGCTTTCCTGGAGCGTCAATTAGATCCAACTAATGCCATAGGTATCGCCAATTTTGCCGAGCAACATGGCTGCATTGAGTTGCAGAAAAAAGCGAACTACTTTATTGAACGGCATTTTATGCAAGTCTGCCAGGAGGAAGAGTTTCTACAACTCTCTGCCTATCAACTAATTGCTCTTATAAGGCGGGACGAGCTGAACGTACAGGAAGAGCGTGAAGTGTATAATGCCGTTCTAAAGTGGGTGAAATACGATGAGGATAACCGACATAGTAAAATGGAGCACATTCTAGGTGCCGTTCGCTGCCAATTTTTGACACCTAACTTCCTTAAAGAACAAATGAAAAATTGCGACGTCCTACGAAAGGTCCCGGCCTGTCGCGAATACCTAGCCAAAATTTTTAAGGACTTAACATTGCACAAATGCCCCGGGGTTAAAGAGCGTACGCCAAACACAACACGCATGATCTTTGTTGCTGGCGGATTTTTCCGGCACTCTTTGGACATACTAGAGGCCTACAATGTCGACGACAAGACCTGGACAACCTTGCCAAACCTGCGCATTCCACGTTCCGGCTTGGGCGCTGCATTTCTCAAAGGAAAATTCTATGCAGTTGGCGGACGGAATAACAACATTGGATCATCTTACGATTCCGACTGGGTTGATCGTTACAGTGCCATAAGCGAAACGTGGCGTCCATGTTCGCCGATGTCTGTGCCGCGCCATCGCGTTGGCGTAGCTGTGATGGATGAGCTAATGTATGCTGTAGGTGGATCAGCAGGCATGGAATATCACAACACAGTAGAGTACTACGATCCAGATCAAGATCGATGGACACTTGTGCAGCCAATGCATTCTAAGCGTTTGGGTGTTGGTGTTGTAGTTGTTAATCGCCTTCTCTATGCAATTGGAGGCTTTGACGGTAACGAACGTTTAGCCAGCGTGGAGTGTTATCATCCTGAAAACAATGAATGGAGTTACTTACCTCCCTTGAAAACTGGTCGCAGTGGTGCAGGTGTTGCGGCGATTAATCAATACATATATGTTGTGGGTGGATTTGATGGCACACGTCAACTAGCTACTGTAGAACGCTATGACACTGACAACGAAATATGGGATATGGTTGCACCAATTCAAATCGCCAGAAGTGCGTTGTCACTCACTCCACTTGATGGAAAGCTGTATGCGATTGGAGGTTTTGACGGCAACAATTTTCTGTCCATTGTTGAAGTATACGATCCCCGCACAAACACTTGGGAGCAGGGCACACCTTTAAAGTCGGGCCGTTCCGGACATGCTTCTGCGGTTATATATCAGCCATCTTGCGCCACTACATTCATGGACTACGAAGAAAGTGAGGTTCCAAAACGTGATGGCAGCAATGGTGAAATGCACACCGAATTGCCGCACGATCCTTGTGGAAGTAGGAGTCCAAACTTTTGTGGCATAACATCCAACATGCAATTCCATGCATCCTACGGTTCCGGGGGATGCCACAATTGTGAATCAGACATTAAAGTCAAGCCAATAACAGGATTATGTGATGAAAACATGAACCGCTCAGGTCGATTGCGCAAGATAAGACTGTCAGAAAACAGTTTTGACCATATGGAGTCAAGAGCTTGCCAGTTGTCAGATCCTTTGCTTCGAACGTCAACAGCTGATTGCGCCACAAGCCATTCATCCAATGGTCACATGATGCTTACTAATCAAAGCAATGCTCGCGAGCGTTGTTTATTGCGTCCAGTGTGCACAGCCATGCAAAACATGATACATAAGGGGTTTGAATGGCGCTTTAGAAAGTTCACAGCAGCCTCATGA
Protein Sequence
MNEHSDSCSLSTSCGRFDAALSIDEHDATDDDMTFCMSNYAKEALKMMFMMRSHGMLTDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESEMSRVQLQGVCPTAMARILYFMYTGQIRVTEVTVCQLLPAATMFQVQNVIDACCAFLERQLDPTNAIGIANFAEQHGCIELQKKANYFIERHFMQVCQEEEFLQLSAYQLIALIRRDELNVQEEREVYNAVLKWVKYDEDNRHSKMEHILGAVRCQFLTPNFLKEQMKNCDVLRKVPACREYLAKIFKDLTLHKCPGVKERTPNTTRMIFVAGGFFRHSLDILEAYNVDDKTWTTLPNLRIPRSGLGAAFLKGKFYAVGGRNNNIGSSYDSDWVDRYSAISETWRPCSPMSVPRHRVGVAVMDELMYAVGGSAGMEYHNTVEYYDPDQDRWTLVQPMHSKRLGVGVVVVNRLLYAIGGFDGNERLASVECYHPENNEWSYLPPLKTGRSGAGVAAINQYIYVVGGFDGTRQLATVERYDTDNEIWDMVAPIQIARSALSLTPLDGKLYAIGGFDGNNFLSIVEVYDPRTNTWEQGTPLKSGRSGHASAVIYQPSCATTFMDYEESEVPKRDGSNGEMHTELPHDPCGSRSPNFCGITSNMQFHASYGSGGCHNCESDIKVKPITGLCDENMNRSGRLRKIRLSENSFDHMESRACQLSDPLLRTSTADCATSHSSNGHMMLTNQSNARERCLLRPVCTAMQNMIHKGFEWRFRKFTAAS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01550337; iTF_01559821; iTF_01551792; iTF_01551061; iTF_01548918; iTF_01557623; iTF_01558360; iTF_00598941; iTF_00533866; iTF_01554767; iTF_01553328; iTF_00806034; iTF_00506933; iTF_01559100; iTF_00802911; iTF_01549632; iTF_00575651; iTF_01325731; iTF_01552515; iTF_01554026; iTF_00599652; iTF_00516329; iTF_00519981; iTF_00544558; iTF_00476688; iTF_00540432; iTF_00586740; iTF_00545308; iTF_00568316; iTF_00559551; iTF_01356197; iTF_00528870; iTF_01321254; iTF_00543809; iTF_00616257; iTF_00518499; iTF_00548867; iTF_00525189; iTF_00542501; iTF_00498214; iTF_00501865; iTF_00521417; iTF_00553097; iTF_00511338; iTF_00564714; iTF_00583022; iTF_00535375; iTF_00500370; iTF_00552370; iTF_00597426; iTF_00513523; iTF_00557267; iTF_00496663; iTF_00498936; iTF_00522233; iTF_00570457; iTF_00576409; iTF_00499642; iTF_00595997; iTF_00514238; iTF_00577118; iTF_00485920; iTF_00523016; iTF_00612136; iTF_00618473; iTF_00555149; iTF_00523758; iTF_00571219; iTF_00503328; iTF_00604160; iTF_00537573; iTF_00510609; iTF_00600379; iTF_00359522; iTF_00555909; iTF_00483756; iTF_00501108; iTF_00577845; iTF_00591031; iTF_00832233; iTF_01364009; iTF_00804458; iTF_00061201; iTF_00062016; iTF_00493014; iTF_00601867; iTF_00601866; iTF_00549612; iTF_00551650; iTF_00479541; iTF_00586029; iTF_00803663; iTF_00805252; iTF_01324975; iTF_01555473; iTF_00538290; iTF_00475277; iTF_00534642; iTF_01327956; iTF_00495924; iTF_00579340; iTF_00607125; iTF_00495173; iTF_00566854; iTF_00558730; iTF_00593163; iTF_00497452; iTF_00528113; iTF_00482297; iTF_00560347; iTF_00609947; iTF_00619899; iTF_00574112; iTF_00470935; iTF_00478792; iTF_00569039; iTF_00519225; iTF_01556185; iTF_00610714; iTF_01320530; iTF_00901564; iTF_01323452; iTF_01556893; iTF_01319102; iTF_01327230; iTF_00583743; iTF_00584480;
90% Identity
-
80% Identity
-